Incidental Mutation 'R0699:Tnrc6c'
| ID |
62966 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnrc6c
|
| Ensembl Gene |
ENSMUSG00000025571 |
| Gene Name |
trinucleotide repeat containing 6C |
| Synonyms |
9930033H14Rik |
| MMRRC Submission |
038883-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0699 (G1)
|
| Quality Score |
158 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
117545115-117654265 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 117613447 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Arginine
at position 535
(Q535R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115221
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026658]
[ENSMUST00000106344]
[ENSMUST00000138299]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000026658
AA Change: Q695R
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000026658
Gene: ENSMUSG00000025571
AA Change: Q695R
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
32 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
58 |
N/A |
INTRINSIC |
|
low complexity region
|
110 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
248 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
394 |
408 |
N/A |
INTRINSIC |
|
low complexity region
|
440 |
457 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
472 |
573 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
594 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
632 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
639 |
704 |
5.49e-5 |
PROSPERO |
|
internal_repeat_1
|
799 |
902 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
964 |
981 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
991 |
1051 |
5.49e-5 |
PROSPERO |
|
low complexity region
|
1063 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1125 |
N/A |
INTRINSIC |
|
UBA
|
1145 |
1182 |
3.68e-4 |
SMART |
|
Pfam:M_domain
|
1232 |
1459 |
6.8e-77 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1468 |
1646 |
4.1e-75 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1643 |
1722 |
3.7e-33 |
PFAM |
|
RRM
|
1725 |
1792 |
1.81e-2 |
SMART |
|
low complexity region
|
1813 |
1823 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106344
AA Change: Q695R
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000101951
Gene: ENSMUSG00000025571
AA Change: Q695R
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
32 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
58 |
N/A |
INTRINSIC |
|
low complexity region
|
110 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
248 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
394 |
408 |
N/A |
INTRINSIC |
|
low complexity region
|
440 |
457 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
472 |
573 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
594 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
632 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
639 |
704 |
5.49e-5 |
PROSPERO |
|
internal_repeat_1
|
799 |
902 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
964 |
981 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
991 |
1051 |
5.49e-5 |
PROSPERO |
|
low complexity region
|
1063 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1125 |
N/A |
INTRINSIC |
|
UBA
|
1145 |
1182 |
3.68e-4 |
SMART |
|
Pfam:M_domain
|
1232 |
1459 |
6.8e-77 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1468 |
1646 |
4.1e-75 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1643 |
1722 |
3.7e-33 |
PFAM |
|
RRM
|
1725 |
1792 |
1.81e-2 |
SMART |
|
low complexity region
|
1813 |
1823 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000138299
AA Change: Q535R
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000115221
Gene: ENSMUSG00000025571
AA Change: Q535R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
88 |
97 |
N/A |
INTRINSIC |
|
low complexity region
|
138 |
158 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
297 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
413 |
9.45e-5 |
PROSPERO |
|
low complexity region
|
434 |
454 |
N/A |
INTRINSIC |
|
low complexity region
|
461 |
472 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
639 |
742 |
9.45e-5 |
PROSPERO |
|
low complexity region
|
804 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
965 |
N/A |
INTRINSIC |
|
UBA
|
985 |
1022 |
3.68e-4 |
SMART |
|
Pfam:M_domain
|
1036 |
1293 |
1.7e-53 |
PFAM |
|
low complexity region
|
1397 |
1406 |
N/A |
INTRINSIC |
|
PDB:3KTP|B
|
1422 |
1443 |
7e-7 |
PDB |
|
low complexity region
|
1507 |
1518 |
N/A |
INTRINSIC |
|
low complexity region
|
1531 |
1552 |
N/A |
INTRINSIC |
|
RRM
|
1557 |
1624 |
1.81e-2 |
SMART |
|
low complexity region
|
1645 |
1655 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141115
|
| Meta Mutation Damage Score |
0.0674 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 94.8%
|
| Validation Efficiency |
98% (120/123) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a gene trap allele exhibit complete neonatal lethality with cyanosis, respiratory distress and thickened mesenchyme in air sacs. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
G |
A |
11: 9,538,508 (GRCm39) |
|
probably benign |
Het |
| Abcb6 |
C |
T |
1: 75,148,553 (GRCm39) |
E89K |
probably damaging |
Het |
| Adam25 |
C |
A |
8: 41,209,011 (GRCm39) |
T759K |
probably benign |
Het |
| Adgrf5 |
G |
A |
17: 43,733,552 (GRCm39) |
|
probably null |
Het |
| Aimp1 |
A |
T |
3: 132,380,626 (GRCm39) |
|
probably benign |
Het |
| Aldh3a2 |
C |
T |
11: 61,153,148 (GRCm39) |
V193I |
probably benign |
Het |
| Ank2 |
C |
T |
3: 126,723,478 (GRCm39) |
V950I |
probably benign |
Het |
| Aspn |
A |
G |
13: 49,705,258 (GRCm39) |
D40G |
possibly damaging |
Het |
| C1rl |
A |
G |
6: 124,485,595 (GRCm39) |
D322G |
probably benign |
Het |
| Car5a |
T |
C |
8: 122,671,555 (GRCm39) |
|
probably benign |
Het |
| Cfap107 |
G |
T |
4: 144,146,322 (GRCm39) |
N110K |
probably damaging |
Het |
| Cfap157 |
T |
A |
2: 32,669,022 (GRCm39) |
K360N |
probably damaging |
Het |
| Cilp |
T |
A |
9: 65,177,608 (GRCm39) |
F117Y |
probably damaging |
Het |
| Cntnap5c |
T |
G |
17: 58,349,493 (GRCm39) |
W269G |
probably damaging |
Het |
| Col6a1 |
A |
G |
10: 76,552,114 (GRCm39) |
V459A |
unknown |
Het |
| Commd3 |
A |
G |
2: 18,679,786 (GRCm39) |
E165G |
possibly damaging |
Het |
| Cops3 |
A |
C |
11: 59,717,148 (GRCm39) |
Y244D |
probably damaging |
Het |
| Cpne5 |
T |
A |
17: 29,428,667 (GRCm39) |
K108N |
probably damaging |
Het |
| Cracdl |
T |
C |
1: 37,651,411 (GRCm39) |
D1152G |
possibly damaging |
Het |
| Ddx41 |
A |
G |
13: 55,679,112 (GRCm39) |
|
probably benign |
Het |
| Dnhd1 |
T |
C |
7: 105,301,113 (GRCm39) |
Y157H |
probably damaging |
Het |
| Dpp8 |
A |
T |
9: 64,962,176 (GRCm39) |
L405F |
probably benign |
Het |
| Dync2h1 |
G |
T |
9: 7,103,680 (GRCm39) |
A365E |
probably benign |
Het |
| Dysf |
C |
T |
6: 84,167,828 (GRCm39) |
R1757W |
probably benign |
Het |
| Eif1ad |
T |
A |
19: 5,418,726 (GRCm39) |
V93D |
possibly damaging |
Het |
| Eif2ak3 |
T |
C |
6: 70,869,514 (GRCm39) |
F734L |
probably benign |
Het |
| F8 |
T |
C |
X: 74,423,230 (GRCm39) |
|
probably benign |
Het |
| Fbxl14 |
T |
C |
6: 119,457,715 (GRCm39) |
Y299H |
probably benign |
Het |
| Fmo1 |
T |
C |
1: 162,661,341 (GRCm39) |
N314S |
probably benign |
Het |
| Fnip2 |
T |
C |
3: 79,388,446 (GRCm39) |
T762A |
probably benign |
Het |
| Gfra1 |
A |
C |
19: 58,258,555 (GRCm39) |
S271A |
probably benign |
Het |
| Gm9932 |
T |
C |
5: 100,346,931 (GRCm39) |
V43A |
probably damaging |
Het |
| Herc6 |
T |
C |
6: 57,558,092 (GRCm39) |
L24P |
probably damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,695,161 (GRCm39) |
T248A |
probably damaging |
Het |
| Hook1 |
T |
A |
4: 95,884,077 (GRCm39) |
|
probably benign |
Het |
| Ifne |
T |
C |
4: 88,798,014 (GRCm39) |
S135G |
probably benign |
Het |
| Igkv13-84 |
G |
A |
6: 68,916,635 (GRCm39) |
|
probably benign |
Het |
| Itm2b |
T |
A |
14: 73,602,065 (GRCm39) |
N211I |
probably damaging |
Het |
| Kcnh5 |
A |
T |
12: 75,023,305 (GRCm39) |
C588S |
possibly damaging |
Het |
| Kif13a |
A |
T |
13: 46,952,689 (GRCm39) |
W699R |
possibly damaging |
Het |
| Kmt2e |
T |
C |
5: 23,678,581 (GRCm39) |
V220A |
probably benign |
Het |
| Macrod2 |
T |
C |
2: 140,260,836 (GRCm39) |
|
probably null |
Het |
| Map3k6 |
A |
G |
4: 132,975,437 (GRCm39) |
E724G |
probably damaging |
Het |
| Mgam |
T |
C |
6: 40,619,953 (GRCm39) |
L14P |
possibly damaging |
Het |
| Morc1 |
T |
A |
16: 48,412,977 (GRCm39) |
M706K |
probably benign |
Het |
| Muc2 |
T |
C |
7: 141,306,037 (GRCm39) |
V242A |
probably damaging |
Het |
| Mx2 |
T |
A |
16: 97,345,753 (GRCm39) |
V57E |
probably damaging |
Het |
| Myh14 |
C |
A |
7: 44,274,395 (GRCm39) |
A1339S |
possibly damaging |
Het |
| Myom1 |
G |
T |
17: 71,374,308 (GRCm39) |
S595I |
probably damaging |
Het |
| Nav1 |
T |
A |
1: 135,380,687 (GRCm39) |
M1471L |
probably benign |
Het |
| Ncapd2 |
A |
C |
6: 125,146,843 (GRCm39) |
S1248A |
probably benign |
Het |
| Ncbp1 |
T |
C |
4: 46,147,528 (GRCm39) |
V125A |
probably benign |
Het |
| Ncor2 |
A |
T |
5: 125,106,176 (GRCm39) |
|
probably benign |
Het |
| Nobox |
T |
A |
6: 43,284,144 (GRCm39) |
Q134L |
probably benign |
Het |
| Npc1 |
T |
C |
18: 12,343,632 (GRCm39) |
T454A |
probably benign |
Het |
| Ntng1 |
G |
T |
3: 109,779,611 (GRCm39) |
T322K |
probably damaging |
Het |
| Olfm5 |
T |
C |
7: 103,803,326 (GRCm39) |
E379G |
probably damaging |
Het |
| Oma1 |
T |
C |
4: 103,210,792 (GRCm39) |
S433P |
probably damaging |
Het |
| Or1ad6 |
T |
C |
11: 50,860,645 (GRCm39) |
S267P |
probably damaging |
Het |
| Or1b1 |
T |
C |
2: 36,995,074 (GRCm39) |
D196G |
possibly damaging |
Het |
| Or4c105 |
A |
T |
2: 88,647,568 (GRCm39) |
N18Y |
probably damaging |
Het |
| Or4c107 |
C |
T |
2: 88,788,960 (GRCm39) |
T50I |
probably benign |
Het |
| Or4c113 |
C |
T |
2: 88,885,636 (GRCm39) |
V45M |
possibly damaging |
Het |
| Parp14 |
G |
A |
16: 35,680,955 (GRCm39) |
T226M |
probably damaging |
Het |
| Parp8 |
A |
T |
13: 117,059,120 (GRCm39) |
H168Q |
probably benign |
Het |
| Pik3cg |
G |
A |
12: 32,247,341 (GRCm39) |
|
probably benign |
Het |
| Pla2g3 |
T |
C |
11: 3,442,000 (GRCm39) |
F388S |
probably damaging |
Het |
| Plaat3 |
T |
A |
19: 7,535,366 (GRCm39) |
|
probably null |
Het |
| Pllp |
T |
C |
8: 95,422,660 (GRCm39) |
|
probably null |
Het |
| Ppfibp1 |
T |
A |
6: 146,927,720 (GRCm39) |
V778E |
probably damaging |
Het |
| Prkci |
T |
C |
3: 31,104,422 (GRCm39) |
V595A |
possibly damaging |
Het |
| Prune2 |
T |
A |
19: 17,101,319 (GRCm39) |
D2274E |
probably damaging |
Het |
| Rad51ap2 |
A |
T |
12: 11,507,601 (GRCm39) |
T508S |
probably benign |
Het |
| Ranbp3l |
T |
C |
15: 9,058,850 (GRCm39) |
|
probably null |
Het |
| Rfc1 |
A |
C |
5: 65,476,742 (GRCm39) |
|
probably null |
Het |
| Rin3 |
G |
A |
12: 102,335,834 (GRCm39) |
V502I |
probably damaging |
Het |
| Rtn4rl1 |
A |
T |
11: 75,156,048 (GRCm39) |
H160L |
possibly damaging |
Het |
| Rtn4rl1 |
A |
T |
11: 75,156,050 (GRCm39) |
I161F |
probably benign |
Het |
| Serpinb9b |
A |
T |
13: 33,217,549 (GRCm39) |
M116L |
probably benign |
Het |
| Sgo2a |
C |
T |
1: 58,037,308 (GRCm39) |
R18* |
probably null |
Het |
| Sh3gl2 |
T |
A |
4: 85,265,408 (GRCm39) |
D31E |
probably benign |
Het |
| Slc38a9 |
T |
C |
13: 112,859,823 (GRCm39) |
L419S |
probably damaging |
Het |
| Sp8 |
AGCGGCGGCGGCGGCGG |
AGCGGCGGCGGCGG |
12: 118,812,555 (GRCm39) |
|
probably benign |
Het |
| Spen |
G |
T |
4: 141,201,702 (GRCm39) |
N2308K |
possibly damaging |
Het |
| Stac2 |
A |
G |
11: 97,933,611 (GRCm39) |
I156T |
possibly damaging |
Het |
| Stambp |
A |
G |
6: 83,533,303 (GRCm39) |
F320S |
probably damaging |
Het |
| Tas2r117 |
A |
T |
6: 132,780,161 (GRCm39) |
N100Y |
probably damaging |
Het |
| Tigd3 |
A |
T |
19: 5,941,974 (GRCm39) |
S385R |
probably benign |
Het |
| Tmem30c |
T |
C |
16: 57,097,152 (GRCm39) |
D136G |
possibly damaging |
Het |
| Tnfrsf21 |
C |
T |
17: 43,349,104 (GRCm39) |
H239Y |
probably benign |
Het |
| Trmt2a |
T |
C |
16: 18,067,393 (GRCm39) |
V22A |
probably benign |
Het |
| Tut7 |
G |
A |
13: 59,929,828 (GRCm39) |
|
probably benign |
Het |
| Wipf3 |
A |
C |
6: 54,460,817 (GRCm39) |
K88N |
probably damaging |
Het |
| Zfp974 |
T |
C |
7: 27,611,416 (GRCm39) |
E103G |
possibly damaging |
Het |
| Zscan10 |
C |
T |
17: 23,827,092 (GRCm39) |
T135I |
probably damaging |
Het |
|
| Other mutations in Tnrc6c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00839:Tnrc6c
|
APN |
11 |
117,605,011 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01013:Tnrc6c
|
APN |
11 |
117,612,855 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01092:Tnrc6c
|
APN |
11 |
117,612,811 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01383:Tnrc6c
|
APN |
11 |
117,605,083 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL01395:Tnrc6c
|
APN |
11 |
117,613,939 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01726:Tnrc6c
|
APN |
11 |
117,640,161 (GRCm39) |
splice site |
probably benign |
|
|
IGL01869:Tnrc6c
|
APN |
11 |
117,646,274 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02108:Tnrc6c
|
APN |
11 |
117,612,025 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL02457:Tnrc6c
|
APN |
11 |
117,613,803 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02612:Tnrc6c
|
APN |
11 |
117,633,826 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02748:Tnrc6c
|
APN |
11 |
117,622,996 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03160:Tnrc6c
|
APN |
11 |
117,640,651 (GRCm39) |
splice site |
probably benign |
|
|
rodion
|
UTSW |
11 |
117,629,176 (GRCm39) |
critical splice donor site |
probably null |
|
|
F5770:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
K3955:Tnrc6c
|
UTSW |
11 |
117,651,564 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0015:Tnrc6c
|
UTSW |
11 |
117,612,284 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0143:Tnrc6c
|
UTSW |
11 |
117,643,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0277:Tnrc6c
|
UTSW |
11 |
117,630,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0323:Tnrc6c
|
UTSW |
11 |
117,630,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0464:Tnrc6c
|
UTSW |
11 |
117,651,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1015:Tnrc6c
|
UTSW |
11 |
117,612,748 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1201:Tnrc6c
|
UTSW |
11 |
117,612,500 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1297:Tnrc6c
|
UTSW |
11 |
117,624,529 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1560:Tnrc6c
|
UTSW |
11 |
117,650,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1596:Tnrc6c
|
UTSW |
11 |
117,648,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Tnrc6c
|
UTSW |
11 |
117,651,556 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1892:Tnrc6c
|
UTSW |
11 |
117,605,188 (GRCm39) |
missense |
probably benign |
|
|
R1901:Tnrc6c
|
UTSW |
11 |
117,613,831 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1936:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1937:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1940:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R3622:Tnrc6c
|
UTSW |
11 |
117,640,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3711:Tnrc6c
|
UTSW |
11 |
117,613,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3725:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3775:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3776:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3836:Tnrc6c
|
UTSW |
11 |
117,614,055 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3844:Tnrc6c
|
UTSW |
11 |
117,646,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3852:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3928:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3929:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3937:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3943:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4501:Tnrc6c
|
UTSW |
11 |
117,613,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Tnrc6c
|
UTSW |
11 |
117,633,784 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4511:Tnrc6c
|
UTSW |
11 |
117,633,784 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4654:Tnrc6c
|
UTSW |
11 |
117,611,797 (GRCm39) |
missense |
probably benign |
|
|
R4765:Tnrc6c
|
UTSW |
11 |
117,633,753 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4824:Tnrc6c
|
UTSW |
11 |
117,613,731 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5004:Tnrc6c
|
UTSW |
11 |
117,611,872 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5094:Tnrc6c
|
UTSW |
11 |
117,611,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5130:Tnrc6c
|
UTSW |
11 |
117,629,176 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5234:Tnrc6c
|
UTSW |
11 |
117,651,555 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5235:Tnrc6c
|
UTSW |
11 |
117,651,555 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5345:Tnrc6c
|
UTSW |
11 |
117,614,113 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5359:Tnrc6c
|
UTSW |
11 |
117,649,731 (GRCm39) |
splice site |
silent |
|
|
R5428:Tnrc6c
|
UTSW |
11 |
117,591,588 (GRCm39) |
start codon destroyed |
probably null |
|
|
R5548:Tnrc6c
|
UTSW |
11 |
117,651,669 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5587:Tnrc6c
|
UTSW |
11 |
117,640,097 (GRCm39) |
nonsense |
probably null |
|
|
R5875:Tnrc6c
|
UTSW |
11 |
117,650,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5947:Tnrc6c
|
UTSW |
11 |
117,613,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6135:Tnrc6c
|
UTSW |
11 |
117,626,831 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6354:Tnrc6c
|
UTSW |
11 |
117,640,440 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6389:Tnrc6c
|
UTSW |
11 |
117,613,567 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7027:Tnrc6c
|
UTSW |
11 |
117,624,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7048:Tnrc6c
|
UTSW |
11 |
117,612,800 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7098:Tnrc6c
|
UTSW |
11 |
117,604,952 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7315:Tnrc6c
|
UTSW |
11 |
117,614,354 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7378:Tnrc6c
|
UTSW |
11 |
117,632,606 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7386:Tnrc6c
|
UTSW |
11 |
117,612,780 (GRCm39) |
missense |
probably benign |
|
|
R7515:Tnrc6c
|
UTSW |
11 |
117,632,507 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7665:Tnrc6c
|
UTSW |
11 |
117,611,777 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7755:Tnrc6c
|
UTSW |
11 |
117,648,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8679:Tnrc6c
|
UTSW |
11 |
117,604,961 (GRCm39) |
missense |
probably benign |
|
|
R8824:Tnrc6c
|
UTSW |
11 |
117,630,680 (GRCm39) |
splice site |
probably benign |
|
|
R8971:Tnrc6c
|
UTSW |
11 |
117,640,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9261:Tnrc6c
|
UTSW |
11 |
117,605,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9283:Tnrc6c
|
UTSW |
11 |
117,591,630 (GRCm39) |
missense |
unknown |
|
|
R9342:Tnrc6c
|
UTSW |
11 |
117,630,720 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9633:Tnrc6c
|
UTSW |
11 |
117,638,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9761:Tnrc6c
|
UTSW |
11 |
117,623,136 (GRCm39) |
missense |
probably benign |
|
|
V7580:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7581:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7582:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7583:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnrc6c
|
UTSW |
11 |
117,623,003 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGGCACATCCAGTTGCCAAG -3'
(R):5'- TTGGTTTACAGTCCCACTCCAAGC -3'
Sequencing Primer
(F):5'- TTGCCAAGGAATGACCTTGAC -3'
(R):5'- CAGCAGTAGAGCTTATTGAGTCCC -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation