Mutagenetix > Incidental Mutation

Incidental Mutation 'R0632:Ptprc'

59682

Institutional Source

Beutler Lab

Gene Symbol

Ptprc

Ensembl Gene

ENSMUSG00000026395

Gene Name

protein tyrosine phosphatase receptor type C

Synonyms

Ly-5, T200, CD45, B220, Lyt-4

MMRRC Submission

038821-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0632 (G1)

Quality Score

171

Status

Validated

Chromosome

Chromosomal Location

137990599-138103446 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 138001348 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 965 (V965I)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000182283] [ENSMUST00000182755] [ENSMUST00000183301]

AlphaFold

P06800

Predicted Effect

probably benign
Transcript: ENSMUST00000027645
AA Change: V965I

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000027645
Gene: ENSMUSG00000026395
AA Change: V965I

Domain	Start	End	E-Value	Type
Pfam:PTP_N	5	30	5e-16	PFAM
low complexity region	109	126	N/A	INTRINSIC
low complexity region	168	203	N/A	INTRINSIC
Pfam:CD45	210	267	3.1e-20	PFAM
FN3	372	456	2.28e0	SMART
FN3	472	550	3.48e-1	SMART
transmembrane domain	565	586	N/A	INTRINSIC
PTPc	639	901	7.57e-127	SMART
PTPc	930	1216	1.39e-102	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000112036

SMART Domains

Protein: ENSMUSP00000107667
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	5	30	5.8e-13	PFAM
low complexity region	31	64	N/A	INTRINSIC
Pfam:CD45	70	129	1.8e-24	PFAM
FN3	233	317	2.28e0	SMART
FN3	333	411	3.48e-1	SMART
transmembrane domain	426	447	N/A	INTRINSIC
PTPc	500	762	7.57e-127	SMART
PTPc	791	1077	1.39e-102	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182283
AA Change: V828I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000138800
Gene: ENSMUSG00000026395
AA Change: V828I

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	32	4.2e-13	PFAM
low complexity region	33	66	N/A	INTRINSIC
Pfam:CD45	72	131	2.3e-24	PFAM
FN3	235	319	2.28e0	SMART
FN3	335	413	3.48e-1	SMART
transmembrane domain	428	449	N/A	INTRINSIC
PTPc	502	764	7.57e-127	SMART
PTPc	793	1079	1.39e-102	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182755
AA Change: V804I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000138275
Gene: ENSMUSG00000026395
AA Change: V804I

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	34	5.5e-13	PFAM
Pfam:CD45	48	107	2.3e-24	PFAM
FN3	211	295	2.28e0	SMART
FN3	311	389	3.48e-1	SMART
transmembrane domain	404	425	N/A	INTRINSIC
PTPc	478	740	7.57e-127	SMART
PTPc	769	1055	1.39e-102	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183301
AA Change: V967I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000138350
Gene: ENSMUSG00000026395
AA Change: V967I

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	2.7e-13	PFAM
low complexity region	111	128	N/A	INTRINSIC
low complexity region	170	205	N/A	INTRINSIC
Pfam:CD45	211	270	2.1e-24	PFAM
FN3	374	458	2.28e0	SMART
FN3	474	552	3.48e-1	SMART
transmembrane domain	567	588	N/A	INTRINSIC
PTPc	641	903	7.57e-127	SMART
PTPc	932	1218	1.39e-102	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 99.0%
10x: 97.8%
20x: 96.0%

Validation Efficiency

95% (81/85)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaa1a	T	A	9: 119,176,884 (GRCm39)		probably benign	Het
Adgrg7	T	A	16: 56,562,952 (GRCm39)	T462S	possibly damaging	Het
Akap6	A	T	12: 52,983,931 (GRCm39)	N825I	probably damaging	Het
Ankib1	T	A	5: 3,822,529 (GRCm39)	N59I	probably benign	Het
Anks6	T	C	4: 47,033,167 (GRCm39)	S633G	possibly damaging	Het
Ap4e1	C	A	2: 126,891,200 (GRCm39)	Y522*	probably null	Het
Art5	G	A	7: 101,747,164 (GRCm39)	T205I	probably damaging	Het
Ascc2	T	A	11: 4,599,855 (GRCm39)	L176H	probably damaging	Het
Atp13a5	T	C	16: 29,117,026 (GRCm39)	D529G	probably benign	Het
C2cd4a	T	C	9: 67,738,845 (GRCm39)	E66G	probably benign	Het
C8a	T	C	4: 104,713,689 (GRCm39)	D147G	probably damaging	Het
Ccdc14	T	C	16: 34,542,019 (GRCm39)	V532A	possibly damaging	Het
Ccdc88a	T	A	11: 29,432,749 (GRCm39)		probably benign	Het
Cfap54	C	T	10: 92,720,958 (GRCm39)	E2543K	unknown	Het
Cldn13	C	T	5: 134,943,601 (GRCm39)	E195K	probably benign	Het
Cp	A	G	3: 20,025,246 (GRCm39)	S402G	probably null	Het
Cpa3	T	C	3: 20,279,358 (GRCm39)	T194A	probably benign	Het
Crygf	C	A	1: 65,967,156 (GRCm39)	Y93*	probably null	Het
Ctsh	A	G	9: 89,943,635 (GRCm39)	R87G	possibly damaging	Het
Cyp2t4	A	G	7: 26,857,671 (GRCm39)	D428G	possibly damaging	Het
Dnah17	C	G	11: 117,958,508 (GRCm39)		probably benign	Het
Dnah3	A	G	7: 119,567,128 (GRCm39)	V2366A	probably benign	Het
Dscaml1	A	T	9: 45,643,432 (GRCm39)	I1284F	probably benign	Het
Dsg1c	T	C	18: 20,405,403 (GRCm39)		probably benign	Het
Dst	G	T	1: 34,310,494 (GRCm39)	R4098L	probably damaging	Het
Efhb	A	G	17: 53,720,487 (GRCm39)		probably benign	Het
Epha7	A	T	4: 28,821,104 (GRCm39)	I90F	probably damaging	Het
Fam171a2	T	A	11: 102,328,707 (GRCm39)	D684V	probably damaging	Het
Fan1	A	G	7: 64,012,947 (GRCm39)	V665A	possibly damaging	Het
Fbn2	A	G	18: 58,170,819 (GRCm39)	C2191R	probably damaging	Het
Fkbp3	G	A	12: 65,120,692 (GRCm39)	A2V	probably benign	Het
G6pd2	A	G	5: 61,967,514 (GRCm39)	N430D	probably benign	Het
Gm13547	T	A	2: 29,651,596 (GRCm39)	D7E	possibly damaging	Het
H4c9	G	T	13: 22,225,197 (GRCm39)	Y99*	probably null	Het
Hdac5	A	T	11: 102,096,638 (GRCm39)	D260E	probably damaging	Het
Hsf2bp	T	C	17: 32,232,320 (GRCm39)	E142G	probably damaging	Het
Igf1r	C	T	7: 67,814,903 (GRCm39)	T268I	probably damaging	Het
Inava	T	C	1: 136,155,356 (GRCm39)	D83G	probably benign	Het
Kcne3	C	T	7: 99,833,646 (GRCm39)	R88C	probably damaging	Het
Klk1b9	G	T	7: 43,628,796 (GRCm39)	G100V	possibly damaging	Het
Kmt2d	G	A	15: 98,751,462 (GRCm39)		probably benign	Het
Lama1	C	T	17: 68,059,363 (GRCm39)		probably benign	Het
Lcp2	C	T	11: 34,032,426 (GRCm39)	P335S	possibly damaging	Het
Lrrk2	T	A	15: 91,680,231 (GRCm39)	N2047K	probably damaging	Het
Mcub	T	C	3: 129,712,375 (GRCm39)	M167V	probably benign	Het
Mia2	T	C	12: 59,182,929 (GRCm39)	L36P	probably damaging	Het
Mmp13	G	A	9: 7,274,032 (GRCm39)	G169R	probably damaging	Het
Mmp13	A	T	9: 7,282,077 (GRCm39)	I460F	possibly damaging	Het
Msh4	A	G	3: 153,602,532 (GRCm39)	I232T	probably damaging	Het
Msra	T	A	14: 64,447,981 (GRCm39)	M145L	probably benign	Het
Myo7a	A	T	7: 97,761,357 (GRCm39)		probably benign	Het
Nme8	A	T	13: 19,842,206 (GRCm39)	N422K	probably damaging	Het
Nol6	A	T	4: 41,121,115 (GRCm39)	F353I	probably damaging	Het
Nphp3	A	G	9: 103,895,473 (GRCm39)	K384E	probably damaging	Het
Or51h5	C	T	7: 102,577,811 (GRCm39)		probably null	Het
Or52e15	A	G	7: 104,645,910 (GRCm39)	I67T	probably benign	Het
Or52h7	A	G	7: 104,213,544 (GRCm39)	I39V	probably benign	Het
Phox2b	T	G	5: 67,253,557 (GRCm39)		probably benign	Het
Plec	A	T	15: 76,057,611 (GRCm39)	S4131T	probably damaging	Het
Pptc7	G	A	5: 122,451,654 (GRCm39)		probably benign	Het
Pramel31	G	A	4: 144,090,352 (GRCm39)	C464Y	probably damaging	Het
Prpf40b	A	G	15: 99,214,170 (GRCm39)	E810G	probably benign	Het
Pum1	T	A	4: 130,455,415 (GRCm39)	M180K	probably benign	Het
Ranbp3	T	C	17: 57,009,896 (GRCm39)		probably benign	Het
Rasgrf2	A	G	13: 92,120,393 (GRCm39)	S787P	probably benign	Het
Rnf19b	T	A	4: 128,967,344 (GRCm39)	N294K	probably damaging	Het
Samd3	A	T	10: 26,120,393 (GRCm39)	H156L	possibly damaging	Het
Serpinb6c	C	T	13: 34,064,014 (GRCm39)	R347Q	possibly damaging	Het
Slc36a3	A	G	11: 55,015,906 (GRCm39)	I416T	probably damaging	Het
Slc4a4	T	A	5: 89,277,500 (GRCm39)	F279Y	probably damaging	Het
Slc6a2	T	A	8: 93,719,429 (GRCm39)		probably benign	Het
Snrnp40	C	G	4: 130,271,836 (GRCm39)		probably null	Het
Tab2	A	G	10: 7,795,565 (GRCm39)	S232P	probably benign	Het
Tacc2	A	T	7: 130,227,325 (GRCm39)	K1356*	probably null	Het
Tmem87a	A	G	2: 120,190,023 (GRCm39)	S544P	probably damaging	Het
Trim52	T	A	14: 106,344,401 (GRCm39)	C20S	probably damaging	Het
Usp38	A	T	8: 81,740,779 (GRCm39)	V96E	probably benign	Het
Vmn2r59	T	C	7: 41,708,308 (GRCm39)	Y33C	probably damaging	Het
Vsig10l	T	G	7: 43,113,561 (GRCm39)	V171G	probably damaging	Het
Zfp957	T	A	14: 79,450,360 (GRCm39)	I480F	probably damaging	Het

Other mutations in Ptprc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
lochy	APN	1	138,011,528 (GRCm39)	splice site	probably benign
IGL00486:Ptprc	APN	1	138,043,359 (GRCm39)	missense	probably damaging	0.97
IGL00771:Ptprc	APN	1	138,041,415 (GRCm39)	missense	probably benign	0.00
IGL00833:Ptprc	APN	1	138,006,230 (GRCm39)	missense	possibly damaging	0.55
IGL00919:Ptprc	APN	1	138,041,380 (GRCm39)	missense	probably damaging	1.00
IGL01020:Ptprc	APN	1	138,047,911 (GRCm39)	critical splice acceptor site	probably null	0.00
IGL01024:Ptprc	APN	1	138,008,650 (GRCm39)	missense	probably damaging	1.00
IGL01302:Ptprc	APN	1	138,027,369 (GRCm39)	missense	possibly damaging	0.82
IGL01548:Ptprc	APN	1	138,027,219 (GRCm39)	critical splice donor site	probably null	0.00
IGL01620:Ptprc	APN	1	137,996,148 (GRCm39)	missense	possibly damaging	0.88
IGL01775:Ptprc	APN	1	137,992,497 (GRCm39)	missense	probably damaging	1.00
IGL01820:Ptprc	APN	1	137,993,936 (GRCm39)	missense	probably damaging	1.00
IGL02340:Ptprc	APN	1	137,998,957 (GRCm39)	missense	probably damaging	1.00
IGL02943:Ptprc	APN	1	138,027,251 (GRCm39)	missense	probably damaging	0.99
IGL03169:Ptprc	APN	1	138,041,357 (GRCm39)	missense	probably benign	0.15
IGL03308:Ptprc	APN	1	138,054,058 (GRCm39)	missense	possibly damaging	0.70
IGL03404:Ptprc	APN	1	138,020,739 (GRCm39)	missense	probably damaging	1.00
belittle	UTSW	1	138,137,493 (GRCm38)	intron	probably benign
Benighted	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
bletchley	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
Blush	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
bruise	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
chor_muang	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
crystal	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
Dumpling	UTSW	1	137,995,628 (GRCm39)	missense	probably damaging	1.00
fluorescent	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
fuchsia	UTSW	1	138,028,779 (GRCm39)	critical splice donor site	probably null
Gentian	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
guotie	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
guotie2	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
Guotie3	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
Gyoza	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
Half_measure	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
jirisan	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
mauve	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
Perverse	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
petechiae	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
ultra	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
violaceous	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R0013:Ptprc	UTSW	1	138,041,297 (GRCm39)	splice site	probably null
R0189:Ptprc	UTSW	1	138,010,453 (GRCm39)	missense	probably benign	0.10
R0390:Ptprc	UTSW	1	138,050,313 (GRCm39)	missense	possibly damaging	0.71
R0504:Ptprc	UTSW	1	138,016,435 (GRCm39)	missense	probably damaging	1.00
R0602:Ptprc	UTSW	1	138,017,223 (GRCm39)	splice site	probably benign
R0627:Ptprc	UTSW	1	137,996,058 (GRCm39)	missense	probably damaging	0.99
R0751:Ptprc	UTSW	1	138,020,668 (GRCm39)	missense	probably damaging	1.00
R0839:Ptprc	UTSW	1	138,028,870 (GRCm39)	missense	possibly damaging	0.47
R0942:Ptprc	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
R0943:Ptprc	UTSW	1	138,038,902 (GRCm39)	missense	probably damaging	0.96
R1159:Ptprc	UTSW	1	138,000,057 (GRCm39)	missense	probably damaging	1.00
R1442:Ptprc	UTSW	1	138,000,050 (GRCm39)	missense	probably damaging	1.00
R1489:Ptprc	UTSW	1	138,047,824 (GRCm39)	missense	possibly damaging	0.91
R1728:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1728:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1728:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1728:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1728:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1729:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1729:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1729:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1730:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1730:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1730:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1730:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1730:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1739:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1739:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1739:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1739:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1739:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1762:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1762:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1762:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1762:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1762:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1783:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1783:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1783:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1784:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1784:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1784:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1785:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1785:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1785:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1785:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1785:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1862:Ptprc	UTSW	1	138,039,965 (GRCm39)	missense	probably benign	0.13
R2145:Ptprc	UTSW	1	138,001,419 (GRCm39)	missense	probably damaging	1.00
R2290:Ptprc	UTSW	1	138,038,926 (GRCm39)	missense	probably benign	0.00
R2403:Ptprc	UTSW	1	138,016,270 (GRCm39)	missense	probably damaging	1.00
R2439:Ptprc	UTSW	1	137,993,890 (GRCm39)	missense	possibly damaging	0.67
R2887:Ptprc	UTSW	1	138,007,916 (GRCm39)	missense	probably damaging	1.00
R2906:Ptprc	UTSW	1	137,992,272 (GRCm39)	missense	possibly damaging	0.93
R3774:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3775:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3776:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3834:Ptprc	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
R4019:Ptprc	UTSW	1	138,006,254 (GRCm39)	missense	probably damaging	1.00
R4377:Ptprc	UTSW	1	137,995,663 (GRCm39)	missense	probably benign	0.04
R4580:Ptprc	UTSW	1	137,998,989 (GRCm39)	missense	probably benign	0.09
R4923:Ptprc	UTSW	1	138,006,236 (GRCm39)	missense	possibly damaging	0.93
R4925:Ptprc	UTSW	1	138,027,235 (GRCm39)	missense	probably benign	0.04
R4937:Ptprc	UTSW	1	138,017,238 (GRCm39)	missense	probably damaging	1.00
R4970:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5112:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5145:Ptprc	UTSW	1	138,017,304 (GRCm39)	missense	probably benign	0.07
R5158:Ptprc	UTSW	1	138,102,822 (GRCm39)	missense	possibly damaging	0.75
R5223:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R5593:Ptprc	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
R5689:Ptprc	UTSW	1	138,045,515 (GRCm39)	missense	probably benign	0.01
R5885:Ptprc	UTSW	1	138,016,246 (GRCm39)	missense	probably damaging	1.00
R6010:Ptprc	UTSW	1	138,028,794 (GRCm39)	missense	probably benign	0.09
R6026:Ptprc	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
R6047:Ptprc	UTSW	1	138,028,779 (GRCm39)	critical splice donor site	probably null
R6173:Ptprc	UTSW	1	137,995,628 (GRCm39)	missense	probably damaging	1.00
R6328:Ptprc	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
R6383:Ptprc	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
R6436:Ptprc	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R6492:Ptprc	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
R6520:Ptprc	UTSW	1	138,007,881 (GRCm39)	nonsense	probably null
R6805:Ptprc	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
R6830:Ptprc	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
R6847:Ptprc	UTSW	1	138,016,283 (GRCm39)	missense	probably damaging	0.99
R6960:Ptprc	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
R6995:Ptprc	UTSW	1	138,016,482 (GRCm39)	missense	probably damaging	1.00
R7009:Ptprc	UTSW	1	137,992,291 (GRCm39)	missense	probably damaging	0.97
R7041:Ptprc	UTSW	1	138,054,047 (GRCm39)	missense	probably benign	0.04
R7055:Ptprc	UTSW	1	138,017,309 (GRCm39)	missense	probably damaging	1.00
R7098:Ptprc	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
R7164:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7188:Ptprc	UTSW	1	137,998,918 (GRCm39)	missense	probably damaging	1.00
R7191:Ptprc	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
R7204:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7316:Ptprc	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
R7644:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01
R7948:Ptprc	UTSW	1	137,992,314 (GRCm39)	missense	probably benign	0.45
R8029:Ptprc	UTSW	1	138,006,197 (GRCm39)	missense	probably damaging	1.00
R8677:Ptprc	UTSW	1	138,011,335 (GRCm39)	missense	probably damaging	1.00
R8704:Ptprc	UTSW	1	138,043,362 (GRCm39)	missense	probably benign	0.34
R8824:Ptprc	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
R8921:Ptprc	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
R8998:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R8999:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R9154:Ptprc	UTSW	1	138,016,302 (GRCm39)	missense	probably damaging	1.00
R9388:Ptprc	UTSW	1	138,011,380 (GRCm39)	missense	possibly damaging	0.87
R9428:Ptprc	UTSW	1	138,041,485 (GRCm39)	missense	probably benign	0.01
R9467:Ptprc	UTSW	1	137,993,960 (GRCm39)	missense	probably damaging	1.00
R9468:Ptprc	UTSW	1	138,044,754 (GRCm39)	missense	probably benign	0.01
R9479:Ptprc	UTSW	1	138,001,388 (GRCm39)	missense	probably benign	0.38
R9526:Ptprc	UTSW	1	137,996,111 (GRCm39)	missense	probably benign	0.02
R9632:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9710:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9714:Ptprc	UTSW	1	138,008,687 (GRCm39)	missense	probably damaging	1.00
R9777:Ptprc	UTSW	1	138,047,901 (GRCm39)	missense
Z1177:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- TGAGGTTGGGGTGGACACACTAAATA -3'
(R):5'- CTGTGGACTCagagactgaactagaagt -3'

Sequencing Primer
(F):5'- tccttccttcctttctttcttcc -3'
(R):5'- gggtgggtgggtggaag -3'

Posted On

2013-07-11