Incidental Mutation 'R0654:Fnd3c2'
ID 62454
Institutional Source Beutler Lab
Gene Symbol Fnd3c2
Ensembl Gene ENSMUSG00000073012
Gene Name fibronectin type III domain containing 3C2
Synonyms 5031408O05Rik
MMRRC Submission 038839-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.034) question?
Stock # R0654 (G1)
Quality Score 225
Status Not validated
Chromosome X
Chromosomal Location 105278852-105298978 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 105290760 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 302 (T302I)
Ref Sequence ENSEMBL: ENSMUSP00000088827 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091282]
AlphaFold A2AP83
Predicted Effect possibly damaging
Transcript: ENSMUST00000091282
AA Change: T302I

PolyPhen 2 Score 0.830 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000088827
Gene: ENSMUSG00000073012
AA Change: T302I

DomainStartEndE-ValueType
low complexity region 14 29 N/A INTRINSIC
FN3 139 223 5.07e0 SMART
FN3 237 317 3.93e-9 SMART
FN3 332 414 5.11e-8 SMART
FN3 429 513 2.21e-3 SMART
FN3 613 688 3.93e-9 SMART
FN3 702 783 2.31e-6 SMART
FN3 798 876 2.14e-1 SMART
low complexity region 896 916 N/A INTRINSIC
transmembrane domain 922 940 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asb13 A C 13: 3,692,092 (GRCm39) H24P probably damaging Het
Avpr1b T A 1: 131,527,480 (GRCm39) M1K probably null Het
Baz1a T C 12: 54,958,182 (GRCm39) E1023G probably benign Het
Bpifb5 A G 2: 154,070,820 (GRCm39) T204A probably benign Het
Cfap157 C T 2: 32,669,954 (GRCm39) V210M probably damaging Het
Clock A G 5: 76,374,976 (GRCm39) V731A possibly damaging Het
Cntn6 C T 6: 104,753,389 (GRCm39) T447I probably benign Het
Dchs1 A G 7: 105,421,556 (GRCm39) I288T probably damaging Het
Far2 T C 6: 148,076,639 (GRCm39) F494S possibly damaging Het
Fibin T A 2: 110,192,962 (GRCm39) D60V probably damaging Het
Foxp3 A G X: 7,457,639 (GRCm39) I281V probably benign Het
Fryl A G 5: 73,240,715 (GRCm39) I1295T probably benign Het
Gpr82 T C X: 13,531,829 (GRCm39) S126P probably benign Het
Gria4 T A 9: 4,464,372 (GRCm39) Q530L probably benign Het
Hivep1 A C 13: 42,313,232 (GRCm39) D1824A probably benign Het
Kif13a A G 13: 46,966,218 (GRCm39) V400A possibly damaging Het
Map3k21 C A 8: 126,668,759 (GRCm39) L782I probably benign Het
Nphs2 A C 1: 156,146,317 (GRCm39) T98P probably damaging Het
Pdss2 CGGAG CG 10: 43,097,927 (GRCm39) probably benign Het
Pkd2l1 A G 19: 44,146,070 (GRCm39) probably null Het
Rbm28 A T 6: 29,128,577 (GRCm39) S48R probably damaging Het
Rimkla C T 4: 119,335,177 (GRCm39) V69M probably damaging Het
Scg3 T A 9: 75,573,017 (GRCm39) I305F probably damaging Het
Slc22a1 T A 17: 12,881,679 (GRCm39) N310I probably damaging Het
Slc26a9 T C 1: 131,692,768 (GRCm39) V700A probably benign Het
Snx15 T C 19: 6,171,915 (GRCm39) I140V probably benign Het
Spryd3 C T 15: 102,036,969 (GRCm39) probably null Het
Srebf1 T C 11: 60,094,942 (GRCm39) T486A probably benign Het
Syne2 AGAGTGAG AGAGTGAGTGAG 12: 76,144,734 (GRCm39) probably null Het
Tbl1xr1 T A 3: 22,258,158 (GRCm39) probably null Het
Tmcc1 A T 6: 116,019,951 (GRCm39) H281Q probably benign Het
Ttc39b T A 4: 83,159,938 (GRCm39) M413L probably benign Het
Vmn2r101 C A 17: 19,810,373 (GRCm39) H386Q probably benign Het
Zbtb47 T C 9: 121,592,327 (GRCm39) F251L probably benign Het
Other mutations in Fnd3c2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00591:Fnd3c2 APN X 105,279,597 (GRCm39) missense probably damaging 1.00
IGL01515:Fnd3c2 APN X 105,282,093 (GRCm39) missense probably damaging 1.00
IGL02484:Fnd3c2 APN X 105,289,092 (GRCm39) missense probably damaging 0.99
IGL03301:Fnd3c2 APN X 105,295,869 (GRCm39) missense probably benign 0.00
R0630:Fnd3c2 UTSW X 105,282,763 (GRCm39) missense probably benign 0.37
R1678:Fnd3c2 UTSW X 105,281,305 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCTTACGTTCTGCACACTGGTACTC -3'
(R):5'- acgcatcttgcttagacctgGTACA -3'

Sequencing Primer
(F):5'- TGCACACTGGTACTCAAGGATG -3'
(R):5'- AACACCTGATTGGGAATGGT -3'
Posted On 2013-07-30