Mutagenetix > Incidental Mutation

Incidental Mutation 'R0682:Vmn1r229'

61030

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r229

Ensembl Gene

ENSMUSG00000061150

Gene Name

vomeronasal 1 receptor 229

Synonyms

V1re1

MMRRC Submission

038867-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R0682 (G1)

Quality Score

124

Status

Not validated

Chromosome

Chromosomal Location

21034757-21035677 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 21034950 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Valine at position 65 (E65V)

Ref Sequence

ENSEMBL: ENSMUSP00000076045 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076759]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000076759
AA Change: E65V

PolyPhen 2 Score 0.434 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000076045
Gene: ENSMUSG00000061150
AA Change: E65V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	286	2.7e-13	PFAM
Pfam:7tm_1	22	285	4.3e-10	PFAM
Pfam:V1R	31	293	6.6e-29	PFAM

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.6%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001J03Rik	T	C	5: 146,121,650 (GRCm39)	H83R	probably benign	Het
Abcd3	A	C	3: 121,563,216 (GRCm39)	I471S	possibly damaging	Het
Abcg1	G	A	17: 31,330,225 (GRCm39)	V509I	probably benign	Het
Adamts9	A	T	6: 92,880,783 (GRCm39)	N497K	possibly damaging	Het
Agap2	A	G	10: 126,919,351 (GRCm39)	S479G	unknown	Het
Asic2	T	C	11: 80,777,506 (GRCm39)	I402V	possibly damaging	Het
Atp1a2	G	A	1: 172,112,164 (GRCm39)	T577I	probably benign	Het
Atraid	T	A	5: 31,209,612 (GRCm39)	I92K	probably damaging	Het
Dpp10	C	A	1: 123,832,852 (GRCm39)	A31S	probably damaging	Het
Erich6	A	T	3: 58,544,232 (GRCm39)	F118L	probably benign	Het
Galnt18	T	C	7: 111,119,222 (GRCm39)	Y418C	probably damaging	Het
Herc1	T	A	9: 66,389,263 (GRCm39)	C3927S	possibly damaging	Het
Ifit2	G	A	19: 34,551,012 (GRCm39)	R184H	probably benign	Het
Kif24	A	T	4: 41,428,620 (GRCm39)	N113K	probably benign	Het
Lrp1b	T	A	2: 41,185,653 (GRCm39)	Y1354F	probably benign	Het
Muc1	T	A	3: 89,138,439 (GRCm39)	I427N	probably damaging	Het
Muc5ac	A	G	7: 141,359,406 (GRCm39)	T1288A	possibly damaging	Het
Or7g32	C	A	9: 19,388,645 (GRCm39)	M300I	probably benign	Het
Or9i14	C	T	19: 13,792,501 (GRCm39)	C151Y	possibly damaging	Het
Pex26	T	A	6: 121,161,363 (GRCm39)	V47E	probably damaging	Het
Plekhm2	T	C	4: 141,355,436 (GRCm39)	I871V	probably damaging	Het
Rasal2	A	G	1: 157,006,779 (GRCm39)	S111P	probably damaging	Het
Rnf133	A	T	6: 23,649,569 (GRCm39)	I163N	probably damaging	Het
Rrp8	A	C	7: 105,383,218 (GRCm39)	D349E	probably damaging	Het
Sdhd	G	T	9: 50,511,905 (GRCm39)	Q38K	probably benign	Het
Ssh1	C	T	5: 114,098,718 (GRCm39)	S117N	probably damaging	Het
Tbc1d2b	A	G	9: 90,131,915 (GRCm39)	M148T	probably benign	Het
Tnni3k	A	G	3: 154,645,665 (GRCm39)	S470P	probably damaging	Het
Tnr	C	T	1: 159,679,877 (GRCm39)	Q284*	probably null	Het
Trim30a	A	C	7: 104,078,389 (GRCm39)	V229G	probably damaging	Het
Trim43a	G	A	9: 88,464,199 (GRCm39)	E37K	probably benign	Het
U2surp	C	T	9: 95,366,496 (GRCm39)	V470I	probably benign	Het
Uck2	T	C	1: 167,064,259 (GRCm39)	D90G	probably damaging	Het
Vmn2r26	A	G	6: 124,038,129 (GRCm39)	E568G	probably damaging	Het
Whamm	A	G	7: 81,235,886 (GRCm39)	E363G	probably damaging	Het
Wrap53	A	G	11: 69,453,272 (GRCm39)	S390P	probably damaging	Het
Wrn	A	G	8: 33,757,848 (GRCm39)	S814P	probably benign	Het
Zfp329	A	G	7: 12,544,211 (GRCm39)	C438R	probably damaging	Het
Zkscan8	T	C	13: 21,710,930 (GRCm39)	Y60C	probably damaging	Het

Other mutations in Vmn1r229

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1401:Vmn1r229	UTSW	17	21,034,904 (GRCm39)	missense	possibly damaging	0.63
R1484:Vmn1r229	UTSW	17	21,034,791 (GRCm39)	missense	probably damaging	1.00
R1551:Vmn1r229	UTSW	17	21,035,051 (GRCm39)	missense	probably benign	0.36
R1568:Vmn1r229	UTSW	17	21,035,067 (GRCm39)	missense	probably damaging	1.00
R1793:Vmn1r229	UTSW	17	21,034,974 (GRCm39)	missense	possibly damaging	0.61
R2157:Vmn1r229	UTSW	17	21,035,638 (GRCm39)	missense	possibly damaging	0.82
R4458:Vmn1r229	UTSW	17	21,034,894 (GRCm39)	missense	probably damaging	1.00
R4556:Vmn1r229	UTSW	17	21,034,953 (GRCm39)	missense	possibly damaging	0.79
R4891:Vmn1r229	UTSW	17	21,035,081 (GRCm39)	missense	probably damaging	1.00
R6310:Vmn1r229	UTSW	17	21,034,976 (GRCm39)	missense	probably benign	0.01
R6995:Vmn1r229	UTSW	17	21,035,277 (GRCm39)	missense	probably damaging	1.00
R8109:Vmn1r229	UTSW	17	21,035,268 (GRCm39)	missense	probably benign	0.05
R8155:Vmn1r229	UTSW	17	21,035,472 (GRCm39)	missense	probably damaging	1.00
R8232:Vmn1r229	UTSW	17	21,035,309 (GRCm39)	missense	probably damaging	0.96
R8828:Vmn1r229	UTSW	17	21,034,990 (GRCm39)	missense	probably damaging	0.97
R8943:Vmn1r229	UTSW	17	21,035,418 (GRCm39)	missense	possibly damaging	0.91
R9147:Vmn1r229	UTSW	17	21,034,758 (GRCm39)	start codon destroyed	probably null	1.00
R9148:Vmn1r229	UTSW	17	21,034,758 (GRCm39)	start codon destroyed	probably null	1.00
R9407:Vmn1r229	UTSW	17	21,035,259 (GRCm39)	missense	probably damaging	1.00
R9621:Vmn1r229	UTSW	17	21,035,315 (GRCm39)	missense	probably benign	0.00
Z1088:Vmn1r229	UTSW	17	21,035,327 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACCATTGATTCTCACAAGGTGGAGC -3'
(R):5'- GGCCCATGAACTTTGCTGTTTGC -3'

Sequencing Primer
(F):5'- cacaatggccttggatatagaaac -3'
(R):5'- GCTCTTTAAATTCCTTCCAGCAGG -3'

Posted On

2013-07-30