Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00543:Lyz3'

6089

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lyz3

Ensembl Gene

ENSMUSG00000020177

Gene Name

lysozyme 3

Synonyms

9530003J23Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL00543

Quality Score

Status

Chromosome

Chromosomal Location

117069658-117074586 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 117074352 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 45 (T45K)

Ref Sequence

ENSEMBL: ENSMUSP00000125436 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020392] [ENSMUST00000159193]

AlphaFold

Q8BM26

Predicted Effect

probably benign
Transcript: ENSMUST00000020392
AA Change: T45K

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000020392
Gene: ENSMUSG00000020177
AA Change: T45K

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
LYZ1	22	150	4.85e-73	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000159193
AA Change: T45K

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000125436
Gene: ENSMUSG00000020177
AA Change: T45K

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
LYZ1	22	150	4.85e-73	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acvr1c	A	G	2: 58,205,835 (GRCm39)	C42R	probably damaging	Het
Adamts1	T	C	16: 85,592,461 (GRCm39)	H649R	probably benign	Het
Capn3	T	C	2: 120,316,963 (GRCm39)		probably benign	Het
Cd44	T	C	2: 102,686,292 (GRCm39)	T135A	possibly damaging	Het
Cntnap5c	T	A	17: 58,601,345 (GRCm39)	I831N	probably benign	Het
Eprs1	G	T	1: 185,139,345 (GRCm39)	C910F	probably benign	Het
Epx	T	C	11: 87,760,751 (GRCm39)	R394G	probably damaging	Het
Hps5	T	C	7: 46,427,497 (GRCm39)	D338G	probably benign	Het
Ikbkg	T	C	X: 73,476,466 (GRCm39)	V14A	probably damaging	Het
Lrp1b	A	G	2: 41,358,960 (GRCm39)	F638L	possibly damaging	Het
Mak	A	T	13: 41,209,189 (GRCm39)	Y87N	probably damaging	Het
Morc2a	T	A	11: 3,630,283 (GRCm39)	I493N	probably damaging	Het
Msl2	T	A	9: 100,978,269 (GRCm39)	H214Q	probably benign	Het
Myom3	A	C	4: 135,489,882 (GRCm39)	T18P	possibly damaging	Het
Ndst3	G	T	3: 123,465,912 (GRCm39)	T20N	probably damaging	Het
Nelfe	T	A	17: 35,072,592 (GRCm39)	S124T	possibly damaging	Het
Niban2	T	A	2: 32,802,483 (GRCm39)	F158Y	probably benign	Het
Nlgn1	T	G	3: 25,487,945 (GRCm39)	T797P	probably damaging	Het
Pcdh18	T	C	3: 49,707,828 (GRCm39)	D414G	probably damaging	Het
Pde4dip	T	C	3: 97,664,940 (GRCm39)	S386G	possibly damaging	Het
Ppig	T	A	2: 69,580,060 (GRCm39)	H531Q	unknown	Het
Ppm1n	T	C	7: 19,012,109 (GRCm39)	Y348C	probably benign	Het
Rdh9	T	C	10: 127,626,853 (GRCm39)	V302A	probably benign	Het
Serpinb3b	A	G	1: 107,085,396 (GRCm39)		probably null	Het
Slc39a10	A	G	1: 46,858,217 (GRCm39)		probably benign	Het

Other mutations in Lyz3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0585:Lyz3	UTSW	10	117,074,356 (GRCm39)	missense	possibly damaging	0.79
R0610:Lyz3	UTSW	10	117,073,635 (GRCm39)	missense	probably benign	0.01
R2925:Lyz3	UTSW	10	117,070,336 (GRCm39)	missense	probably benign	0.02
R6656:Lyz3	UTSW	10	117,071,534 (GRCm39)	missense	probably benign	0.00
R6934:Lyz3	UTSW	10	117,074,413 (GRCm39)	missense	probably benign	0.00
R7150:Lyz3	UTSW	10	117,073,647 (GRCm39)	missense	probably benign	0.01
R7255:Lyz3	UTSW	10	117,070,327 (GRCm39)	missense	probably benign
R7439:Lyz3	UTSW	10	117,074,602 (GRCm39)	unclassified	probably benign
R8759:Lyz3	UTSW	10	117,070,340 (GRCm39)	missense	probably damaging	0.98
R9783:Lyz3	UTSW	10	117,073,653 (GRCm39)	missense	possibly damaging	0.78
RF014:Lyz3	UTSW	10	117,070,322 (GRCm39)	makesense	probably null
Z1177:Lyz3	UTSW	10	117,071,546 (GRCm39)	missense	probably benign	0.01

Posted On

2012-04-20