Incidental Mutation 'R0632:Vmn2r59'
| ID |
59704 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r59
|
| Ensembl Gene |
ENSMUSG00000092032 |
| Gene Name |
vomeronasal 2, receptor 59 |
| Synonyms |
EG628444 |
| MMRRC Submission |
038821-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R0632 (G1)
|
| Quality Score |
221 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
41661216-41708405 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 41708308 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 33
(Y33C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168489]
|
| AlphaFold |
E9PUT5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168489
AA Change: Y33C
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: Y33C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
1.8e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
4.3e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
5.4e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 99.0%
- 10x: 97.8%
- 20x: 96.0%
|
| Validation Efficiency |
95% (81/85) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaa1a |
T |
A |
9: 119,176,884 (GRCm39) |
|
probably benign |
Het |
| Adgrg7 |
T |
A |
16: 56,562,952 (GRCm39) |
T462S |
possibly damaging |
Het |
| Akap6 |
A |
T |
12: 52,983,931 (GRCm39) |
N825I |
probably damaging |
Het |
| Ankib1 |
T |
A |
5: 3,822,529 (GRCm39) |
N59I |
probably benign |
Het |
| Anks6 |
T |
C |
4: 47,033,167 (GRCm39) |
S633G |
possibly damaging |
Het |
| Ap4e1 |
C |
A |
2: 126,891,200 (GRCm39) |
Y522* |
probably null |
Het |
| Art5 |
G |
A |
7: 101,747,164 (GRCm39) |
T205I |
probably damaging |
Het |
| Ascc2 |
T |
A |
11: 4,599,855 (GRCm39) |
L176H |
probably damaging |
Het |
| Atp13a5 |
T |
C |
16: 29,117,026 (GRCm39) |
D529G |
probably benign |
Het |
| C2cd4a |
T |
C |
9: 67,738,845 (GRCm39) |
E66G |
probably benign |
Het |
| C8a |
T |
C |
4: 104,713,689 (GRCm39) |
D147G |
probably damaging |
Het |
| Ccdc14 |
T |
C |
16: 34,542,019 (GRCm39) |
V532A |
possibly damaging |
Het |
| Ccdc88a |
T |
A |
11: 29,432,749 (GRCm39) |
|
probably benign |
Het |
| Cfap54 |
C |
T |
10: 92,720,958 (GRCm39) |
E2543K |
unknown |
Het |
| Cldn13 |
C |
T |
5: 134,943,601 (GRCm39) |
E195K |
probably benign |
Het |
| Cp |
A |
G |
3: 20,025,246 (GRCm39) |
S402G |
probably null |
Het |
| Cpa3 |
T |
C |
3: 20,279,358 (GRCm39) |
T194A |
probably benign |
Het |
| Crygf |
C |
A |
1: 65,967,156 (GRCm39) |
Y93* |
probably null |
Het |
| Ctsh |
A |
G |
9: 89,943,635 (GRCm39) |
R87G |
possibly damaging |
Het |
| Cyp2t4 |
A |
G |
7: 26,857,671 (GRCm39) |
D428G |
possibly damaging |
Het |
| Dnah17 |
C |
G |
11: 117,958,508 (GRCm39) |
|
probably benign |
Het |
| Dnah3 |
A |
G |
7: 119,567,128 (GRCm39) |
V2366A |
probably benign |
Het |
| Dscaml1 |
A |
T |
9: 45,643,432 (GRCm39) |
I1284F |
probably benign |
Het |
| Dsg1c |
T |
C |
18: 20,405,403 (GRCm39) |
|
probably benign |
Het |
| Dst |
G |
T |
1: 34,310,494 (GRCm39) |
R4098L |
probably damaging |
Het |
| Efhb |
A |
G |
17: 53,720,487 (GRCm39) |
|
probably benign |
Het |
| Epha7 |
A |
T |
4: 28,821,104 (GRCm39) |
I90F |
probably damaging |
Het |
| Fam171a2 |
T |
A |
11: 102,328,707 (GRCm39) |
D684V |
probably damaging |
Het |
| Fan1 |
A |
G |
7: 64,012,947 (GRCm39) |
V665A |
possibly damaging |
Het |
| Fbn2 |
A |
G |
18: 58,170,819 (GRCm39) |
C2191R |
probably damaging |
Het |
| Fkbp3 |
G |
A |
12: 65,120,692 (GRCm39) |
A2V |
probably benign |
Het |
| G6pd2 |
A |
G |
5: 61,967,514 (GRCm39) |
N430D |
probably benign |
Het |
| Gm13547 |
T |
A |
2: 29,651,596 (GRCm39) |
D7E |
possibly damaging |
Het |
| H4c9 |
G |
T |
13: 22,225,197 (GRCm39) |
Y99* |
probably null |
Het |
| Hdac5 |
A |
T |
11: 102,096,638 (GRCm39) |
D260E |
probably damaging |
Het |
| Hsf2bp |
T |
C |
17: 32,232,320 (GRCm39) |
E142G |
probably damaging |
Het |
| Igf1r |
C |
T |
7: 67,814,903 (GRCm39) |
T268I |
probably damaging |
Het |
| Inava |
T |
C |
1: 136,155,356 (GRCm39) |
D83G |
probably benign |
Het |
| Kcne3 |
C |
T |
7: 99,833,646 (GRCm39) |
R88C |
probably damaging |
Het |
| Klk1b9 |
G |
T |
7: 43,628,796 (GRCm39) |
G100V |
possibly damaging |
Het |
| Kmt2d |
G |
A |
15: 98,751,462 (GRCm39) |
|
probably benign |
Het |
| Lama1 |
C |
T |
17: 68,059,363 (GRCm39) |
|
probably benign |
Het |
| Lcp2 |
C |
T |
11: 34,032,426 (GRCm39) |
P335S |
possibly damaging |
Het |
| Lrrk2 |
T |
A |
15: 91,680,231 (GRCm39) |
N2047K |
probably damaging |
Het |
| Mcub |
T |
C |
3: 129,712,375 (GRCm39) |
M167V |
probably benign |
Het |
| Mia2 |
T |
C |
12: 59,182,929 (GRCm39) |
L36P |
probably damaging |
Het |
| Mmp13 |
G |
A |
9: 7,274,032 (GRCm39) |
G169R |
probably damaging |
Het |
| Mmp13 |
A |
T |
9: 7,282,077 (GRCm39) |
I460F |
possibly damaging |
Het |
| Msh4 |
A |
G |
3: 153,602,532 (GRCm39) |
I232T |
probably damaging |
Het |
| Msra |
T |
A |
14: 64,447,981 (GRCm39) |
M145L |
probably benign |
Het |
| Myo7a |
A |
T |
7: 97,761,357 (GRCm39) |
|
probably benign |
Het |
| Nme8 |
A |
T |
13: 19,842,206 (GRCm39) |
N422K |
probably damaging |
Het |
| Nol6 |
A |
T |
4: 41,121,115 (GRCm39) |
F353I |
probably damaging |
Het |
| Nphp3 |
A |
G |
9: 103,895,473 (GRCm39) |
K384E |
probably damaging |
Het |
| Or51h5 |
C |
T |
7: 102,577,811 (GRCm39) |
|
probably null |
Het |
| Or52e15 |
A |
G |
7: 104,645,910 (GRCm39) |
I67T |
probably benign |
Het |
| Or52h7 |
A |
G |
7: 104,213,544 (GRCm39) |
I39V |
probably benign |
Het |
| Phox2b |
T |
G |
5: 67,253,557 (GRCm39) |
|
probably benign |
Het |
| Plec |
A |
T |
15: 76,057,611 (GRCm39) |
S4131T |
probably damaging |
Het |
| Pptc7 |
G |
A |
5: 122,451,654 (GRCm39) |
|
probably benign |
Het |
| Pramel31 |
G |
A |
4: 144,090,352 (GRCm39) |
C464Y |
probably damaging |
Het |
| Prpf40b |
A |
G |
15: 99,214,170 (GRCm39) |
E810G |
probably benign |
Het |
| Ptprc |
C |
T |
1: 138,001,348 (GRCm39) |
V965I |
probably benign |
Het |
| Pum1 |
T |
A |
4: 130,455,415 (GRCm39) |
M180K |
probably benign |
Het |
| Ranbp3 |
T |
C |
17: 57,009,896 (GRCm39) |
|
probably benign |
Het |
| Rasgrf2 |
A |
G |
13: 92,120,393 (GRCm39) |
S787P |
probably benign |
Het |
| Rnf19b |
T |
A |
4: 128,967,344 (GRCm39) |
N294K |
probably damaging |
Het |
| Samd3 |
A |
T |
10: 26,120,393 (GRCm39) |
H156L |
possibly damaging |
Het |
| Serpinb6c |
C |
T |
13: 34,064,014 (GRCm39) |
R347Q |
possibly damaging |
Het |
| Slc36a3 |
A |
G |
11: 55,015,906 (GRCm39) |
I416T |
probably damaging |
Het |
| Slc4a4 |
T |
A |
5: 89,277,500 (GRCm39) |
F279Y |
probably damaging |
Het |
| Slc6a2 |
T |
A |
8: 93,719,429 (GRCm39) |
|
probably benign |
Het |
| Snrnp40 |
C |
G |
4: 130,271,836 (GRCm39) |
|
probably null |
Het |
| Tab2 |
A |
G |
10: 7,795,565 (GRCm39) |
S232P |
probably benign |
Het |
| Tacc2 |
A |
T |
7: 130,227,325 (GRCm39) |
K1356* |
probably null |
Het |
| Tmem87a |
A |
G |
2: 120,190,023 (GRCm39) |
S544P |
probably damaging |
Het |
| Trim52 |
T |
A |
14: 106,344,401 (GRCm39) |
C20S |
probably damaging |
Het |
| Usp38 |
A |
T |
8: 81,740,779 (GRCm39) |
V96E |
probably benign |
Het |
| Vsig10l |
T |
G |
7: 43,113,561 (GRCm39) |
V171G |
probably damaging |
Het |
| Zfp957 |
T |
A |
14: 79,450,360 (GRCm39) |
I480F |
probably damaging |
Het |
|
| Other mutations in Vmn2r59 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00088:Vmn2r59
|
APN |
7 |
41,661,488 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01432:Vmn2r59
|
APN |
7 |
41,661,983 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02119:Vmn2r59
|
APN |
7 |
41,695,593 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02216:Vmn2r59
|
APN |
7 |
41,661,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02327:Vmn2r59
|
APN |
7 |
41,661,655 (GRCm39) |
missense |
probably benign |
|
|
IGL03346:Vmn2r59
|
APN |
7 |
41,693,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03411:Vmn2r59
|
APN |
7 |
41,708,340 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03412:Vmn2r59
|
APN |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
PIT4366001:Vmn2r59
|
UTSW |
7 |
41,695,205 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0068:Vmn2r59
|
UTSW |
7 |
41,695,725 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0094:Vmn2r59
|
UTSW |
7 |
41,661,722 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0179:Vmn2r59
|
UTSW |
7 |
41,696,432 (GRCm39) |
nonsense |
probably null |
|
|
R0370:Vmn2r59
|
UTSW |
7 |
41,662,150 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0412:Vmn2r59
|
UTSW |
7 |
41,695,916 (GRCm39) |
splice site |
probably benign |
|
|
R0465:Vmn2r59
|
UTSW |
7 |
41,696,332 (GRCm39) |
missense |
probably benign |
|
|
R0487:Vmn2r59
|
UTSW |
7 |
41,696,528 (GRCm39) |
nonsense |
probably null |
|
|
R0576:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1356:Vmn2r59
|
UTSW |
7 |
41,661,218 (GRCm39) |
makesense |
probably null |
|
|
R1387:Vmn2r59
|
UTSW |
7 |
41,695,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1388:Vmn2r59
|
UTSW |
7 |
41,695,133 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1435:Vmn2r59
|
UTSW |
7 |
41,695,629 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1750:Vmn2r59
|
UTSW |
7 |
41,695,251 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2020:Vmn2r59
|
UTSW |
7 |
41,693,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Vmn2r59
|
UTSW |
7 |
41,708,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2256:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2257:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2441:Vmn2r59
|
UTSW |
7 |
41,695,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2511:Vmn2r59
|
UTSW |
7 |
41,693,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2861:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3690:Vmn2r59
|
UTSW |
7 |
41,661,370 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3912:Vmn2r59
|
UTSW |
7 |
41,695,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4167:Vmn2r59
|
UTSW |
7 |
41,670,732 (GRCm39) |
intron |
probably benign |
|
|
R4357:Vmn2r59
|
UTSW |
7 |
41,661,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4445:Vmn2r59
|
UTSW |
7 |
41,691,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Vmn2r59
|
UTSW |
7 |
41,695,497 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4587:Vmn2r59
|
UTSW |
7 |
41,695,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4616:Vmn2r59
|
UTSW |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
R4653:Vmn2r59
|
UTSW |
7 |
41,693,228 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4703:Vmn2r59
|
UTSW |
7 |
41,661,686 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4895:Vmn2r59
|
UTSW |
7 |
41,695,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4910:Vmn2r59
|
UTSW |
7 |
41,693,077 (GRCm39) |
missense |
probably benign |
|
|
R5045:Vmn2r59
|
UTSW |
7 |
41,695,496 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5105:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5153:Vmn2r59
|
UTSW |
7 |
41,691,834 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5566:Vmn2r59
|
UTSW |
7 |
41,696,247 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5586:Vmn2r59
|
UTSW |
7 |
41,695,105 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5606:Vmn2r59
|
UTSW |
7 |
41,695,318 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5616:Vmn2r59
|
UTSW |
7 |
41,708,191 (GRCm39) |
splice site |
probably null |
|
|
R5625:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5696:Vmn2r59
|
UTSW |
7 |
41,695,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5982:Vmn2r59
|
UTSW |
7 |
41,695,491 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6106:Vmn2r59
|
UTSW |
7 |
41,661,749 (GRCm39) |
nonsense |
probably null |
|
|
R6196:Vmn2r59
|
UTSW |
7 |
41,661,679 (GRCm39) |
missense |
probably benign |
0.36 |
|
R6228:Vmn2r59
|
UTSW |
7 |
41,691,835 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6590:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6625:Vmn2r59
|
UTSW |
7 |
41,693,177 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6690:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6768:Vmn2r59
|
UTSW |
7 |
41,661,392 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6830:Vmn2r59
|
UTSW |
7 |
41,693,171 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6859:Vmn2r59
|
UTSW |
7 |
41,693,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7036:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7145:Vmn2r59
|
UTSW |
7 |
41,695,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r59
|
UTSW |
7 |
41,695,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7733:Vmn2r59
|
UTSW |
7 |
41,661,443 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7770:Vmn2r59
|
UTSW |
7 |
41,708,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Vmn2r59
|
UTSW |
7 |
41,695,196 (GRCm39) |
nonsense |
probably null |
|
|
R7867:Vmn2r59
|
UTSW |
7 |
41,661,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7975:Vmn2r59
|
UTSW |
7 |
41,693,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Vmn2r59
|
UTSW |
7 |
41,696,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Vmn2r59
|
UTSW |
7 |
41,661,521 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8367:Vmn2r59
|
UTSW |
7 |
41,661,247 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9106:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,127 (GRCm39) |
missense |
|
|
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,125 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9234:Vmn2r59
|
UTSW |
7 |
41,661,907 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9273:Vmn2r59
|
UTSW |
7 |
41,695,286 (GRCm39) |
nonsense |
probably null |
|
|
R9432:Vmn2r59
|
UTSW |
7 |
41,696,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9433:Vmn2r59
|
UTSW |
7 |
41,695,590 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9616:Vmn2r59
|
UTSW |
7 |
41,661,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9654:Vmn2r59
|
UTSW |
7 |
41,693,217 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9741:Vmn2r59
|
UTSW |
7 |
41,708,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0025:Vmn2r59
|
UTSW |
7 |
41,695,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r59
|
UTSW |
7 |
41,661,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1176:Vmn2r59
|
UTSW |
7 |
41,691,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCACTCAGTTGTCTATCCACTCAGTTAC -3'
(R):5'- GCTGCACTCATTAACAGTCAGAAGCAC -3'
Sequencing Primer
(F):5'- CCCAGAAGTTCAAGGTAATACTTAG -3'
(R):5'- GTCAGAAGCACAAAATGTTCAC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation