Incidental Mutation 'I2289:Lrp1b'
ID 610
Institutional Source Beutler Lab
Gene Symbol Lrp1b
Ensembl Gene ENSMUSG00000049252
Gene Name low density lipoprotein-related protein 1B
Synonyms 9630004P12Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # I2289 (G3) of strain 633
Quality Score
Status Validated
Chromosome 2
Chromosomal Location 40485258-42543636 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 41012944 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 2001 (I2001K)
Ref Sequence ENSEMBL: ENSMUSP00000054275 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052550] [ENSMUST00000167270]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000052550
AA Change: I2001K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000054275
Gene: ENSMUSG00000049252
AA Change: I2001K

DomainStartEndE-ValueType
low complexity region 3 19 N/A INTRINSIC
low complexity region 35 46 N/A INTRINSIC
LDLa 62 102 2.97e-12 SMART
LDLa 107 146 1.31e-8 SMART
EGF 150 185 1.95e1 SMART
EGF_CA 186 225 8.37e-8 SMART
LY 256 300 4.06e1 SMART
LY 304 348 1.15e-5 SMART
LY 349 392 1.17e-11 SMART
LY 393 435 1.12e-8 SMART
LY 436 478 2.21e1 SMART
EGF 505 548 2.45e0 SMART
LY 579 621 1.32e-5 SMART
LY 622 665 1.88e-10 SMART
LY 668 717 1.47e-12 SMART
LY 718 760 5.78e-11 SMART
LY 761 802 1.45e0 SMART
EGF_like 828 865 4.55e1 SMART
LDLa 875 914 7.15e-15 SMART
LDLa 916 955 5.26e-13 SMART
LDLa 957 995 6.13e-14 SMART
LDLa 997 1035 6.47e-13 SMART
LDLa 1036 1075 1.76e-14 SMART
LDLa 1083 1121 2.29e-13 SMART
LDLa 1125 1164 3.36e-11 SMART
LDLa 1166 1206 2.57e-7 SMART
EGF 1206 1244 1.58e-3 SMART
EGF 1248 1284 4.56e0 SMART
LY 1311 1353 4.85e-4 SMART
LY 1358 1400 6.49e-14 SMART
LY 1401 1445 8.18e-11 SMART
LY 1446 1490 4.25e-9 SMART
LY 1492 1534 5.4e-2 SMART
EGF 1561 1601 9.41e-2 SMART
LY 1629 1671 3.03e-5 SMART
LY 1672 1716 1.22e-9 SMART
LY 1718 1756 1.02e-2 SMART
LY 1757 1798 8.25e-7 SMART
EGF 1868 1906 4.03e-1 SMART
LY 1933 1975 1.01e-1 SMART
LY 1976 2018 3.03e-14 SMART
LY 2019 2062 2.16e-10 SMART
LY 2063 2105 4.09e-11 SMART
LY 2107 2149 9.96e0 SMART
EGF 2177 2214 2.13e0 SMART
LY 2292 2334 6.96e-5 SMART
LY 2340 2385 1.07e-5 SMART
LY 2386 2428 1.1e-11 SMART
LY 2429 2470 4.78e-3 SMART
EGF 2498 2535 2.03e1 SMART
LDLa 2540 2580 1.1e-6 SMART
LDLa 2582 2619 1.72e-8 SMART
LDLa 2621 2658 2.45e-13 SMART
LDLa 2669 2707 6.53e-9 SMART
LDLa 2712 2749 7.97e-13 SMART
LDLa 2750 2789 1.22e-8 SMART
LDLa 2791 2832 3.07e-14 SMART
LDLa 2835 2873 7.32e-12 SMART
LDLa 2875 2917 1.85e-8 SMART
LDLa 2921 2958 4.76e-11 SMART
EGF_CA 2957 2998 1.79e-7 SMART
EGF_CA 2999 3039 1.85e-9 SMART
LY 3066 3111 2.58e-8 SMART
LY 3112 3152 1.22e-9 SMART
LY 3153 3196 8.84e-7 SMART
LY 3197 3237 3.22e-9 SMART
LY 3238 3279 1.04e-3 SMART
EGF 3307 3345 7.13e-2 SMART
LDLa 3347 3385 9.29e-14 SMART
LDLa 3387 3424 2.25e-12 SMART
LDLa 3426 3464 5.63e-13 SMART
LDLa 3466 3504 1.07e-13 SMART
LDLa 3506 3543 1.35e-15 SMART
EGF_like 3545 3581 2.8e1 SMART
LDLa 3545 3582 1.49e-12 SMART
LDLa 3583 3620 4.21e-12 SMART
LDLa 3624 3661 4.9e-13 SMART
LDLa 3662 3700 9.58e-16 SMART
LDLa 3704 3743 5.38e-10 SMART
LDLa 3745 3784 1.42e-9 SMART
LDLa 3792 3829 3.66e-12 SMART
EGF 3835 3874 3.71e0 SMART
EGF_CA 3875 3912 6.8e-8 SMART
LY 3987 4033 4.24e0 SMART
LY 4050 4093 4.46e-3 SMART
LY 4094 4136 1.73e-9 SMART
EGF 4206 4239 2.45e0 SMART
EGF 4247 4280 2.48e-1 SMART
EGF 4283 4316 1.49e-4 SMART
EGF 4319 4352 1.69e-3 SMART
EGF 4355 4388 1.18e1 SMART
EGF_like 4391 4423 6.67e1 SMART
EGF 4424 4458 1.61e0 SMART
transmembrane domain 4476 4498 N/A INTRINSIC
low complexity region 4499 4509 N/A INTRINSIC
low complexity region 4512 4523 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000167270
AA Change: I1887K

PolyPhen 2 Score 0.871 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000129192
Gene: ENSMUSG00000049252
AA Change: I1887K

DomainStartEndE-ValueType
EGF 5 40 1.95e1 SMART
EGF_CA 41 80 8.37e-8 SMART
LY 111 155 4.06e1 SMART
LY 159 203 1.15e-5 SMART
LY 204 247 1.17e-11 SMART
LY 248 290 1.12e-8 SMART
LY 291 333 2.21e1 SMART
EGF 360 403 2.45e0 SMART
LY 434 476 1.32e-5 SMART
LY 477 520 1.88e-10 SMART
LY 523 572 1.47e-12 SMART
LY 573 615 5.78e-11 SMART
LY 616 657 1.45e0 SMART
EGF_like 683 720 4.55e1 SMART
LDLa 730 769 7.15e-15 SMART
LDLa 771 810 5.26e-13 SMART
LDLa 812 850 6.13e-14 SMART
LDLa 852 890 6.47e-13 SMART
LDLa 891 930 1.76e-14 SMART
LDLa 938 976 2.29e-13 SMART
LDLa 980 1019 3.36e-11 SMART
LDLa 1021 1061 2.57e-7 SMART
EGF 1061 1099 1.58e-3 SMART
EGF 1103 1139 4.56e0 SMART
LY 1166 1208 4.85e-4 SMART
LY 1213 1255 6.49e-14 SMART
LY 1256 1300 8.18e-11 SMART
LY 1301 1345 4.25e-9 SMART
LY 1347 1389 5.4e-2 SMART
EGF 1416 1456 9.41e-2 SMART
LY 1484 1526 3.03e-5 SMART
LY 1527 1571 1.22e-9 SMART
LY 1573 1611 1.02e-2 SMART
LY 1612 1653 8.25e-7 SMART
EGF 1723 1761 4.03e-1 SMART
LY 1788 1830 1.01e-1 SMART
LY 1831 1873 3.03e-14 SMART
LY 1874 1917 2.16e-10 SMART
LY 1918 1960 4.09e-11 SMART
LY 1962 2004 9.96e0 SMART
EGF 2032 2069 2.13e0 SMART
LY 2147 2189 6.96e-5 SMART
LY 2195 2240 1.07e-5 SMART
LY 2241 2283 1.1e-11 SMART
LY 2284 2325 4.78e-3 SMART
EGF 2353 2390 2.03e1 SMART
LDLa 2395 2435 1.1e-6 SMART
LDLa 2437 2474 1.72e-8 SMART
LDLa 2476 2513 2.45e-13 SMART
LDLa 2524 2562 6.53e-9 SMART
LDLa 2567 2604 7.97e-13 SMART
LDLa 2605 2644 1.22e-8 SMART
LDLa 2646 2687 3.07e-14 SMART
LDLa 2690 2728 7.32e-12 SMART
LDLa 2730 2772 1.85e-8 SMART
LDLa 2776 2813 4.76e-11 SMART
EGF_CA 2812 2853 1.79e-7 SMART
EGF_CA 2854 2894 1.85e-9 SMART
LY 2921 2966 2.58e-8 SMART
LY 2967 3007 1.22e-9 SMART
LY 3008 3051 8.84e-7 SMART
LY 3052 3092 3.22e-9 SMART
LY 3093 3134 1.04e-3 SMART
EGF 3162 3200 7.13e-2 SMART
LDLa 3202 3240 9.29e-14 SMART
LDLa 3242 3279 2.25e-12 SMART
LDLa 3281 3319 5.63e-13 SMART
LDLa 3321 3357 5.86e-11 SMART
Meta Mutation Damage Score 0.8276 question?
Coding Region Coverage
  • 1x: 87.8%
  • 3x: 75.8%
Het Detection Efficiency 55.8%
Validation Efficiency 88% (46/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]
PHENOTYPE: Homozygous null mice appear normal, are fertile, have normal brain histology and function, normal plasma cholesterol and fasting triglycerides, and do not develop tumors. [provided by MGI curators]
Allele List at MGI

All alleles(9) : Targeted, knock-out(3) Targeted, other(2) Gene trapped(4)

Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 T A 15: 11,071,894 (GRCm39) L146Q probably benign Homo
Adgrv1 A G 13: 81,585,643 (GRCm39) L4607P probably damaging Het
Amelx A G X: 167,961,009 (GRCm39) probably null Homo
Ankfy1 A G 11: 72,621,311 (GRCm39) K199R probably benign Het
Arfgef1 T C 1: 10,243,478 (GRCm39) K1024E probably damaging Het
Bank1 T A 3: 135,760,179 (GRCm39) D782V probably damaging Homo
Csmd1 A T 8: 15,962,381 (GRCm39) I3271K probably benign Homo
Fat1 A G 8: 45,478,033 (GRCm39) I2360V probably benign Homo
Gldc G A 19: 30,124,576 (GRCm39) R241* probably null Het
Golgb1 A G 16: 36,718,904 (GRCm39) H270R probably benign Het
Heg1 T C 16: 33,583,829 (GRCm39) I1212T probably damaging Het
Hes1 T A 16: 29,884,699 (GRCm39) S53R probably damaging Het
Ibsp G A 5: 104,450,353 (GRCm39) R57Q possibly damaging Homo
Nf1 G A 11: 79,438,602 (GRCm39) R2181H probably damaging Het
Nrcam C A 12: 44,611,098 (GRCm39) H567Q probably benign Homo
Or51a10 T C 7: 103,698,961 (GRCm39) Y200C probably damaging Homo
Or5bw2 A T 7: 6,573,818 (GRCm39) Y276F probably damaging Het
Rraga T C 4: 86,494,522 (GRCm39) F123L probably damaging Het
Spam1 A G 6: 24,796,477 (GRCm39) I143V probably benign Het
Synj2 A G 17: 6,072,542 (GRCm39) probably benign Homo
T A T 17: 8,657,474 (GRCm39) T112S probably benign Homo
Other mutations in Lrp1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00484:Lrp1b APN 2 41,000,873 (GRCm39) missense probably damaging 1.00
IGL00543:Lrp1b APN 2 41,358,960 (GRCm39) missense possibly damaging 0.69
IGL00578:Lrp1b APN 2 40,569,185 (GRCm39) missense unknown
IGL01020:Lrp1b APN 2 40,888,259 (GRCm39) missense probably damaging 1.00
IGL01092:Lrp1b APN 2 40,640,959 (GRCm39) missense probably damaging 0.97
IGL01155:Lrp1b APN 2 41,660,947 (GRCm39) missense probably benign 0.17
IGL01361:Lrp1b APN 2 41,000,763 (GRCm39) splice site probably benign
IGL01377:Lrp1b APN 2 40,491,550 (GRCm39) missense probably damaging 1.00
IGL01459:Lrp1b APN 2 40,750,726 (GRCm39) missense probably damaging 0.97
IGL01473:Lrp1b APN 2 40,501,498 (GRCm39) missense probably damaging 0.97
IGL01528:Lrp1b APN 2 40,809,194 (GRCm39) missense probably damaging 0.99
IGL01536:Lrp1b APN 2 41,000,895 (GRCm39) missense probably benign 0.01
IGL01564:Lrp1b APN 2 40,567,498 (GRCm39) splice site probably benign
IGL01747:Lrp1b APN 2 40,750,697 (GRCm39) missense probably damaging 1.00
IGL01764:Lrp1b APN 2 40,587,454 (GRCm39) missense unknown
IGL01783:Lrp1b APN 2 41,202,584 (GRCm39) missense probably damaging 1.00
IGL01802:Lrp1b APN 2 41,401,494 (GRCm39) missense probably benign 0.07
IGL01826:Lrp1b APN 2 41,339,246 (GRCm39) missense probably damaging 1.00
IGL01884:Lrp1b APN 2 41,174,225 (GRCm39) nonsense probably null
IGL01908:Lrp1b APN 2 40,592,816 (GRCm39) missense probably benign
IGL01935:Lrp1b APN 2 41,158,367 (GRCm39) missense probably damaging 1.00
IGL01959:Lrp1b APN 2 41,202,539 (GRCm39) missense probably damaging 0.99
IGL02010:Lrp1b APN 2 41,358,954 (GRCm39) missense probably damaging 1.00
IGL02022:Lrp1b APN 2 41,172,172 (GRCm39) missense probably damaging 1.00
IGL02028:Lrp1b APN 2 41,401,464 (GRCm39) missense probably damaging 1.00
IGL02034:Lrp1b APN 2 41,158,382 (GRCm39) nonsense probably null
IGL02043:Lrp1b APN 2 40,587,537 (GRCm39) missense probably null 0.44
IGL02066:Lrp1b APN 2 41,001,091 (GRCm39) nonsense probably null
IGL02085:Lrp1b APN 2 40,779,321 (GRCm39) missense probably benign
IGL02137:Lrp1b APN 2 40,620,700 (GRCm39) splice site probably benign
IGL02218:Lrp1b APN 2 41,185,684 (GRCm39) missense probably benign 0.11
IGL02409:Lrp1b APN 2 41,335,208 (GRCm39) missense possibly damaging 0.93
IGL02513:Lrp1b APN 2 41,000,765 (GRCm39) critical splice donor site probably null
IGL02543:Lrp1b APN 2 40,760,413 (GRCm39) missense possibly damaging 0.89
IGL02701:Lrp1b APN 2 41,136,029 (GRCm39) missense possibly damaging 0.50
IGL02728:Lrp1b APN 2 40,691,410 (GRCm39) missense probably benign 0.03
IGL02739:Lrp1b APN 2 41,388,227 (GRCm39) missense probably damaging 1.00
IGL02748:Lrp1b APN 2 40,592,761 (GRCm39) missense probably damaging 0.99
IGL02754:Lrp1b APN 2 40,592,806 (GRCm39) missense probably benign 0.02
IGL02797:Lrp1b APN 2 41,561,069 (GRCm39) missense
IGL02813:Lrp1b APN 2 40,569,229 (GRCm39) critical splice acceptor site probably null
IGL02831:Lrp1b APN 2 41,083,603 (GRCm39) missense probably damaging 1.00
IGL02869:Lrp1b APN 2 40,591,842 (GRCm39) missense unknown
IGL02946:Lrp1b APN 2 41,202,571 (GRCm39) missense probably damaging 1.00
IGL02952:Lrp1b APN 2 41,396,715 (GRCm39) missense probably benign 0.33
IGL02958:Lrp1b APN 2 41,192,928 (GRCm39) missense probably damaging 1.00
IGL02977:Lrp1b APN 2 40,620,747 (GRCm39) missense probably damaging 1.00
IGL03001:Lrp1b APN 2 40,817,901 (GRCm39) missense probably damaging 1.00
IGL03010:Lrp1b APN 2 42,213,618 (GRCm39) missense possibly damaging 0.94
IGL03060:Lrp1b APN 2 40,527,765 (GRCm39) missense probably benign 0.04
IGL03129:Lrp1b APN 2 41,202,478 (GRCm39) splice site probably benign
IGL03166:Lrp1b APN 2 41,001,050 (GRCm39) missense probably damaging 1.00
IGL03170:Lrp1b APN 2 40,587,456 (GRCm39) missense unknown
IGL03195:Lrp1b APN 2 41,361,134 (GRCm39) missense possibly damaging 0.95
IGL03224:Lrp1b APN 2 41,361,043 (GRCm39) missense possibly damaging 0.92
IGL03251:Lrp1b APN 2 40,490,279 (GRCm39) missense probably benign 0.20
IGL03281:Lrp1b APN 2 40,615,526 (GRCm39) missense probably benign 0.01
IGL03295:Lrp1b APN 2 40,568,999 (GRCm39) splice site probably null
IGL03340:Lrp1b APN 2 41,358,981 (GRCm39) missense probably damaging 0.97
IGL03391:Lrp1b APN 2 41,185,653 (GRCm39) missense possibly damaging 0.95
IGL03401:Lrp1b APN 2 41,000,790 (GRCm39) missense probably benign 0.18
IGL03403:Lrp1b APN 2 40,592,836 (GRCm39) missense probably benign 0.16
IGL03408:Lrp1b APN 2 40,748,594 (GRCm39) missense probably damaging 0.97
Fetching UTSW 2 40,769,567 (GRCm39) missense probably benign 0.00
Heiden UTSW 2 40,527,787 (GRCm39) missense probably benign 0.00
hither UTSW 2 40,592,860 (GRCm39) missense probably benign 0.00
Roeslein UTSW 2 40,615,919 (GRCm39) missense probably damaging 1.00
I2288:Lrp1b UTSW 2 41,012,944 (GRCm39) missense probably damaging 0.99
LCD18:Lrp1b UTSW 2 42,127,574 (GRCm39) intron probably benign
PIT4431001:Lrp1b UTSW 2 40,894,767 (GRCm39) missense
PIT4585001:Lrp1b UTSW 2 41,159,216 (GRCm39) missense
R0022:Lrp1b UTSW 2 40,888,050 (GRCm39) splice site probably benign
R0022:Lrp1b UTSW 2 40,888,050 (GRCm39) splice site probably benign
R0054:Lrp1b UTSW 2 40,632,829 (GRCm39) missense probably benign 0.11
R0054:Lrp1b UTSW 2 40,632,829 (GRCm39) missense probably benign 0.11
R0094:Lrp1b UTSW 2 41,172,042 (GRCm39) unclassified probably benign
R0102:Lrp1b UTSW 2 41,298,997 (GRCm39) splice site probably benign
R0123:Lrp1b UTSW 2 40,486,995 (GRCm39) missense probably damaging 1.00
R0128:Lrp1b UTSW 2 41,401,520 (GRCm39) missense probably damaging 1.00
R0130:Lrp1b UTSW 2 41,401,520 (GRCm39) missense probably damaging 1.00
R0134:Lrp1b UTSW 2 40,486,995 (GRCm39) missense probably damaging 1.00
R0135:Lrp1b UTSW 2 41,159,251 (GRCm39) missense probably damaging 0.99
R0153:Lrp1b UTSW 2 41,013,031 (GRCm39) missense possibly damaging 0.92
R0178:Lrp1b UTSW 2 40,615,919 (GRCm39) missense probably damaging 1.00
R0225:Lrp1b UTSW 2 40,486,995 (GRCm39) missense probably damaging 1.00
R0242:Lrp1b UTSW 2 40,888,195 (GRCm39) missense probably benign 0.01
R0242:Lrp1b UTSW 2 40,888,195 (GRCm39) missense probably benign 0.01
R0312:Lrp1b UTSW 2 41,172,183 (GRCm39) missense probably damaging 1.00
R0325:Lrp1b UTSW 2 40,741,723 (GRCm39) missense probably damaging 1.00
R0330:Lrp1b UTSW 2 40,591,773 (GRCm39) nonsense probably null
R0372:Lrp1b UTSW 2 40,620,810 (GRCm39) missense probably benign 0.30
R0400:Lrp1b UTSW 2 40,640,926 (GRCm39) missense probably benign 0.40
R0408:Lrp1b UTSW 2 40,567,603 (GRCm39) missense probably damaging 1.00
R0498:Lrp1b UTSW 2 41,348,417 (GRCm39) missense probably benign 0.19
R0563:Lrp1b UTSW 2 40,640,926 (GRCm39) missense probably benign 0.40
R0569:Lrp1b UTSW 2 40,779,251 (GRCm39) missense probably benign 0.11
R0622:Lrp1b UTSW 2 41,618,563 (GRCm39) critical splice donor site probably null
R0682:Lrp1b UTSW 2 41,185,653 (GRCm39) missense probably benign 0.01
R0727:Lrp1b UTSW 2 40,640,956 (GRCm39) missense probably benign 0.40
R0747:Lrp1b UTSW 2 40,760,353 (GRCm39) missense probably damaging 1.00
R0761:Lrp1b UTSW 2 41,075,947 (GRCm39) missense probably damaging 0.99
R0905:Lrp1b UTSW 2 41,174,197 (GRCm39) missense probably damaging 1.00
R0959:Lrp1b UTSW 2 41,158,366 (GRCm39) missense possibly damaging 0.83
R1124:Lrp1b UTSW 2 40,765,063 (GRCm39) missense probably damaging 1.00
R1158:Lrp1b UTSW 2 40,567,506 (GRCm39) missense unknown
R1265:Lrp1b UTSW 2 41,366,666 (GRCm39) missense probably damaging 1.00
R1276:Lrp1b UTSW 2 41,618,588 (GRCm39) missense probably benign 0.35
R1277:Lrp1b UTSW 2 40,615,957 (GRCm39) missense probably benign
R1282:Lrp1b UTSW 2 40,750,773 (GRCm39) missense probably damaging 1.00
R1291:Lrp1b UTSW 2 41,231,907 (GRCm39) missense probably benign 0.05
R1316:Lrp1b UTSW 2 40,592,816 (GRCm39) missense probably benign
R1340:Lrp1b UTSW 2 40,592,806 (GRCm39) missense probably benign 0.02
R1371:Lrp1b UTSW 2 40,537,165 (GRCm39) missense probably damaging 1.00
R1415:Lrp1b UTSW 2 40,519,676 (GRCm39) missense probably damaging 1.00
R1416:Lrp1b UTSW 2 40,888,228 (GRCm39) missense probably damaging 1.00
R1417:Lrp1b UTSW 2 40,894,653 (GRCm39) missense probably benign 0.14
R1465:Lrp1b UTSW 2 41,001,071 (GRCm39) missense probably benign 0.00
R1465:Lrp1b UTSW 2 41,001,071 (GRCm39) missense probably benign 0.00
R1467:Lrp1b UTSW 2 40,547,368 (GRCm39) splice site probably benign
R1468:Lrp1b UTSW 2 40,817,841 (GRCm39) critical splice donor site probably null
R1468:Lrp1b UTSW 2 40,817,841 (GRCm39) critical splice donor site probably null
R1480:Lrp1b UTSW 2 40,793,401 (GRCm39) missense probably damaging 1.00
R1488:Lrp1b UTSW 2 41,392,036 (GRCm39) missense probably benign 0.01
R1496:Lrp1b UTSW 2 42,213,674 (GRCm39) missense probably damaging 0.98
R1542:Lrp1b UTSW 2 41,013,724 (GRCm39) missense probably damaging 1.00
R1571:Lrp1b UTSW 2 41,366,658 (GRCm39) missense probably damaging 1.00
R1598:Lrp1b UTSW 2 41,401,490 (GRCm39) missense probably damaging 1.00
R1619:Lrp1b UTSW 2 40,587,601 (GRCm39) missense unknown
R1697:Lrp1b UTSW 2 40,712,695 (GRCm39) missense probably damaging 0.99
R1698:Lrp1b UTSW 2 40,741,818 (GRCm39) nonsense probably null
R1699:Lrp1b UTSW 2 41,075,974 (GRCm39) missense possibly damaging 0.91
R1715:Lrp1b UTSW 2 41,075,993 (GRCm39) missense probably damaging 1.00
R1748:Lrp1b UTSW 2 41,618,718 (GRCm39) missense possibly damaging 0.56
R1756:Lrp1b UTSW 2 41,000,837 (GRCm39) missense probably damaging 1.00
R1889:Lrp1b UTSW 2 40,809,179 (GRCm39) nonsense probably null
R1895:Lrp1b UTSW 2 40,555,159 (GRCm39) missense unknown
R1902:Lrp1b UTSW 2 40,750,673 (GRCm39) missense probably damaging 1.00
R1919:Lrp1b UTSW 2 41,618,741 (GRCm39) missense probably benign 0.00
R1939:Lrp1b UTSW 2 40,587,601 (GRCm39) missense unknown
R1946:Lrp1b UTSW 2 40,555,159 (GRCm39) missense unknown
R1954:Lrp1b UTSW 2 40,748,453 (GRCm39) missense probably damaging 1.00
R1970:Lrp1b UTSW 2 40,765,081 (GRCm39) missense probably damaging 1.00
R1983:Lrp1b UTSW 2 41,401,416 (GRCm39) critical splice donor site probably null
R2029:Lrp1b UTSW 2 41,231,861 (GRCm39) missense probably benign 0.02
R2054:Lrp1b UTSW 2 40,587,494 (GRCm39) missense unknown
R2108:Lrp1b UTSW 2 41,000,769 (GRCm39) missense probably damaging 1.00
R2158:Lrp1b UTSW 2 40,769,567 (GRCm39) missense probably benign 0.00
R2168:Lrp1b UTSW 2 41,265,858 (GRCm39) missense probably damaging 1.00
R2184:Lrp1b UTSW 2 40,620,714 (GRCm39) missense probably benign
R2188:Lrp1b UTSW 2 41,298,971 (GRCm39) missense probably benign 0.25
R2200:Lrp1b UTSW 2 41,174,177 (GRCm39) missense probably benign 0.43
R2342:Lrp1b UTSW 2 40,809,208 (GRCm39) missense possibly damaging 0.89
R2421:Lrp1b UTSW 2 40,772,145 (GRCm39) splice site probably benign
R2656:Lrp1b UTSW 2 41,401,593 (GRCm39) missense probably damaging 0.99
R2864:Lrp1b UTSW 2 40,765,007 (GRCm39) missense possibly damaging 0.92
R2874:Lrp1b UTSW 2 40,741,705 (GRCm39) missense probably damaging 1.00
R2911:Lrp1b UTSW 2 41,396,704 (GRCm39) missense probably benign 0.00
R2919:Lrp1b UTSW 2 41,660,911 (GRCm39) missense probably damaging 1.00
R3027:Lrp1b UTSW 2 40,760,283 (GRCm39) missense probably benign 0.33
R3083:Lrp1b UTSW 2 40,490,336 (GRCm39) missense probably damaging 0.99
R3545:Lrp1b UTSW 2 40,490,300 (GRCm39) missense probably damaging 1.00
R3546:Lrp1b UTSW 2 40,490,300 (GRCm39) missense probably damaging 1.00
R3547:Lrp1b UTSW 2 40,490,300 (GRCm39) missense probably damaging 1.00
R3709:Lrp1b UTSW 2 40,587,454 (GRCm39) missense unknown
R3817:Lrp1b UTSW 2 40,766,670 (GRCm39) missense probably damaging 1.00
R3876:Lrp1b UTSW 2 41,335,206 (GRCm39) missense probably damaging 1.00
R3877:Lrp1b UTSW 2 41,335,206 (GRCm39) missense probably damaging 1.00
R3896:Lrp1b UTSW 2 40,812,440 (GRCm39) splice site probably null
R3901:Lrp1b UTSW 2 40,712,707 (GRCm39) missense probably damaging 1.00
R3915:Lrp1b UTSW 2 41,339,248 (GRCm39) missense probably damaging 1.00
R3922:Lrp1b UTSW 2 40,567,593 (GRCm39) missense unknown
R3964:Lrp1b UTSW 2 41,202,482 (GRCm39) splice site probably benign
R4013:Lrp1b UTSW 2 40,692,996 (GRCm39) missense possibly damaging 0.66
R4014:Lrp1b UTSW 2 40,692,996 (GRCm39) missense possibly damaging 0.66
R4015:Lrp1b UTSW 2 40,692,996 (GRCm39) missense possibly damaging 0.66
R4017:Lrp1b UTSW 2 40,692,996 (GRCm39) missense possibly damaging 0.66
R4031:Lrp1b UTSW 2 40,592,860 (GRCm39) missense probably benign 0.00
R4095:Lrp1b UTSW 2 41,339,203 (GRCm39) missense probably benign 0.03
R4108:Lrp1b UTSW 2 40,555,099 (GRCm39) missense unknown
R4176:Lrp1b UTSW 2 41,298,405 (GRCm39) missense probably damaging 1.00
R4181:Lrp1b UTSW 2 40,501,446 (GRCm39) missense probably damaging 1.00
R4359:Lrp1b UTSW 2 40,793,077 (GRCm39) missense probably damaging 1.00
R4410:Lrp1b UTSW 2 40,555,094 (GRCm39) missense possibly damaging 0.96
R4416:Lrp1b UTSW 2 40,553,679 (GRCm39) missense unknown
R4489:Lrp1b UTSW 2 40,551,501 (GRCm39) unclassified probably benign
R4577:Lrp1b UTSW 2 40,711,731 (GRCm39) missense probably damaging 1.00
R4623:Lrp1b UTSW 2 41,136,033 (GRCm39) missense probably damaging 1.00
R4677:Lrp1b UTSW 2 40,691,496 (GRCm39) missense probably damaging 1.00
R4684:Lrp1b UTSW 2 40,812,316 (GRCm39) missense probably benign 0.44
R4714:Lrp1b UTSW 2 41,000,771 (GRCm39) missense possibly damaging 0.90
R4721:Lrp1b UTSW 2 40,605,381 (GRCm39) splice site probably null
R4755:Lrp1b UTSW 2 41,361,028 (GRCm39) missense probably benign
R4755:Lrp1b UTSW 2 41,159,285 (GRCm39) missense probably benign 0.07
R4774:Lrp1b UTSW 2 40,551,544 (GRCm39) missense probably null 1.00
R4854:Lrp1b UTSW 2 41,001,089 (GRCm39) missense probably damaging 1.00
R4880:Lrp1b UTSW 2 41,660,931 (GRCm39) missense probably benign 0.07
R4885:Lrp1b UTSW 2 41,358,905 (GRCm39) missense probably benign
R4901:Lrp1b UTSW 2 40,711,657 (GRCm39) missense probably damaging 1.00
R4919:Lrp1b UTSW 2 40,537,246 (GRCm39) missense probably benign 0.25
R4935:Lrp1b UTSW 2 41,388,405 (GRCm39) missense probably benign 0.01
R4937:Lrp1b UTSW 2 40,692,897 (GRCm39) splice site probably null
R4967:Lrp1b UTSW 2 41,678,986 (GRCm39) missense probably damaging 1.00
R4968:Lrp1b UTSW 2 41,679,074 (GRCm39) missense probably damaging 1.00
R4968:Lrp1b UTSW 2 40,592,719 (GRCm39) splice site probably null
R5155:Lrp1b UTSW 2 41,618,634 (GRCm39) splice site probably null
R5221:Lrp1b UTSW 2 41,002,994 (GRCm39) missense possibly damaging 0.79
R5224:Lrp1b UTSW 2 41,000,852 (GRCm39) missense possibly damaging 0.61
R5227:Lrp1b UTSW 2 40,741,805 (GRCm39) missense possibly damaging 0.95
R5246:Lrp1b UTSW 2 41,360,952 (GRCm39) critical splice donor site probably null
R5263:Lrp1b UTSW 2 41,850,691 (GRCm39) missense probably damaging 1.00
R5274:Lrp1b UTSW 2 41,234,456 (GRCm39) missense probably null 1.00
R5291:Lrp1b UTSW 2 40,793,015 (GRCm39) missense probably damaging 1.00
R5362:Lrp1b UTSW 2 41,265,914 (GRCm39) missense probably damaging 1.00
R5365:Lrp1b UTSW 2 40,537,137 (GRCm39) missense possibly damaging 0.55
R5369:Lrp1b UTSW 2 40,894,625 (GRCm39) nonsense probably null
R5419:Lrp1b UTSW 2 40,620,716 (GRCm39) nonsense probably null
R5434:Lrp1b UTSW 2 41,660,880 (GRCm39) missense probably damaging 0.96
R5452:Lrp1b UTSW 2 40,812,328 (GRCm39) missense probably damaging 1.00
R5453:Lrp1b UTSW 2 41,172,249 (GRCm39) missense probably damaging 1.00
R5496:Lrp1b UTSW 2 40,817,985 (GRCm39) missense probably benign 0.02
R5524:Lrp1b UTSW 2 41,000,900 (GRCm39) missense probably damaging 1.00
R5538:Lrp1b UTSW 2 40,587,486 (GRCm39) missense unknown
R5571:Lrp1b UTSW 2 41,298,354 (GRCm39) missense probably damaging 0.97
R5577:Lrp1b UTSW 2 40,765,135 (GRCm39) missense possibly damaging 0.70
R5609:Lrp1b UTSW 2 41,231,807 (GRCm39) missense probably damaging 1.00
R5635:Lrp1b UTSW 2 42,542,834 (GRCm39) utr 5 prime probably benign
R5669:Lrp1b UTSW 2 41,001,050 (GRCm39) missense probably damaging 1.00
R5672:Lrp1b UTSW 2 41,231,771 (GRCm39) missense probably benign 0.01
R5690:Lrp1b UTSW 2 40,640,906 (GRCm39) splice site probably null
R5752:Lrp1b UTSW 2 41,185,624 (GRCm39) missense probably damaging 1.00
R5853:Lrp1b UTSW 2 40,553,738 (GRCm39) missense unknown
R5869:Lrp1b UTSW 2 40,894,615 (GRCm39) missense probably damaging 0.98
R5880:Lrp1b UTSW 2 41,231,826 (GRCm39) missense probably benign 0.23
R5887:Lrp1b UTSW 2 40,711,719 (GRCm39) missense possibly damaging 0.91
R5893:Lrp1b UTSW 2 40,491,599 (GRCm39) missense probably damaging 1.00
R5894:Lrp1b UTSW 2 41,388,233 (GRCm39) missense probably benign 0.11
R6019:Lrp1b UTSW 2 41,192,982 (GRCm39) missense probably damaging 1.00
R6019:Lrp1b UTSW 2 41,366,821 (GRCm39) missense probably damaging 1.00
R6021:Lrp1b UTSW 2 41,234,439 (GRCm39) missense probably benign 0.02
R6045:Lrp1b UTSW 2 40,591,825 (GRCm39) missense unknown
R6047:Lrp1b UTSW 2 40,527,787 (GRCm39) missense probably benign 0.00
R6060:Lrp1b UTSW 2 40,640,946 (GRCm39) missense
R6063:Lrp1b UTSW 2 41,174,156 (GRCm39) nonsense probably null
R6090:Lrp1b UTSW 2 41,075,880 (GRCm39) critical splice donor site probably null
R6112:Lrp1b UTSW 2 41,231,894 (GRCm39) missense probably benign 0.14
R6128:Lrp1b UTSW 2 40,750,667 (GRCm39) missense probably benign
R6149:Lrp1b UTSW 2 40,765,165 (GRCm39) splice site probably null
R6174:Lrp1b UTSW 2 41,339,275 (GRCm39) missense probably benign
R6177:Lrp1b UTSW 2 41,013,748 (GRCm39) splice site probably null
R6257:Lrp1b UTSW 2 40,486,981 (GRCm39) splice site probably null
R6267:Lrp1b UTSW 2 40,547,537 (GRCm39) missense probably benign 0.00
R6268:Lrp1b UTSW 2 40,711,729 (GRCm39) missense probably benign 0.01
R6331:Lrp1b UTSW 2 40,693,221 (GRCm39) missense probably damaging 1.00
R6334:Lrp1b UTSW 2 41,679,045 (GRCm39) missense probably benign
R6359:Lrp1b UTSW 2 41,185,608 (GRCm39) missense probably damaging 1.00
R6371:Lrp1b UTSW 2 40,741,666 (GRCm39) missense possibly damaging 0.61
R6421:Lrp1b UTSW 2 40,779,282 (GRCm39) missense probably damaging 1.00
R6524:Lrp1b UTSW 2 40,741,816 (GRCm39) missense possibly damaging 0.95
R6616:Lrp1b UTSW 2 40,589,643 (GRCm39) missense unknown
R6632:Lrp1b UTSW 2 40,615,454 (GRCm39) missense probably benign 0.23
R6656:Lrp1b UTSW 2 40,527,876 (GRCm39) nonsense probably null
R6698:Lrp1b UTSW 2 41,192,958 (GRCm39) missense probably damaging 1.00
R6741:Lrp1b UTSW 2 41,136,001 (GRCm39) missense possibly damaging 0.82
R6742:Lrp1b UTSW 2 41,361,132 (GRCm39) missense probably benign 0.31
R6811:Lrp1b UTSW 2 41,339,206 (GRCm39) missense probably benign 0.01
R6811:Lrp1b UTSW 2 40,605,512 (GRCm39) splice site probably null
R6855:Lrp1b UTSW 2 40,518,708 (GRCm39) missense possibly damaging 0.66
R6888:Lrp1b UTSW 2 41,361,138 (GRCm39) missense probably benign 0.18
R6946:Lrp1b UTSW 2 40,587,451 (GRCm39) missense probably benign
R6984:Lrp1b UTSW 2 40,712,640 (GRCm39) missense probably damaging 0.97
R7026:Lrp1b UTSW 2 41,159,234 (GRCm39) missense probably damaging 1.00
R7028:Lrp1b UTSW 2 41,136,023 (GRCm39) missense probably benign 0.45
R7036:Lrp1b UTSW 2 41,002,354 (GRCm39) missense possibly damaging 0.89
R7043:Lrp1b UTSW 2 40,812,426 (GRCm39) missense possibly damaging 0.84
R7071:Lrp1b UTSW 2 41,298,276 (GRCm39) missense
R7077:Lrp1b UTSW 2 41,660,858 (GRCm39) missense
R7115:Lrp1b UTSW 2 40,888,247 (GRCm39) missense
R7143:Lrp1b UTSW 2 41,202,655 (GRCm39) missense
R7146:Lrp1b UTSW 2 41,266,006 (GRCm39) nonsense probably null
R7149:Lrp1b UTSW 2 40,527,872 (GRCm39) missense
R7185:Lrp1b UTSW 2 40,691,524 (GRCm39) critical splice acceptor site probably null
R7239:Lrp1b UTSW 2 40,894,725 (GRCm39) missense
R7247:Lrp1b UTSW 2 41,159,224 (GRCm39) missense
R7331:Lrp1b UTSW 2 40,553,622 (GRCm39) splice site probably null
R7369:Lrp1b UTSW 2 41,172,051 (GRCm39) missense
R7378:Lrp1b UTSW 2 41,185,681 (GRCm39) missense
R7381:Lrp1b UTSW 2 40,692,929 (GRCm39) missense
R7406:Lrp1b UTSW 2 41,266,030 (GRCm39) critical splice acceptor site probably null
R7437:Lrp1b UTSW 2 40,712,658 (GRCm39) missense
R7437:Lrp1b UTSW 2 40,712,657 (GRCm39) missense
R7446:Lrp1b UTSW 2 41,561,069 (GRCm39) missense
R7460:Lrp1b UTSW 2 40,488,478 (GRCm39) missense
R7462:Lrp1b UTSW 2 41,003,041 (GRCm39) missense
R7475:Lrp1b UTSW 2 41,234,588 (GRCm39) missense
R7479:Lrp1b UTSW 2 40,691,517 (GRCm39) missense
R7523:Lrp1b UTSW 2 41,401,473 (GRCm39) missense
R7525:Lrp1b UTSW 2 40,547,428 (GRCm39) missense
R7549:Lrp1b UTSW 2 40,765,134 (GRCm39) missense
R7552:Lrp1b UTSW 2 40,567,582 (GRCm39) missense
R7558:Lrp1b UTSW 2 41,231,948 (GRCm39) missense
R7587:Lrp1b UTSW 2 40,620,729 (GRCm39) missense
R7599:Lrp1b UTSW 2 40,551,561 (GRCm39) missense
R7635:Lrp1b UTSW 2 41,013,609 (GRCm39) critical splice donor site probably null
R7663:Lrp1b UTSW 2 42,543,047 (GRCm39) unclassified probably benign
R7674:Lrp1b UTSW 2 42,542,921 (GRCm39) start gained probably benign
R7681:Lrp1b UTSW 2 40,765,011 (GRCm39) nonsense probably null
R7703:Lrp1b UTSW 2 41,000,798 (GRCm39) missense
R7742:Lrp1b UTSW 2 40,712,641 (GRCm39) missense
R7767:Lrp1b UTSW 2 40,691,517 (GRCm39) missense
R7829:Lrp1b UTSW 2 40,793,460 (GRCm39) nonsense probably null
R7861:Lrp1b UTSW 2 40,587,570 (GRCm39) missense
R7868:Lrp1b UTSW 2 41,339,246 (GRCm39) missense
R7883:Lrp1b UTSW 2 40,555,141 (GRCm39) missense
R7956:Lrp1b UTSW 2 41,172,161 (GRCm39) splice site probably null
R7963:Lrp1b UTSW 2 40,817,947 (GRCm39) missense
R7964:Lrp1b UTSW 2 40,488,523 (GRCm39) missense
R8035:Lrp1b UTSW 2 40,750,667 (GRCm39) missense
R8046:Lrp1b UTSW 2 41,159,199 (GRCm39) missense
R8128:Lrp1b UTSW 2 41,159,248 (GRCm39) missense probably null
R8234:Lrp1b UTSW 2 41,202,668 (GRCm39) missense
R8237:Lrp1b UTSW 2 40,741,786 (GRCm39) missense
R8244:Lrp1b UTSW 2 41,396,794 (GRCm39) missense
R8370:Lrp1b UTSW 2 40,888,117 (GRCm39) missense
R8395:Lrp1b UTSW 2 40,547,411 (GRCm39) missense
R8398:Lrp1b UTSW 2 40,591,819 (GRCm39) missense
R8421:Lrp1b UTSW 2 40,615,435 (GRCm39) missense
R8426:Lrp1b UTSW 2 41,388,318 (GRCm39) missense
R8443:Lrp1b UTSW 2 41,265,867 (GRCm39) nonsense probably null
R8444:Lrp1b UTSW 2 40,760,272 (GRCm39) missense
R8486:Lrp1b UTSW 2 41,618,702 (GRCm39) missense probably damaging 1.00
R8500:Lrp1b UTSW 2 41,396,791 (GRCm39) missense probably benign 0.12
R8507:Lrp1b UTSW 2 41,298,387 (GRCm39) missense
R8552:Lrp1b UTSW 2 41,298,993 (GRCm39) missense probably benign 0.00
R8554:Lrp1b UTSW 2 41,234,495 (GRCm39) missense probably benign 0.28
R8669:Lrp1b UTSW 2 41,172,047 (GRCm39) critical splice donor site probably null
R8699:Lrp1b UTSW 2 41,172,207 (GRCm39) missense
R8796:Lrp1b UTSW 2 40,793,426 (GRCm39) missense
R8815:Lrp1b UTSW 2 40,555,171 (GRCm39) missense
R8842:Lrp1b UTSW 2 41,158,417 (GRCm39) missense
R8858:Lrp1b UTSW 2 41,560,827 (GRCm39) intron probably benign
R8864:Lrp1b UTSW 2 41,002,718 (GRCm39) missense
R8918:Lrp1b UTSW 2 40,615,893 (GRCm39) missense
R8920:Lrp1b UTSW 2 42,213,610 (GRCm39) missense
R8963:Lrp1b UTSW 2 40,888,196 (GRCm39) missense probably benign 0.28
R8971:Lrp1b UTSW 2 41,325,640 (GRCm39) missense
R9007:Lrp1b UTSW 2 40,587,564 (GRCm39) missense
R9042:Lrp1b UTSW 2 41,392,029 (GRCm39) missense
R9053:Lrp1b UTSW 2 40,748,501 (GRCm39) missense
R9063:Lrp1b UTSW 2 41,231,838 (GRCm39) missense
R9072:Lrp1b UTSW 2 40,615,457 (GRCm39) nonsense probably null
R9105:Lrp1b UTSW 2 41,396,803 (GRCm39) missense
R9131:Lrp1b UTSW 2 40,589,590 (GRCm39) nonsense probably null
R9226:Lrp1b UTSW 2 41,401,460 (GRCm39) missense
R9245:Lrp1b UTSW 2 40,488,456 (GRCm39) missense
R9275:Lrp1b UTSW 2 40,487,076 (GRCm39) missense
R9278:Lrp1b UTSW 2 40,487,076 (GRCm39) missense
R9303:Lrp1b UTSW 2 41,618,574 (GRCm39) missense
R9305:Lrp1b UTSW 2 41,618,574 (GRCm39) missense
R9306:Lrp1b UTSW 2 40,518,762 (GRCm39) missense possibly damaging 0.66
R9320:Lrp1b UTSW 2 41,335,111 (GRCm39) critical splice donor site probably null
R9330:Lrp1b UTSW 2 41,012,993 (GRCm39) missense
R9352:Lrp1b UTSW 2 40,748,438 (GRCm39) missense
R9386:Lrp1b UTSW 2 41,013,640 (GRCm39) missense
R9397:Lrp1b UTSW 2 40,640,922 (GRCm39) missense
R9444:Lrp1b UTSW 2 41,013,730 (GRCm39) missense
R9452:Lrp1b UTSW 2 41,850,726 (GRCm39) nonsense probably null
R9474:Lrp1b UTSW 2 40,491,599 (GRCm39) missense probably damaging 1.00
R9501:Lrp1b UTSW 2 41,172,247 (GRCm39) missense
R9523:Lrp1b UTSW 2 41,660,978 (GRCm39) missense
R9541:Lrp1b UTSW 2 41,234,600 (GRCm39) missense
R9555:Lrp1b UTSW 2 40,748,438 (GRCm39) missense
R9555:Lrp1b UTSW 2 40,741,693 (GRCm39) missense
R9563:Lrp1b UTSW 2 41,185,711 (GRCm39) missense
R9568:Lrp1b UTSW 2 40,569,227 (GRCm39) missense
R9622:Lrp1b UTSW 2 40,779,354 (GRCm39) nonsense probably null
R9623:Lrp1b UTSW 2 41,366,648 (GRCm39) missense
R9634:Lrp1b UTSW 2 41,135,951 (GRCm39) critical splice donor site probably null
R9640:Lrp1b UTSW 2 41,078,929 (GRCm39) missense
R9664:Lrp1b UTSW 2 40,765,004 (GRCm39) missense
R9668:Lrp1b UTSW 2 41,075,982 (GRCm39) missense
R9672:Lrp1b UTSW 2 40,779,291 (GRCm39) missense
R9717:Lrp1b UTSW 2 41,158,395 (GRCm39) missense
R9741:Lrp1b UTSW 2 41,002,300 (GRCm39) missense
RF018:Lrp1b UTSW 2 41,000,919 (GRCm39) missense
RF020:Lrp1b UTSW 2 41,660,858 (GRCm39) missense
V1662:Lrp1b UTSW 2 41,012,944 (GRCm39) missense probably damaging 0.99
X0028:Lrp1b UTSW 2 41,361,157 (GRCm39) missense probably damaging 1.00
X0064:Lrp1b UTSW 2 41,392,055 (GRCm39) missense probably damaging 1.00
Z1176:Lrp1b UTSW 2 40,812,395 (GRCm39) missense
Z1176:Lrp1b UTSW 2 40,587,594 (GRCm39) missense
Z1176:Lrp1b UTSW 2 40,567,518 (GRCm39) missense
Z1176:Lrp1b UTSW 2 41,618,722 (GRCm39) missense
Z1177:Lrp1b UTSW 2 41,078,860 (GRCm39) missense
Z1177:Lrp1b UTSW 2 40,527,761 (GRCm39) missense
Z1187:Lrp1b UTSW 2 40,640,946 (GRCm39) missense
Z1188:Lrp1b UTSW 2 40,640,946 (GRCm39) missense
Nature of Mutation

DNA sequencing using the SOLiD technique identified an A to G transition at position 6784 of the Lrp1b transcript in exon 37 of 91 exons using Genbank record NM_053011.2.  Multiple transcripts of the Lrp1b gene are displayed on Ensembl and Vega. The mutated nucleotide causes an isoleucine to lysine substitution at amino acid 2001 of the encoded protein (amino acid 2032 in the Ensembl record). The mutation has been confirmed by DNA sequencing using the Sanger method.

Protein Function and Prediction

The Lrp1b gene encodes a 4599 amino acid single-pass type I membrane protein that belongs to the LDLR (low density lipoprotein receptor) family.  LRP1B binds and internalizes ligands, such as LRPAP1, PLAU, PLAT and SERPINE1, in the process of receptor-mediated endocytosis.  The protein contains 17 EGF-like domains, 32 LDLR class A domains and 35 LDLR class B repeats. The transmembrane domain occurs at amino acids 4445-4467 (Uniprot Q9JI18). Homozygous null mice appear normal, are fertile, have normal brain histology and function, normal plasma cholesterol and fasting triglycerides, and do not develop tumors.  Homozygous deletions of the human LRP1B gene are found in some nonsmall cell lung cancer (NSCLC) cell lines.

The I2001K alteration occurs in the nineteenth LDLR class B repeats.

Posted On 2011-03-04