Incidental Mutation 'R0659:Slitrk5'
ID 61802
Institutional Source Beutler Lab
Gene Symbol Slitrk5
Ensembl Gene ENSMUSG00000033214
Gene Name SLIT and NTRK-like family, member 5
Synonyms 2610019D03Rik
MMRRC Submission 038844-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.472) question?
Stock # R0659 (G1)
Quality Score 84
Status Validated
Chromosome 14
Chromosomal Location 111912547-111920576 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111918121 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 582 (K582E)
Ref Sequence ENSEMBL: ENSMUSP00000041499 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042767] [ENSMUST00000227891]
AlphaFold Q810B7
Predicted Effect probably benign
Transcript: ENSMUST00000042767
AA Change: K582E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000041499
Gene: ENSMUSG00000033214
AA Change: K582E

DomainStartEndE-ValueType
Blast:LRRNT 47 85 3e-18 BLAST
low complexity region 86 96 N/A INTRINSIC
LRR 108 127 2.76e2 SMART
LRR_TYP 128 151 1.67e-2 SMART
LRR 152 175 2.67e-1 SMART
LRR 176 199 1.08e-1 SMART
LRR 202 223 7.38e1 SMART
LRRCT 235 285 2.13e-5 SMART
low complexity region 308 323 N/A INTRINSIC
LRRNT 373 410 9.53e-2 SMART
LRR 433 455 1.45e1 SMART
LRR_TYP 456 479 4.94e-5 SMART
LRR_TYP 480 503 7.78e-3 SMART
LRR_TYP 504 527 2.43e-4 SMART
LRR 528 551 1.86e2 SMART
LRRCT 563 613 3.59e-3 SMART
low complexity region 618 632 N/A INTRINSIC
transmembrane domain 666 688 N/A INTRINSIC
low complexity region 794 816 N/A INTRINSIC
low complexity region 818 823 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000227891
Meta Mutation Damage Score 0.1237 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 95.6%
Validation Efficiency 99% (72/73)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a null allele have abnormal medium spiny neuron morphology and exhibit behavioral abnormalities. [provided by MGI curators]
Allele List at MGI

All alleles(3) : Targeted(3)

Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 A G 18: 59,140,565 (GRCm39) probably benign Het
Ahnak A G 19: 8,992,366 (GRCm39) H4550R possibly damaging Het
Anxa6 A G 11: 54,874,173 (GRCm39) V591A probably damaging Het
Apol7c A G 15: 77,410,473 (GRCm39) S158P probably damaging Het
Asxl1 T A 2: 153,242,644 (GRCm39) S1065T possibly damaging Het
Cacna2d4 A G 6: 119,322,067 (GRCm39) probably benign Het
Cd109 T C 9: 78,587,452 (GRCm39) probably benign Het
Cep78 C T 19: 15,933,554 (GRCm39) V675M probably damaging Het
Ces4a T C 8: 105,871,554 (GRCm39) probably benign Het
Chpf A G 1: 75,454,367 (GRCm39) V137A probably damaging Het
Comp T C 8: 70,831,751 (GRCm39) S457P possibly damaging Het
Cth A G 3: 157,625,752 (GRCm39) probably benign Het
Cyp2a12 T C 7: 26,733,563 (GRCm39) L314P probably damaging Het
Ets1 C T 9: 32,649,589 (GRCm39) R309C probably damaging Het
Foxp2 T C 6: 15,254,278 (GRCm39) probably benign Het
Gm9875 T G 2: 13,562,995 (GRCm39) F108V unknown Het
Golga5 G T 12: 102,442,467 (GRCm39) V269F possibly damaging Het
Greb1 T C 12: 16,730,213 (GRCm39) Y1738C probably damaging Het
Grin2a G T 16: 9,810,336 (GRCm39) P21Q probably damaging Het
Hdac5 A T 11: 102,086,850 (GRCm39) V70E probably damaging Het
Hdac9 T C 12: 34,487,221 (GRCm39) Q60R probably damaging Het
Hsd17b3 T C 13: 64,221,750 (GRCm39) T92A possibly damaging Het
Itpk1 C T 12: 102,572,337 (GRCm39) probably benign Het
Lin28a T C 4: 133,735,410 (GRCm39) probably benign Het
Mapk6 T C 9: 75,305,244 (GRCm39) S58G probably damaging Het
Mmp21 G A 7: 133,279,396 (GRCm39) probably benign Het
Mroh2a C A 1: 88,170,142 (GRCm39) A685D possibly damaging Het
Mroh2a G A 1: 88,178,064 (GRCm39) D1053N probably damaging Het
Msh3 T C 13: 92,481,604 (GRCm39) N303D possibly damaging Het
Mto1 T A 9: 78,364,790 (GRCm39) I343N probably damaging Het
Mto1 C T 9: 78,378,072 (GRCm39) T638M probably damaging Het
Myo18b T C 5: 112,908,193 (GRCm39) K2027E possibly damaging Het
Myo7a T C 7: 97,703,545 (GRCm39) probably benign Het
Nlrp9a T C 7: 26,256,703 (GRCm39) I107T probably damaging Het
Or5k17 C A 16: 58,746,772 (GRCm39) R54L possibly damaging Het
Or8g37 T G 9: 39,731,112 (GRCm39) M59R possibly damaging Het
Osbpl5 A G 7: 143,258,767 (GRCm39) S268P probably damaging Het
Pih1d1 T A 7: 44,809,399 (GRCm39) S289T probably benign Het
Pik3c2b A G 1: 132,998,938 (GRCm39) D353G probably damaging Het
Ppef2 A G 5: 92,378,368 (GRCm39) L609P probably damaging Het
Prune2 A T 19: 17,100,199 (GRCm39) D1901V probably damaging Het
Rdh9 T C 10: 127,612,444 (GRCm39) Y31H possibly damaging Het
Slc5a9 T A 4: 111,741,068 (GRCm39) Y526F possibly damaging Het
Sult1c2 A T 17: 54,138,806 (GRCm39) M257K probably damaging Het
Tasor2 T C 13: 3,624,448 (GRCm39) D1834G probably damaging Het
Tmem132d A G 5: 128,061,351 (GRCm39) I417T possibly damaging Het
Tmem229b T C 12: 79,011,908 (GRCm39) T8A probably benign Het
Tmem237 T C 1: 59,153,253 (GRCm39) I89M possibly damaging Het
Tnfrsf17 A T 16: 11,137,683 (GRCm39) D140V probably damaging Het
Tnrc6b T A 15: 80,807,647 (GRCm39) probably benign Het
Trio A G 15: 27,831,485 (GRCm39) L194P probably damaging Het
Vmn2r74 T C 7: 85,605,122 (GRCm39) probably benign Het
Vps13c T A 9: 67,828,217 (GRCm39) M1457K probably benign Het
Zfhx2 A G 14: 55,311,258 (GRCm39) C479R possibly damaging Het
Zfp420 T A 7: 29,574,964 (GRCm39) C395S probably damaging Het
Zfp740 A G 15: 102,121,094 (GRCm39) T136A possibly damaging Het
Zfp82 C T 7: 29,755,754 (GRCm39) E443K probably damaging Het
Zranb2 A G 3: 157,247,400 (GRCm39) S193G probably benign Het
Other mutations in Slitrk5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Slitrk5 APN 14 111,918,097 (GRCm39) missense probably benign 0.05
IGL01624:Slitrk5 APN 14 111,918,526 (GRCm39) missense probably damaging 1.00
IGL01680:Slitrk5 APN 14 111,916,432 (GRCm39) missense probably benign 0.23
IGL03234:Slitrk5 APN 14 111,916,717 (GRCm39) missense probably benign 0.00
P0019:Slitrk5 UTSW 14 111,918,026 (GRCm39) missense possibly damaging 0.88
R0323:Slitrk5 UTSW 14 111,919,055 (GRCm39) missense probably damaging 0.99
R0334:Slitrk5 UTSW 14 111,918,256 (GRCm39) missense probably benign
R0392:Slitrk5 UTSW 14 111,916,465 (GRCm39) missense probably benign 0.06
R1344:Slitrk5 UTSW 14 111,917,821 (GRCm39) missense probably benign 0.04
R1754:Slitrk5 UTSW 14 111,917,951 (GRCm39) missense probably damaging 1.00
R1983:Slitrk5 UTSW 14 111,917,821 (GRCm39) missense probably benign 0.04
R2070:Slitrk5 UTSW 14 111,917,621 (GRCm39) missense probably damaging 0.99
R2071:Slitrk5 UTSW 14 111,917,621 (GRCm39) missense probably damaging 0.99
R3001:Slitrk5 UTSW 14 111,917,014 (GRCm39) missense probably damaging 1.00
R3002:Slitrk5 UTSW 14 111,917,014 (GRCm39) missense probably damaging 1.00
R3003:Slitrk5 UTSW 14 111,917,014 (GRCm39) missense probably damaging 1.00
R3885:Slitrk5 UTSW 14 111,917,229 (GRCm39) nonsense probably null
R3886:Slitrk5 UTSW 14 111,917,229 (GRCm39) nonsense probably null
R3888:Slitrk5 UTSW 14 111,917,229 (GRCm39) nonsense probably null
R4962:Slitrk5 UTSW 14 111,918,679 (GRCm39) missense probably benign 0.02
R4999:Slitrk5 UTSW 14 111,917,648 (GRCm39) missense probably damaging 0.99
R5036:Slitrk5 UTSW 14 111,918,316 (GRCm39) missense possibly damaging 0.87
R5190:Slitrk5 UTSW 14 111,916,852 (GRCm39) missense probably damaging 1.00
R5237:Slitrk5 UTSW 14 111,919,118 (GRCm39) missense possibly damaging 0.94
R5669:Slitrk5 UTSW 14 111,919,055 (GRCm39) missense probably damaging 0.99
R5793:Slitrk5 UTSW 14 111,917,345 (GRCm39) missense probably damaging 1.00
R5839:Slitrk5 UTSW 14 111,917,030 (GRCm39) missense probably benign 0.00
R6083:Slitrk5 UTSW 14 111,919,157 (GRCm39) missense probably benign 0.01
R6224:Slitrk5 UTSW 14 111,917,248 (GRCm39) unclassified probably benign
R6225:Slitrk5 UTSW 14 111,917,248 (GRCm39) unclassified probably benign
R6230:Slitrk5 UTSW 14 111,917,248 (GRCm39) unclassified probably benign
R6337:Slitrk5 UTSW 14 111,917,684 (GRCm39) missense probably damaging 0.96
R6666:Slitrk5 UTSW 14 111,917,534 (GRCm39) missense probably damaging 0.96
R6818:Slitrk5 UTSW 14 111,917,726 (GRCm39) missense probably benign 0.32
R6895:Slitrk5 UTSW 14 111,919,085 (GRCm39) missense probably damaging 1.00
R7094:Slitrk5 UTSW 14 111,918,268 (GRCm39) missense probably benign 0.02
R7385:Slitrk5 UTSW 14 111,918,131 (GRCm39) missense probably benign 0.32
R8532:Slitrk5 UTSW 14 111,916,909 (GRCm39) missense probably benign
R8994:Slitrk5 UTSW 14 111,918,227 (GRCm39) missense probably benign 0.00
R9344:Slitrk5 UTSW 14 111,916,702 (GRCm39) missense probably damaging 0.97
R9374:Slitrk5 UTSW 14 111,916,496 (GRCm39) missense probably benign 0.23
R9499:Slitrk5 UTSW 14 111,916,496 (GRCm39) missense probably benign 0.23
R9500:Slitrk5 UTSW 14 111,916,726 (GRCm39) missense possibly damaging 0.89
R9512:Slitrk5 UTSW 14 111,917,252 (GRCm39) missense probably damaging 1.00
R9552:Slitrk5 UTSW 14 111,916,496 (GRCm39) missense probably benign 0.23
Z1177:Slitrk5 UTSW 14 111,917,285 (GRCm39) missense probably benign 0.37
Predicted Primers PCR Primer
(F):5'- TGAACCTGAGGGGTAACAGCTTCAC -3'
(R):5'- GCTGCCACAAAGACGGACATGATG -3'

Sequencing Primer
(F):5'- ACTTCCTTGCCAGTGAGTG -3'
(R):5'- GGGTCCCAGTGCTATTCAAC -3'
Posted On 2013-07-30