Incidental Mutation 'R0662:Or2ag19'
ID 61894
Institutional Source Beutler Lab
Gene Symbol Or2ag19
Ensembl Gene ENSMUSG00000073901
Gene Name olfactory receptor family 2 subfamily AG member 19
Synonyms MOR283-7, Olfr703, GA_x6K02T2PBJ9-9222217-9223176
MMRRC Submission 038847-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.217) question?
Stock # R0662 (G1)
Quality Score 133
Status Not validated
Chromosome 7
Chromosomal Location 106443820-106444779 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 106443856 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 13 (I13F)
Ref Sequence ENSEMBL: ENSMUSP00000149022 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098142] [ENSMUST00000216254]
AlphaFold Q9EPF5
Predicted Effect probably benign
Transcript: ENSMUST00000098142
AA Change: I13F

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000095746
Gene: ENSMUSG00000073901
AA Change: I13F

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.8e-47 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.4e-8 PFAM
Pfam:7tm_1 41 290 1.7e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216254
AA Change: I13F

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.6%
  • 20x: 91.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1cf T C 19: 31,898,338 (GRCm39) S241P probably benign Het
Ankrd53 G T 6: 83,740,625 (GRCm39) V83L probably damaging Het
Armcx2 G A X: 133,706,385 (GRCm39) T416I possibly damaging Het
C4b G A 17: 34,949,862 (GRCm39) R1441C probably damaging Het
Cacng3 T C 7: 122,367,582 (GRCm39) I154T probably damaging Het
Cand2 A G 6: 115,764,171 (GRCm39) D315G probably benign Het
Celsr2 A T 3: 108,305,836 (GRCm39) S2089R probably damaging Het
Chd9 A C 8: 91,704,304 (GRCm39) K247Q probably damaging Het
Chi3l1 A C 1: 134,116,311 (GRCm39) S263R probably damaging Het
Clec12b A C 6: 129,353,200 (GRCm39) C262W probably damaging Het
Cpsf7 T C 19: 10,503,372 (GRCm39) M1T probably null Het
Cul3 T C 1: 80,249,282 (GRCm39) D597G probably damaging Het
Dcaf11 T C 14: 55,802,964 (GRCm39) V251A possibly damaging Het
Dennd2b G T 7: 109,156,633 (GRCm39) P39Q probably damaging Het
Eno2 A T 6: 124,740,774 (GRCm39) F218I probably damaging Het
Frmd6 A T 12: 70,946,218 (GRCm39) R549* probably null Het
Fyb2 G A 4: 104,852,895 (GRCm39) S461N possibly damaging Het
Gm5709 A T 3: 59,514,164 (GRCm39) noncoding transcript Het
Hormad1 T C 3: 95,482,910 (GRCm39) I132T probably benign Het
Itga7 G T 10: 128,789,400 (GRCm39) R981L probably damaging Het
Itgbl1 T A 14: 124,065,306 (GRCm39) N153K probably damaging Het
Itih1 T C 14: 30,655,317 (GRCm39) E626G possibly damaging Het
Kat6b AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA 14: 21,712,417 (GRCm39) probably benign Het
Kcna2 A T 3: 107,012,717 (GRCm39) T433S probably benign Het
Map4k5 A G 12: 69,859,927 (GRCm39) V673A probably damaging Het
Mmp27 T A 9: 7,577,651 (GRCm39) V281E probably benign Het
Nr2c1 A T 10: 94,026,600 (GRCm39) I492F probably damaging Het
Or14c39 A G 7: 86,343,838 (GRCm39) Y58C possibly damaging Het
Or2r3 C T 6: 42,448,708 (GRCm39) V135M possibly damaging Het
Or2y3 A G 17: 38,393,824 (GRCm39) I15T probably benign Het
Or7d10 G C 9: 19,831,796 (GRCm39) C97S probably damaging Het
Or7e170 T C 9: 19,795,248 (GRCm39) M118V probably benign Het
Or8b47 T A 9: 38,435,322 (GRCm39) M98K probably damaging Het
Pank3 T C 11: 35,669,477 (GRCm39) M237T probably damaging Het
Plekhh1 A G 12: 79,125,767 (GRCm39) T1268A probably benign Het
Ptchd4 A G 17: 42,813,467 (GRCm39) Y456C probably damaging Het
Rhcg C T 7: 79,249,477 (GRCm39) V310M probably damaging Het
Ryr1 A T 7: 28,799,614 (GRCm39) D906E probably damaging Het
Sez6l A T 5: 112,621,288 (GRCm39) L262Q probably damaging Het
Shprh G A 10: 11,062,591 (GRCm39) V1233I probably damaging Het
Slc3a1 A G 17: 85,344,635 (GRCm39) E267G possibly damaging Het
Slc5a5 T A 8: 71,336,519 (GRCm39) T616S probably benign Het
Syne3 T G 12: 104,927,769 (GRCm39) E318A probably benign Het
Tecpr2 A G 12: 110,862,662 (GRCm39) T25A probably benign Het
Ubxn1 T A 19: 8,852,561 (GRCm39) probably null Het
Unc5b C A 10: 60,608,362 (GRCm39) R616L possibly damaging Het
Ush2a A G 1: 188,083,290 (GRCm39) T278A probably benign Het
Utp14b A G 1: 78,642,716 (GRCm39) T205A probably damaging Het
Vmn1r219 T C 13: 23,347,623 (GRCm39) S271P possibly damaging Het
Vmn2r76 C T 7: 85,879,578 (GRCm39) V241M probably benign Het
Zbtb24 G A 10: 41,338,275 (GRCm39) G429D probably damaging Het
Zdhhc2 T C 8: 40,900,139 (GRCm39) S68P probably damaging Het
Zfp719 G A 7: 43,233,678 (GRCm39) M32I possibly damaging Het
Zfp975 T C 7: 42,311,950 (GRCm39) N221S probably benign Het
Other mutations in Or2ag19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Or2ag19 APN 7 106,444,574 (GRCm39) missense possibly damaging 0.78
IGL01321:Or2ag19 APN 7 106,443,956 (GRCm39) missense probably damaging 1.00
IGL02169:Or2ag19 APN 7 106,444,473 (GRCm39) nonsense probably null
IGL03376:Or2ag19 APN 7 106,444,677 (GRCm39) missense probably damaging 1.00
R0045:Or2ag19 UTSW 7 106,444,596 (GRCm39) nonsense probably null
R1589:Or2ag19 UTSW 7 106,444,403 (GRCm39) missense possibly damaging 0.57
R1869:Or2ag19 UTSW 7 106,444,301 (GRCm39) missense probably benign 0.01
R2431:Or2ag19 UTSW 7 106,444,598 (GRCm39) missense possibly damaging 0.95
R4021:Or2ag19 UTSW 7 106,444,226 (GRCm39) missense probably damaging 1.00
R5280:Or2ag19 UTSW 7 106,443,902 (GRCm39) missense probably benign 0.01
R6352:Or2ag19 UTSW 7 106,444,429 (GRCm39) missense probably damaging 1.00
R6932:Or2ag19 UTSW 7 106,444,009 (GRCm39) nonsense probably null
R7037:Or2ag19 UTSW 7 106,444,543 (GRCm39) missense probably damaging 1.00
R7909:Or2ag19 UTSW 7 106,444,199 (GRCm39) missense probably benign 0.29
R8510:Or2ag19 UTSW 7 106,444,130 (GRCm39) missense probably benign 0.44
R8825:Or2ag19 UTSW 7 106,444,636 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CATCTGGGAATGGTTGTACTGGGAC -3'
(R):5'- TCCAAGTAGGAGATACATGGGCACG -3'

Sequencing Primer
(F):5'- CTTGTAGTCTAGAGTTGAATACCTCC -3'
(R):5'- TACATGGGCACGCGGAG -3'
Posted On 2013-07-30