Incidental Mutation 'R0678:Ptgr3'
ID |
61718 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Ptgr3
|
Ensembl Gene |
ENSMUSG00000049090 |
Gene Name |
prostaglandin reductase 3 |
Synonyms |
C530046K17Rik, Pthr3, Zadh2 |
MMRRC Submission |
038863-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.189)
|
Stock # |
R0678 (G1)
|
Quality Score |
87 |
Status
|
Not validated
|
Chromosome |
18 |
Chromosomal Location |
84106250-84115579 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 84113287 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 321
(E321G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000052544
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060223]
|
AlphaFold |
Q8BGC4 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000060223
AA Change: E321G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000052544 Gene: ENSMUSG00000049090 AA Change: E321G
Domain | Start | End | E-Value | Type |
Pfam:ADH_N_2
|
42 |
183 |
1.5e-14 |
PFAM |
Pfam:ADH_N
|
62 |
126 |
4e-8 |
PFAM |
Pfam:ADH_zinc_N
|
184 |
321 |
9e-30 |
PFAM |
Pfam:ADH_zinc_N_2
|
216 |
367 |
1.7e-16 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 94.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 21 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Egfl7 |
C |
T |
2: 26,480,952 (GRCm39) |
R155C |
probably benign |
Het |
Fat4 |
T |
C |
3: 38,943,843 (GRCm39) |
I912T |
probably damaging |
Het |
H2-M5 |
A |
G |
17: 37,300,034 (GRCm39) |
F47L |
possibly damaging |
Het |
H2-T24 |
A |
T |
17: 36,328,333 (GRCm39) |
F50Y |
probably damaging |
Het |
Hif1a |
A |
G |
12: 73,990,965 (GRCm39) |
|
probably null |
Het |
Ints11 |
T |
C |
4: 155,972,210 (GRCm39) |
I405T |
probably damaging |
Het |
Kmt2d |
A |
T |
15: 98,748,294 (GRCm39) |
|
probably benign |
Het |
Pld1 |
T |
A |
3: 28,174,933 (GRCm39) |
V857D |
probably damaging |
Het |
Rab11fip3 |
G |
A |
17: 26,287,821 (GRCm39) |
P111S |
probably benign |
Het |
Rad17 |
A |
T |
13: 100,781,692 (GRCm39) |
I35N |
possibly damaging |
Het |
Rnf31 |
C |
A |
14: 55,839,170 (GRCm39) |
Y66* |
probably null |
Het |
Sec31a |
T |
C |
5: 100,555,084 (GRCm39) |
I45M |
possibly damaging |
Het |
Sele |
T |
C |
1: 163,882,298 (GRCm39) |
|
probably null |
Het |
Serpina3i |
G |
T |
12: 104,232,978 (GRCm39) |
|
probably null |
Het |
Sp6 |
T |
A |
11: 96,912,607 (GRCm39) |
W107R |
probably damaging |
Het |
Sphkap |
A |
T |
1: 83,256,349 (GRCm39) |
W467R |
probably benign |
Het |
Thbs1 |
T |
C |
2: 117,953,387 (GRCm39) |
F935L |
probably damaging |
Het |
Vmn2r8 |
T |
A |
5: 108,948,412 (GRCm39) |
H492L |
probably benign |
Het |
Xrcc2 |
A |
G |
5: 25,903,261 (GRCm39) |
S37P |
possibly damaging |
Het |
Zfand1 |
T |
A |
3: 10,413,577 (GRCm39) |
I31L |
probably benign |
Het |
Zfr |
G |
A |
15: 12,184,171 (GRCm39) |
D1058N |
probably damaging |
Het |
|
Other mutations in Ptgr3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02063:Ptgr3
|
APN |
18 |
84,113,390 (GRCm39) |
nonsense |
probably null |
|
IGL02653:Ptgr3
|
APN |
18 |
84,113,443 (GRCm39) |
missense |
possibly damaging |
0.82 |
R0905:Ptgr3
|
UTSW |
18 |
84,113,332 (GRCm39) |
missense |
probably benign |
0.00 |
R1434:Ptgr3
|
UTSW |
18 |
84,112,596 (GRCm39) |
missense |
probably benign |
0.42 |
R1524:Ptgr3
|
UTSW |
18 |
84,112,831 (GRCm39) |
missense |
probably benign |
|
R1862:Ptgr3
|
UTSW |
18 |
84,113,443 (GRCm39) |
missense |
possibly damaging |
0.82 |
R2141:Ptgr3
|
UTSW |
18 |
84,112,668 (GRCm39) |
missense |
probably benign |
0.00 |
R4299:Ptgr3
|
UTSW |
18 |
84,112,626 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5378:Ptgr3
|
UTSW |
18 |
84,112,803 (GRCm39) |
missense |
probably damaging |
1.00 |
R7322:Ptgr3
|
UTSW |
18 |
84,113,260 (GRCm39) |
missense |
probably damaging |
1.00 |
R7394:Ptgr3
|
UTSW |
18 |
84,106,315 (GRCm39) |
missense |
probably benign |
0.00 |
R8141:Ptgr3
|
UTSW |
18 |
84,112,651 (GRCm39) |
missense |
probably benign |
0.01 |
R9731:Ptgr3
|
UTSW |
18 |
84,113,128 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Ptgr3
|
UTSW |
18 |
84,113,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- ACTACAGAACAGAGCCTGTGGAGAC -3'
(R):5'- TGACAGGGTGTGGTAACTCAACAAC -3'
Sequencing Primer
(F):5'- GTTCTGAAGCAGGAGTACCC -3'
(R):5'- TGTGGTAACTCAACAACAAGCTTC -3'
|
Posted On |
2013-07-30 |