Incidental Mutation 'R0675:Or1e26'
ID 61620
Institutional Source Beutler Lab
Gene Symbol Or1e26
Ensembl Gene ENSMUSG00000095095
Gene Name olfactory receptor family 1 subfamily E member 26
Synonyms Olfr385, GA_x6K02T2P1NL-3760313-3759375, MOR135-3
MMRRC Submission 038860-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R0675 (G1)
Quality Score 148
Status Validated
Chromosome 11
Chromosomal Location 73479624-73480562 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 73480078 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 162 (L162R)
Ref Sequence ENSEMBL: ENSMUSP00000149293 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071553] [ENSMUST00000215689]
AlphaFold Q8VGT1
Predicted Effect probably damaging
Transcript: ENSMUST00000071553
AA Change: L162R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071484
Gene: ENSMUSG00000095095
AA Change: L162R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.1e-55 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.7e-6 PFAM
Pfam:7tm_1 41 290 2.2e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215689
AA Change: L162R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.8095 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 96.1%
Validation Efficiency 97% (88/91)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim2 C T 5: 36,024,124 (GRCm39) probably benign Het
Aire T C 10: 77,870,327 (GRCm39) probably benign Het
Akap12 T C 10: 4,303,315 (GRCm39) S42P probably benign Het
Amigo1 T C 3: 108,098,985 (GRCm39) probably benign Het
Angptl3 A G 4: 98,921,499 (GRCm39) T206A probably benign Het
Ank1 T A 8: 23,600,400 (GRCm39) probably benign Het
Ano5 A T 7: 51,224,558 (GRCm39) T472S probably damaging Het
Arid3c T C 4: 41,725,958 (GRCm39) D215G probably damaging Het
Cd200 T C 16: 45,217,473 (GRCm39) I73V probably benign Het
Cd47 T C 16: 49,727,162 (GRCm39) I318T possibly damaging Het
Cep290 A G 10: 100,404,675 (GRCm39) probably null Het
Cep350 A G 1: 155,835,499 (GRCm39) S66P possibly damaging Het
Cfap46 C T 7: 139,255,950 (GRCm39) C300Y probably damaging Het
Chd1 T A 17: 15,978,523 (GRCm39) probably benign Het
Chd5 C A 4: 152,470,407 (GRCm39) T1913K probably benign Het
Cimip3 T C 17: 47,724,701 (GRCm39) E140G probably benign Het
Clec4b1 A G 6: 123,048,405 (GRCm39) Y180C probably damaging Het
Cntnap5c A T 17: 58,341,990 (GRCm39) D227V probably damaging Het
Col19a1 C G 1: 24,614,536 (GRCm39) probably benign Het
Csmd1 A T 8: 16,208,145 (GRCm39) M1270K probably benign Het
Cyp2c66 T A 19: 39,175,060 (GRCm39) F487I possibly damaging Het
Dpp8 T C 9: 64,973,784 (GRCm39) probably benign Het
Duoxa1 A T 2: 122,136,861 (GRCm39) probably benign Het
Edil3 A G 13: 89,325,399 (GRCm39) K263E probably damaging Het
Fat2 A G 11: 55,200,035 (GRCm39) L1013P probably damaging Het
Fras1 T C 5: 96,815,246 (GRCm39) probably benign Het
Gab1 A G 8: 81,496,297 (GRCm39) S668P probably damaging Het
Galnt14 T C 17: 73,852,030 (GRCm39) T130A probably damaging Het
Gm10192 G A 4: 97,071,109 (GRCm39) H99Y unknown Het
Gm5592 A G 7: 40,938,811 (GRCm39) T698A possibly damaging Het
Gm6605 C A 7: 38,147,699 (GRCm39) noncoding transcript Het
Gsdma3 A G 11: 98,522,017 (GRCm39) K149R probably benign Het
Igkv4-71 A G 6: 69,220,411 (GRCm39) S29P probably damaging Het
Igsf10 C T 3: 59,236,015 (GRCm39) V1389I probably benign Het
Ik T C 18: 36,880,386 (GRCm39) probably benign Het
Ino80 G A 2: 119,213,962 (GRCm39) P1203S probably damaging Het
Iqsec2 G A X: 150,987,120 (GRCm39) E398K possibly damaging Het
Jmjd6 A G 11: 116,731,353 (GRCm39) V232A probably damaging Het
Klhdc9 G A 1: 171,187,895 (GRCm39) T112M possibly damaging Het
Marcks A G 10: 37,017,181 (GRCm39) probably benign Het
Mctp2 T A 7: 71,732,918 (GRCm39) T829S probably damaging Het
Mroh2a C A 1: 88,156,102 (GRCm39) A78E probably damaging Het
Mroh2a G A 1: 88,178,064 (GRCm39) D1053N probably damaging Het
Mtmr14 A T 6: 113,247,608 (GRCm39) H518L probably damaging Het
Myo5c T C 9: 75,185,571 (GRCm39) M978T probably benign Het
Nlrc3 T C 16: 3,766,775 (GRCm39) I1015V probably benign Het
Nlrp5 C A 7: 23,116,842 (GRCm39) Q189K possibly damaging Het
Or2h2c G C 17: 37,422,347 (GRCm39) L176V probably benign Het
Or51f1d A G 7: 102,700,909 (GRCm39) I135V probably benign Het
Or8k35 T C 2: 86,424,423 (GRCm39) I250V probably benign Het
Otof T A 5: 30,539,705 (GRCm39) Y1051F probably benign Het
Pcdhb14 C A 18: 37,581,392 (GRCm39) T166K possibly damaging Het
Pla2g4e A G 2: 120,030,679 (GRCm39) probably benign Het
Polr3gl T C 3: 96,489,471 (GRCm39) E20G probably damaging Het
Psmd1 A G 1: 86,009,761 (GRCm39) D295G probably benign Het
Ptpn21 C A 12: 98,654,475 (GRCm39) A831S probably benign Het
Pwwp3a T A 10: 80,065,914 (GRCm39) V56E probably damaging Het
Rd3l T C 12: 111,946,596 (GRCm39) D60G probably benign Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rnf213 A G 11: 119,332,660 (GRCm39) D2624G probably benign Het
Sec31a T C 5: 100,541,066 (GRCm39) D347G probably damaging Het
Sema4g G A 19: 44,986,026 (GRCm39) R289H probably damaging Het
Sema5b C T 16: 35,480,703 (GRCm39) T761I probably benign Het
Septin1 A T 7: 126,816,171 (GRCm39) F86L probably damaging Het
Shank3 T C 15: 89,415,591 (GRCm39) V627A possibly damaging Het
Slc25a46 C A 18: 31,742,641 (GRCm39) G75V probably benign Het
Slc45a2 T A 15: 11,025,864 (GRCm39) Y405N probably damaging Het
Spidr T C 16: 15,855,498 (GRCm39) E339G probably damaging Het
Sptbn1 A T 11: 30,067,903 (GRCm39) H1770Q probably damaging Het
Srgap1 T C 10: 121,628,140 (GRCm39) Y944C probably damaging Het
Supt20 C T 3: 54,614,390 (GRCm39) T169I probably damaging Het
Tie1 G A 4: 118,336,966 (GRCm39) Q587* probably null Het
Tmem214 A G 5: 31,029,169 (GRCm39) T203A possibly damaging Het
Tmprss15 C A 16: 78,782,838 (GRCm39) S742I probably damaging Het
Wdr87-ps T C 7: 29,231,942 (GRCm39) noncoding transcript Het
Zfhx2 A G 14: 55,300,620 (GRCm39) V2377A probably damaging Het
Zfp763 G A 17: 33,238,774 (GRCm39) H124Y possibly damaging Het
Zfp846 T C 9: 20,504,853 (GRCm39) S238P probably benign Het
Other mutations in Or1e26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01570:Or1e26 APN 11 73,480,209 (GRCm39) missense probably benign 0.34
IGL02045:Or1e26 APN 11 73,480,058 (GRCm39) missense probably damaging 1.00
IGL02324:Or1e26 APN 11 73,480,081 (GRCm39) missense probably benign 0.02
IGL02328:Or1e26 APN 11 73,480,081 (GRCm39) missense probably benign 0.02
IGL02562:Or1e26 APN 11 73,480,237 (GRCm39) missense probably benign
IGL02715:Or1e26 APN 11 73,479,947 (GRCm39) missense probably benign 0.00
IGL03182:Or1e26 APN 11 73,480,268 (GRCm39) missense probably benign 0.04
IGL03048:Or1e26 UTSW 11 73,479,831 (GRCm39) missense possibly damaging 0.56
R0346:Or1e26 UTSW 11 73,480,283 (GRCm39) missense probably damaging 1.00
R0751:Or1e26 UTSW 11 73,479,970 (GRCm39) missense probably benign 0.02
R1220:Or1e26 UTSW 11 73,480,203 (GRCm39) nonsense probably null
R1389:Or1e26 UTSW 11 73,480,369 (GRCm39) missense possibly damaging 0.88
R1484:Or1e26 UTSW 11 73,480,187 (GRCm39) missense possibly damaging 0.91
R1619:Or1e26 UTSW 11 73,480,118 (GRCm39) missense probably damaging 1.00
R2290:Or1e26 UTSW 11 73,479,745 (GRCm39) missense probably benign 0.37
R3713:Or1e26 UTSW 11 73,479,731 (GRCm39) missense probably damaging 1.00
R3781:Or1e26 UTSW 11 73,480,194 (GRCm39) nonsense probably null
R3781:Or1e26 UTSW 11 73,479,839 (GRCm39) missense probably damaging 1.00
R3782:Or1e26 UTSW 11 73,480,194 (GRCm39) nonsense probably null
R3782:Or1e26 UTSW 11 73,479,839 (GRCm39) missense probably damaging 1.00
R4402:Or1e26 UTSW 11 73,480,081 (GRCm39) missense probably benign 0.02
R4721:Or1e26 UTSW 11 73,480,273 (GRCm39) missense probably damaging 1.00
R5157:Or1e26 UTSW 11 73,480,549 (GRCm39) missense probably damaging 1.00
R5995:Or1e26 UTSW 11 73,480,076 (GRCm39) missense probably benign
R6373:Or1e26 UTSW 11 73,479,724 (GRCm39) missense probably benign 0.42
R6658:Or1e26 UTSW 11 73,479,874 (GRCm39) missense probably damaging 0.99
R7046:Or1e26 UTSW 11 73,480,558 (GRCm39) missense probably benign
R7096:Or1e26 UTSW 11 73,480,463 (GRCm39) missense probably benign 0.03
R7238:Or1e26 UTSW 11 73,480,561 (GRCm39) start codon destroyed probably null 0.99
R7537:Or1e26 UTSW 11 73,480,094 (GRCm39) missense probably benign 0.04
R7548:Or1e26 UTSW 11 73,479,802 (GRCm39) missense possibly damaging 0.56
R7888:Or1e26 UTSW 11 73,480,354 (GRCm39) missense probably damaging 0.99
R7968:Or1e26 UTSW 11 73,480,154 (GRCm39) missense probably benign 0.05
R8923:Or1e26 UTSW 11 73,480,076 (GRCm39) missense probably benign
R9006:Or1e26 UTSW 11 73,480,036 (GRCm39) missense probably benign 0.40
R9281:Or1e26 UTSW 11 73,480,133 (GRCm39) missense probably benign
R9689:Or1e26 UTSW 11 73,479,686 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGGGATTCAGCATGGGAGTCACC -3'
(R):5'- GTCACAATGCCCAAGTTGCTGC -3'

Sequencing Primer
(F):5'- GCAGTGTCCTTCACAGTAGAG -3'
(R):5'- GGTTGTCTGACACAAATGTACTTTCC -3'
Posted On 2013-07-30