Incidental Mutation 'R0234:Ccni'
ID 59021
Institutional Source Beutler Lab
Gene Symbol Ccni
Ensembl Gene ENSMUSG00000063015
Gene Name cyclin I
Synonyms
MMRRC Submission 038475-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0234 (G1)
Quality Score 138
Status Not validated
Chromosome 5
Chromosomal Location 93329792-93354354 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 93350186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 31 (V31A)
Ref Sequence ENSEMBL: ENSMUSP00000116224 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031330] [ENSMUST00000058550] [ENSMUST00000144514] [ENSMUST00000151568]
AlphaFold Q9Z2V9
Predicted Effect probably benign
Transcript: ENSMUST00000031330
Predicted Effect probably benign
Transcript: ENSMUST00000058550
AA Change: V31A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000050189
Gene: ENSMUSG00000063015
AA Change: V31A

DomainStartEndE-ValueType
CYCLIN 50 136 1.18e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000144514
AA Change: V31A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000122434
Gene: ENSMUSG00000063015
AA Change: V31A

DomainStartEndE-ValueType
Pfam:Cyclin_N 14 81 2.1e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000151568
AA Change: V31A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000116224
Gene: ENSMUSG00000063015
AA Change: V31A

DomainStartEndE-ValueType
CYCLIN 50 136 1.18e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201993
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted null mutation are viable and fertile and do not display any gross physical or behavioral abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A3galt2 A G 4: 128,660,941 (GRCm39) R197G possibly damaging Het
Acacb A T 5: 114,347,878 (GRCm39) H983L probably damaging Het
Adal T A 2: 120,978,798 (GRCm39) D139E probably benign Het
Adam6b G A 12: 113,454,230 (GRCm39) R349H probably damaging Het
Agap1 A G 1: 89,598,934 (GRCm39) K331E probably damaging Het
Alyref T C 11: 120,489,133 (GRCm39) D11G probably damaging Het
B3gat1 A G 9: 26,667,377 (GRCm39) E203G probably damaging Het
Bsn T C 9: 107,993,595 (GRCm39) E719G possibly damaging Het
Cap2 G C 13: 46,791,498 (GRCm39) probably null Het
Cdcp3 T A 7: 130,796,032 (GRCm39) probably null Het
Cfap54 A T 10: 92,735,022 (GRCm39) L2343* probably null Het
Clns1a T A 7: 97,363,239 (GRCm39) Y204N possibly damaging Het
Cox11 C T 11: 90,535,326 (GRCm39) T259I probably damaging Het
Dsp A G 13: 38,371,869 (GRCm39) N940S probably benign Het
Erbb2 T C 11: 98,327,265 (GRCm39) V1181A probably benign Het
Exoc4 T C 6: 33,839,022 (GRCm39) V686A possibly damaging Het
F830045P16Rik A G 2: 129,305,384 (GRCm39) V330A possibly damaging Het
Fbf1 A C 11: 116,045,860 (GRCm39) F245V probably damaging Het
Fut10 T A 8: 31,726,225 (GRCm39) F327I probably damaging Het
Galnt1 C T 18: 24,387,690 (GRCm39) P144S probably damaging Het
Garin4 T C 1: 190,895,105 (GRCm39) S513G probably benign Het
Ghrhr A T 6: 55,356,171 (GRCm39) D88V possibly damaging Het
Greb1l T A 18: 10,560,331 (GRCm39) C1864S probably damaging Het
H1f2 T C 13: 23,923,106 (GRCm39) I92T probably benign Het
Hps1 T C 19: 42,750,992 (GRCm39) E336G probably damaging Het
Ibsp GGAAGAAGAAGAAGAAGA GGAAGAAGAAGAAGA 5: 104,457,935 (GRCm39) probably benign Het
Irgc C A 7: 24,132,753 (GRCm39) E21D possibly damaging Het
Itsn1 A T 16: 91,625,168 (GRCm39) R590* probably null Het
Katnip T C 7: 125,394,557 (GRCm39) V211A probably benign Het
Lmln T C 16: 32,886,694 (GRCm39) V67A probably damaging Het
Lsm14a T C 7: 34,065,042 (GRCm39) Q179R probably damaging Het
Ltbr A C 6: 125,289,836 (GRCm39) D119E probably benign Het
Mrc1 A G 2: 14,284,705 (GRCm39) T565A possibly damaging Het
Muc6 A C 7: 141,235,939 (GRCm39) N473K possibly damaging Het
Myocd A T 11: 65,078,066 (GRCm39) D448E probably benign Het
Neil2 T A 14: 63,420,975 (GRCm39) I239F probably damaging Het
Npnt A G 3: 132,620,175 (GRCm39) F123S possibly damaging Het
Or2g25 T A 17: 37,970,997 (GRCm39) I76F probably damaging Het
Or4f15 T C 2: 111,813,645 (GRCm39) Y258C probably damaging Het
Or52x1 C A 7: 104,852,821 (GRCm39) C243F probably damaging Het
Or56a5 T C 7: 104,793,281 (GRCm39) D73G probably damaging Het
Or5d37 T A 2: 87,923,366 (GRCm39) R305* probably null Het
Or8d1b A C 9: 38,887,547 (GRCm39) probably null Het
Or9i2 C T 19: 13,815,902 (GRCm39) V212M possibly damaging Het
Pcnx3 T C 19: 5,722,646 (GRCm39) T941A probably benign Het
Phldb3 G A 7: 24,312,004 (GRCm39) R106Q probably benign Het
Pitrm1 C A 13: 6,625,115 (GRCm39) Y864* probably null Het
Plcb4 T C 2: 135,823,995 (GRCm39) I844T probably benign Het
Plekhg5 T C 4: 152,196,676 (GRCm39) C695R probably damaging Het
Ppp1r3b T A 8: 35,851,655 (GRCm39) F165I probably damaging Het
Prr5 T A 15: 84,587,322 (GRCm39) F357L probably damaging Het
Rasgrf1 A T 9: 89,891,419 (GRCm39) I1046F probably damaging Het
Rbm15b T C 9: 106,762,563 (GRCm39) Y535C probably damaging Het
Rbp3 A T 14: 33,677,858 (GRCm39) E602V probably damaging Het
Rimklb T C 6: 122,433,292 (GRCm39) N343S probably benign Het
Rrp12 A G 19: 41,860,199 (GRCm39) L1008P probably damaging Het
Sec63 C T 10: 42,674,794 (GRCm39) R226C probably damaging Het
Sirpa T C 2: 129,457,388 (GRCm39) V154A probably damaging Het
Slc13a5 C G 11: 72,141,626 (GRCm39) V405L probably damaging Het
Slc17a3 C T 13: 24,039,841 (GRCm39) S293F probably damaging Het
Slc22a23 G A 13: 34,367,244 (GRCm39) T588I probably damaging Het
Slc22a27 C A 19: 7,904,156 (GRCm39) probably benign Het
Slc4a4 A C 5: 89,304,195 (GRCm39) H502P possibly damaging Het
Slc5a5 A T 8: 71,342,277 (GRCm39) M258K probably damaging Het
Spry4 A G 18: 38,723,142 (GRCm39) I207T possibly damaging Het
Stk11ip A G 1: 75,505,711 (GRCm39) D460G possibly damaging Het
Syn3 T A 10: 86,284,750 (GRCm39) I117F possibly damaging Het
Tead4 C T 6: 128,220,365 (GRCm39) A224T probably damaging Het
Tmtc3 A T 10: 100,286,184 (GRCm39) N546K probably benign Het
Tnn T A 1: 159,916,036 (GRCm39) H1227L probably damaging Het
Tor2a G A 2: 32,648,716 (GRCm39) G62D probably damaging Het
Trf T C 9: 103,104,078 (GRCm39) probably null Het
Ubr5 T C 15: 37,968,737 (GRCm39) T2727A probably damaging Het
Vmn2r27 T A 6: 124,208,578 (GRCm39) T56S probably benign Het
Wipf3 T G 6: 54,473,486 (GRCm39) L458R probably damaging Het
Zfp236 T C 18: 82,648,119 (GRCm39) K966R probably damaging Het
Zfp27 T A 7: 29,593,532 (GRCm39) H811L possibly damaging Het
Zfp366 A G 13: 99,370,768 (GRCm39) H496R probably damaging Het
Zfp467 A T 6: 48,415,689 (GRCm39) V321E probably damaging Het
Other mutations in Ccni
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02301:Ccni APN 5 93,336,034 (GRCm39) missense possibly damaging 0.77
IGL02545:Ccni APN 5 93,335,636 (GRCm39) missense probably benign 0.01
IGL02865:Ccni APN 5 93,331,195 (GRCm39) missense probably benign 0.04
R0234:Ccni UTSW 5 93,350,186 (GRCm39) missense probably benign 0.02
R0541:Ccni UTSW 5 93,335,563 (GRCm39) missense probably benign 0.00
R0718:Ccni UTSW 5 93,350,175 (GRCm39) missense probably benign 0.00
R0760:Ccni UTSW 5 93,331,188 (GRCm39) missense possibly damaging 0.89
R1656:Ccni UTSW 5 93,335,933 (GRCm39) splice site probably null
R1752:Ccni UTSW 5 93,350,315 (GRCm39) start gained probably benign
R1817:Ccni UTSW 5 93,335,967 (GRCm39) missense possibly damaging 0.89
R3551:Ccni UTSW 5 93,335,620 (GRCm39) missense probably benign 0.05
R3552:Ccni UTSW 5 93,335,620 (GRCm39) missense probably benign 0.05
R3956:Ccni UTSW 5 93,331,263 (GRCm39) missense probably damaging 1.00
R4809:Ccni UTSW 5 93,335,429 (GRCm39) intron probably benign
R4901:Ccni UTSW 5 93,331,003 (GRCm39) missense probably damaging 1.00
R4937:Ccni UTSW 5 93,336,113 (GRCm39) splice site probably null
R4975:Ccni UTSW 5 93,335,553 (GRCm39) missense possibly damaging 0.83
R7120:Ccni UTSW 5 93,331,190 (GRCm39) nonsense probably null
R8923:Ccni UTSW 5 93,335,943 (GRCm39) missense probably damaging 1.00
R9697:Ccni UTSW 5 93,350,201 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTAAACGAGCCttttgcttccttga -3'
(R):5'- TCCCTTAAAGCAGTCTTCACCCTCA -3'

Sequencing Primer
(F):5'- tccatctaatactggccttgaac -3'
(R):5'- GAGCTATAAAATCGTATACTGCCTC -3'
Posted On 2013-07-11