Mutagenetix > Incidental Mutation

Incidental Mutation 'R0241:Tango6'

59491

Institutional Source

Beutler Lab

Gene Symbol

Tango6

Ensembl Gene

ENSMUSG00000041949

Gene Name

transport and golgi organization 6

Synonyms

Tango6, Tmco7

MMRRC Submission

038479-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0241 (G1)

Quality Score

152

Status

Validated

Chromosome

Chromosomal Location

107409700-107578071 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 107473993 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000043953 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048359]

AlphaFold

Q8C3S2

Predicted Effect

probably benign
Transcript: ENSMUST00000048359

SMART Domains

Protein: ENSMUSP00000043953
Gene: ENSMUSG00000041949

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
low complexity region	20	41	N/A	INTRINSIC
low complexity region	102	115	N/A	INTRINSIC
low complexity region	246	259	N/A	INTRINSIC
low complexity region	334	350	N/A	INTRINSIC
low complexity region	472	486	N/A	INTRINSIC
Pfam:RTP1_C1	824	935	1.6e-35	PFAM
low complexity region	998	1013	N/A	INTRINSIC
Pfam:RTP1_C2	1026	1059	7.5e-14	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212764

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.4%
20x: 94.8%

Validation Efficiency

99% (72/73)

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck2	T	A	6: 39,560,752 (GRCm39)	V380E	probably benign	Het
Anapc1	A	T	2: 128,470,549 (GRCm39)	M1527K	possibly damaging	Het
Arfgef3	T	A	10: 18,474,962 (GRCm39)	I1575F	probably damaging	Het
Atp4a	G	T	7: 30,416,560 (GRCm39)	G446C	probably benign	Het
Bicra	A	T	7: 15,709,070 (GRCm39)	M1188K	probably damaging	Het
Brd7	G	A	8: 89,072,478 (GRCm39)	R331W	probably benign	Het
Cactin	A	G	10: 81,158,486 (GRCm39)	T151A	probably benign	Het
Cadps	G	A	14: 12,376,675 (GRCm38)	T1274M	probably damaging	Het
Catsper3	T	C	13: 55,952,667 (GRCm39)	M175T	probably damaging	Het
Chd5	A	G	4: 152,450,589 (GRCm39)	D605G	probably damaging	Het
Chst12	G	A	5: 140,510,054 (GRCm39)	R227H	possibly damaging	Het
Cic	T	A	7: 24,986,565 (GRCm39)	S1299T	probably damaging	Het
Cic	C	A	7: 24,986,566 (GRCm39)	S1299Y	probably damaging	Het
Cimap1d	C	T	10: 79,480,564 (GRCm39)		probably null	Het
Cobl	A	T	11: 12,204,524 (GRCm39)	V644E	probably benign	Het
Ddx31	A	G	2: 28,738,303 (GRCm39)	T155A	probably damaging	Het
Dnah3	T	C	7: 119,521,953 (GRCm39)	Q4069R	probably damaging	Het
Dnah8	T	C	17: 30,984,653 (GRCm39)	I3117T	probably damaging	Het
Doc2b	A	G	11: 75,663,387 (GRCm39)	V355A	probably damaging	Het
Dock10	A	T	1: 80,556,340 (GRCm39)	S578T	probably benign	Het
Duox1	T	C	2: 122,163,878 (GRCm39)		probably benign	Het
Epb41l5	T	C	1: 119,495,509 (GRCm39)		probably null	Het
Fbp2	A	T	13: 63,001,862 (GRCm39)	F118I	probably damaging	Het
Fcer2a	A	G	8: 3,738,796 (GRCm39)		probably null	Het
Fmnl1	G	A	11: 103,072,996 (GRCm39)		probably null	Het
Fry	A	T	5: 150,183,811 (GRCm39)		probably benign	Het
Git2	T	C	5: 114,871,290 (GRCm39)	E208G	probably damaging	Het
Hs6st3	T	C	14: 119,376,232 (GRCm39)	F136L	probably benign	Het
Hydin	G	A	8: 111,124,655 (GRCm39)	V555I	probably benign	Het
Kcns1	A	T	2: 164,010,300 (GRCm39)	I153N	probably damaging	Het
Kmt2b	A	G	7: 30,276,494 (GRCm39)	L1726S	probably damaging	Het
Loxl3	A	G	6: 83,027,114 (GRCm39)	D615G	probably damaging	Het
Negr1	T	A	3: 156,914,036 (GRCm39)		probably benign	Het
Nfasc	C	A	1: 132,564,731 (GRCm39)	A70S	probably benign	Het
Or4d1	T	A	11: 87,804,860 (GRCm39)	N291Y	probably damaging	Het
Or4p21	A	T	2: 88,276,889 (GRCm39)	M131K	possibly damaging	Het
Or52n4	A	G	7: 104,294,450 (GRCm39)	M41T	probably benign	Het
Or5g29	A	G	2: 85,421,154 (GRCm39)	K90R	probably benign	Het
Otud7a	T	C	7: 63,346,992 (GRCm39)		probably benign	Het
Pacs2	T	C	12: 113,032,890 (GRCm39)		probably benign	Het
Pde7b	A	G	10: 20,311,962 (GRCm39)	C239R	probably damaging	Het
Pdzd2	A	T	15: 12,368,027 (GRCm39)	L2654Q	probably damaging	Het
Pgap1	T	C	1: 54,575,110 (GRCm39)		probably null	Het
Proz	T	A	8: 13,115,356 (GRCm39)	M124K	probably benign	Het
Raet1d	A	G	10: 22,247,328 (GRCm39)	T135A	probably benign	Het
Rapgef1	A	G	2: 29,592,682 (GRCm39)	N558S	possibly damaging	Het
Rpl7	C	G	1: 16,173,446 (GRCm39)	G101A	possibly damaging	Het
Sec14l1	G	A	11: 117,037,924 (GRCm39)		probably benign	Het
Sfi1	CCTCTC	CCTCTCTC	11: 3,127,419 (GRCm39)		probably benign	Het
Simc1	G	T	13: 54,698,338 (GRCm39)	L1319F	probably damaging	Het
Sspo	A	G	6: 48,438,429 (GRCm39)	E1499G	possibly damaging	Het
Tas2r118	T	C	6: 23,969,338 (GRCm39)	Y241C	probably damaging	Het
Tbck	A	G	3: 132,430,636 (GRCm39)	E344G	probably benign	Het
Tcam1	G	A	11: 106,174,904 (GRCm39)	E120K	probably benign	Het
Thop1	T	A	10: 80,916,079 (GRCm39)		probably benign	Het
Tmbim7	A	T	5: 3,716,866 (GRCm39)	Y66F	probably benign	Het
Tmc8	C	T	11: 117,677,207 (GRCm39)		probably benign	Het
Tnfrsf19	A	G	14: 61,211,041 (GRCm39)	S216P	possibly damaging	Het
Trappc2l	A	G	8: 123,341,132 (GRCm39)		probably benign	Het
Trim67	A	G	8: 125,549,929 (GRCm39)	R520G	probably damaging	Het
Ubp1	T	A	9: 113,795,655 (GRCm39)		probably null	Het
Vil1	T	C	1: 74,465,853 (GRCm39)	L548P	probably damaging	Het
Wdr3	A	G	3: 100,052,973 (GRCm39)	V593A	probably damaging	Het
Wdr5	A	G	2: 27,423,025 (GRCm39)	Y243C	probably damaging	Het
Zan	T	C	5: 137,420,084 (GRCm39)	T2858A	unknown	Het
Zbtb37	A	T	1: 160,847,939 (GRCm39)	V356E	probably benign	Het
Zfp36	C	T	7: 28,077,759 (GRCm39)	V50I	probably damaging	Het
Zfp563	A	T	17: 33,323,659 (GRCm39)	S85C	possibly damaging	Het

Other mutations in Tango6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00905:Tango6	APN	8	107,469,104 (GRCm39)	critical splice donor site	probably null
IGL00925:Tango6	APN	8	107,422,077 (GRCm39)	splice site	probably benign
IGL00965:Tango6	APN	8	107,468,642 (GRCm39)	splice site	probably benign
IGL01412:Tango6	APN	8	107,545,131 (GRCm39)	missense	probably benign	0.02
IGL02888:Tango6	APN	8	107,447,297 (GRCm39)	missense	probably damaging	1.00
IGL02892:Tango6	APN	8	107,468,642 (GRCm39)	splice site	probably benign
R0494:Tango6	UTSW	8	107,462,314 (GRCm39)	splice site	probably benign
R1127:Tango6	UTSW	8	107,415,527 (GRCm39)	missense	probably benign	0.00
R1440:Tango6	UTSW	8	107,415,671 (GRCm39)	missense	probably damaging	1.00
R1547:Tango6	UTSW	8	107,508,418 (GRCm39)	missense	probably damaging	0.98
R1921:Tango6	UTSW	8	107,415,426 (GRCm39)	missense	probably benign	0.06
R2255:Tango6	UTSW	8	107,415,926 (GRCm39)	critical splice donor site	probably null
R2761:Tango6	UTSW	8	107,425,664 (GRCm39)	missense	possibly damaging	0.93
R4211:Tango6	UTSW	8	107,415,856 (GRCm39)	missense	probably benign	0.02
R4463:Tango6	UTSW	8	107,415,706 (GRCm39)	missense	probably benign	0.29
R4696:Tango6	UTSW	8	107,426,863 (GRCm39)	missense	possibly damaging	0.73
R4867:Tango6	UTSW	8	107,545,158 (GRCm39)	missense	probably damaging	1.00
R4946:Tango6	UTSW	8	107,444,722 (GRCm39)	nonsense	probably null
R5459:Tango6	UTSW	8	107,576,921 (GRCm39)	missense	probably damaging	1.00
R5522:Tango6	UTSW	8	107,422,230 (GRCm39)	critical splice donor site	probably null
R5795:Tango6	UTSW	8	107,444,709 (GRCm39)	missense	probably damaging	1.00
R5878:Tango6	UTSW	8	107,415,800 (GRCm39)	missense	possibly damaging	0.77
R6318:Tango6	UTSW	8	107,545,129 (GRCm39)	missense	probably benign
R6335:Tango6	UTSW	8	107,419,308 (GRCm39)	missense	possibly damaging	0.94
R6633:Tango6	UTSW	8	107,444,637 (GRCm39)	missense	probably benign	0.00
R6664:Tango6	UTSW	8	107,468,746 (GRCm39)	missense	probably damaging	1.00
R6838:Tango6	UTSW	8	107,468,706 (GRCm39)	missense	probably benign	0.00
R6866:Tango6	UTSW	8	107,469,104 (GRCm39)	critical splice donor site	probably null
R7046:Tango6	UTSW	8	107,533,748 (GRCm39)	missense	possibly damaging	0.86
R7130:Tango6	UTSW	8	107,533,733 (GRCm39)	missense	probably damaging	1.00
R7199:Tango6	UTSW	8	107,415,791 (GRCm39)	missense	probably benign	0.01
R7418:Tango6	UTSW	8	107,415,466 (GRCm39)	missense	probably benign	0.26
R7480:Tango6	UTSW	8	107,423,359 (GRCm39)	missense	possibly damaging	0.63
R7704:Tango6	UTSW	8	107,425,621 (GRCm39)	missense	probably benign	0.03
R7809:Tango6	UTSW	8	107,415,926 (GRCm39)	critical splice donor site	probably null
R7826:Tango6	UTSW	8	107,419,245 (GRCm39)	missense	probably benign	0.02
R8085:Tango6	UTSW	8	107,447,366 (GRCm39)	missense	probably benign	0.32
R8098:Tango6	UTSW	8	107,468,990 (GRCm39)	missense	possibly damaging	0.81
R8162:Tango6	UTSW	8	107,409,882 (GRCm39)	missense	possibly damaging	0.93
R8892:Tango6	UTSW	8	107,468,845 (GRCm39)	missense	probably benign	0.00
R8970:Tango6	UTSW	8	107,415,871 (GRCm39)	missense	probably damaging	0.98
R9336:Tango6	UTSW	8	107,415,701 (GRCm39)	missense	probably benign	0.03
R9760:Tango6	UTSW	8	107,576,911 (GRCm39)	missense	probably damaging	1.00
Z1177:Tango6	UTSW	8	107,423,248 (GRCm39)	missense	probably damaging	1.00
Z1177:Tango6	UTSW	8	107,415,424 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TGACCTCAAGAAGTTTTCCCCAACC -3'
(R):5'- CTTGGCACCAAAGGAAATGGCTAAC -3'

Sequencing Primer
(F):5'- TGTCAGACCAGTTTCTACCAAGAG -3'
(R):5'- GGAAATGGCTAACTCTAGCTGTC -3'

Posted On

2013-07-11