Incidental Mutation 'IGL00566:Ice2'
ID6159
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ice2
Ensembl Gene ENSMUSG00000032235
Gene Nameinteractor of little elongation complex ELL subunit 2
SynonymsNarg2, B230343B06Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.883) question?
Stock #IGL00566
Quality Score
Status
Chromosome9
Chromosomal Location69397906-69433122 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 69416113 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 630 (V630A)
Ref Sequence ENSEMBL: ENSMUSP00000034761 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034761]
Predicted Effect probably benign
Transcript: ENSMUST00000034761
AA Change: V630A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000034761
Gene: ENSMUSG00000032235
AA Change: V630A

DomainStartEndE-ValueType
low complexity region 408 422 N/A INTRINSIC
low complexity region 434 473 N/A INTRINSIC
low complexity region 563 580 N/A INTRINSIC
low complexity region 615 629 N/A INTRINSIC
Pfam:NARG2_C 726 936 1.7e-85 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142743
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146368
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147558
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik A G 7: 41,625,391 T173A possibly damaging Het
Acaa2 G A 18: 74,793,378 G135E probably damaging Het
Actr2 C A 11: 20,072,487 R328L possibly damaging Het
Adam1b T C 5: 121,500,993 D663G probably damaging Het
Adcy10 A T 1: 165,551,914 E915V probably benign Het
Antxr2 G A 5: 97,886,607 probably benign Het
Ckap5 T A 2: 91,568,627 probably benign Het
Clec4g T C 8: 3,716,410 probably benign Het
Cramp1l A G 17: 24,983,951 V368A probably benign Het
Diaph3 C T 14: 87,002,871 R248K probably benign Het
Fut10 T C 8: 31,235,684 Y156H probably damaging Het
Ints13 A T 6: 146,565,676 V179D probably damaging Het
Kcnj2 A C 11: 111,071,827 E15A probably damaging Het
Kif1bp G T 10: 62,559,339 S508* probably null Het
Lpcat2b T A 5: 107,433,804 L333Q probably damaging Het
Lrguk A C 6: 34,056,174 L258F probably damaging Het
M6pr A T 6: 122,313,378 K100M probably damaging Het
Nop14 T C 5: 34,641,313 probably benign Het
Pcdh20 A G 14: 88,467,881 V661A possibly damaging Het
Vcan A T 13: 89,688,979 H2815Q probably benign Het
Other mutations in Ice2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01626:Ice2 APN 9 69407332 missense probably benign 0.39
IGL03035:Ice2 APN 9 69425688 missense probably benign 0.06
R0227:Ice2 UTSW 9 69412228 missense probably benign 0.08
R1373:Ice2 UTSW 9 69407119 missense probably benign 0.01
R1381:Ice2 UTSW 9 69400527 missense probably damaging 1.00
R1599:Ice2 UTSW 9 69411442 missense probably null 0.01
R1778:Ice2 UTSW 9 69415648 missense probably benign 0.04
R1818:Ice2 UTSW 9 69432101 missense probably benign 0.00
R1829:Ice2 UTSW 9 69407353 missense probably damaging 0.99
R1876:Ice2 UTSW 9 69415575 missense possibly damaging 0.85
R1878:Ice2 UTSW 9 69428576 critical splice donor site probably null
R2026:Ice2 UTSW 9 69416325 missense probably benign 0.00
R2915:Ice2 UTSW 9 69410840 missense probably benign 0.19
R4097:Ice2 UTSW 9 69421671 missense possibly damaging 0.95
R4815:Ice2 UTSW 9 69407118 missense probably damaging 1.00
R4861:Ice2 UTSW 9 69415448 missense probably benign 0.00
R4861:Ice2 UTSW 9 69415448 missense probably benign 0.00
R5066:Ice2 UTSW 9 69408291 missense probably benign 0.00
R5653:Ice2 UTSW 9 69428380 missense probably benign 0.00
R5898:Ice2 UTSW 9 69408262 missense probably benign 0.08
R5951:Ice2 UTSW 9 69412369 missense possibly damaging 0.67
R6176:Ice2 UTSW 9 69417072 missense probably damaging 1.00
R6566:Ice2 UTSW 9 69416229 missense probably benign
R6632:Ice2 UTSW 9 69428452 missense probably benign 0.07
R7195:Ice2 UTSW 9 69428500 missense possibly damaging 0.91
R7272:Ice2 UTSW 9 69417083 missense possibly damaging 0.46
R7365:Ice2 UTSW 9 69400512 missense probably damaging 1.00
Posted On2012-04-20