Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00434:Slc35f1'

6106

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc35f1

Ensembl Gene

ENSMUSG00000038602

Gene Name

solute carrier family 35, member F1

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00434

Quality Score

Status

Chromosome

Chromosomal Location

52566629-52987718 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 52938548 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 160 (L160P)

Ref Sequence

ENSEMBL: ENSMUSP00000101113 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105473]

AlphaFold

Q8BGK5

Predicted Effect

probably damaging
Transcript: ENSMUST00000105473
AA Change: L160P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000101113
Gene: ENSMUSG00000038602
AA Change: L160P

Domain	Start	End	E-Value	Type
low complexity region	3	20	N/A	INTRINSIC
Pfam:SLC35F	56	355	1.4e-151	PFAM
Pfam:CRT-like	66	315	2.3e-13	PFAM
Pfam:EamA	217	355	1.7e-9	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arid2	T	C	15: 96,269,181 (GRCm39)	V1098A	probably damaging	Het
Bltp1	T	C	3: 37,041,448 (GRCm39)	F2609L	probably damaging	Het
Ccdc126	C	T	6: 49,311,239 (GRCm39)		probably benign	Het
Cds2	T	C	2: 132,135,271 (GRCm39)	L54P	probably damaging	Het
Cdsn	A	T	17: 35,865,740 (GRCm39)	S90C	unknown	Het
Clcn6	G	T	4: 148,098,195 (GRCm39)	D581E	probably damaging	Het
Clec4f	T	A	6: 83,630,198 (GRCm39)	H120L	possibly damaging	Het
Col12a1	T	C	9: 79,560,614 (GRCm39)	T1838A	probably benign	Het
Col22a1	T	C	15: 71,878,524 (GRCm39)	D211G	possibly damaging	Het
Cpne8	T	C	15: 90,381,261 (GRCm39)		probably benign	Het
Dgkk	T	A	X: 6,772,697 (GRCm39)	M462K	probably benign	Het
Dhx29	T	A	13: 113,091,759 (GRCm39)	H834Q	probably benign	Het
Esyt1	A	G	10: 128,353,504 (GRCm39)	Y578H	possibly damaging	Het
Fnip2	C	A	3: 79,419,796 (GRCm39)		probably benign	Het
Fut1	T	G	7: 45,268,855 (GRCm39)	C270G	probably damaging	Het
Ganab	T	A	19: 8,884,707 (GRCm39)	V170D	probably damaging	Het
Gys1	T	A	7: 45,094,256 (GRCm39)	M364K	possibly damaging	Het
Ighv1-85	A	C	12: 115,963,654 (GRCm39)	C115W	probably damaging	Het
Igkv4-74	T	G	6: 69,162,044 (GRCm39)	T42P	probably damaging	Het
Jmjd4	A	G	11: 59,341,321 (GRCm39)	Y84C	probably damaging	Het
Kif11	A	C	19: 37,399,857 (GRCm39)	E781D	possibly damaging	Het
Kif14	G	A	1: 136,396,756 (GRCm39)	S354N	probably benign	Het
Klf1	C	T	8: 85,628,628 (GRCm39)	P9S	possibly damaging	Het
Lrrn3	T	C	12: 41,502,191 (GRCm39)		probably benign	Het
Ltbp4	C	A	7: 27,028,230 (GRCm39)	R309L	probably damaging	Het
Marchf10	T	C	11: 105,293,014 (GRCm39)	E131G	possibly damaging	Het
Men1	G	A	19: 6,387,237 (GRCm39)		probably null	Het
Mgme1	T	A	2: 144,121,056 (GRCm39)		probably benign	Het
Nkiras2	G	A	11: 100,515,808 (GRCm39)	G45D	probably damaging	Het
Orc2	A	T	1: 58,532,875 (GRCm39)	D16E	possibly damaging	Het
Pcyox1l	T	C	18: 61,830,613 (GRCm39)	T420A	probably benign	Het
Pira13	C	A	7: 3,826,088 (GRCm39)	G302C	probably damaging	Het
Pm20d1	A	G	1: 131,741,738 (GRCm39)		probably benign	Het
Ppp1r3c	T	C	19: 36,711,503 (GRCm39)	D89G	probably damaging	Het
Ppp2ca	G	A	11: 52,012,776 (GRCm39)	R302H	probably benign	Het
Riok3	T	C	18: 12,281,904 (GRCm39)	V291A	probably damaging	Het
Rragd	A	G	4: 33,007,219 (GRCm39)		probably benign	Het
Scai	C	A	2: 38,998,406 (GRCm39)	L174F	probably damaging	Het
Slc25a44	T	C	3: 88,323,369 (GRCm39)	I227V	probably benign	Het
Slc38a1	A	G	15: 96,483,504 (GRCm39)	Y275H	possibly damaging	Het
Slco6b1	A	G	1: 96,916,375 (GRCm39)		noncoding transcript	Het
Spag8	G	T	4: 43,652,890 (GRCm39)	C190*	probably null	Het
Tbr1	T	C	2: 61,635,625 (GRCm39)	F192L	probably benign	Het
Tti1	C	T	2: 157,850,886 (GRCm39)	E118K	probably damaging	Het
Tti1	T	A	2: 157,850,885 (GRCm39)	E118V	probably damaging	Het
Vcan	G	T	13: 89,852,821 (GRCm39)	P713Q	probably damaging	Het
Vcf2	A	T	X: 149,181,395 (GRCm39)	V132E	possibly damaging	Het
Wt1	G	T	2: 104,974,486 (GRCm39)		probably null	Het
Xylt1	T	A	7: 117,249,912 (GRCm39)	I694N	probably damaging	Het
Zfp516	T	A	18: 82,975,233 (GRCm39)	M477K	probably benign	Het

Other mutations in Slc35f1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01073:Slc35f1	APN	10	52,898,056 (GRCm39)	missense	probably benign	0.16
IGL01433:Slc35f1	APN	10	52,949,542 (GRCm39)	splice site	probably benign
IGL01566:Slc35f1	APN	10	52,965,551 (GRCm39)	missense	probably damaging	1.00
IGL02693:Slc35f1	APN	10	52,809,224 (GRCm39)	missense	probably damaging	1.00
IGL02870:Slc35f1	APN	10	52,809,303 (GRCm39)	missense	possibly damaging	0.82
IGL03082:Slc35f1	APN	10	52,809,234 (GRCm39)	missense	probably benign
R0884:Slc35f1	UTSW	10	52,965,443 (GRCm39)	missense	probably damaging	1.00
R1340:Slc35f1	UTSW	10	52,965,550 (GRCm39)	missense	probably damaging	1.00
R1781:Slc35f1	UTSW	10	52,938,532 (GRCm39)	splice site	probably null
R1813:Slc35f1	UTSW	10	52,809,291 (GRCm39)	missense	probably damaging	1.00
R1908:Slc35f1	UTSW	10	52,898,000 (GRCm39)	missense	possibly damaging	0.84
R2044:Slc35f1	UTSW	10	52,965,443 (GRCm39)	missense	probably damaging	1.00
R2518:Slc35f1	UTSW	10	52,949,630 (GRCm39)	missense	probably benign	0.07
R3872:Slc35f1	UTSW	10	52,898,006 (GRCm39)	missense	possibly damaging	0.87
R3934:Slc35f1	UTSW	10	52,984,314 (GRCm39)	missense	probably damaging	1.00
R3935:Slc35f1	UTSW	10	52,984,314 (GRCm39)	missense	probably damaging	1.00
R3936:Slc35f1	UTSW	10	52,984,314 (GRCm39)	missense	probably damaging	1.00
R4118:Slc35f1	UTSW	10	52,965,464 (GRCm39)	missense	probably damaging	0.98
R4921:Slc35f1	UTSW	10	52,938,698 (GRCm39)	missense	probably damaging	0.99
R5116:Slc35f1	UTSW	10	52,897,991 (GRCm39)	missense	probably benign	0.39
R5378:Slc35f1	UTSW	10	52,567,157 (GRCm39)	missense	possibly damaging	0.86
R5387:Slc35f1	UTSW	10	52,984,260 (GRCm39)	missense	probably damaging	1.00
R5500:Slc35f1	UTSW	10	52,809,318 (GRCm39)	missense	probably damaging	0.99
R5590:Slc35f1	UTSW	10	52,984,274 (GRCm39)	missense	possibly damaging	0.63
R5743:Slc35f1	UTSW	10	52,965,546 (GRCm39)	missense	probably benign	0.06
R5916:Slc35f1	UTSW	10	52,809,317 (GRCm39)	nonsense	probably null
R6985:Slc35f1	UTSW	10	52,898,007 (GRCm39)	missense	probably benign	0.02
R7068:Slc35f1	UTSW	10	52,938,596 (GRCm39)	missense	probably damaging	1.00
R7295:Slc35f1	UTSW	10	52,938,637 (GRCm39)	missense	probably benign	0.00
R7427:Slc35f1	UTSW	10	52,965,510 (GRCm39)	missense	probably damaging	1.00
R7428:Slc35f1	UTSW	10	52,965,510 (GRCm39)	missense	probably damaging	1.00
R8334:Slc35f1	UTSW	10	52,984,244 (GRCm39)	missense	possibly damaging	0.84

Posted On

2012-04-20