Incidental Mutation 'R0664:Stk26'
ID 61961
Institutional Source Beutler Lab
Gene Symbol Stk26
Ensembl Gene ENSMUSG00000031112
Gene Name serine/threonine kinase 26
Synonyms 2610018G03Rik, Mst4
MMRRC Submission 038849-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R0664 (G1)
Quality Score 225
Status Validated
Chromosome X
Chromosomal Location 49930052-49981980 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 49976803 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 283 (Y283*)
Ref Sequence ENSEMBL: ENSMUSP00000110537 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033444] [ENSMUST00000114887]
AlphaFold Q99JT2
Predicted Effect probably null
Transcript: ENSMUST00000033444
AA Change: Y283*
SMART Domains Protein: ENSMUSP00000033444
Gene: ENSMUSG00000031112
AA Change: Y283*

DomainStartEndE-ValueType
S_TKc 24 274 1.07e-96 SMART
low complexity region 300 318 N/A INTRINSIC
PDB:4GEH|D 325 413 2e-54 PDB
Predicted Effect probably null
Transcript: ENSMUST00000114887
AA Change: Y283*
SMART Domains Protein: ENSMUSP00000110537
Gene: ENSMUSG00000031112
AA Change: Y283*

DomainStartEndE-ValueType
S_TKc 24 274 1.07e-96 SMART
low complexity region 300 318 N/A INTRINSIC
PDB:4GEH|D 325 389 1e-31 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146956
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.1%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921517D22Rik GCC GC 13: 59,839,412 (GRCm39) probably null Het
A530064D06Rik T C 17: 48,473,759 (GRCm39) I53V probably benign Het
Abtb3 G A 10: 85,224,234 (GRCm39) A348T possibly damaging Het
Agmo A T 12: 37,302,571 (GRCm39) H136L probably damaging Het
B020004C17Rik G A 14: 57,254,225 (GRCm39) R116H possibly damaging Het
Cacna1b A G 2: 24,544,458 (GRCm39) S1243P probably damaging Het
Champ1 G A 8: 13,929,485 (GRCm39) V548M probably damaging Het
Dnah7b A T 1: 46,364,002 (GRCm39) M3541L probably damaging Het
Emc9 A G 14: 55,819,365 (GRCm39) L138P possibly damaging Het
Epcam T A 17: 87,947,398 (GRCm39) Y51N possibly damaging Het
Gpr55 A T 1: 85,868,739 (GRCm39) S281T probably benign Het
Grid2ip T A 5: 143,349,732 (GRCm39) probably null Het
Hgfac G T 5: 35,205,522 (GRCm39) V601F probably benign Het
Hlcs A G 16: 94,032,170 (GRCm39) W545R probably damaging Het
Hsd17b2 T C 8: 118,485,440 (GRCm39) V301A possibly damaging Het
Ipo8 A T 6: 148,701,711 (GRCm39) L466I probably benign Het
Jcad A G 18: 4,676,063 (GRCm39) D1275G probably damaging Het
Mdn1 G T 4: 32,768,011 (GRCm39) E5315* probably null Het
Nfam1 T C 15: 82,899,139 (GRCm39) T176A probably damaging Het
Nsd3 T C 8: 26,204,267 (GRCm39) F432S probably damaging Het
Or4c31 C T 2: 88,292,515 (GRCm39) P296L probably damaging Het
Prmt5 G T 14: 54,745,313 (GRCm39) T618K probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Serpinb7 A G 1: 107,356,037 (GRCm39) D20G probably damaging Het
Slco1a4 T C 6: 141,758,467 (GRCm39) I515V probably benign Het
Tanc1 A T 2: 59,674,228 (GRCm39) K1778* probably null Het
Thada A G 17: 84,644,257 (GRCm39) L1288P probably damaging Het
Ttbk2 C A 2: 120,579,302 (GRCm39) V607F probably damaging Het
Other mutations in Stk26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02253:Stk26 APN X 49,975,565 (GRCm39) missense probably damaging 1.00
IGL03353:Stk26 APN X 49,959,275 (GRCm39) missense probably damaging 0.99
R4067:Stk26 UTSW X 49,977,910 (GRCm39) missense probably benign 0.27
R9393:Stk26 UTSW X 49,930,618 (GRCm39) start gained probably benign
R9394:Stk26 UTSW X 49,930,618 (GRCm39) start gained probably benign
R9579:Stk26 UTSW X 49,930,618 (GRCm39) start gained probably benign
R9580:Stk26 UTSW X 49,930,618 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- CGGTTTACCTTGAGCCACTTCAAGC -3'
(R):5'- GTCTAAAGCAAGCATCCCAGGTCAC -3'

Sequencing Primer
(F):5'- TTGAGCCACTTCAAGCAAATAG -3'
(R):5'- ATTCCTCATCACTGTGGCCT -3'
Posted On 2013-07-30