Incidental Mutation 'R0678:Ints11'
ID 61702
Institutional Source Beutler Lab
Gene Symbol Ints11
Ensembl Gene ENSMUSG00000029034
Gene Name integrator complex subunit 11
Synonyms Cpsf3l, 2410006F12Rik
MMRRC Submission 038863-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0678 (G1)
Quality Score 106
Status Not validated
Chromosome 4
Chromosomal Location 155954006-155973561 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 155972210 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 405 (I405T)
Ref Sequence ENSEMBL: ENSMUSP00000112656 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030901] [ENSMUST00000079031] [ENSMUST00000097737] [ENSMUST00000105584] [ENSMUST00000120794] [ENSMUST00000156460]
AlphaFold Q9CWS4
Predicted Effect probably damaging
Transcript: ENSMUST00000030901
AA Change: I427T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000030901
Gene: ENSMUSG00000029034
AA Change: I427T

DomainStartEndE-ValueType
Lactamase_B 16 233 3.38e-17 SMART
Beta-Casp 245 363 6.94e-37 SMART
Pfam:RMMBL 376 418 1.1e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079031
SMART Domains Protein: ENSMUSP00000078040
Gene: ENSMUSG00000029033

DomainStartEndE-ValueType
low complexity region 17 31 N/A INTRINSIC
PH 265 361 6.35e-16 SMART
low complexity region 377 391 N/A INTRINSIC
ArfGap 399 521 4.62e-56 SMART
low complexity region 554 566 N/A INTRINSIC
low complexity region 601 617 N/A INTRINSIC
low complexity region 628 650 N/A INTRINSIC
low complexity region 669 686 N/A INTRINSIC
ANK 696 725 3.91e-3 SMART
ANK 729 758 2.43e1 SMART
low complexity region 781 796 N/A INTRINSIC
low complexity region 797 809 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000097737
SMART Domains Protein: ENSMUSP00000095344
Gene: ENSMUSG00000051557

DomainStartEndE-ValueType
Pfam:PseudoU_synth_1 16 124 2.5e-12 PFAM
Pfam:PseudoU_synth_1 168 285 1.1e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105584
SMART Domains Protein: ENSMUSP00000101209
Gene: ENSMUSG00000029033

DomainStartEndE-ValueType
Pfam:BAR_3 3 236 4.1e-95 PFAM
PH 269 365 6.35e-16 SMART
low complexity region 381 395 N/A INTRINSIC
ArfGap 403 525 4.62e-56 SMART
low complexity region 558 570 N/A INTRINSIC
low complexity region 605 621 N/A INTRINSIC
low complexity region 632 654 N/A INTRINSIC
low complexity region 673 690 N/A INTRINSIC
ANK 700 729 3.91e-3 SMART
ANK 733 762 2.43e1 SMART
low complexity region 785 800 N/A INTRINSIC
low complexity region 801 813 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000120794
AA Change: I405T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000112656
Gene: ENSMUSG00000029034
AA Change: I405T

DomainStartEndE-ValueType
Lactamase_B 16 211 6.42e-9 SMART
Beta-Casp 223 341 6.94e-37 SMART
Pfam:RMMBL 354 396 3.6e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123504
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132632
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135844
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134678
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137726
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150446
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142566
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142724
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130146
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126582
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131168
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129637
Predicted Effect probably benign
Transcript: ENSMUST00000156460
SMART Domains Protein: ENSMUSP00000118803
Gene: ENSMUSG00000029034

DomainStartEndE-ValueType
SCOP:d1smla_ 1 66 7e-7 SMART
PDB:2I7V|A 3 38 1e-9 PDB
Blast:Lactamase_B 16 66 4e-30 BLAST
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Egfl7 C T 2: 26,480,952 (GRCm39) R155C probably benign Het
Fat4 T C 3: 38,943,843 (GRCm39) I912T probably damaging Het
H2-M5 A G 17: 37,300,034 (GRCm39) F47L possibly damaging Het
H2-T24 A T 17: 36,328,333 (GRCm39) F50Y probably damaging Het
Hif1a A G 12: 73,990,965 (GRCm39) probably null Het
Kmt2d A T 15: 98,748,294 (GRCm39) probably benign Het
Pld1 T A 3: 28,174,933 (GRCm39) V857D probably damaging Het
Ptgr3 A G 18: 84,113,287 (GRCm39) E321G probably benign Het
Rab11fip3 G A 17: 26,287,821 (GRCm39) P111S probably benign Het
Rad17 A T 13: 100,781,692 (GRCm39) I35N possibly damaging Het
Rnf31 C A 14: 55,839,170 (GRCm39) Y66* probably null Het
Sec31a T C 5: 100,555,084 (GRCm39) I45M possibly damaging Het
Sele T C 1: 163,882,298 (GRCm39) probably null Het
Serpina3i G T 12: 104,232,978 (GRCm39) probably null Het
Sp6 T A 11: 96,912,607 (GRCm39) W107R probably damaging Het
Sphkap A T 1: 83,256,349 (GRCm39) W467R probably benign Het
Thbs1 T C 2: 117,953,387 (GRCm39) F935L probably damaging Het
Vmn2r8 T A 5: 108,948,412 (GRCm39) H492L probably benign Het
Xrcc2 A G 5: 25,903,261 (GRCm39) S37P possibly damaging Het
Zfand1 T A 3: 10,413,577 (GRCm39) I31L probably benign Het
Zfr G A 15: 12,184,171 (GRCm39) D1058N probably damaging Het
Other mutations in Ints11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01145:Ints11 APN 4 155,969,583 (GRCm39) missense probably damaging 1.00
IGL01515:Ints11 APN 4 155,959,689 (GRCm39) missense probably damaging 1.00
IGL01613:Ints11 APN 4 155,969,655 (GRCm39) critical splice donor site probably null
IGL02024:Ints11 APN 4 155,972,972 (GRCm39) missense probably damaging 1.00
IGL02127:Ints11 APN 4 155,971,320 (GRCm39) missense probably damaging 1.00
IGL02850:Ints11 APN 4 155,959,761 (GRCm39) missense probably benign 0.03
IGL02926:Ints11 APN 4 155,972,568 (GRCm39) critical splice donor site probably null
IGL03296:Ints11 APN 4 155,969,780 (GRCm39) critical splice donor site probably null
IGL03357:Ints11 APN 4 155,956,581 (GRCm39) splice site probably benign
R0013:Ints11 UTSW 4 155,971,625 (GRCm39) missense probably damaging 1.00
R0013:Ints11 UTSW 4 155,971,625 (GRCm39) missense probably damaging 1.00
R0449:Ints11 UTSW 4 155,972,405 (GRCm39) missense probably benign 0.17
R0480:Ints11 UTSW 4 155,972,081 (GRCm39) missense probably damaging 1.00
R0589:Ints11 UTSW 4 155,971,343 (GRCm39) missense probably damaging 1.00
R0865:Ints11 UTSW 4 155,971,564 (GRCm39) splice site probably null
R1135:Ints11 UTSW 4 155,972,384 (GRCm39) splice site probably null
R1466:Ints11 UTSW 4 155,972,567 (GRCm39) critical splice donor site probably null
R1466:Ints11 UTSW 4 155,972,567 (GRCm39) critical splice donor site probably null
R1658:Ints11 UTSW 4 155,972,185 (GRCm39) missense probably damaging 0.97
R1707:Ints11 UTSW 4 155,959,655 (GRCm39) missense probably benign 0.21
R2199:Ints11 UTSW 4 155,959,738 (GRCm39) missense probably benign 0.07
R2876:Ints11 UTSW 4 155,971,882 (GRCm39) unclassified probably benign
R4567:Ints11 UTSW 4 155,970,132 (GRCm39) missense probably damaging 1.00
R4900:Ints11 UTSW 4 155,972,887 (GRCm39) missense probably benign 0.01
R4964:Ints11 UTSW 4 155,971,385 (GRCm39) missense probably damaging 1.00
R4966:Ints11 UTSW 4 155,971,385 (GRCm39) missense probably damaging 1.00
R5306:Ints11 UTSW 4 155,959,665 (GRCm39) missense probably damaging 1.00
R5963:Ints11 UTSW 4 155,957,369 (GRCm39) nonsense probably null
R6246:Ints11 UTSW 4 155,972,546 (GRCm39) missense probably benign
R7285:Ints11 UTSW 4 155,970,568 (GRCm39) missense probably damaging 1.00
R7365:Ints11 UTSW 4 155,956,687 (GRCm39) splice site probably null
R7768:Ints11 UTSW 4 155,971,396 (GRCm39) missense probably damaging 0.97
R7774:Ints11 UTSW 4 155,970,140 (GRCm39) missense probably benign 0.00
R7999:Ints11 UTSW 4 155,971,413 (GRCm39) missense probably benign 0.12
R8103:Ints11 UTSW 4 155,972,687 (GRCm39) missense possibly damaging 0.93
R8785:Ints11 UTSW 4 155,954,165 (GRCm39) missense probably benign 0.17
R8825:Ints11 UTSW 4 155,969,587 (GRCm39) nonsense probably null
Z1088:Ints11 UTSW 4 155,971,427 (GRCm39) missense probably benign 0.41
Predicted Primers PCR Primer
(F):5'- AGGCTCTTGCTGCTGCTAACTCTG -3'
(R):5'- GCAATACCCACCCTACCACTGTTTG -3'

Sequencing Primer
(F):5'- GCTTACATCTTGTGATGCCAC -3'
(R):5'- TTCAGGCAACAGTCCTGTGAG -3'
Posted On 2013-07-30