Incidental Mutation 'R0680:Or14a257'
ID 61750
Institutional Source Beutler Lab
Gene Symbol Or14a257
Ensembl Gene ENSMUSG00000062878
Gene Name olfactory receptor family 14 subfamily A member 257
Synonyms GA_x6K02T2NHDJ-9619796-9620794, Olfr298, MOR219-4
MMRRC Submission 038865-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # R0680 (G1)
Quality Score 129
Status Not validated
Chromosome 7
Chromosomal Location 86137759-86138757 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86138545 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 71 (F71L)
Ref Sequence ENSEMBL: ENSMUSP00000150228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077800] [ENSMUST00000213223] [ENSMUST00000216968] [ENSMUST00000217110]
AlphaFold Q7TS06
Predicted Effect probably benign
Transcript: ENSMUST00000077800
AA Change: F71L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000076973
Gene: ENSMUSG00000062878
AA Change: F71L

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 4.2e-37 PFAM
Pfam:7tm_1 39 288 8.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213223
AA Change: F71L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216968
AA Change: F71L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217110
AA Change: F71L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.7%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Clca4a A T 3: 144,675,128 (GRCm39) F167L probably damaging Het
Col6a3 T C 1: 90,706,703 (GRCm39) M2137V unknown Het
Dennd2a A T 6: 39,459,996 (GRCm39) L703Q probably damaging Het
Fsip2 T A 2: 82,821,703 (GRCm39) I5812N possibly damaging Het
Gen1 T A 12: 11,291,870 (GRCm39) S640C probably benign Het
Il9 T C 13: 56,629,693 (GRCm39) T61A probably benign Het
Lrp1 A G 10: 127,425,530 (GRCm39) L700P probably damaging Het
Lyst G A 13: 13,824,926 (GRCm39) V1514I probably benign Het
Med1 A T 11: 98,070,992 (GRCm39) probably null Het
Or4c11c A T 2: 88,662,124 (GRCm39) Y221F probably benign Het
Or52n2 A G 7: 104,542,211 (GRCm39) I208T probably benign Het
Or6c69b T A 10: 129,626,687 (GRCm39) Y257F probably damaging Het
Pcdhb18 G C 18: 37,623,347 (GRCm39) A226P probably damaging Het
Pirb T A 7: 3,720,360 (GRCm39) N338Y possibly damaging Het
Rc3h2 A C 2: 37,289,847 (GRCm39) I360R probably damaging Het
Rnf139 T C 15: 58,771,501 (GRCm39) Y509H probably damaging Het
Shisa7 T A 7: 4,834,722 (GRCm39) D279V probably benign Het
Shoc1 T C 4: 59,043,967 (GRCm39) D1449G probably benign Het
Slc6a3 T C 13: 73,686,846 (GRCm39) L71P probably damaging Het
Slc9a5 T A 8: 106,082,539 (GRCm39) L268Q probably null Het
St7 T C 6: 17,942,732 (GRCm39) S563P probably damaging Het
Stx1b A G 7: 127,406,895 (GRCm39) V240A possibly damaging Het
Sugt1 A G 14: 79,847,751 (GRCm39) I200M possibly damaging Het
Trp53bp1 C A 2: 121,082,349 (GRCm39) A317S probably null Het
Tut7 G A 13: 59,948,413 (GRCm39) T636I possibly damaging Het
Ube4a T A 9: 44,859,358 (GRCm39) Q380L probably damaging Het
Ugt1a2 A G 1: 88,128,933 (GRCm39) Y192C probably damaging Het
Ulbp3 T A 10: 3,075,133 (GRCm39) noncoding transcript Het
Unc93b1 G A 19: 3,997,093 (GRCm39) V505I probably benign Het
Usp29 T C 7: 6,965,884 (GRCm39) S576P possibly damaging Het
Vcan A T 13: 89,827,941 (GRCm39) H2208Q probably damaging Het
Zfp106 T A 2: 120,357,497 (GRCm39) S1133C probably damaging Het
Zfp148 A G 16: 33,316,174 (GRCm39) D282G possibly damaging Het
Zswim9 A C 7: 12,994,248 (GRCm39) V636G probably benign Het
Other mutations in Or14a257
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01517:Or14a257 APN 7 86,138,765 (GRCm39) utr 5 prime probably benign
IGL01603:Or14a257 APN 7 86,138,139 (GRCm39) missense possibly damaging 0.92
IGL02389:Or14a257 APN 7 86,138,336 (GRCm39) missense probably damaging 0.98
IGL03146:Or14a257 APN 7 86,138,402 (GRCm39) missense probably damaging 1.00
R0834:Or14a257 UTSW 7 86,138,698 (GRCm39) missense probably benign 0.11
R1132:Or14a257 UTSW 7 86,138,425 (GRCm39) missense probably benign 0.03
R1519:Or14a257 UTSW 7 86,138,333 (GRCm39) missense probably damaging 0.99
R1881:Or14a257 UTSW 7 86,138,646 (GRCm39) missense probably benign 0.01
R2170:Or14a257 UTSW 7 86,137,778 (GRCm39) missense probably benign 0.03
R4500:Or14a257 UTSW 7 86,138,127 (GRCm39) missense probably benign 0.00
R4524:Or14a257 UTSW 7 86,138,034 (GRCm39) missense probably damaging 1.00
R5184:Or14a257 UTSW 7 86,138,499 (GRCm39) frame shift probably null
R5521:Or14a257 UTSW 7 86,137,839 (GRCm39) missense probably benign 0.08
R7448:Or14a257 UTSW 7 86,138,417 (GRCm39) missense probably damaging 1.00
R7643:Or14a257 UTSW 7 86,138,776 (GRCm39) critical splice acceptor site probably null
R7688:Or14a257 UTSW 7 86,138,183 (GRCm39) missense probably benign 0.01
R8104:Or14a257 UTSW 7 86,138,231 (GRCm39) missense probably damaging 1.00
R8732:Or14a257 UTSW 7 86,138,061 (GRCm39) missense probably damaging 0.96
R8973:Or14a257 UTSW 7 86,138,487 (GRCm39) missense probably damaging 1.00
R9235:Or14a257 UTSW 7 86,138,306 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGTGGGATCACAATGGAGCCACAG -3'
(R):5'- GCATACCTGACAGGCTATGGAAGAC -3'

Sequencing Primer
(F):5'- ACCACTACTCATGATGGTCTCATAG -3'
(R):5'- GCTATGGAAGACTCTAGCATGTCC -3'
Posted On 2013-07-30