Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00331:Trmt11'

6116

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trmt11

Ensembl Gene

ENSMUSG00000019792

Gene Name

tRNA methyltransferase 11

Synonyms

2410075D05Rik, 3110045I18Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.852) question?

Stock #

IGL00331

Quality Score

Status

Chromosome

Chromosomal Location

30410221-30476745 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 30442445 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 246 (D246G)

Ref Sequence

ENSEMBL: ENSMUSP00000019927 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019927] [ENSMUST00000215595] [ENSMUST00000216790]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000019927
AA Change: D246G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000019927
Gene: ENSMUSG00000019792
AA Change: D246G

Domain	Start	End	E-Value	Type
Pfam:UPF0020	189	324	1.9e-14	PFAM
Pfam:Methyltransf_26	216	373	1.2e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215041

Predicted Effect

probably benign
Transcript: ENSMUST00000215595

Predicted Effect

probably benign
Transcript: ENSMUST00000216790

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aamp	C	A	1: 74,320,595 (GRCm39)		probably benign	Het
Adamts19	T	A	18: 59,140,397 (GRCm39)		probably benign	Het
Afg3l1	T	A	8: 124,214,128 (GRCm39)	F190I	probably benign	Het
Alms1	T	A	6: 85,618,353 (GRCm39)	S2800T	possibly damaging	Het
Alox5	A	T	6: 116,392,478 (GRCm39)	W348R	probably damaging	Het
Atp13a5	G	A	16: 29,085,766 (GRCm39)	Q823*	probably null	Het
Atp6v1b2	T	C	8: 69,541,586 (GRCm39)		probably null	Het
Chuk	T	C	19: 44,076,462 (GRCm39)	I416M	possibly damaging	Het
Cimip2b	G	A	4: 43,428,158 (GRCm39)	R100W	possibly damaging	Het
Dmbt1	A	T	7: 130,701,020 (GRCm39)	Q1066L	possibly damaging	Het
Dnah5	A	G	15: 28,421,766 (GRCm39)	T3873A	probably damaging	Het
Endog	C	T	2: 30,062,912 (GRCm39)	T184M	probably damaging	Het
Fcgbp	T	C	7: 27,800,966 (GRCm39)		probably benign	Het
Flii	A	G	11: 60,606,659 (GRCm39)	I1061T	probably benign	Het
Hdac2	T	A	10: 36,873,067 (GRCm39)	N308K	probably damaging	Het
Hoxa2	T	G	6: 52,140,497 (GRCm39)	Y163S	probably damaging	Het
Hsd3b7	T	C	7: 127,402,144 (GRCm39)	L263P	probably damaging	Het
Klf17	T	C	4: 117,618,235 (GRCm39)	T41A	probably benign	Het
Lrrfip1	T	C	1: 90,996,343 (GRCm39)	M42T	probably damaging	Het
Mapk8ip1	C	T	2: 92,215,533 (GRCm39)	V614I	probably benign	Het
Mocs1	T	G	17: 49,742,292 (GRCm39)		probably null	Het
Moxd1	T	C	10: 24,158,453 (GRCm39)		probably benign	Het
Mterf1a	T	C	5: 3,941,610 (GRCm39)	E86G	probably damaging	Het
Muc4	A	G	16: 32,574,613 (GRCm39)	D1021G	probably benign	Het
Nomo1	T	C	7: 45,694,760 (GRCm39)	S212P	possibly damaging	Het
Or5b116	A	G	19: 13,422,988 (GRCm39)	D204G	probably benign	Het
Or8c15	T	A	9: 38,120,534 (GRCm39)	Y60N	probably damaging	Het
Phf21a	A	C	2: 92,178,374 (GRCm39)	T385P	probably damaging	Het
Piwil4	A	T	9: 14,626,327 (GRCm39)		probably benign	Het
Pknox1	T	C	17: 31,818,619 (GRCm39)		probably null	Het
Prr14l	T	C	5: 32,988,410 (GRCm39)	I362V	probably benign	Het
Sergef	C	T	7: 46,284,844 (GRCm39)		probably null	Het
Sez6l	T	C	5: 112,572,511 (GRCm39)	D948G	probably damaging	Het
Skor1	A	T	9: 63,053,723 (GRCm39)	L54Q	probably damaging	Het
Sntn	C	T	14: 13,679,086 (GRCm38)	Q87*	probably null	Het
Syde2	A	G	3: 145,720,096 (GRCm39)	K772E	possibly damaging	Het
Taf2	T	A	15: 54,934,845 (GRCm39)		probably null	Het
Tbc1d13	T	A	2: 30,030,523 (GRCm39)	Y113N	probably damaging	Het
Tmem154	T	C	3: 84,591,722 (GRCm39)	F91L	probably benign	Het
Tmem63a	A	G	1: 180,794,062 (GRCm39)	D533G	possibly damaging	Het
Tmprss15	A	T	16: 78,782,882 (GRCm39)	N712K	possibly damaging	Het
Trip12	A	T	1: 84,708,262 (GRCm39)	D603E	probably damaging	Het
Vmn1r174	T	A	7: 23,453,958 (GRCm39)	M208K	possibly damaging	Het
Wdr54	T	C	6: 83,132,755 (GRCm39)	H33R	probably benign	Het
Zfp207	A	G	11: 80,279,828 (GRCm39)	D111G	probably benign	Het

Other mutations in Trmt11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01586:Trmt11	APN	10	30,473,747 (GRCm39)	missense	probably benign	0.01
IGL02307:Trmt11	APN	10	30,470,150 (GRCm39)	missense	possibly damaging	0.92
IGL02319:Trmt11	APN	10	30,436,869 (GRCm39)	missense	probably damaging	1.00
IGL02622:Trmt11	APN	10	30,435,169 (GRCm39)	missense	probably benign	0.00
R0047:Trmt11	UTSW	10	30,411,239 (GRCm39)	missense	probably benign
R0047:Trmt11	UTSW	10	30,411,239 (GRCm39)	missense	probably benign
R0269:Trmt11	UTSW	10	30,463,485 (GRCm39)	missense	probably benign	0.01
R1240:Trmt11	UTSW	10	30,466,821 (GRCm39)	intron	probably benign
R1694:Trmt11	UTSW	10	30,411,221 (GRCm39)	missense	probably benign	0.02
R1765:Trmt11	UTSW	10	30,435,184 (GRCm39)	missense	probably benign
R2293:Trmt11	UTSW	10	30,423,744 (GRCm39)	missense	probably damaging	0.98
R2295:Trmt11	UTSW	10	30,423,744 (GRCm39)	missense	probably damaging	0.98
R2857:Trmt11	UTSW	10	30,423,744 (GRCm39)	missense	probably damaging	0.98
R4631:Trmt11	UTSW	10	30,435,200 (GRCm39)	missense	probably benign	0.00
R5684:Trmt11	UTSW	10	30,423,706 (GRCm39)	missense	probably damaging	1.00
R5952:Trmt11	UTSW	10	30,436,838 (GRCm39)	missense	probably benign	0.01
R6022:Trmt11	UTSW	10	30,463,497 (GRCm39)	missense	possibly damaging	0.76
R7044:Trmt11	UTSW	10	30,466,930 (GRCm39)	missense	probably benign	0.27
R7459:Trmt11	UTSW	10	30,466,039 (GRCm39)	missense	probably benign	0.02
R7538:Trmt11	UTSW	10	30,436,870 (GRCm39)	missense	probably damaging	1.00
R7672:Trmt11	UTSW	10	30,463,520 (GRCm39)	missense	probably damaging	1.00
R7728:Trmt11	UTSW	10	30,463,497 (GRCm39)	missense	possibly damaging	0.76
R8116:Trmt11	UTSW	10	30,442,490 (GRCm39)	missense	possibly damaging	0.88
R8988:Trmt11	UTSW	10	30,467,027 (GRCm39)	missense	probably benign
R9225:Trmt11	UTSW	10	30,423,753 (GRCm39)	missense	probably damaging	1.00
R9507:Trmt11	UTSW	10	30,434,938 (GRCm39)	nonsense	probably null
R9555:Trmt11	UTSW	10	30,470,150 (GRCm39)	missense	possibly damaging	0.92
R9690:Trmt11	UTSW	10	30,436,938 (GRCm39)	missense	probably damaging	0.98

Posted On

2012-04-20