Incidental Mutation 'R0632:Igf1r'
| ID |
59708 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Igf1r
|
| Ensembl Gene |
ENSMUSG00000005533 |
| Gene Name |
insulin-like growth factor I receptor |
| Synonyms |
IGF-1R, line 186, A330103N21Rik, hyft, CD221 |
| MMRRC Submission |
038821-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0632 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
67602575-67883416 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 67814903 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 268
(T268I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005671
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005671]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000005671
AA Change: T268I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000005671
Gene: ENSMUSG00000005533
AA Change: T268I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Recep_L_domain
|
51 |
161 |
1.6e-29 |
PFAM |
|
FU
|
227 |
270 |
2.98e-12 |
SMART |
|
Pfam:Recep_L_domain
|
353 |
467 |
3.8e-32 |
PFAM |
|
FN3
|
490 |
593 |
4.67e-2 |
SMART |
|
FN3
|
612 |
815 |
1.95e-4 |
SMART |
|
FN3
|
833 |
915 |
7.4e-5 |
SMART |
|
low complexity region
|
937 |
954 |
N/A |
INTRINSIC |
|
TyrKc
|
1000 |
1268 |
8.51e-141 |
SMART |
|
low complexity region
|
1285 |
1303 |
N/A |
INTRINSIC |
|
low complexity region
|
1306 |
1319 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207621
|
| Meta Mutation Damage Score |
0.7596 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 99.0%
- 10x: 97.8%
- 20x: 96.0%
|
| Validation Efficiency |
95% (81/85) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
PHENOTYPE: Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaa1a |
T |
A |
9: 119,176,884 (GRCm39) |
|
probably benign |
Het |
| Adgrg7 |
T |
A |
16: 56,562,952 (GRCm39) |
T462S |
possibly damaging |
Het |
| Akap6 |
A |
T |
12: 52,983,931 (GRCm39) |
N825I |
probably damaging |
Het |
| Ankib1 |
T |
A |
5: 3,822,529 (GRCm39) |
N59I |
probably benign |
Het |
| Anks6 |
T |
C |
4: 47,033,167 (GRCm39) |
S633G |
possibly damaging |
Het |
| Ap4e1 |
C |
A |
2: 126,891,200 (GRCm39) |
Y522* |
probably null |
Het |
| Art5 |
G |
A |
7: 101,747,164 (GRCm39) |
T205I |
probably damaging |
Het |
| Ascc2 |
T |
A |
11: 4,599,855 (GRCm39) |
L176H |
probably damaging |
Het |
| Atp13a5 |
T |
C |
16: 29,117,026 (GRCm39) |
D529G |
probably benign |
Het |
| C2cd4a |
T |
C |
9: 67,738,845 (GRCm39) |
E66G |
probably benign |
Het |
| C8a |
T |
C |
4: 104,713,689 (GRCm39) |
D147G |
probably damaging |
Het |
| Ccdc14 |
T |
C |
16: 34,542,019 (GRCm39) |
V532A |
possibly damaging |
Het |
| Ccdc88a |
T |
A |
11: 29,432,749 (GRCm39) |
|
probably benign |
Het |
| Cfap54 |
C |
T |
10: 92,720,958 (GRCm39) |
E2543K |
unknown |
Het |
| Cldn13 |
C |
T |
5: 134,943,601 (GRCm39) |
E195K |
probably benign |
Het |
| Cp |
A |
G |
3: 20,025,246 (GRCm39) |
S402G |
probably null |
Het |
| Cpa3 |
T |
C |
3: 20,279,358 (GRCm39) |
T194A |
probably benign |
Het |
| Crygf |
C |
A |
1: 65,967,156 (GRCm39) |
Y93* |
probably null |
Het |
| Ctsh |
A |
G |
9: 89,943,635 (GRCm39) |
R87G |
possibly damaging |
Het |
| Cyp2t4 |
A |
G |
7: 26,857,671 (GRCm39) |
D428G |
possibly damaging |
Het |
| Dnah17 |
C |
G |
11: 117,958,508 (GRCm39) |
|
probably benign |
Het |
| Dnah3 |
A |
G |
7: 119,567,128 (GRCm39) |
V2366A |
probably benign |
Het |
| Dscaml1 |
A |
T |
9: 45,643,432 (GRCm39) |
I1284F |
probably benign |
Het |
| Dsg1c |
T |
C |
18: 20,405,403 (GRCm39) |
|
probably benign |
Het |
| Dst |
G |
T |
1: 34,310,494 (GRCm39) |
R4098L |
probably damaging |
Het |
| Efhb |
A |
G |
17: 53,720,487 (GRCm39) |
|
probably benign |
Het |
| Epha7 |
A |
T |
4: 28,821,104 (GRCm39) |
I90F |
probably damaging |
Het |
| Fam171a2 |
T |
A |
11: 102,328,707 (GRCm39) |
D684V |
probably damaging |
Het |
| Fan1 |
A |
G |
7: 64,012,947 (GRCm39) |
V665A |
possibly damaging |
Het |
| Fbn2 |
A |
G |
18: 58,170,819 (GRCm39) |
C2191R |
probably damaging |
Het |
| Fkbp3 |
G |
A |
12: 65,120,692 (GRCm39) |
A2V |
probably benign |
Het |
| G6pd2 |
A |
G |
5: 61,967,514 (GRCm39) |
N430D |
probably benign |
Het |
| Gm13547 |
T |
A |
2: 29,651,596 (GRCm39) |
D7E |
possibly damaging |
Het |
| H4c9 |
G |
T |
13: 22,225,197 (GRCm39) |
Y99* |
probably null |
Het |
| Hdac5 |
A |
T |
11: 102,096,638 (GRCm39) |
D260E |
probably damaging |
Het |
| Hsf2bp |
T |
C |
17: 32,232,320 (GRCm39) |
E142G |
probably damaging |
Het |
| Inava |
T |
C |
1: 136,155,356 (GRCm39) |
D83G |
probably benign |
Het |
| Kcne3 |
C |
T |
7: 99,833,646 (GRCm39) |
R88C |
probably damaging |
Het |
| Klk1b9 |
G |
T |
7: 43,628,796 (GRCm39) |
G100V |
possibly damaging |
Het |
| Kmt2d |
G |
A |
15: 98,751,462 (GRCm39) |
|
probably benign |
Het |
| Lama1 |
C |
T |
17: 68,059,363 (GRCm39) |
|
probably benign |
Het |
| Lcp2 |
C |
T |
11: 34,032,426 (GRCm39) |
P335S |
possibly damaging |
Het |
| Lrrk2 |
T |
A |
15: 91,680,231 (GRCm39) |
N2047K |
probably damaging |
Het |
| Mcub |
T |
C |
3: 129,712,375 (GRCm39) |
M167V |
probably benign |
Het |
| Mia2 |
T |
C |
12: 59,182,929 (GRCm39) |
L36P |
probably damaging |
Het |
| Mmp13 |
G |
A |
9: 7,274,032 (GRCm39) |
G169R |
probably damaging |
Het |
| Mmp13 |
A |
T |
9: 7,282,077 (GRCm39) |
I460F |
possibly damaging |
Het |
| Msh4 |
A |
G |
3: 153,602,532 (GRCm39) |
I232T |
probably damaging |
Het |
| Msra |
T |
A |
14: 64,447,981 (GRCm39) |
M145L |
probably benign |
Het |
| Myo7a |
A |
T |
7: 97,761,357 (GRCm39) |
|
probably benign |
Het |
| Nme8 |
A |
T |
13: 19,842,206 (GRCm39) |
N422K |
probably damaging |
Het |
| Nol6 |
A |
T |
4: 41,121,115 (GRCm39) |
F353I |
probably damaging |
Het |
| Nphp3 |
A |
G |
9: 103,895,473 (GRCm39) |
K384E |
probably damaging |
Het |
| Or51h5 |
C |
T |
7: 102,577,811 (GRCm39) |
|
probably null |
Het |
| Or52e15 |
A |
G |
7: 104,645,910 (GRCm39) |
I67T |
probably benign |
Het |
| Or52h7 |
A |
G |
7: 104,213,544 (GRCm39) |
I39V |
probably benign |
Het |
| Phox2b |
T |
G |
5: 67,253,557 (GRCm39) |
|
probably benign |
Het |
| Plec |
A |
T |
15: 76,057,611 (GRCm39) |
S4131T |
probably damaging |
Het |
| Pptc7 |
G |
A |
5: 122,451,654 (GRCm39) |
|
probably benign |
Het |
| Pramel31 |
G |
A |
4: 144,090,352 (GRCm39) |
C464Y |
probably damaging |
Het |
| Prpf40b |
A |
G |
15: 99,214,170 (GRCm39) |
E810G |
probably benign |
Het |
| Ptprc |
C |
T |
1: 138,001,348 (GRCm39) |
V965I |
probably benign |
Het |
| Pum1 |
T |
A |
4: 130,455,415 (GRCm39) |
M180K |
probably benign |
Het |
| Ranbp3 |
T |
C |
17: 57,009,896 (GRCm39) |
|
probably benign |
Het |
| Rasgrf2 |
A |
G |
13: 92,120,393 (GRCm39) |
S787P |
probably benign |
Het |
| Rnf19b |
T |
A |
4: 128,967,344 (GRCm39) |
N294K |
probably damaging |
Het |
| Samd3 |
A |
T |
10: 26,120,393 (GRCm39) |
H156L |
possibly damaging |
Het |
| Serpinb6c |
C |
T |
13: 34,064,014 (GRCm39) |
R347Q |
possibly damaging |
Het |
| Slc36a3 |
A |
G |
11: 55,015,906 (GRCm39) |
I416T |
probably damaging |
Het |
| Slc4a4 |
T |
A |
5: 89,277,500 (GRCm39) |
F279Y |
probably damaging |
Het |
| Slc6a2 |
T |
A |
8: 93,719,429 (GRCm39) |
|
probably benign |
Het |
| Snrnp40 |
C |
G |
4: 130,271,836 (GRCm39) |
|
probably null |
Het |
| Tab2 |
A |
G |
10: 7,795,565 (GRCm39) |
S232P |
probably benign |
Het |
| Tacc2 |
A |
T |
7: 130,227,325 (GRCm39) |
K1356* |
probably null |
Het |
| Tmem87a |
A |
G |
2: 120,190,023 (GRCm39) |
S544P |
probably damaging |
Het |
| Trim52 |
T |
A |
14: 106,344,401 (GRCm39) |
C20S |
probably damaging |
Het |
| Usp38 |
A |
T |
8: 81,740,779 (GRCm39) |
V96E |
probably benign |
Het |
| Vmn2r59 |
T |
C |
7: 41,708,308 (GRCm39) |
Y33C |
probably damaging |
Het |
| Vsig10l |
T |
G |
7: 43,113,561 (GRCm39) |
V171G |
probably damaging |
Het |
| Zfp957 |
T |
A |
14: 79,450,360 (GRCm39) |
I480F |
probably damaging |
Het |
|
| Other mutations in Igf1r |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00742:Igf1r
|
APN |
7 |
67,839,771 (GRCm39) |
missense |
probably benign |
|
|
IGL00837:Igf1r
|
APN |
7 |
67,851,100 (GRCm39) |
splice site |
probably benign |
|
|
IGL01515:Igf1r
|
APN |
7 |
67,857,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01572:Igf1r
|
APN |
7 |
67,843,189 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02100:Igf1r
|
APN |
7 |
67,839,706 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02506:Igf1r
|
APN |
7 |
67,843,144 (GRCm39) |
missense |
probably benign |
|
|
IGL02672:Igf1r
|
APN |
7 |
67,839,781 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02701:Igf1r
|
APN |
7 |
67,850,997 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02742:Igf1r
|
APN |
7 |
67,839,739 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03073:Igf1r
|
APN |
7 |
67,864,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03257:Igf1r
|
APN |
7 |
67,864,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Frufru
|
UTSW |
7 |
67,653,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hungarian
|
UTSW |
7 |
67,864,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mimi
|
UTSW |
7 |
67,844,774 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
Piroshka
|
UTSW |
7 |
67,857,084 (GRCm39) |
nonsense |
probably null |
|
|
Romanian
|
UTSW |
7 |
67,653,885 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Sublime
|
UTSW |
7 |
67,653,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Toy
|
UTSW |
7 |
67,653,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB009:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
BB019:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
FR4548:Igf1r
|
UTSW |
7 |
67,875,934 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Igf1r
|
UTSW |
7 |
67,875,929 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
67,875,934 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
67,875,929 (GRCm39) |
small insertion |
probably benign |
|
|
PIT4445001:Igf1r
|
UTSW |
7 |
67,857,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Igf1r
|
UTSW |
7 |
67,814,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0184:Igf1r
|
UTSW |
7 |
67,875,941 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0538:Igf1r
|
UTSW |
7 |
67,857,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0727:Igf1r
|
UTSW |
7 |
67,861,906 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0750:Igf1r
|
UTSW |
7 |
67,861,839 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1104:Igf1r
|
UTSW |
7 |
67,844,774 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1169:Igf1r
|
UTSW |
7 |
67,814,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1348:Igf1r
|
UTSW |
7 |
67,868,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Igf1r
|
UTSW |
7 |
67,653,585 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1580:Igf1r
|
UTSW |
7 |
67,857,617 (GRCm39) |
missense |
probably benign |
|
|
R1745:Igf1r
|
UTSW |
7 |
67,819,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1772:Igf1r
|
UTSW |
7 |
67,844,822 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1789:Igf1r
|
UTSW |
7 |
67,864,681 (GRCm39) |
nonsense |
probably null |
|
|
R1823:Igf1r
|
UTSW |
7 |
67,844,729 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1902:Igf1r
|
UTSW |
7 |
67,850,997 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1962:Igf1r
|
UTSW |
7 |
67,857,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2179:Igf1r
|
UTSW |
7 |
67,653,698 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2215:Igf1r
|
UTSW |
7 |
67,814,982 (GRCm39) |
missense |
probably benign |
|
|
R2221:Igf1r
|
UTSW |
7 |
67,851,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2233:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2234:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2235:Igf1r
|
UTSW |
7 |
67,861,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3023:Igf1r
|
UTSW |
7 |
67,833,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4044:Igf1r
|
UTSW |
7 |
67,839,810 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4226:Igf1r
|
UTSW |
7 |
67,844,826 (GRCm39) |
nonsense |
probably null |
|
|
R4387:Igf1r
|
UTSW |
7 |
67,819,757 (GRCm39) |
missense |
probably benign |
|
|
R4388:Igf1r
|
UTSW |
7 |
67,819,757 (GRCm39) |
missense |
probably benign |
|
|
R4728:Igf1r
|
UTSW |
7 |
67,839,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Igf1r
|
UTSW |
7 |
67,814,947 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5254:Igf1r
|
UTSW |
7 |
67,857,067 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5278:Igf1r
|
UTSW |
7 |
67,843,166 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5510:Igf1r
|
UTSW |
7 |
67,843,107 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5522:Igf1r
|
UTSW |
7 |
67,833,258 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5527:Igf1r
|
UTSW |
7 |
67,857,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5761:Igf1r
|
UTSW |
7 |
67,857,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5849:Igf1r
|
UTSW |
7 |
67,839,781 (GRCm39) |
missense |
probably benign |
|
|
R6189:Igf1r
|
UTSW |
7 |
67,857,084 (GRCm39) |
nonsense |
probably null |
|
|
R6262:Igf1r
|
UTSW |
7 |
67,653,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Igf1r
|
UTSW |
7 |
67,653,885 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6318:Igf1r
|
UTSW |
7 |
67,814,981 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6365:Igf1r
|
UTSW |
7 |
67,839,798 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6377:Igf1r
|
UTSW |
7 |
67,850,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6831:Igf1r
|
UTSW |
7 |
67,857,067 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R6848:Igf1r
|
UTSW |
7 |
67,653,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6902:Igf1r
|
UTSW |
7 |
67,653,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7193:Igf1r
|
UTSW |
7 |
67,836,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7373:Igf1r
|
UTSW |
7 |
67,844,826 (GRCm39) |
nonsense |
probably null |
|
|
R7442:Igf1r
|
UTSW |
7 |
67,823,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7903:Igf1r
|
UTSW |
7 |
67,834,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Igf1r
|
UTSW |
7 |
67,839,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7932:Igf1r
|
UTSW |
7 |
67,861,802 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8368:Igf1r
|
UTSW |
7 |
67,836,796 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8458:Igf1r
|
UTSW |
7 |
67,845,377 (GRCm39) |
missense |
probably benign |
|
|
R8539:Igf1r
|
UTSW |
7 |
67,653,596 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8704:Igf1r
|
UTSW |
7 |
67,819,802 (GRCm39) |
splice site |
probably benign |
|
|
R8746:Igf1r
|
UTSW |
7 |
67,864,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8829:Igf1r
|
UTSW |
7 |
67,875,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Igf1r
|
UTSW |
7 |
67,875,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8859:Igf1r
|
UTSW |
7 |
67,833,211 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9057:Igf1r
|
UTSW |
7 |
67,833,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9243:Igf1r
|
UTSW |
7 |
67,861,775 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9342:Igf1r
|
UTSW |
7 |
67,844,746 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9412:Igf1r
|
UTSW |
7 |
67,857,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9525:Igf1r
|
UTSW |
7 |
67,864,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9727:Igf1r
|
UTSW |
7 |
67,857,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9730:Igf1r
|
UTSW |
7 |
67,839,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9779:Igf1r
|
UTSW |
7 |
67,654,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF025:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
RF034:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF037:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Igf1r
|
UTSW |
7 |
67,875,924 (GRCm39) |
small insertion |
probably benign |
|
|
RF044:Igf1r
|
UTSW |
7 |
67,875,927 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,916 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,930 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,928 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,922 (GRCm39) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
67,875,917 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,918 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,917 (GRCm39) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
67,875,921 (GRCm39) |
small insertion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCTCATCCCATAGCAAACCAGG -3'
(R):5'- GGCCAGCAAGCTAATTCTTACGCTC -3'
Sequencing Primer
(F):5'- GACGGTAAGATCTACGCAGATTTC -3'
(R):5'- CTACACTTAGGGGCTATGCAG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation