Incidental Mutation 'R0678:Ptgr3'
ID 61718
Institutional Source Beutler Lab
Gene Symbol Ptgr3
Ensembl Gene ENSMUSG00000049090
Gene Name prostaglandin reductase 3
Synonyms C530046K17Rik, Pthr3, Zadh2
MMRRC Submission 038863-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R0678 (G1)
Quality Score 87
Status Not validated
Chromosome 18
Chromosomal Location 84106250-84115579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 84113287 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 321 (E321G)
Ref Sequence ENSEMBL: ENSMUSP00000052544 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060223]
AlphaFold Q8BGC4
Predicted Effect probably benign
Transcript: ENSMUST00000060223
AA Change: E321G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000052544
Gene: ENSMUSG00000049090
AA Change: E321G

DomainStartEndE-ValueType
Pfam:ADH_N_2 42 183 1.5e-14 PFAM
Pfam:ADH_N 62 126 4e-8 PFAM
Pfam:ADH_zinc_N 184 321 9e-30 PFAM
Pfam:ADH_zinc_N_2 216 367 1.7e-16 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 94.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Egfl7 C T 2: 26,480,952 (GRCm39) R155C probably benign Het
Fat4 T C 3: 38,943,843 (GRCm39) I912T probably damaging Het
H2-M5 A G 17: 37,300,034 (GRCm39) F47L possibly damaging Het
H2-T24 A T 17: 36,328,333 (GRCm39) F50Y probably damaging Het
Hif1a A G 12: 73,990,965 (GRCm39) probably null Het
Ints11 T C 4: 155,972,210 (GRCm39) I405T probably damaging Het
Kmt2d A T 15: 98,748,294 (GRCm39) probably benign Het
Pld1 T A 3: 28,174,933 (GRCm39) V857D probably damaging Het
Rab11fip3 G A 17: 26,287,821 (GRCm39) P111S probably benign Het
Rad17 A T 13: 100,781,692 (GRCm39) I35N possibly damaging Het
Rnf31 C A 14: 55,839,170 (GRCm39) Y66* probably null Het
Sec31a T C 5: 100,555,084 (GRCm39) I45M possibly damaging Het
Sele T C 1: 163,882,298 (GRCm39) probably null Het
Serpina3i G T 12: 104,232,978 (GRCm39) probably null Het
Sp6 T A 11: 96,912,607 (GRCm39) W107R probably damaging Het
Sphkap A T 1: 83,256,349 (GRCm39) W467R probably benign Het
Thbs1 T C 2: 117,953,387 (GRCm39) F935L probably damaging Het
Vmn2r8 T A 5: 108,948,412 (GRCm39) H492L probably benign Het
Xrcc2 A G 5: 25,903,261 (GRCm39) S37P possibly damaging Het
Zfand1 T A 3: 10,413,577 (GRCm39) I31L probably benign Het
Zfr G A 15: 12,184,171 (GRCm39) D1058N probably damaging Het
Other mutations in Ptgr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02063:Ptgr3 APN 18 84,113,390 (GRCm39) nonsense probably null
IGL02653:Ptgr3 APN 18 84,113,443 (GRCm39) missense possibly damaging 0.82
R0905:Ptgr3 UTSW 18 84,113,332 (GRCm39) missense probably benign 0.00
R1434:Ptgr3 UTSW 18 84,112,596 (GRCm39) missense probably benign 0.42
R1524:Ptgr3 UTSW 18 84,112,831 (GRCm39) missense probably benign
R1862:Ptgr3 UTSW 18 84,113,443 (GRCm39) missense possibly damaging 0.82
R2141:Ptgr3 UTSW 18 84,112,668 (GRCm39) missense probably benign 0.00
R4299:Ptgr3 UTSW 18 84,112,626 (GRCm39) missense possibly damaging 0.94
R5378:Ptgr3 UTSW 18 84,112,803 (GRCm39) missense probably damaging 1.00
R7322:Ptgr3 UTSW 18 84,113,260 (GRCm39) missense probably damaging 1.00
R7394:Ptgr3 UTSW 18 84,106,315 (GRCm39) missense probably benign 0.00
R8141:Ptgr3 UTSW 18 84,112,651 (GRCm39) missense probably benign 0.01
R9731:Ptgr3 UTSW 18 84,113,128 (GRCm39) missense probably damaging 1.00
Z1088:Ptgr3 UTSW 18 84,113,052 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTACAGAACAGAGCCTGTGGAGAC -3'
(R):5'- TGACAGGGTGTGGTAACTCAACAAC -3'

Sequencing Primer
(F):5'- GTTCTGAAGCAGGAGTACCC -3'
(R):5'- TGTGGTAACTCAACAACAAGCTTC -3'
Posted On 2013-07-30