Incidental Mutation 'R0667:Scart2'
ID 62063
Institutional Source Beutler Lab
Gene Symbol Scart2
Ensembl Gene ENSMUSG00000054672
Gene Name scavenger receptor family member expressed on T cells 2
Synonyms 5830411N06Rik
MMRRC Submission 038852-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0667 (G1)
Quality Score 110
Status Not validated
Chromosome 7
Chromosomal Location 139827197-139880649 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 139841450 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 251 (S251R)
Ref Sequence ENSEMBL: ENSMUSP00000131905 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093984] [ENSMUST00000164583]
AlphaFold B3F5L4
Predicted Effect noncoding transcript
Transcript: ENSMUST00000059882
SMART Domains Protein: ENSMUSP00000061346
Gene: ENSMUSG00000054672

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
SR 238 336 1.65e-34 SMART
SR 340 440 4.53e-32 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000093984
SMART Domains Protein: ENSMUSP00000091520
Gene: ENSMUSG00000054672

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
SR 238 336 1.65e-34 SMART
SR 340 440 4.53e-32 SMART
SR 446 546 8.78e-30 SMART
SR 551 651 1.26e-53 SMART
SR 656 756 2.88e-16 SMART
SR 783 883 7.62e-48 SMART
transmembrane domain 903 925 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000164583
AA Change: S251R

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000131905
Gene: ENSMUSG00000054672
AA Change: S251R

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
Blast:SR 291 349 5e-12 BLAST
SR 354 452 1.65e-34 SMART
SR 456 556 4.53e-32 SMART
SR 562 662 8.78e-30 SMART
SR 667 767 1.26e-53 SMART
SR 772 872 2.88e-16 SMART
SR 899 999 7.62e-48 SMART
transmembrane domain 1019 1041 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210212
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.8%
Validation Efficiency 98% (64/65)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 G T 11: 110,218,637 (GRCm39) N76K probably benign Het
Adamts12 C T 15: 11,215,710 (GRCm39) R244C probably damaging Het
Atad2 A G 15: 57,962,115 (GRCm39) S1143P probably benign Het
Avl9 G T 6: 56,713,468 (GRCm39) R242L probably benign Het
Cand1 A G 10: 119,052,425 (GRCm39) S234P probably benign Het
Cd200 T A 16: 45,215,220 (GRCm39) I144L probably benign Het
Cep76 A T 18: 67,767,848 (GRCm39) L228Q possibly damaging Het
Col12a1 A G 9: 79,535,744 (GRCm39) L2584S probably damaging Het
Col6a3 A C 1: 90,755,823 (GRCm39) D155E probably damaging Het
Col6a4 G A 9: 105,907,158 (GRCm39) probably benign Het
Dsg2 A C 18: 20,706,556 (GRCm39) D24A possibly damaging Het
Gm5901 G A 7: 105,026,697 (GRCm39) S155N possibly damaging Het
Hkdc1 T C 10: 62,247,644 (GRCm39) probably benign Het
Kansl1 A G 11: 104,234,364 (GRCm39) V714A probably benign Het
Kcnh1 T A 1: 192,188,346 (GRCm39) S936T probably benign Het
Klhdc3 A T 17: 46,988,151 (GRCm39) F205I probably benign Het
Krt31 T A 11: 99,938,951 (GRCm39) H290L probably benign Het
Lama2 T A 10: 27,220,406 (GRCm39) probably null Het
Mep1a T G 17: 43,789,081 (GRCm39) D565A probably benign Het
Mgme1 T A 2: 144,120,907 (GRCm39) probably benign Het
Mtf2 C T 5: 108,252,369 (GRCm39) T409I probably damaging Het
Mylk3 A G 8: 86,081,794 (GRCm39) probably null Het
Myo1c A G 11: 75,559,338 (GRCm39) E650G probably damaging Het
Nipbl A C 15: 8,390,488 (GRCm39) D260E possibly damaging Het
Nufip2 T A 11: 77,582,839 (GRCm39) V251D possibly damaging Het
Or2n1e C A 17: 38,586,048 (GRCm39) P129T probably damaging Het
Or4a2 T C 2: 89,248,032 (GRCm39) I242V probably benign Het
Or7g35 T A 9: 19,496,743 (GRCm39) N303K probably benign Het
Osm G T 11: 4,189,918 (GRCm39) R234L possibly damaging Het
Pabpc1 G A 15: 36,598,275 (GRCm39) A515V probably benign Het
Piwil1 T A 5: 128,818,542 (GRCm39) probably null Het
Pld1 A G 3: 28,133,327 (GRCm39) probably null Het
Plekhg3 C T 12: 76,623,372 (GRCm39) R871C probably damaging Het
Ppfia2 A T 10: 106,749,555 (GRCm39) Y1147F probably damaging Het
Prmt3 A G 7: 49,441,743 (GRCm39) Y240C probably damaging Het
Prr36 G T 8: 4,266,311 (GRCm39) probably benign Het
Ptprd A G 4: 75,875,583 (GRCm39) I908T probably damaging Het
Sae1 A T 7: 16,102,457 (GRCm39) N172K probably damaging Het
Satb1 T G 17: 52,089,889 (GRCm39) Q319H probably damaging Het
Scn2a A T 2: 65,582,340 (GRCm39) I1563F possibly damaging Het
Scn3a C A 2: 65,314,755 (GRCm39) R1102L probably null Het
Serpinb9b T A 13: 33,216,909 (GRCm39) L60* probably null Het
Setd1a A G 7: 127,385,765 (GRCm39) D281G probably damaging Het
Slc8a1 C A 17: 81,956,310 (GRCm39) V243F probably damaging Het
Tgfbr3 A T 5: 107,325,716 (GRCm39) H115Q probably benign Het
Tiam1 C A 16: 89,694,872 (GRCm39) S195I probably damaging Het
Tjp2 A G 19: 24,086,113 (GRCm39) V803A probably benign Het
Ttc5 T A 14: 51,003,415 (GRCm39) Q423L probably benign Het
Tyk2 A C 9: 21,020,167 (GRCm39) V997G probably damaging Het
Uhrf1 T C 17: 56,617,677 (GRCm39) V133A probably benign Het
Vmn2r107 A C 17: 20,575,916 (GRCm39) Y82S possibly damaging Het
Vmn2r93 T C 17: 18,546,503 (GRCm39) F792L probably damaging Het
Vps13c G A 9: 67,858,855 (GRCm39) W2768* probably null Het
Zfp456 A T 13: 67,514,861 (GRCm39) C282S probably benign Het
Zhx1 T C 15: 57,916,561 (GRCm39) N562D possibly damaging Het
Zmynd15 G T 11: 70,355,944 (GRCm39) G481C probably damaging Het
Other mutations in Scart2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Scart2 APN 7 139,874,755 (GRCm39) missense probably damaging 0.99
IGL01101:Scart2 APN 7 139,876,017 (GRCm39) missense probably benign 0.35
IGL01120:Scart2 APN 7 139,876,472 (GRCm39) missense probably benign 0.02
IGL01958:Scart2 APN 7 139,854,040 (GRCm39) missense probably damaging 1.00
IGL02150:Scart2 APN 7 139,877,772 (GRCm39) missense possibly damaging 0.84
IGL02193:Scart2 APN 7 139,828,913 (GRCm39) missense probably benign 0.17
IGL02239:Scart2 APN 7 139,875,756 (GRCm39) missense probably damaging 1.00
IGL02335:Scart2 APN 7 139,876,453 (GRCm39) missense probably damaging 1.00
IGL02569:Scart2 APN 7 139,878,275 (GRCm39) missense probably benign 0.01
IGL02993:Scart2 APN 7 139,876,486 (GRCm39) missense probably benign 0.07
IGL03261:Scart2 APN 7 139,874,746 (GRCm39) missense probably benign 0.00
IGL03365:Scart2 APN 7 139,876,682 (GRCm39) missense probably damaging 1.00
IGL03399:Scart2 APN 7 139,827,869 (GRCm39) missense probably benign 0.00
IGL03052:Scart2 UTSW 7 139,828,827 (GRCm39) missense probably damaging 1.00
PIT4791001:Scart2 UTSW 7 139,853,975 (GRCm39) missense possibly damaging 0.53
R0021:Scart2 UTSW 7 139,876,310 (GRCm39) missense probably benign 0.15
R0021:Scart2 UTSW 7 139,876,310 (GRCm39) missense probably benign 0.15
R0347:Scart2 UTSW 7 139,877,767 (GRCm39) missense probably damaging 1.00
R0374:Scart2 UTSW 7 139,828,874 (GRCm39) missense probably damaging 1.00
R0639:Scart2 UTSW 7 139,827,872 (GRCm39) missense probably benign 0.01
R0789:Scart2 UTSW 7 139,828,133 (GRCm39) missense probably damaging 1.00
R0959:Scart2 UTSW 7 139,874,704 (GRCm39) missense probably damaging 1.00
R1316:Scart2 UTSW 7 139,879,583 (GRCm39) missense probably benign 0.09
R1764:Scart2 UTSW 7 139,877,178 (GRCm39) missense probably benign 0.00
R2247:Scart2 UTSW 7 139,829,042 (GRCm39) missense probably null 0.96
R2379:Scart2 UTSW 7 139,879,682 (GRCm39) missense probably benign 0.15
R4112:Scart2 UTSW 7 139,878,281 (GRCm39) nonsense probably null
R4114:Scart2 UTSW 7 139,877,823 (GRCm39) missense probably damaging 1.00
R4346:Scart2 UTSW 7 139,827,878 (GRCm39) missense probably damaging 0.97
R4836:Scart2 UTSW 7 139,879,021 (GRCm39) missense probably benign
R4956:Scart2 UTSW 7 139,878,275 (GRCm39) missense probably benign 0.00
R5208:Scart2 UTSW 7 139,877,949 (GRCm39) missense probably benign 0.00
R5571:Scart2 UTSW 7 139,829,036 (GRCm39) missense probably damaging 1.00
R5583:Scart2 UTSW 7 139,876,739 (GRCm39) missense probably damaging 1.00
R5645:Scart2 UTSW 7 139,828,853 (GRCm39) missense possibly damaging 0.95
R6183:Scart2 UTSW 7 139,875,947 (GRCm39) missense possibly damaging 0.82
R6995:Scart2 UTSW 7 139,841,514 (GRCm39) missense probably benign
R7436:Scart2 UTSW 7 139,841,520 (GRCm39) missense probably benign
R7621:Scart2 UTSW 7 139,876,742 (GRCm39) missense probably damaging 1.00
R7662:Scart2 UTSW 7 139,874,725 (GRCm39) missense possibly damaging 0.58
R7669:Scart2 UTSW 7 139,876,234 (GRCm39) missense possibly damaging 0.47
R7686:Scart2 UTSW 7 139,828,965 (GRCm39) missense probably benign 0.00
R7985:Scart2 UTSW 7 139,876,806 (GRCm39) missense probably damaging 1.00
R8330:Scart2 UTSW 7 139,876,231 (GRCm39) nonsense probably null
R8843:Scart2 UTSW 7 139,828,913 (GRCm39) missense possibly damaging 0.93
R8888:Scart2 UTSW 7 139,841,532 (GRCm39) missense possibly damaging 0.93
R8895:Scart2 UTSW 7 139,841,532 (GRCm39) missense possibly damaging 0.93
R9044:Scart2 UTSW 7 139,828,010 (GRCm39) missense probably damaging 1.00
R9142:Scart2 UTSW 7 139,877,806 (GRCm39) missense probably damaging 1.00
R9152:Scart2 UTSW 7 139,877,256 (GRCm39) missense possibly damaging 0.55
R9470:Scart2 UTSW 7 139,827,345 (GRCm39) missense probably benign 0.07
R9509:Scart2 UTSW 7 139,879,644 (GRCm39) nonsense probably null
R9522:Scart2 UTSW 7 139,853,987 (GRCm39) missense possibly damaging 0.73
R9755:Scart2 UTSW 7 139,841,544 (GRCm39) critical splice donor site probably null
R9794:Scart2 UTSW 7 139,874,716 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTCAGACCTTGCTGGGAGGAGAC -3'
(R):5'- TGTGCCATTCCTGAATACAGTCACC -3'

Sequencing Primer
(F):5'- GACTGCTTCGGATACTAGCTACAG -3'
(R):5'- CCTGAATACAGTCACCTATATTTCAC -3'
Posted On 2013-07-30