Incidental Mutation 'IGL00561:Zfp747l1'
| ID |
6255 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp747l1
|
| Ensembl Gene |
ENSMUSG00000030823 |
| Gene Name |
zinc finger protein 747 like 1 |
| Synonyms |
9130019O22Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.065)
|
| Stock # |
IGL00561
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
126981432-126986338 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to A
at 126985716 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126288
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049052]
[ENSMUST00000074249]
[ENSMUST00000164345]
[ENSMUST00000165495]
|
| AlphaFold |
G3X941 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000049052
AA Change: M92L
|
| SMART Domains |
Protein: ENSMUSP00000038195
Gene: ENSMUSG00000030823
AA Change: M92L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
22 |
82 |
5.44e-25 |
SMART |
|
low complexity region
|
102 |
115 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
152 |
174 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
180 |
202 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
208 |
230 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
236 |
258 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
264 |
286 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
292 |
314 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
320 |
342 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
348 |
370 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
376 |
398 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
404 |
427 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
433 |
455 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
461 |
483 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
489 |
511 |
1.67e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000074249
|
| SMART Domains |
Protein: ENSMUSP00000073867
Gene: ENSMUSG00000078580
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
22 |
79 |
4.43e-7 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000164345
AA Change: H67L
|
| SMART Domains |
Protein: ENSMUSP00000131610
Gene: ENSMUSG00000030823
AA Change: H67L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
22 |
67 |
1.65e0 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165495
|
| SMART Domains |
Protein: ENSMUSP00000126288
Gene: ENSMUSG00000078580
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
22 |
82 |
4.09e-29 |
SMART |
|
ZnF_C2H2
|
168 |
190 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
196 |
218 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
224 |
246 |
4.3e-5 |
SMART |
|
ZnF_C2H2
|
252 |
274 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
280 |
302 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
308 |
331 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
337 |
359 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
365 |
387 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
393 |
415 |
2.2e-2 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310002L09Rik |
T |
A |
4: 73,860,956 (GRCm39) |
T215S |
possibly damaging |
Het |
| Bcl6b |
T |
C |
11: 70,119,310 (GRCm39) |
|
probably benign |
Het |
| C8a |
G |
A |
4: 104,722,642 (GRCm39) |
|
probably benign |
Het |
| Cep152 |
G |
A |
2: 125,405,643 (GRCm39) |
Q1630* |
probably null |
Het |
| Dnah6 |
T |
C |
6: 73,172,603 (GRCm39) |
N285S |
possibly damaging |
Het |
| Elovl5 |
G |
A |
9: 77,868,256 (GRCm39) |
R56Q |
probably benign |
Het |
| Fcf1 |
T |
C |
12: 85,019,835 (GRCm39) |
V36A |
probably benign |
Het |
| Gdf3 |
A |
G |
6: 122,584,085 (GRCm39) |
L94P |
probably damaging |
Het |
| Kcnt2 |
A |
T |
1: 140,450,836 (GRCm39) |
H705L |
probably damaging |
Het |
| Ly75 |
A |
T |
2: 60,206,421 (GRCm39) |
C83S |
probably damaging |
Het |
| Med12l |
T |
A |
3: 59,135,245 (GRCm39) |
S798T |
probably benign |
Het |
| Morc3 |
G |
T |
16: 93,670,283 (GRCm39) |
|
probably null |
Het |
| Neb |
A |
T |
2: 52,096,117 (GRCm39) |
N1049K |
probably benign |
Het |
| Nlrp6 |
A |
G |
7: 140,503,037 (GRCm39) |
D381G |
probably damaging |
Het |
| Pcnx1 |
A |
T |
12: 82,042,827 (GRCm39) |
D2303V |
probably damaging |
Het |
| Prss45 |
A |
T |
9: 110,669,578 (GRCm39) |
N227I |
probably damaging |
Het |
| Rbbp6 |
G |
A |
7: 122,570,286 (GRCm39) |
M34I |
probably damaging |
Het |
| Slc30a7 |
T |
C |
3: 115,740,369 (GRCm39) |
|
probably null |
Het |
| Smpdl3a |
T |
C |
10: 57,684,042 (GRCm39) |
Y267H |
probably benign |
Het |
| Snw1 |
A |
G |
12: 87,497,574 (GRCm39) |
|
probably null |
Het |
| Sp140 |
G |
A |
1: 85,549,393 (GRCm39) |
R208K |
probably benign |
Het |
| Tbx19 |
A |
G |
1: 164,987,968 (GRCm39) |
V55A |
probably benign |
Het |
| Tmem131 |
A |
G |
1: 36,850,508 (GRCm39) |
S1059P |
probably damaging |
Het |
| Tpo |
G |
A |
12: 30,134,619 (GRCm39) |
P780S |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,570,055 (GRCm39) |
T26946M |
probably damaging |
Het |
| Vps33b |
A |
G |
7: 79,935,591 (GRCm39) |
E372G |
probably damaging |
Het |
| Vwf |
T |
C |
6: 125,619,684 (GRCm39) |
V1454A |
possibly damaging |
Het |
| Zbbx |
C |
T |
3: 74,968,839 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Zfp747l1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03102:Zfp747l1
|
APN |
7 |
126,983,951 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03264:Zfp747l1
|
APN |
7 |
126,984,811 (GRCm39) |
unclassified |
probably benign |
|
|
R1653:Zfp747l1
|
UTSW |
7 |
126,983,652 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1692:Zfp747l1
|
UTSW |
7 |
126,983,652 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2042:Zfp747l1
|
UTSW |
7 |
126,984,641 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2132:Zfp747l1
|
UTSW |
7 |
126,986,107 (GRCm39) |
missense |
probably benign |
|
|
R3768:Zfp747l1
|
UTSW |
7 |
126,984,035 (GRCm39) |
unclassified |
probably benign |
|
|
R3769:Zfp747l1
|
UTSW |
7 |
126,984,035 (GRCm39) |
unclassified |
probably benign |
|
|
R3770:Zfp747l1
|
UTSW |
7 |
126,984,035 (GRCm39) |
unclassified |
probably benign |
|
|
R4459:Zfp747l1
|
UTSW |
7 |
126,983,917 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4461:Zfp747l1
|
UTSW |
7 |
126,983,917 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4839:Zfp747l1
|
UTSW |
7 |
126,984,179 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4903:Zfp747l1
|
UTSW |
7 |
126,984,578 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5231:Zfp747l1
|
UTSW |
7 |
126,984,586 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5324:Zfp747l1
|
UTSW |
7 |
126,984,079 (GRCm39) |
unclassified |
probably benign |
|
|
R5735:Zfp747l1
|
UTSW |
7 |
126,984,579 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R5808:Zfp747l1
|
UTSW |
7 |
126,984,085 (GRCm39) |
unclassified |
probably benign |
|
|
R6429:Zfp747l1
|
UTSW |
7 |
126,984,214 (GRCm39) |
unclassified |
probably benign |
|
|
R6571:Zfp747l1
|
UTSW |
7 |
126,984,310 (GRCm39) |
unclassified |
probably benign |
|
|
R6655:Zfp747l1
|
UTSW |
7 |
126,983,512 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6806:Zfp747l1
|
UTSW |
7 |
126,985,766 (GRCm39) |
unclassified |
probably benign |
|
|
R6962:Zfp747l1
|
UTSW |
7 |
126,983,487 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7091:Zfp747l1
|
UTSW |
7 |
126,983,534 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7204:Zfp747l1
|
UTSW |
7 |
126,983,518 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7218:Zfp747l1
|
UTSW |
7 |
126,983,852 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7570:Zfp747l1
|
UTSW |
7 |
126,984,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7604:Zfp747l1
|
UTSW |
7 |
126,985,707 (GRCm39) |
missense |
unknown |
|
|
R7661:Zfp747l1
|
UTSW |
7 |
126,984,135 (GRCm39) |
nonsense |
probably null |
|
|
R7893:Zfp747l1
|
UTSW |
7 |
126,985,716 (GRCm39) |
unclassified |
probably benign |
|
|
R8323:Zfp747l1
|
UTSW |
7 |
126,983,621 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9172:Zfp747l1
|
UTSW |
7 |
126,984,626 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9204:Zfp747l1
|
UTSW |
7 |
126,984,332 (GRCm39) |
missense |
unknown |
|
|
| Posted On |
2012-04-20 |
Incidental Mutation