Incidental Mutation 'R0662:Zfp975'
ID 61889
Institutional Source Beutler Lab
Gene Symbol Zfp975
Ensembl Gene ENSMUSG00000069727
Gene Name zinc finger protein 975
Synonyms Gm5595
MMRRC Submission 038847-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R0662 (G1)
Quality Score 180
Status Not validated
Chromosome 7
Chromosomal Location 42309529-42342166 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42311950 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 221 (N221S)
Ref Sequence ENSEMBL: ENSMUSP00000103626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107992]
AlphaFold Q6NVD6
Predicted Effect probably benign
Transcript: ENSMUST00000107992
AA Change: N221S

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000103626
Gene: ENSMUSG00000069727
AA Change: N221S

DomainStartEndE-ValueType
KRAB 4 66 1.53e-19 SMART
ZnF_C2H2 131 153 7.78e-3 SMART
ZnF_C2H2 159 181 9.73e-4 SMART
ZnF_C2H2 187 209 1.47e-3 SMART
ZnF_C2H2 215 237 3.89e-3 SMART
ZnF_C2H2 243 265 2.57e-3 SMART
ZnF_C2H2 271 293 7.26e-3 SMART
ZnF_C2H2 299 321 1.58e-3 SMART
ZnF_C2H2 327 349 7.9e-4 SMART
ZnF_C2H2 355 377 5.9e-3 SMART
ZnF_C2H2 383 405 1.58e-3 SMART
ZnF_C2H2 411 433 6.32e-3 SMART
ZnF_C2H2 439 461 8.47e-4 SMART
ZnF_C2H2 467 489 2.57e-3 SMART
ZnF_C2H2 495 517 3.16e-3 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.6%
  • 20x: 91.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1cf T C 19: 31,898,338 (GRCm39) S241P probably benign Het
Ankrd53 G T 6: 83,740,625 (GRCm39) V83L probably damaging Het
Armcx2 G A X: 133,706,385 (GRCm39) T416I possibly damaging Het
C4b G A 17: 34,949,862 (GRCm39) R1441C probably damaging Het
Cacng3 T C 7: 122,367,582 (GRCm39) I154T probably damaging Het
Cand2 A G 6: 115,764,171 (GRCm39) D315G probably benign Het
Celsr2 A T 3: 108,305,836 (GRCm39) S2089R probably damaging Het
Chd9 A C 8: 91,704,304 (GRCm39) K247Q probably damaging Het
Chi3l1 A C 1: 134,116,311 (GRCm39) S263R probably damaging Het
Clec12b A C 6: 129,353,200 (GRCm39) C262W probably damaging Het
Cpsf7 T C 19: 10,503,372 (GRCm39) M1T probably null Het
Cul3 T C 1: 80,249,282 (GRCm39) D597G probably damaging Het
Dcaf11 T C 14: 55,802,964 (GRCm39) V251A possibly damaging Het
Dennd2b G T 7: 109,156,633 (GRCm39) P39Q probably damaging Het
Eno2 A T 6: 124,740,774 (GRCm39) F218I probably damaging Het
Frmd6 A T 12: 70,946,218 (GRCm39) R549* probably null Het
Fyb2 G A 4: 104,852,895 (GRCm39) S461N possibly damaging Het
Gm5709 A T 3: 59,514,164 (GRCm39) noncoding transcript Het
Hormad1 T C 3: 95,482,910 (GRCm39) I132T probably benign Het
Itga7 G T 10: 128,789,400 (GRCm39) R981L probably damaging Het
Itgbl1 T A 14: 124,065,306 (GRCm39) N153K probably damaging Het
Itih1 T C 14: 30,655,317 (GRCm39) E626G possibly damaging Het
Kat6b AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA 14: 21,712,417 (GRCm39) probably benign Het
Kcna2 A T 3: 107,012,717 (GRCm39) T433S probably benign Het
Map4k5 A G 12: 69,859,927 (GRCm39) V673A probably damaging Het
Mmp27 T A 9: 7,577,651 (GRCm39) V281E probably benign Het
Nr2c1 A T 10: 94,026,600 (GRCm39) I492F probably damaging Het
Or14c39 A G 7: 86,343,838 (GRCm39) Y58C possibly damaging Het
Or2ag19 A T 7: 106,443,856 (GRCm39) I13F probably benign Het
Or2r3 C T 6: 42,448,708 (GRCm39) V135M possibly damaging Het
Or2y3 A G 17: 38,393,824 (GRCm39) I15T probably benign Het
Or7d10 G C 9: 19,831,796 (GRCm39) C97S probably damaging Het
Or7e170 T C 9: 19,795,248 (GRCm39) M118V probably benign Het
Or8b47 T A 9: 38,435,322 (GRCm39) M98K probably damaging Het
Pank3 T C 11: 35,669,477 (GRCm39) M237T probably damaging Het
Plekhh1 A G 12: 79,125,767 (GRCm39) T1268A probably benign Het
Ptchd4 A G 17: 42,813,467 (GRCm39) Y456C probably damaging Het
Rhcg C T 7: 79,249,477 (GRCm39) V310M probably damaging Het
Ryr1 A T 7: 28,799,614 (GRCm39) D906E probably damaging Het
Sez6l A T 5: 112,621,288 (GRCm39) L262Q probably damaging Het
Shprh G A 10: 11,062,591 (GRCm39) V1233I probably damaging Het
Slc3a1 A G 17: 85,344,635 (GRCm39) E267G possibly damaging Het
Slc5a5 T A 8: 71,336,519 (GRCm39) T616S probably benign Het
Syne3 T G 12: 104,927,769 (GRCm39) E318A probably benign Het
Tecpr2 A G 12: 110,862,662 (GRCm39) T25A probably benign Het
Ubxn1 T A 19: 8,852,561 (GRCm39) probably null Het
Unc5b C A 10: 60,608,362 (GRCm39) R616L possibly damaging Het
Ush2a A G 1: 188,083,290 (GRCm39) T278A probably benign Het
Utp14b A G 1: 78,642,716 (GRCm39) T205A probably damaging Het
Vmn1r219 T C 13: 23,347,623 (GRCm39) S271P possibly damaging Het
Vmn2r76 C T 7: 85,879,578 (GRCm39) V241M probably benign Het
Zbtb24 G A 10: 41,338,275 (GRCm39) G429D probably damaging Het
Zdhhc2 T C 8: 40,900,139 (GRCm39) S68P probably damaging Het
Zfp719 G A 7: 43,233,678 (GRCm39) M32I possibly damaging Het
Other mutations in Zfp975
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02008:Zfp975 APN 7 42,312,215 (GRCm39) missense probably damaging 1.00
R0194:Zfp975 UTSW 7 42,311,916 (GRCm39) missense probably benign 0.02
R1491:Zfp975 UTSW 7 42,312,236 (GRCm39) missense probably benign 0.19
R1573:Zfp975 UTSW 7 42,311,507 (GRCm39) missense probably benign 0.03
R1738:Zfp975 UTSW 7 42,312,373 (GRCm39) missense probably benign 0.05
R1833:Zfp975 UTSW 7 42,311,263 (GRCm39) missense probably benign 0.01
R2185:Zfp975 UTSW 7 42,311,105 (GRCm39) missense possibly damaging 0.90
R4031:Zfp975 UTSW 7 42,312,377 (GRCm39) nonsense probably null
R4090:Zfp975 UTSW 7 42,312,298 (GRCm39) missense probably benign 0.10
R4356:Zfp975 UTSW 7 42,311,251 (GRCm39) missense probably damaging 1.00
R4631:Zfp975 UTSW 7 42,312,369 (GRCm39) missense probably benign 0.09
R4795:Zfp975 UTSW 7 42,314,570 (GRCm39) critical splice acceptor site probably null
R4896:Zfp975 UTSW 7 42,311,716 (GRCm39) missense probably damaging 1.00
R5266:Zfp975 UTSW 7 42,311,654 (GRCm39) missense probably damaging 1.00
R5267:Zfp975 UTSW 7 42,311,654 (GRCm39) missense probably damaging 1.00
R5580:Zfp975 UTSW 7 42,314,513 (GRCm39) nonsense probably null
R5874:Zfp975 UTSW 7 42,312,312 (GRCm39) missense probably benign 0.00
R5898:Zfp975 UTSW 7 42,311,963 (GRCm39) missense probably damaging 1.00
R6529:Zfp975 UTSW 7 42,311,325 (GRCm39) missense possibly damaging 0.79
R6782:Zfp975 UTSW 7 42,311,454 (GRCm39) missense probably benign 0.41
R6937:Zfp975 UTSW 7 42,314,480 (GRCm39) missense possibly damaging 0.61
R7088:Zfp975 UTSW 7 42,312,096 (GRCm39) missense probably benign 0.02
R7233:Zfp975 UTSW 7 42,311,918 (GRCm39) missense probably benign 0.38
R7253:Zfp975 UTSW 7 42,311,036 (GRCm39) makesense probably null
R7358:Zfp975 UTSW 7 42,312,215 (GRCm39) missense probably damaging 1.00
R7659:Zfp975 UTSW 7 42,311,848 (GRCm39) missense probably benign 0.00
R7999:Zfp975 UTSW 7 42,312,356 (GRCm39) missense probably benign 0.02
R8676:Zfp975 UTSW 7 42,312,264 (GRCm39) missense probably benign 0.44
R8957:Zfp975 UTSW 7 42,311,157 (GRCm39) missense probably damaging 1.00
R9274:Zfp975 UTSW 7 42,312,299 (GRCm39) missense probably benign 0.02
R9326:Zfp975 UTSW 7 42,311,837 (GRCm39) nonsense probably null
R9536:Zfp975 UTSW 7 42,312,345 (GRCm39) missense probably benign 0.11
R9569:Zfp975 UTSW 7 42,311,413 (GRCm39) missense probably benign 0.00
R9717:Zfp975 UTSW 7 42,312,332 (GRCm39) missense possibly damaging 0.50
Predicted Primers
Posted On 2013-07-30