Incidental Mutation 'R0240:Sdk1'
| ID |
59304 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sdk1
|
| Ensembl Gene |
ENSMUSG00000039683 |
| Gene Name |
sidekick cell adhesion molecule 1 |
| Synonyms |
6720466O15Rik |
| MMRRC Submission |
038478-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R0240 (G1)
|
| Quality Score |
141 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
141227245-142201341 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 141984502 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 696
(W696R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000082928
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074546]
[ENSMUST00000085774]
|
| AlphaFold |
Q3UH53 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000074546
AA Change: W436R
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000074133
Gene: ENSMUSG00000039683
AA Change: W436R
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
28 |
91 |
4.67e-4 |
SMART |
|
IGc2
|
121 |
187 |
1.45e-9 |
SMART |
|
IGc2
|
214 |
282 |
1.58e-10 |
SMART |
|
IG
|
302 |
387 |
1.8e-5 |
SMART |
|
FN3
|
390 |
474 |
7.39e-14 |
SMART |
|
FN3
|
490 |
576 |
8.96e-13 |
SMART |
|
FN3
|
591 |
679 |
1.95e-4 |
SMART |
|
FN3
|
694 |
776 |
2e-10 |
SMART |
|
FN3
|
792 |
879 |
4.22e-9 |
SMART |
|
FN3
|
896 |
983 |
1.41e-10 |
SMART |
|
FN3
|
999 |
1084 |
2.7e-7 |
SMART |
|
FN3
|
1100 |
1183 |
1.3e-9 |
SMART |
|
FN3
|
1199 |
1284 |
2.19e-7 |
SMART |
|
FN3
|
1300 |
1408 |
5.73e-11 |
SMART |
|
FN3
|
1424 |
1509 |
1.79e-12 |
SMART |
|
FN3
|
1524 |
1611 |
1.16e-11 |
SMART |
|
FN3
|
1625 |
1709 |
1.32e-10 |
SMART |
|
transmembrane domain
|
1730 |
1752 |
N/A |
INTRINSIC |
|
low complexity region
|
1806 |
1815 |
N/A |
INTRINSIC |
|
low complexity region
|
1846 |
1858 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000085774
AA Change: W696R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000082928
Gene: ENSMUSG00000039683
AA Change: W696R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
80 |
N/A |
INTRINSIC |
|
IGc2
|
99 |
158 |
2.77e-6 |
SMART |
|
IG
|
179 |
264 |
3.74e-3 |
SMART |
|
IGc2
|
288 |
351 |
4.67e-4 |
SMART |
|
IGc2
|
381 |
447 |
1.45e-9 |
SMART |
|
IGc2
|
474 |
542 |
1.58e-10 |
SMART |
|
IG
|
562 |
647 |
1.8e-5 |
SMART |
|
FN3
|
650 |
734 |
7.39e-14 |
SMART |
|
FN3
|
750 |
836 |
8.96e-13 |
SMART |
|
FN3
|
851 |
939 |
1.95e-4 |
SMART |
|
FN3
|
954 |
1036 |
2e-10 |
SMART |
|
FN3
|
1052 |
1139 |
4.22e-9 |
SMART |
|
FN3
|
1156 |
1243 |
1.41e-10 |
SMART |
|
FN3
|
1259 |
1344 |
2.7e-7 |
SMART |
|
FN3
|
1360 |
1443 |
1.3e-9 |
SMART |
|
FN3
|
1459 |
1544 |
2.19e-7 |
SMART |
|
FN3
|
1560 |
1668 |
5.73e-11 |
SMART |
|
FN3
|
1684 |
1769 |
1.79e-12 |
SMART |
|
FN3
|
1784 |
1871 |
1.16e-11 |
SMART |
|
FN3
|
1885 |
1969 |
1.32e-10 |
SMART |
|
transmembrane domain
|
1990 |
2012 |
N/A |
INTRINSIC |
|
low complexity region
|
2066 |
2075 |
N/A |
INTRINSIC |
|
low complexity region
|
2106 |
2118 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.7657 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.3%
|
| Validation Efficiency |
100% (112/112) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 110 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsf3 |
T |
C |
8: 123,506,920 (GRCm39) |
L71P |
probably damaging |
Het |
| Adamts2 |
A |
T |
11: 50,666,201 (GRCm39) |
D399V |
probably damaging |
Het |
| Adck2 |
T |
A |
6: 39,560,752 (GRCm39) |
V380E |
probably benign |
Het |
| Alg11 |
T |
A |
8: 22,555,468 (GRCm39) |
V243D |
possibly damaging |
Het |
| Ankrd27 |
T |
A |
7: 35,318,864 (GRCm39) |
L585Q |
probably damaging |
Het |
| Armh4 |
A |
G |
14: 50,005,859 (GRCm39) |
|
probably benign |
Het |
| Atp7a |
T |
A |
X: 105,153,447 (GRCm39) |
N1117K |
probably damaging |
Het |
| Bltp3a |
T |
A |
17: 28,114,844 (GRCm39) |
|
probably benign |
Het |
| Cacna1b |
G |
A |
2: 24,528,669 (GRCm39) |
|
probably benign |
Het |
| Cacna1d |
T |
A |
14: 29,818,926 (GRCm39) |
M1210L |
probably benign |
Het |
| Cacna1s |
T |
C |
1: 136,001,234 (GRCm39) |
|
probably benign |
Het |
| Chd7 |
T |
C |
4: 8,852,670 (GRCm39) |
|
probably benign |
Het |
| Col12a1 |
A |
T |
9: 79,559,315 (GRCm39) |
S1858T |
probably benign |
Het |
| Cotl1 |
C |
T |
8: 120,567,063 (GRCm39) |
W26* |
probably null |
Het |
| Csmd3 |
T |
C |
15: 47,492,635 (GRCm39) |
T3000A |
probably benign |
Het |
| Dcp1a |
T |
A |
14: 30,206,551 (GRCm39) |
|
probably benign |
Het |
| Ddhd2 |
A |
T |
8: 26,229,617 (GRCm39) |
|
probably null |
Het |
| Dnah8 |
T |
C |
17: 30,984,653 (GRCm39) |
I3117T |
probably damaging |
Het |
| Dnm3 |
G |
T |
1: 162,181,194 (GRCm39) |
Q162K |
probably benign |
Het |
| Dpy19l2 |
G |
T |
9: 24,569,876 (GRCm39) |
A359D |
probably damaging |
Het |
| Ece1 |
T |
A |
4: 137,676,746 (GRCm39) |
|
probably benign |
Het |
| Eif4g3 |
A |
G |
4: 137,897,873 (GRCm39) |
K1025R |
probably damaging |
Het |
| Eml2 |
C |
A |
7: 18,918,797 (GRCm39) |
Y82* |
probably null |
Het |
| Eml6 |
A |
G |
11: 29,742,367 (GRCm39) |
V1057A |
possibly damaging |
Het |
| Eral1 |
A |
G |
11: 77,966,884 (GRCm39) |
|
probably benign |
Het |
| Espl1 |
T |
C |
15: 102,220,976 (GRCm39) |
S911P |
probably benign |
Het |
| Fbxo8 |
A |
G |
8: 57,043,296 (GRCm39) |
|
probably benign |
Het |
| Flrt1 |
A |
T |
19: 7,074,475 (GRCm39) |
|
probably benign |
Het |
| Fndc7 |
A |
G |
3: 108,766,235 (GRCm39) |
|
probably benign |
Het |
| G3bp1 |
G |
A |
11: 55,382,854 (GRCm39) |
G139D |
probably damaging |
Het |
| Gabra6 |
C |
T |
11: 42,205,774 (GRCm39) |
V351I |
probably benign |
Het |
| Galc |
A |
T |
12: 98,218,293 (GRCm39) |
H186Q |
probably damaging |
Het |
| Ganab |
A |
G |
19: 8,890,177 (GRCm39) |
D702G |
possibly damaging |
Het |
| Hdac10 |
T |
C |
15: 89,010,085 (GRCm39) |
E291G |
possibly damaging |
Het |
| Hectd3 |
T |
G |
4: 116,859,810 (GRCm39) |
V749G |
probably damaging |
Het |
| Kash5 |
C |
T |
7: 44,849,675 (GRCm39) |
A83T |
probably benign |
Het |
| Kcnh1 |
T |
A |
1: 192,187,648 (GRCm39) |
I703N |
probably benign |
Het |
| Kcnma1 |
G |
A |
14: 23,544,647 (GRCm39) |
T505I |
probably damaging |
Het |
| Kctd11 |
A |
G |
11: 69,770,640 (GRCm39) |
C133R |
probably damaging |
Het |
| Lama3 |
A |
T |
18: 12,672,880 (GRCm39) |
|
probably null |
Het |
| Lamb3 |
T |
C |
1: 193,017,335 (GRCm39) |
L842P |
probably damaging |
Het |
| Ldlr |
T |
C |
9: 21,649,295 (GRCm39) |
|
probably benign |
Het |
| Lipk |
G |
A |
19: 34,024,210 (GRCm39) |
R336H |
probably benign |
Het |
| Lrrc24 |
T |
A |
15: 76,607,409 (GRCm39) |
D58V |
probably damaging |
Het |
| Lrsam1 |
A |
G |
2: 32,845,197 (GRCm39) |
L106P |
probably damaging |
Het |
| Milr1 |
G |
A |
11: 106,645,722 (GRCm39) |
W88* |
probably null |
Het |
| Mmp10 |
A |
G |
9: 7,506,544 (GRCm39) |
D340G |
probably damaging |
Het |
| Mybpc1 |
T |
A |
10: 88,391,600 (GRCm39) |
Y285F |
possibly damaging |
Het |
| Ncoa3 |
A |
G |
2: 165,896,320 (GRCm39) |
T408A |
probably benign |
Het |
| Nefm |
T |
A |
14: 68,358,583 (GRCm39) |
K484* |
probably null |
Het |
| Nfasc |
A |
G |
1: 132,529,721 (GRCm39) |
S814P |
probably damaging |
Het |
| Nlrp4a |
T |
C |
7: 26,161,941 (GRCm39) |
V863A |
probably benign |
Het |
| Nos1 |
C |
T |
5: 118,005,948 (GRCm39) |
P223S |
probably benign |
Het |
| Nr2f2 |
G |
C |
7: 70,009,923 (GRCm39) |
P52R |
probably damaging |
Het |
| Or13c7 |
T |
A |
4: 43,854,512 (GRCm39) |
S68T |
probably damaging |
Het |
| Or4c108 |
A |
T |
2: 88,803,740 (GRCm39) |
L165Q |
probably damaging |
Het |
| Or5an6 |
A |
T |
19: 12,372,327 (GRCm39) |
E233D |
probably benign |
Het |
| Or8k41 |
A |
G |
2: 86,313,730 (GRCm39) |
S119P |
possibly damaging |
Het |
| Osbpl5 |
T |
C |
7: 143,295,406 (GRCm39) |
|
probably null |
Het |
| Otog |
C |
A |
7: 45,913,456 (GRCm39) |
|
probably null |
Het |
| Pacs1 |
A |
T |
19: 5,206,402 (GRCm39) |
I261N |
possibly damaging |
Het |
| Pbx1 |
G |
A |
1: 168,031,051 (GRCm39) |
T189I |
possibly damaging |
Het |
| Pcnx1 |
T |
C |
12: 81,993,792 (GRCm39) |
I908T |
possibly damaging |
Het |
| Pdxdc1 |
A |
T |
16: 13,697,309 (GRCm39) |
W124R |
probably damaging |
Het |
| Phex |
C |
A |
X: 155,969,214 (GRCm39) |
D587Y |
probably damaging |
Het |
| Plcb3 |
A |
T |
19: 6,940,363 (GRCm39) |
D435E |
probably benign |
Het |
| Plce1 |
A |
C |
19: 38,717,330 (GRCm39) |
K1373T |
probably damaging |
Het |
| Prkcd |
G |
A |
14: 30,324,045 (GRCm39) |
A311V |
probably damaging |
Het |
| Ptpn3 |
A |
T |
4: 57,232,374 (GRCm39) |
S421T |
probably benign |
Het |
| Ptprs |
T |
C |
17: 56,743,087 (GRCm39) |
|
probably null |
Het |
| Qrich1 |
A |
G |
9: 108,411,333 (GRCm39) |
D286G |
probably damaging |
Het |
| Rcc1 |
C |
A |
4: 132,060,226 (GRCm39) |
G393V |
probably damaging |
Het |
| Reln |
T |
C |
5: 22,311,043 (GRCm39) |
N290S |
probably benign |
Het |
| Rgl1 |
T |
C |
1: 152,430,175 (GRCm39) |
|
probably benign |
Het |
| Rhpn1 |
C |
T |
15: 75,585,971 (GRCm39) |
T628I |
probably benign |
Het |
| Rilp |
A |
G |
11: 75,401,747 (GRCm39) |
R176G |
probably benign |
Het |
| Riok3 |
C |
T |
18: 12,288,284 (GRCm39) |
A487V |
probably benign |
Het |
| Rnf224 |
T |
C |
2: 25,126,219 (GRCm39) |
T45A |
probably damaging |
Het |
| Rpa1 |
A |
G |
11: 75,219,513 (GRCm39) |
V137A |
probably benign |
Het |
| Rps6ka1 |
C |
A |
4: 133,575,842 (GRCm39) |
Q693H |
probably benign |
Het |
| Scn2a |
G |
T |
2: 65,566,118 (GRCm39) |
V1381F |
probably benign |
Het |
| Scp2 |
T |
A |
4: 107,955,275 (GRCm39) |
H112L |
probably benign |
Het |
| Slc26a7 |
C |
A |
4: 14,532,651 (GRCm39) |
V408F |
probably damaging |
Het |
| Slc28a2 |
T |
A |
2: 122,285,008 (GRCm39) |
I332N |
probably benign |
Het |
| Slc37a3 |
A |
G |
6: 39,314,172 (GRCm39) |
V480A |
probably benign |
Het |
| Slc45a4 |
T |
A |
15: 73,453,755 (GRCm39) |
E674D |
probably benign |
Het |
| Smpd3 |
T |
C |
8: 106,991,788 (GRCm39) |
E255G |
probably damaging |
Het |
| Snx29 |
C |
T |
16: 11,478,417 (GRCm39) |
R658W |
probably damaging |
Het |
| Sppl2a |
A |
T |
2: 126,762,256 (GRCm39) |
M275K |
probably benign |
Het |
| Stac |
T |
C |
9: 111,464,089 (GRCm39) |
N59S |
probably damaging |
Het |
| Stk25 |
A |
T |
1: 93,554,782 (GRCm39) |
L131Q |
probably damaging |
Het |
| Tep1 |
C |
T |
14: 51,100,486 (GRCm39) |
|
probably benign |
Het |
| Thbs1 |
C |
A |
2: 117,944,874 (GRCm39) |
N229K |
probably damaging |
Het |
| Tmx2 |
A |
T |
2: 84,506,186 (GRCm39) |
H89Q |
probably damaging |
Het |
| Tnfrsf21 |
C |
T |
17: 43,349,104 (GRCm39) |
H239Y |
probably benign |
Het |
| Tradd |
T |
C |
8: 105,985,924 (GRCm39) |
N209S |
possibly damaging |
Het |
| Trappc3l |
A |
T |
10: 33,974,928 (GRCm39) |
R119* |
probably null |
Het |
| Trmt1l |
G |
A |
1: 151,333,205 (GRCm39) |
|
probably benign |
Het |
| Ublcp1 |
G |
T |
11: 44,349,104 (GRCm39) |
Y243* |
probably null |
Het |
| Usp24 |
C |
A |
4: 106,271,601 (GRCm39) |
C2158* |
probably null |
Het |
| Usp34 |
A |
T |
11: 23,383,206 (GRCm39) |
K2088N |
probably damaging |
Het |
| Vmn1r53 |
G |
C |
6: 90,200,925 (GRCm39) |
S133C |
probably damaging |
Het |
| Vmn2r52 |
A |
G |
7: 9,893,327 (GRCm39) |
V604A |
probably damaging |
Het |
| Vmn2r93 |
A |
G |
17: 18,525,061 (GRCm39) |
K240E |
probably benign |
Het |
| Wdr13 |
T |
G |
X: 7,994,284 (GRCm39) |
D242A |
probably damaging |
Het |
| Wwp1 |
C |
T |
4: 19,641,734 (GRCm39) |
|
probably null |
Het |
| Zan |
G |
A |
5: 137,396,624 (GRCm39) |
H4311Y |
unknown |
Het |
| Zc3h12c |
C |
A |
9: 52,055,383 (GRCm39) |
R123L |
possibly damaging |
Het |
| Zfp125 |
A |
T |
12: 20,950,562 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp318 |
C |
T |
17: 46,707,739 (GRCm39) |
P266S |
probably benign |
Het |
|
| Other mutations in Sdk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00498:Sdk1
|
APN |
5 |
142,071,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00945:Sdk1
|
APN |
5 |
142,070,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00946:Sdk1
|
APN |
5 |
142,070,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01394:Sdk1
|
APN |
5 |
141,598,970 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01398:Sdk1
|
APN |
5 |
141,923,332 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01410:Sdk1
|
APN |
5 |
142,197,875 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01525:Sdk1
|
APN |
5 |
141,985,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01548:Sdk1
|
APN |
5 |
142,071,520 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01672:Sdk1
|
APN |
5 |
142,170,930 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL01676:Sdk1
|
APN |
5 |
142,113,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01679:Sdk1
|
APN |
5 |
142,031,919 (GRCm39) |
missense |
probably benign |
|
|
IGL01929:Sdk1
|
APN |
5 |
141,938,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01970:Sdk1
|
APN |
5 |
142,071,437 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02016:Sdk1
|
APN |
5 |
142,020,184 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02060:Sdk1
|
APN |
5 |
141,938,767 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02457:Sdk1
|
APN |
5 |
141,938,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02634:Sdk1
|
APN |
5 |
141,595,787 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02637:Sdk1
|
APN |
5 |
142,080,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02731:Sdk1
|
APN |
5 |
142,158,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03180:Sdk1
|
APN |
5 |
142,071,497 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03259:Sdk1
|
APN |
5 |
141,938,788 (GRCm39) |
nonsense |
probably null |
|
|
PIT4453001:Sdk1
|
UTSW |
5 |
142,197,793 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4544001:Sdk1
|
UTSW |
5 |
141,941,987 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0149:Sdk1
|
UTSW |
5 |
141,842,809 (GRCm39) |
intron |
probably benign |
|
|
R0173:Sdk1
|
UTSW |
5 |
142,159,564 (GRCm39) |
splice site |
probably benign |
|
|
R0240:Sdk1
|
UTSW |
5 |
141,984,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0242:Sdk1
|
UTSW |
5 |
142,129,677 (GRCm39) |
splice site |
probably benign |
|
|
R0245:Sdk1
|
UTSW |
5 |
141,940,713 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0270:Sdk1
|
UTSW |
5 |
142,070,321 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0398:Sdk1
|
UTSW |
5 |
141,948,476 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0401:Sdk1
|
UTSW |
5 |
142,031,916 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R0501:Sdk1
|
UTSW |
5 |
141,923,473 (GRCm39) |
missense |
probably benign |
|
|
R0558:Sdk1
|
UTSW |
5 |
142,117,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Sdk1
|
UTSW |
5 |
141,940,713 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0834:Sdk1
|
UTSW |
5 |
141,227,779 (GRCm39) |
missense |
probably benign |
|
|
R0962:Sdk1
|
UTSW |
5 |
142,147,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1424:Sdk1
|
UTSW |
5 |
142,147,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1438:Sdk1
|
UTSW |
5 |
142,024,078 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1517:Sdk1
|
UTSW |
5 |
142,113,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1519:Sdk1
|
UTSW |
5 |
141,985,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1539:Sdk1
|
UTSW |
5 |
142,080,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1574:Sdk1
|
UTSW |
5 |
141,984,634 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1574:Sdk1
|
UTSW |
5 |
141,984,634 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1673:Sdk1
|
UTSW |
5 |
141,934,261 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1686:Sdk1
|
UTSW |
5 |
142,020,292 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1806:Sdk1
|
UTSW |
5 |
142,147,681 (GRCm39) |
missense |
probably benign |
|
|
R1806:Sdk1
|
UTSW |
5 |
141,598,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1925:Sdk1
|
UTSW |
5 |
142,171,040 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1956:Sdk1
|
UTSW |
5 |
142,080,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1976:Sdk1
|
UTSW |
5 |
142,129,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Sdk1
|
UTSW |
5 |
142,170,943 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R2152:Sdk1
|
UTSW |
5 |
141,778,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2186:Sdk1
|
UTSW |
5 |
142,032,047 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2187:Sdk1
|
UTSW |
5 |
142,100,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2306:Sdk1
|
UTSW |
5 |
141,948,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2520:Sdk1
|
UTSW |
5 |
142,071,526 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2698:Sdk1
|
UTSW |
5 |
142,197,805 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2763:Sdk1
|
UTSW |
5 |
142,070,306 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3023:Sdk1
|
UTSW |
5 |
142,031,991 (GRCm39) |
missense |
probably benign |
|
|
R3500:Sdk1
|
UTSW |
5 |
141,992,371 (GRCm39) |
splice site |
probably benign |
|
|
R3613:Sdk1
|
UTSW |
5 |
142,105,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3824:Sdk1
|
UTSW |
5 |
141,921,804 (GRCm39) |
missense |
probably benign |
|
|
R3916:Sdk1
|
UTSW |
5 |
142,036,999 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3917:Sdk1
|
UTSW |
5 |
142,036,999 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4158:Sdk1
|
UTSW |
5 |
142,100,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4160:Sdk1
|
UTSW |
5 |
142,100,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4161:Sdk1
|
UTSW |
5 |
142,100,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4386:Sdk1
|
UTSW |
5 |
142,080,381 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4649:Sdk1
|
UTSW |
5 |
141,992,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Sdk1
|
UTSW |
5 |
142,170,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4780:Sdk1
|
UTSW |
5 |
141,944,993 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4787:Sdk1
|
UTSW |
5 |
141,568,168 (GRCm39) |
missense |
probably benign |
|
|
R4825:Sdk1
|
UTSW |
5 |
141,568,049 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4853:Sdk1
|
UTSW |
5 |
142,132,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4857:Sdk1
|
UTSW |
5 |
142,147,531 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4928:Sdk1
|
UTSW |
5 |
141,842,758 (GRCm39) |
intron |
probably benign |
|
|
R5111:Sdk1
|
UTSW |
5 |
142,113,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5188:Sdk1
|
UTSW |
5 |
141,942,015 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5246:Sdk1
|
UTSW |
5 |
142,100,317 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5273:Sdk1
|
UTSW |
5 |
141,984,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5484:Sdk1
|
UTSW |
5 |
142,085,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Sdk1
|
UTSW |
5 |
142,171,020 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5578:Sdk1
|
UTSW |
5 |
141,598,880 (GRCm39) |
nonsense |
probably null |
|
|
R5593:Sdk1
|
UTSW |
5 |
141,941,879 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5654:Sdk1
|
UTSW |
5 |
141,921,853 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5672:Sdk1
|
UTSW |
5 |
142,173,900 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5768:Sdk1
|
UTSW |
5 |
142,129,626 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5781:Sdk1
|
UTSW |
5 |
141,921,803 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5846:Sdk1
|
UTSW |
5 |
142,100,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5851:Sdk1
|
UTSW |
5 |
141,948,424 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6164:Sdk1
|
UTSW |
5 |
142,117,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6235:Sdk1
|
UTSW |
5 |
142,020,181 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6364:Sdk1
|
UTSW |
5 |
141,948,464 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6453:Sdk1
|
UTSW |
5 |
142,082,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6892:Sdk1
|
UTSW |
5 |
142,032,053 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6996:Sdk1
|
UTSW |
5 |
142,197,769 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7003:Sdk1
|
UTSW |
5 |
142,082,489 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7022:Sdk1
|
UTSW |
5 |
142,080,412 (GRCm39) |
splice site |
probably null |
|
|
R7027:Sdk1
|
UTSW |
5 |
142,082,481 (GRCm39) |
splice site |
probably null |
|
|
R7098:Sdk1
|
UTSW |
5 |
142,082,625 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7107:Sdk1
|
UTSW |
5 |
142,067,471 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7203:Sdk1
|
UTSW |
5 |
142,031,931 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7313:Sdk1
|
UTSW |
5 |
141,923,377 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7363:Sdk1
|
UTSW |
5 |
142,173,897 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7375:Sdk1
|
UTSW |
5 |
141,984,598 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7446:Sdk1
|
UTSW |
5 |
142,130,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7527:Sdk1
|
UTSW |
5 |
141,778,731 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7598:Sdk1
|
UTSW |
5 |
141,595,753 (GRCm39) |
nonsense |
probably null |
|
|
R7747:Sdk1
|
UTSW |
5 |
142,070,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Sdk1
|
UTSW |
5 |
141,923,434 (GRCm39) |
missense |
probably benign |
|
|
R7985:Sdk1
|
UTSW |
5 |
142,113,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8129:Sdk1
|
UTSW |
5 |
142,177,648 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8217:Sdk1
|
UTSW |
5 |
142,197,713 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8249:Sdk1
|
UTSW |
5 |
142,173,770 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8376:Sdk1
|
UTSW |
5 |
142,144,376 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8779:Sdk1
|
UTSW |
5 |
141,948,457 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8807:Sdk1
|
UTSW |
5 |
142,071,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8907:Sdk1
|
UTSW |
5 |
142,070,278 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8942:Sdk1
|
UTSW |
5 |
142,082,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8945:Sdk1
|
UTSW |
5 |
141,598,935 (GRCm39) |
missense |
probably benign |
|
|
R9006:Sdk1
|
UTSW |
5 |
141,923,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9249:Sdk1
|
UTSW |
5 |
142,129,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9275:Sdk1
|
UTSW |
5 |
141,941,953 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9345:Sdk1
|
UTSW |
5 |
142,147,708 (GRCm39) |
missense |
probably benign |
|
|
R9463:Sdk1
|
UTSW |
5 |
141,948,548 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9549:Sdk1
|
UTSW |
5 |
141,940,657 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9572:Sdk1
|
UTSW |
5 |
141,595,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9602:Sdk1
|
UTSW |
5 |
142,071,353 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9703:Sdk1
|
UTSW |
5 |
142,100,283 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9720:Sdk1
|
UTSW |
5 |
142,197,796 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9771:Sdk1
|
UTSW |
5 |
142,082,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0017:Sdk1
|
UTSW |
5 |
141,984,535 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Sdk1
|
UTSW |
5 |
141,945,065 (GRCm39) |
missense |
probably null |
0.58 |
|
Z1177:Sdk1
|
UTSW |
5 |
141,948,463 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGGAATAACAGGAGGTTCTGCCCC -3'
(R):5'- TAGGAGGACATCAGGCTCACTCAC -3'
Sequencing Primer
(F):5'- CCCAGATTTAGGGTGAGTCTCC -3'
(R):5'- AGGCTCACTCACCTGCTTG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation