Incidental Mutation 'R0668:Vmn1r32'
| ID |
62091 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r32
|
| Ensembl Gene |
ENSMUSG00000062905 |
| Gene Name |
vomeronasal 1 receptor 32 |
| Synonyms |
V1rc15 |
| MMRRC Submission |
038853-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.049)
|
| Stock # |
R0668 (G1)
|
| Quality Score |
182 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
66529167-66536692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 66530644 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Leucine
at position 44
(Q44L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153723
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079584]
[ENSMUST00000227014]
|
| AlphaFold |
Q8R2D9 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000079584
AA Change: Q44L
PolyPhen 2
Score 0.905 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000078536
Gene: ENSMUSG00000062905
AA Change: Q44L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
9.7e-56 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227014
AA Change: Q44L
PolyPhen 2
Score 0.905 (Sensitivity: 0.82; Specificity: 0.94)
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.6%
- 20x: 91.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
G |
T |
1: 71,302,773 (GRCm39) |
Q2149K |
probably damaging |
Het |
| Aifm1 |
T |
C |
X: 47,583,668 (GRCm39) |
Q210R |
probably benign |
Het |
| Arhgef1 |
A |
G |
7: 24,607,345 (GRCm39) |
N31D |
possibly damaging |
Het |
| Asic5 |
T |
A |
3: 81,928,308 (GRCm39) |
Y424N |
probably damaging |
Het |
| Bltp3a |
A |
T |
17: 28,114,913 (GRCm39) |
I1408F |
probably benign |
Het |
| Cfb |
G |
T |
17: 35,076,079 (GRCm39) |
Q1176K |
probably benign |
Het |
| Chdh |
A |
G |
14: 29,757,837 (GRCm39) |
H447R |
probably damaging |
Het |
| Cpd |
A |
C |
11: 76,675,224 (GRCm39) |
V1299G |
probably damaging |
Het |
| Dnase1l3 |
A |
G |
14: 7,968,086 (GRCm38) |
|
probably null |
Het |
| Dnhd1 |
A |
G |
7: 105,344,958 (GRCm39) |
T2101A |
probably benign |
Het |
| Efcab3 |
A |
T |
11: 104,611,318 (GRCm39) |
I387F |
probably benign |
Het |
| Fchsd2 |
A |
G |
7: 100,846,127 (GRCm39) |
K188E |
possibly damaging |
Het |
| Gm10549 |
A |
G |
18: 33,603,903 (GRCm39) |
T129A |
unknown |
Het |
| Jph1 |
T |
A |
1: 17,161,895 (GRCm39) |
T256S |
probably damaging |
Het |
| Kcnma1 |
A |
G |
14: 23,417,563 (GRCm39) |
Y768H |
probably damaging |
Het |
| Lcmt1 |
G |
A |
7: 123,002,094 (GRCm39) |
D120N |
probably damaging |
Het |
| Ly6g6d |
G |
A |
17: 35,290,715 (GRCm39) |
H72Y |
probably damaging |
Het |
| Myom3 |
A |
G |
4: 135,492,237 (GRCm39) |
D127G |
possibly damaging |
Het |
| Or10c1 |
T |
A |
17: 37,522,535 (GRCm39) |
I70F |
probably damaging |
Het |
| Pira13 |
G |
A |
7: 3,825,699 (GRCm39) |
T390I |
probably damaging |
Het |
| Sart1 |
T |
C |
19: 5,434,284 (GRCm39) |
Y249C |
probably damaging |
Het |
| Scin |
A |
G |
12: 40,130,948 (GRCm39) |
Y322H |
probably damaging |
Het |
| Slc44a3 |
T |
C |
3: 121,303,852 (GRCm39) |
T295A |
probably damaging |
Het |
| Slc4a5 |
T |
A |
6: 83,248,054 (GRCm39) |
L535Q |
probably damaging |
Het |
| Them5 |
A |
T |
3: 94,251,720 (GRCm39) |
K110N |
probably benign |
Het |
| Vmn2r93 |
T |
A |
17: 18,518,667 (GRCm39) |
M42K |
probably benign |
Het |
| Zfp143 |
A |
T |
7: 109,660,481 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Vmn1r32 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01449:Vmn1r32
|
APN |
6 |
66,529,916 (GRCm39) |
missense |
probably benign |
|
|
IGL02399:Vmn1r32
|
APN |
6 |
66,529,913 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02964:Vmn1r32
|
APN |
6 |
66,529,922 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL03161:Vmn1r32
|
APN |
6 |
66,530,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL03244:Vmn1r32
|
APN |
6 |
66,530,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03248:Vmn1r32
|
APN |
6 |
66,529,897 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0732:Vmn1r32
|
UTSW |
6 |
66,530,690 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1205:Vmn1r32
|
UTSW |
6 |
66,530,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1638:Vmn1r32
|
UTSW |
6 |
66,529,939 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1732:Vmn1r32
|
UTSW |
6 |
66,530,285 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2049:Vmn1r32
|
UTSW |
6 |
66,530,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2127:Vmn1r32
|
UTSW |
6 |
66,530,533 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3773:Vmn1r32
|
UTSW |
6 |
66,530,351 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3834:Vmn1r32
|
UTSW |
6 |
66,530,647 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3980:Vmn1r32
|
UTSW |
6 |
66,530,698 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4737:Vmn1r32
|
UTSW |
6 |
66,530,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5569:Vmn1r32
|
UTSW |
6 |
66,530,156 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6382:Vmn1r32
|
UTSW |
6 |
66,530,345 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6894:Vmn1r32
|
UTSW |
6 |
66,530,345 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7394:Vmn1r32
|
UTSW |
6 |
66,530,173 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7980:Vmn1r32
|
UTSW |
6 |
66,530,305 (GRCm39) |
nonsense |
probably null |
|
|
R8833:Vmn1r32
|
UTSW |
6 |
66,530,623 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8867:Vmn1r32
|
UTSW |
6 |
66,530,651 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8975:Vmn1r32
|
UTSW |
6 |
66,530,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9131:Vmn1r32
|
UTSW |
6 |
66,530,020 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9135:Vmn1r32
|
UTSW |
6 |
66,530,120 (GRCm39) |
nonsense |
probably null |
|
|
R9429:Vmn1r32
|
UTSW |
6 |
66,530,237 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACACACTCAGGAGACAGGTGATGC -3'
(R):5'- ACTGGATTTCTACCTATGAGGCTCAGG -3'
Sequencing Primer
(F):5'- CAGGTGATGCAGATAGAGAGGC -3'
(R):5'- GGCTCAGGTATAATAAATACACAGC -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation