Mutagenetix > Incidental Mutation

Incidental Mutation 'R0716:Vmn2r110'

62857

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r110

Ensembl Gene

ENSMUSG00000091259

Gene Name

vomeronasal 2, receptor 110

Synonyms

EG224582

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.211) question?

Stock #

R0716 (G1)

Quality Score

156

Status

Not validated

Chromosome

Chromosomal Location

20794091-20816521 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20794165 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 835 (R835G)

Ref Sequence

ENSEMBL: ENSMUSP00000129347 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095633] [ENSMUST00000169559]

AlphaFold

E9PWD5

Predicted Effect

probably benign
Transcript: ENSMUST00000095633

SMART Domains

Protein: ENSMUSP00000093293
Gene: ENSMUSG00000071273

Domain	Start	End	E-Value	Type
RRM	17	84	5.29e-5	SMART
low complexity region	101	113	N/A	INTRINSIC
low complexity region	119	130	N/A	INTRINSIC
low complexity region	160	175	N/A	INTRINSIC
low complexity region	179	199	N/A	INTRINSIC
RRM	207	274	1.55e-11	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000169559
AA Change: R835G

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: R835G

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	3.1e-33	PFAM
Pfam:NCD3G	510	563	5.2e-22	PFAM
Pfam:7tm_3	594	831	4.2e-51	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.3%
20x: 94.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 5 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bmal2	A	G	6: 146,731,218 (GRCm39)	S508G	possibly damaging	Het
Gm5444	A	G	13: 4,884,192 (GRCm39)		noncoding transcript	Het
Pkd1l2	A	T	8: 117,777,839 (GRCm39)	V904E	probably damaging	Het
Prl3b1	A	G	13: 27,427,779 (GRCm39)	T30A	probably benign	Het
Ssb	A	G	2: 69,697,703 (GRCm39)	T145A	probably benign	Het

Other mutations in Vmn2r110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01774:Vmn2r110	APN	17	20,803,889 (GRCm39)	missense	probably benign	0.01
IGL01824:Vmn2r110	APN	17	20,794,929 (GRCm39)	missense	probably benign	0.44
IGL01879:Vmn2r110	APN	17	20,794,122 (GRCm39)	missense	probably benign	0.01
IGL02168:Vmn2r110	APN	17	20,804,062 (GRCm39)	splice site	probably benign
IGL02178:Vmn2r110	APN	17	20,804,706 (GRCm39)	splice site	probably null
IGL02322:Vmn2r110	APN	17	20,794,197 (GRCm39)	missense	probably damaging	1.00
IGL02323:Vmn2r110	APN	17	20,816,399 (GRCm39)	missense	probably damaging	0.98
IGL02415:Vmn2r110	APN	17	20,804,033 (GRCm39)	missense	probably benign	0.03
IGL02491:Vmn2r110	APN	17	20,816,400 (GRCm39)	missense	probably damaging	0.99
IGL02876:Vmn2r110	APN	17	20,794,558 (GRCm39)	missense	probably damaging	0.98
IGL03141:Vmn2r110	APN	17	20,803,976 (GRCm39)	missense	possibly damaging	0.79
IGL03270:Vmn2r110	APN	17	20,803,778 (GRCm39)	missense	probably benign	0.00
IGL03286:Vmn2r110	APN	17	20,804,468 (GRCm39)	missense	possibly damaging	0.95
IGL03379:Vmn2r110	APN	17	20,803,906 (GRCm39)	missense	probably damaging	0.99
PIT4243001:Vmn2r110	UTSW	17	20,802,379 (GRCm39)	missense	probably benign	0.01
R0040:Vmn2r110	UTSW	17	20,816,346 (GRCm39)	missense	probably benign	0.10
R0195:Vmn2r110	UTSW	17	20,794,317 (GRCm39)	missense	probably benign	0.31
R1199:Vmn2r110	UTSW	17	20,803,525 (GRCm39)	missense	probably benign	0.03
R1767:Vmn2r110	UTSW	17	20,800,840 (GRCm39)	missense	possibly damaging	0.83
R2212:Vmn2r110	UTSW	17	20,794,209 (GRCm39)	splice site	probably null
R3056:Vmn2r110	UTSW	17	20,803,360 (GRCm39)	missense	probably damaging	1.00
R4093:Vmn2r110	UTSW	17	20,803,642 (GRCm39)	missense	possibly damaging	0.83
R4418:Vmn2r110	UTSW	17	20,803,951 (GRCm39)	nonsense	probably null
R4598:Vmn2r110	UTSW	17	20,804,029 (GRCm39)	nonsense	probably null
R4754:Vmn2r110	UTSW	17	20,816,458 (GRCm39)	missense	probably benign	0.00
R5283:Vmn2r110	UTSW	17	20,800,899 (GRCm39)	missense	probably benign	0.00
R5421:Vmn2r110	UTSW	17	20,803,882 (GRCm39)	missense	probably damaging	1.00
R5672:Vmn2r110	UTSW	17	20,816,494 (GRCm39)	missense	probably benign
R5865:Vmn2r110	UTSW	17	20,804,557 (GRCm39)	missense	probably benign	0.00
R6642:Vmn2r110	UTSW	17	20,803,779 (GRCm39)	missense	possibly damaging	0.94
R6799:Vmn2r110	UTSW	17	20,803,798 (GRCm39)	missense	probably benign
R7167:Vmn2r110	UTSW	17	20,794,441 (GRCm39)	missense	probably benign	0.01
R7291:Vmn2r110	UTSW	17	20,794,471 (GRCm39)	missense	probably benign	0.13
R7320:Vmn2r110	UTSW	17	20,816,316 (GRCm39)	missense	probably benign
R7519:Vmn2r110	UTSW	17	20,804,524 (GRCm39)	missense	probably benign
R8089:Vmn2r110	UTSW	17	20,803,807 (GRCm39)	missense	probably benign	0.00
R8234:Vmn2r110	UTSW	17	20,804,691 (GRCm39)	missense	probably benign	0.12
R8272:Vmn2r110	UTSW	17	20,816,490 (GRCm39)	missense	probably damaging	0.97
R8307:Vmn2r110	UTSW	17	20,803,319 (GRCm39)	missense	probably benign	0.00
R8506:Vmn2r110	UTSW	17	20,804,627 (GRCm39)	missense	probably benign	0.00
R8516:Vmn2r110	UTSW	17	20,794,875 (GRCm39)	missense	probably damaging	1.00
R8555:Vmn2r110	UTSW	17	20,804,618 (GRCm39)	missense	probably damaging	0.97
R8691:Vmn2r110	UTSW	17	20,803,404 (GRCm39)	missense	probably benign	0.19
R8859:Vmn2r110	UTSW	17	20,794,560 (GRCm39)	missense	probably damaging	0.99
R8935:Vmn2r110	UTSW	17	20,803,957 (GRCm39)	missense	probably benign	0.40
R8986:Vmn2r110	UTSW	17	20,803,823 (GRCm39)	missense	probably damaging	0.97
R9012:Vmn2r110	UTSW	17	20,803,627 (GRCm39)	missense	probably damaging	1.00
R9101:Vmn2r110	UTSW	17	20,794,471 (GRCm39)	missense
R9744:Vmn2r110	UTSW	17	20,794,848 (GRCm39)	missense	probably damaging	0.98
R9803:Vmn2r110	UTSW	17	20,803,730 (GRCm39)	missense	probably benign	0.00
Z1088:Vmn2r110	UTSW	17	20,803,942 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCTGGCAGCTATTATGGAAGTGAG -3'
(R):5'- GGATACCTCTGCTCCTTGGCTCTTG -3'

Sequencing Primer
(F):5'- GGCTTGTTGCTCATAAATGGAAAAAC -3'
(R):5'- GGCATTCCTATCTAGAAATCTGC -3'

Posted On

2013-07-30