|Institutional Source||Beutler Lab|
|Gene Name||DnaJ heat shock protein family (Hsp40) member A2|
|Synonyms||2010206B19Rik, mDj3, HIRIP4, 1500017M13Rik, PRO3015, DNJ3|
|Is this an essential gene?||Possibly essential (E-score: 0.508)|
|Stock #||R0689 (G1)|
|Chromosomal Location||85537633-85555344 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to G at 85546718 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000034138 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000034138]|
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
|Validation Efficiency||99% (80/81)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dnaja2||
(F):5'- GACTGAACCTACCCACTGTGCATC -3'
(R):5'- AGCATTCATAGAAGCTCCAGCAGC -3'
(F):5'- acataaaggaaaatgaggtgcag -3'
(R):5'- CTGACTGTCCAAGGAGCTAAG -3'