Incidental Mutation 'R0699:Nav1'
| ID |
62937 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav1
|
| Ensembl Gene |
ENSMUSG00000009418 |
| Gene Name |
neuron navigator 1 |
| Synonyms |
9930003A20Rik, unc53H1, steerin-1, POMFIL3, C230080M11Rik |
| MMRRC Submission |
038883-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.944)
|
| Stock # |
R0699 (G1)
|
| Quality Score |
115 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
135362318-135615843 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 135380687 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 1471
(M1471L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000067241
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040599]
[ENSMUST00000067414]
[ENSMUST00000190298]
|
| AlphaFold |
Q8CH77 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040599
AA Change: M1471L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000043803
Gene: ENSMUSG00000009418
AA Change: M1471L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000067414
AA Change: M1471L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000067241
Gene: ENSMUSG00000009418
AA Change: M1471L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175639
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187311
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189252
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000189362
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000190298
AA Change: M1411L
|
| SMART Domains |
Protein: ENSMUSP00000140322
Gene: ENSMUSG00000009418
AA Change: M1411L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1013 |
1048 |
N/A |
INTRINSIC |
|
low complexity region
|
1122 |
1153 |
N/A |
INTRINSIC |
|
low complexity region
|
1200 |
1221 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1244 |
N/A |
INTRINSIC |
|
coiled coil region
|
1268 |
1300 |
N/A |
INTRINSIC |
|
AAA
|
1488 |
1642 |
3.16e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190735
|
| Meta Mutation Damage Score |
0.0587 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 94.8%
|
| Validation Efficiency |
98% (120/123) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
G |
A |
11: 9,538,508 (GRCm39) |
|
probably benign |
Het |
| Abcb6 |
C |
T |
1: 75,148,553 (GRCm39) |
E89K |
probably damaging |
Het |
| Adam25 |
C |
A |
8: 41,209,011 (GRCm39) |
T759K |
probably benign |
Het |
| Adgrf5 |
G |
A |
17: 43,733,552 (GRCm39) |
|
probably null |
Het |
| Aimp1 |
A |
T |
3: 132,380,626 (GRCm39) |
|
probably benign |
Het |
| Aldh3a2 |
C |
T |
11: 61,153,148 (GRCm39) |
V193I |
probably benign |
Het |
| Ank2 |
C |
T |
3: 126,723,478 (GRCm39) |
V950I |
probably benign |
Het |
| Aspn |
A |
G |
13: 49,705,258 (GRCm39) |
D40G |
possibly damaging |
Het |
| C1rl |
A |
G |
6: 124,485,595 (GRCm39) |
D322G |
probably benign |
Het |
| Car5a |
T |
C |
8: 122,671,555 (GRCm39) |
|
probably benign |
Het |
| Cfap107 |
G |
T |
4: 144,146,322 (GRCm39) |
N110K |
probably damaging |
Het |
| Cfap157 |
T |
A |
2: 32,669,022 (GRCm39) |
K360N |
probably damaging |
Het |
| Cilp |
T |
A |
9: 65,177,608 (GRCm39) |
F117Y |
probably damaging |
Het |
| Cntnap5c |
T |
G |
17: 58,349,493 (GRCm39) |
W269G |
probably damaging |
Het |
| Col6a1 |
A |
G |
10: 76,552,114 (GRCm39) |
V459A |
unknown |
Het |
| Commd3 |
A |
G |
2: 18,679,786 (GRCm39) |
E165G |
possibly damaging |
Het |
| Cops3 |
A |
C |
11: 59,717,148 (GRCm39) |
Y244D |
probably damaging |
Het |
| Cpne5 |
T |
A |
17: 29,428,667 (GRCm39) |
K108N |
probably damaging |
Het |
| Cracdl |
T |
C |
1: 37,651,411 (GRCm39) |
D1152G |
possibly damaging |
Het |
| Ddx41 |
A |
G |
13: 55,679,112 (GRCm39) |
|
probably benign |
Het |
| Dnhd1 |
T |
C |
7: 105,301,113 (GRCm39) |
Y157H |
probably damaging |
Het |
| Dpp8 |
A |
T |
9: 64,962,176 (GRCm39) |
L405F |
probably benign |
Het |
| Dync2h1 |
G |
T |
9: 7,103,680 (GRCm39) |
A365E |
probably benign |
Het |
| Dysf |
C |
T |
6: 84,167,828 (GRCm39) |
R1757W |
probably benign |
Het |
| Eif1ad |
T |
A |
19: 5,418,726 (GRCm39) |
V93D |
possibly damaging |
Het |
| Eif2ak3 |
T |
C |
6: 70,869,514 (GRCm39) |
F734L |
probably benign |
Het |
| F8 |
T |
C |
X: 74,423,230 (GRCm39) |
|
probably benign |
Het |
| Fbxl14 |
T |
C |
6: 119,457,715 (GRCm39) |
Y299H |
probably benign |
Het |
| Fmo1 |
T |
C |
1: 162,661,341 (GRCm39) |
N314S |
probably benign |
Het |
| Fnip2 |
T |
C |
3: 79,388,446 (GRCm39) |
T762A |
probably benign |
Het |
| Gfra1 |
A |
C |
19: 58,258,555 (GRCm39) |
S271A |
probably benign |
Het |
| Gm9932 |
T |
C |
5: 100,346,931 (GRCm39) |
V43A |
probably damaging |
Het |
| Herc6 |
T |
C |
6: 57,558,092 (GRCm39) |
L24P |
probably damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,695,161 (GRCm39) |
T248A |
probably damaging |
Het |
| Hook1 |
T |
A |
4: 95,884,077 (GRCm39) |
|
probably benign |
Het |
| Ifne |
T |
C |
4: 88,798,014 (GRCm39) |
S135G |
probably benign |
Het |
| Igkv13-84 |
G |
A |
6: 68,916,635 (GRCm39) |
|
probably benign |
Het |
| Itm2b |
T |
A |
14: 73,602,065 (GRCm39) |
N211I |
probably damaging |
Het |
| Kcnh5 |
A |
T |
12: 75,023,305 (GRCm39) |
C588S |
possibly damaging |
Het |
| Kif13a |
A |
T |
13: 46,952,689 (GRCm39) |
W699R |
possibly damaging |
Het |
| Kmt2e |
T |
C |
5: 23,678,581 (GRCm39) |
V220A |
probably benign |
Het |
| Macrod2 |
T |
C |
2: 140,260,836 (GRCm39) |
|
probably null |
Het |
| Map3k6 |
A |
G |
4: 132,975,437 (GRCm39) |
E724G |
probably damaging |
Het |
| Mgam |
T |
C |
6: 40,619,953 (GRCm39) |
L14P |
possibly damaging |
Het |
| Morc1 |
T |
A |
16: 48,412,977 (GRCm39) |
M706K |
probably benign |
Het |
| Muc2 |
T |
C |
7: 141,306,037 (GRCm39) |
V242A |
probably damaging |
Het |
| Mx2 |
T |
A |
16: 97,345,753 (GRCm39) |
V57E |
probably damaging |
Het |
| Myh14 |
C |
A |
7: 44,274,395 (GRCm39) |
A1339S |
possibly damaging |
Het |
| Myom1 |
G |
T |
17: 71,374,308 (GRCm39) |
S595I |
probably damaging |
Het |
| Ncapd2 |
A |
C |
6: 125,146,843 (GRCm39) |
S1248A |
probably benign |
Het |
| Ncbp1 |
T |
C |
4: 46,147,528 (GRCm39) |
V125A |
probably benign |
Het |
| Ncor2 |
A |
T |
5: 125,106,176 (GRCm39) |
|
probably benign |
Het |
| Nobox |
T |
A |
6: 43,284,144 (GRCm39) |
Q134L |
probably benign |
Het |
| Npc1 |
T |
C |
18: 12,343,632 (GRCm39) |
T454A |
probably benign |
Het |
| Ntng1 |
G |
T |
3: 109,779,611 (GRCm39) |
T322K |
probably damaging |
Het |
| Olfm5 |
T |
C |
7: 103,803,326 (GRCm39) |
E379G |
probably damaging |
Het |
| Oma1 |
T |
C |
4: 103,210,792 (GRCm39) |
S433P |
probably damaging |
Het |
| Or1ad6 |
T |
C |
11: 50,860,645 (GRCm39) |
S267P |
probably damaging |
Het |
| Or1b1 |
T |
C |
2: 36,995,074 (GRCm39) |
D196G |
possibly damaging |
Het |
| Or4c105 |
A |
T |
2: 88,647,568 (GRCm39) |
N18Y |
probably damaging |
Het |
| Or4c107 |
C |
T |
2: 88,788,960 (GRCm39) |
T50I |
probably benign |
Het |
| Or4c113 |
C |
T |
2: 88,885,636 (GRCm39) |
V45M |
possibly damaging |
Het |
| Parp14 |
G |
A |
16: 35,680,955 (GRCm39) |
T226M |
probably damaging |
Het |
| Parp8 |
A |
T |
13: 117,059,120 (GRCm39) |
H168Q |
probably benign |
Het |
| Pik3cg |
G |
A |
12: 32,247,341 (GRCm39) |
|
probably benign |
Het |
| Pla2g3 |
T |
C |
11: 3,442,000 (GRCm39) |
F388S |
probably damaging |
Het |
| Plaat3 |
T |
A |
19: 7,535,366 (GRCm39) |
|
probably null |
Het |
| Pllp |
T |
C |
8: 95,422,660 (GRCm39) |
|
probably null |
Het |
| Ppfibp1 |
T |
A |
6: 146,927,720 (GRCm39) |
V778E |
probably damaging |
Het |
| Prkci |
T |
C |
3: 31,104,422 (GRCm39) |
V595A |
possibly damaging |
Het |
| Prune2 |
T |
A |
19: 17,101,319 (GRCm39) |
D2274E |
probably damaging |
Het |
| Rad51ap2 |
A |
T |
12: 11,507,601 (GRCm39) |
T508S |
probably benign |
Het |
| Ranbp3l |
T |
C |
15: 9,058,850 (GRCm39) |
|
probably null |
Het |
| Rfc1 |
A |
C |
5: 65,476,742 (GRCm39) |
|
probably null |
Het |
| Rin3 |
G |
A |
12: 102,335,834 (GRCm39) |
V502I |
probably damaging |
Het |
| Rtn4rl1 |
A |
T |
11: 75,156,048 (GRCm39) |
H160L |
possibly damaging |
Het |
| Rtn4rl1 |
A |
T |
11: 75,156,050 (GRCm39) |
I161F |
probably benign |
Het |
| Serpinb9b |
A |
T |
13: 33,217,549 (GRCm39) |
M116L |
probably benign |
Het |
| Sgo2a |
C |
T |
1: 58,037,308 (GRCm39) |
R18* |
probably null |
Het |
| Sh3gl2 |
T |
A |
4: 85,265,408 (GRCm39) |
D31E |
probably benign |
Het |
| Slc38a9 |
T |
C |
13: 112,859,823 (GRCm39) |
L419S |
probably damaging |
Het |
| Sp8 |
AGCGGCGGCGGCGGCGG |
AGCGGCGGCGGCGG |
12: 118,812,555 (GRCm39) |
|
probably benign |
Het |
| Spen |
G |
T |
4: 141,201,702 (GRCm39) |
N2308K |
possibly damaging |
Het |
| Stac2 |
A |
G |
11: 97,933,611 (GRCm39) |
I156T |
possibly damaging |
Het |
| Stambp |
A |
G |
6: 83,533,303 (GRCm39) |
F320S |
probably damaging |
Het |
| Tas2r117 |
A |
T |
6: 132,780,161 (GRCm39) |
N100Y |
probably damaging |
Het |
| Tigd3 |
A |
T |
19: 5,941,974 (GRCm39) |
S385R |
probably benign |
Het |
| Tmem30c |
T |
C |
16: 57,097,152 (GRCm39) |
D136G |
possibly damaging |
Het |
| Tnfrsf21 |
C |
T |
17: 43,349,104 (GRCm39) |
H239Y |
probably benign |
Het |
| Tnrc6c |
A |
G |
11: 117,613,447 (GRCm39) |
Q535R |
probably benign |
Het |
| Trmt2a |
T |
C |
16: 18,067,393 (GRCm39) |
V22A |
probably benign |
Het |
| Tut7 |
G |
A |
13: 59,929,828 (GRCm39) |
|
probably benign |
Het |
| Wipf3 |
A |
C |
6: 54,460,817 (GRCm39) |
K88N |
probably damaging |
Het |
| Zfp974 |
T |
C |
7: 27,611,416 (GRCm39) |
E103G |
possibly damaging |
Het |
| Zscan10 |
C |
T |
17: 23,827,092 (GRCm39) |
T135I |
probably damaging |
Het |
|
| Other mutations in Nav1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01061:Nav1
|
APN |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01455:Nav1
|
APN |
1 |
135,397,373 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01650:Nav1
|
APN |
1 |
135,382,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01872:Nav1
|
APN |
1 |
135,381,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01967:Nav1
|
APN |
1 |
135,464,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02167:Nav1
|
APN |
1 |
135,398,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02278:Nav1
|
APN |
1 |
135,391,452 (GRCm39) |
splice site |
probably benign |
|
|
IGL02343:Nav1
|
APN |
1 |
135,382,490 (GRCm39) |
nonsense |
probably null |
|
|
IGL02378:Nav1
|
APN |
1 |
135,397,716 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02554:Nav1
|
APN |
1 |
135,512,651 (GRCm39) |
synonymous |
silent |
|
|
IGL03148:Nav1
|
APN |
1 |
135,397,762 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03286:Nav1
|
APN |
1 |
135,382,274 (GRCm39) |
missense |
probably benign |
|
|
IGL03372:Nav1
|
APN |
1 |
135,378,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4802001:Nav1
|
UTSW |
1 |
135,380,671 (GRCm39) |
missense |
unknown |
|
|
R0388:Nav1
|
UTSW |
1 |
135,376,655 (GRCm39) |
splice site |
probably benign |
|
|
R0390:Nav1
|
UTSW |
1 |
135,377,704 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,359 (GRCm39) |
nonsense |
probably null |
|
|
R0416:Nav1
|
UTSW |
1 |
135,398,864 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0463:Nav1
|
UTSW |
1 |
135,379,945 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0538:Nav1
|
UTSW |
1 |
135,392,430 (GRCm39) |
splice site |
probably benign |
|
|
R0594:Nav1
|
UTSW |
1 |
135,395,381 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0696:Nav1
|
UTSW |
1 |
135,460,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0759:Nav1
|
UTSW |
1 |
135,382,998 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1164:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
|
|
R1169:Nav1
|
UTSW |
1 |
135,382,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1401:Nav1
|
UTSW |
1 |
135,388,163 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1421:Nav1
|
UTSW |
1 |
135,512,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Nav1
|
UTSW |
1 |
135,380,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1705:Nav1
|
UTSW |
1 |
135,512,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1713:Nav1
|
UTSW |
1 |
135,522,972 (GRCm39) |
intron |
probably benign |
|
|
R1728:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1729:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1730:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1739:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1740:Nav1
|
UTSW |
1 |
135,386,127 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1762:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1783:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1784:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1785:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1895:Nav1
|
UTSW |
1 |
135,386,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1896:Nav1
|
UTSW |
1 |
135,388,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1902:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1925:Nav1
|
UTSW |
1 |
135,534,967 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R1939:Nav1
|
UTSW |
1 |
135,393,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Nav1
|
UTSW |
1 |
135,460,091 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2063:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2084:Nav1
|
UTSW |
1 |
135,535,158 (GRCm39) |
unclassified |
probably benign |
|
|
R2090:Nav1
|
UTSW |
1 |
135,534,903 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R2107:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2110:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Nav1
|
UTSW |
1 |
135,382,174 (GRCm39) |
missense |
probably null |
0.18 |
|
R2268:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2269:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Nav1
|
UTSW |
1 |
135,378,382 (GRCm39) |
splice site |
probably null |
|
|
R2869:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2871:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2872:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2904:Nav1
|
UTSW |
1 |
135,512,976 (GRCm39) |
missense |
probably benign |
|
|
R3690:Nav1
|
UTSW |
1 |
135,395,382 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3716:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3717:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3718:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3815:Nav1
|
UTSW |
1 |
135,398,862 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4282:Nav1
|
UTSW |
1 |
135,385,651 (GRCm39) |
intron |
probably benign |
|
|
R4361:Nav1
|
UTSW |
1 |
135,535,175 (GRCm39) |
unclassified |
probably benign |
|
|
R4610:Nav1
|
UTSW |
1 |
135,520,186 (GRCm39) |
intron |
probably benign |
|
|
R4730:Nav1
|
UTSW |
1 |
135,535,049 (GRCm39) |
unclassified |
probably benign |
|
|
R4784:Nav1
|
UTSW |
1 |
135,386,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Nav1
|
UTSW |
1 |
135,397,461 (GRCm39) |
missense |
probably benign |
|
|
R4808:Nav1
|
UTSW |
1 |
135,382,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4996:Nav1
|
UTSW |
1 |
135,393,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5284:Nav1
|
UTSW |
1 |
135,377,701 (GRCm39) |
nonsense |
probably null |
|
|
R5514:Nav1
|
UTSW |
1 |
135,398,299 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5769:Nav1
|
UTSW |
1 |
135,379,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5834:Nav1
|
UTSW |
1 |
135,460,144 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5898:Nav1
|
UTSW |
1 |
135,512,884 (GRCm39) |
missense |
probably benign |
|
|
R6081:Nav1
|
UTSW |
1 |
135,398,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6344:Nav1
|
UTSW |
1 |
135,378,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Nav1
|
UTSW |
1 |
135,382,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7001:Nav1
|
UTSW |
1 |
135,382,349 (GRCm39) |
splice site |
probably null |
|
|
R7185:Nav1
|
UTSW |
1 |
135,398,746 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7291:Nav1
|
UTSW |
1 |
135,393,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Nav1
|
UTSW |
1 |
135,380,591 (GRCm39) |
missense |
unknown |
|
|
R7390:Nav1
|
UTSW |
1 |
135,512,656 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7464:Nav1
|
UTSW |
1 |
135,512,647 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7502:Nav1
|
UTSW |
1 |
135,397,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7601:Nav1
|
UTSW |
1 |
135,388,176 (GRCm39) |
missense |
unknown |
|
|
R7625:Nav1
|
UTSW |
1 |
135,395,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7639:Nav1
|
UTSW |
1 |
135,398,860 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7786:Nav1
|
UTSW |
1 |
135,397,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Nav1
|
UTSW |
1 |
135,379,986 (GRCm39) |
missense |
unknown |
|
|
R7815:Nav1
|
UTSW |
1 |
135,512,377 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7825:Nav1
|
UTSW |
1 |
135,377,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8030:Nav1
|
UTSW |
1 |
135,464,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8370:Nav1
|
UTSW |
1 |
135,398,882 (GRCm39) |
nonsense |
probably null |
|
|
R8405:Nav1
|
UTSW |
1 |
135,382,508 (GRCm39) |
missense |
unknown |
|
|
R8720:Nav1
|
UTSW |
1 |
135,388,464 (GRCm39) |
missense |
unknown |
|
|
R8868:Nav1
|
UTSW |
1 |
135,512,943 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8973:Nav1
|
UTSW |
1 |
135,512,463 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9039:Nav1
|
UTSW |
1 |
135,371,487 (GRCm39) |
missense |
unknown |
|
|
R9261:Nav1
|
UTSW |
1 |
135,388,095 (GRCm39) |
missense |
unknown |
|
|
R9523:Nav1
|
UTSW |
1 |
135,379,929 (GRCm39) |
missense |
unknown |
|
|
Z1088:Nav1
|
UTSW |
1 |
135,398,462 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Nav1
|
UTSW |
1 |
135,400,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Nav1
|
UTSW |
1 |
135,380,624 (GRCm39) |
missense |
unknown |
|
|
Z1177:Nav1
|
UTSW |
1 |
135,397,469 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGTGGTACACTACGTCACACCAAG -3'
(R):5'- CTCACACTCACAGAGGTTGCTCATC -3'
Sequencing Primer
(F):5'- GAGACAAAAACTAACCTTTGAGAGC -3'
(R):5'- ACAGAGGTTGCTCATCTTCTCAAG -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation