Incidental Mutation 'IGL00498:Fcgbp'
ID 6300
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fcgbp
Ensembl Gene ENSMUSG00000047730
Gene Name Fc fragment of IgG binding protein
Synonyms A430096B05Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00498
Quality Score
Status
Chromosome 7
Chromosomal Location 27770661-27820287 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 27791222 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 828 (C828R)
Ref Sequence ENSEMBL: ENSMUSP00000075945 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076648] [ENSMUST00000138392]
AlphaFold E9Q0B5
Predicted Effect probably damaging
Transcript: ENSMUST00000076648
AA Change: C828R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075945
Gene: ENSMUSG00000047730
AA Change: C828R

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
FOLN 27 49 2.3e-4 SMART
VWD 46 211 5.26e-45 SMART
low complexity region 226 237 N/A INTRINSIC
C8 251 326 1.17e-34 SMART
Pfam:TIL 329 383 1.2e-12 PFAM
VWC 385 431 2.34e-1 SMART
FOLN 418 441 3.48e1 SMART
VWD 438 603 6.85e-35 SMART
C8 642 717 1.4e-32 SMART
Pfam:TIL 720 773 4.7e-14 PFAM
VWC 775 829 9.42e-1 SMART
VWD 824 990 7.86e-44 SMART
C8 1034 1109 1.66e-34 SMART
Pfam:TIL 1112 1165 6.7e-13 PFAM
VWC 1167 1225 9.8e-3 SMART
FOLN 1198 1220 9.55e-1 SMART
FOLN 1224 1246 2.41e0 SMART
VWD 1243 1411 6.59e-37 SMART
C8 1451 1527 5.6e-32 SMART
low complexity region 1541 1551 N/A INTRINSIC
EGF_like 1558 1581 6.15e1 SMART
VWC 1589 1682 1.6e-2 SMART
VWD 1640 1807 5.15e-39 SMART
C8 1839 1914 4.62e-33 SMART
EGF_like 1942 1965 4.46e1 SMART
VWC 1972 2064 1.92e-1 SMART
VWD 2024 2180 6.34e-39 SMART
low complexity region 2201 2214 N/A INTRINSIC
C8 2221 2296 3.7e-32 SMART
Pfam:TIL 2299 2352 5e-12 PFAM
VWC 2354 2413 8.29e-1 SMART
FOLN 2385 2407 4.96e1 SMART
VWD 2404 2566 1.89e-5 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000138392
AA Change: C828R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000114271
Gene: ENSMUSG00000047730
AA Change: C828R

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
FOLN 27 49 2.3e-4 SMART
VWD 46 211 5.26e-45 SMART
low complexity region 226 237 N/A INTRINSIC
C8 251 326 1.17e-34 SMART
Pfam:TIL 329 383 8.4e-13 PFAM
VWC 385 431 2.34e-1 SMART
FOLN 418 441 3.48e1 SMART
VWD 438 603 7.99e-36 SMART
C8 642 717 1.4e-32 SMART
Pfam:TIL 720 773 3.3e-14 PFAM
VWC 775 829 9.42e-1 SMART
VWD 824 990 7.86e-44 SMART
C8 1034 1109 1.66e-34 SMART
Pfam:TIL 1112 1165 6.9e-13 PFAM
VWC 1167 1225 9.8e-3 SMART
FOLN 1198 1220 9.55e-1 SMART
FOLN 1224 1246 2.41e0 SMART
VWD 1243 1411 6.59e-37 SMART
C8 1451 1527 5.6e-32 SMART
low complexity region 1541 1551 N/A INTRINSIC
EGF_like 1558 1581 6.15e1 SMART
VWC 1589 1682 1.6e-2 SMART
VWD 1640 1807 5.15e-39 SMART
C8 1839 1914 4.62e-33 SMART
EGF_like 1942 1965 4.46e1 SMART
VWC 1972 2064 1.92e-1 SMART
VWD 2024 2180 6.34e-39 SMART
low complexity region 2201 2214 N/A INTRINSIC
C8 2221 2296 3.7e-32 SMART
Pfam:TIL 2299 2352 1e-11 PFAM
VWC 2354 2413 8.29e-1 SMART
FOLN 2385 2407 4.96e1 SMART
VWD 2404 2566 1.89e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140004
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933409G03Rik G A 2: 68,432,242 (GRCm39) G128R unknown Het
Acsm5 T C 7: 119,141,661 (GRCm39) probably null Het
Atad2 A C 15: 57,980,216 (GRCm39) F423V probably damaging Het
Carmil3 T A 14: 55,739,352 (GRCm39) probably null Het
Cdc42bpa A C 1: 179,933,686 (GRCm39) E775A probably damaging Het
Cfdp1 T C 8: 112,567,110 (GRCm39) E133G probably benign Het
Chst3 A G 10: 60,021,441 (GRCm39) F469L possibly damaging Het
Dbx1 T C 7: 49,286,222 (GRCm39) D81G probably benign Het
Dmp1 A G 5: 104,358,021 (GRCm39) probably benign Het
Dnah8 A G 17: 30,896,150 (GRCm39) T855A probably benign Het
Fbxw2 C T 2: 34,695,953 (GRCm39) A250T probably damaging Het
Gmfg G T 7: 28,145,810 (GRCm39) R83L possibly damaging Het
Gpr37l1 A G 1: 135,089,440 (GRCm39) probably benign Het
Hcfc1r1 G A 17: 23,892,982 (GRCm39) R9Q probably damaging Het
Hsd17b1 A T 11: 100,970,884 (GRCm39) H280L possibly damaging Het
Hsd17b12 A C 2: 93,913,510 (GRCm39) probably null Het
Itga1 A G 13: 115,167,729 (GRCm39) V99A probably benign Het
Kcnn1 A G 8: 71,305,524 (GRCm39) S229P probably damaging Het
Klhdc8a A G 1: 132,230,756 (GRCm39) N207S probably benign Het
Lrrtm4 T C 6: 79,999,529 (GRCm39) W314R probably damaging Het
Malrd1 T C 2: 16,146,997 (GRCm39) probably benign Het
Marcks T C 10: 37,014,513 (GRCm39) K7E probably damaging Het
Mov10 A G 3: 104,708,263 (GRCm39) probably benign Het
Pclo A T 5: 14,590,753 (GRCm39) T1018S unknown Het
Sdk1 T C 5: 142,071,361 (GRCm39) Y1184H probably damaging Het
Slc6a18 A T 13: 73,819,838 (GRCm39) M244K possibly damaging Het
Snx19 C T 9: 30,340,233 (GRCm39) T457I possibly damaging Het
Stard3 T A 11: 98,267,356 (GRCm39) V158D possibly damaging Het
Tnks G T 8: 35,328,843 (GRCm39) probably benign Het
Ugt2b34 A G 5: 87,049,084 (GRCm39) S314P probably damaging Het
Usp15 G A 10: 122,949,501 (GRCm39) S952L probably benign Het
Utp11 A G 4: 124,573,532 (GRCm39) V214A possibly damaging Het
Other mutations in Fcgbp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Fcgbp APN 7 27,784,555 (GRCm39) missense probably damaging 1.00
IGL00331:Fcgbp APN 7 27,800,966 (GRCm39) splice site probably benign
IGL00335:Fcgbp APN 7 27,785,560 (GRCm39) missense possibly damaging 0.90
IGL00470:Fcgbp APN 7 27,774,511 (GRCm39) nonsense probably null
IGL00491:Fcgbp APN 7 27,792,827 (GRCm39) missense probably damaging 1.00
IGL01296:Fcgbp APN 7 27,789,072 (GRCm39) missense probably benign 0.15
IGL01582:Fcgbp APN 7 27,793,067 (GRCm39) missense probably benign 0.19
IGL01929:Fcgbp APN 7 27,803,388 (GRCm39) missense probably damaging 1.00
IGL02024:Fcgbp APN 7 27,805,799 (GRCm39) missense probably damaging 1.00
IGL02027:Fcgbp APN 7 27,774,629 (GRCm39) missense probably damaging 1.00
IGL02140:Fcgbp APN 7 27,791,379 (GRCm39) missense probably damaging 1.00
IGL02162:Fcgbp APN 7 27,774,660 (GRCm39) missense probably damaging 1.00
IGL02345:Fcgbp APN 7 27,771,068 (GRCm39) splice site probably benign
IGL02377:Fcgbp APN 7 27,806,395 (GRCm39) missense possibly damaging 0.67
IGL02389:Fcgbp APN 7 27,774,596 (GRCm39) missense probably damaging 1.00
IGL02423:Fcgbp APN 7 27,789,378 (GRCm39) missense probably benign 0.02
IGL02523:Fcgbp APN 7 27,804,157 (GRCm39) missense possibly damaging 0.89
IGL02561:Fcgbp APN 7 27,800,599 (GRCm39) intron probably benign
IGL02631:Fcgbp APN 7 27,784,723 (GRCm39) missense probably damaging 1.00
IGL02716:Fcgbp APN 7 27,800,859 (GRCm39) missense probably damaging 0.98
IGL02836:Fcgbp APN 7 27,816,783 (GRCm39) missense possibly damaging 0.91
IGL02957:Fcgbp APN 7 27,791,272 (GRCm39) nonsense probably null
IGL02971:Fcgbp APN 7 27,800,898 (GRCm39) missense probably damaging 1.00
IGL03284:Fcgbp APN 7 27,784,857 (GRCm39) missense possibly damaging 0.93
IGL03379:Fcgbp APN 7 27,789,342 (GRCm39) missense possibly damaging 0.76
bilge UTSW 7 27,816,762 (GRCm39) missense probably benign 0.00
R6548_fcgbp_365 UTSW 7 27,791,343 (GRCm39) missense probably benign 0.00
swill UTSW 7 27,789,159 (GRCm39) missense probably damaging 1.00
G1citation:Fcgbp UTSW 7 27,806,781 (GRCm39) missense probably damaging 1.00
IGL02796:Fcgbp UTSW 7 27,800,576 (GRCm39) intron probably benign
PIT4486001:Fcgbp UTSW 7 27,774,698 (GRCm39) missense possibly damaging 0.52
R0277:Fcgbp UTSW 7 27,784,918 (GRCm39) critical splice donor site probably null
R0387:Fcgbp UTSW 7 27,790,879 (GRCm39) splice site probably benign
R0586:Fcgbp UTSW 7 27,789,138 (GRCm39) missense probably damaging 1.00
R0981:Fcgbp UTSW 7 27,784,535 (GRCm39) nonsense probably null
R0987:Fcgbp UTSW 7 27,793,599 (GRCm39) missense probably damaging 1.00
R1240:Fcgbp UTSW 7 27,819,950 (GRCm39) missense probably damaging 1.00
R1394:Fcgbp UTSW 7 27,792,804 (GRCm39) missense probably damaging 0.98
R1395:Fcgbp UTSW 7 27,792,804 (GRCm39) missense probably damaging 0.98
R1438:Fcgbp UTSW 7 27,803,158 (GRCm39) nonsense probably null
R1474:Fcgbp UTSW 7 27,791,273 (GRCm39) missense probably benign 0.00
R1521:Fcgbp UTSW 7 27,774,585 (GRCm39) missense probably benign 0.00
R1740:Fcgbp UTSW 7 27,800,674 (GRCm39) missense possibly damaging 0.87
R1750:Fcgbp UTSW 7 27,792,868 (GRCm39) nonsense probably null
R1772:Fcgbp UTSW 7 27,804,600 (GRCm39) missense possibly damaging 0.90
R1804:Fcgbp UTSW 7 27,785,564 (GRCm39) missense probably benign
R1808:Fcgbp UTSW 7 27,784,515 (GRCm39) missense probably benign 0.04
R1819:Fcgbp UTSW 7 27,784,708 (GRCm39) missense probably benign 0.00
R1934:Fcgbp UTSW 7 27,806,518 (GRCm39) missense probably damaging 1.00
R1972:Fcgbp UTSW 7 27,793,617 (GRCm39) missense probably benign 0.11
R2051:Fcgbp UTSW 7 27,819,785 (GRCm39) missense probably damaging 0.97
R2072:Fcgbp UTSW 7 27,819,814 (GRCm39) missense probably damaging 0.98
R2074:Fcgbp UTSW 7 27,819,814 (GRCm39) missense probably damaging 0.98
R2124:Fcgbp UTSW 7 27,791,444 (GRCm39) missense probably benign 0.03
R2155:Fcgbp UTSW 7 27,806,628 (GRCm39) missense probably benign 0.00
R3015:Fcgbp UTSW 7 27,774,838 (GRCm39) splice site probably benign
R3037:Fcgbp UTSW 7 27,802,127 (GRCm39) missense possibly damaging 0.62
R3151:Fcgbp UTSW 7 27,816,665 (GRCm39) missense probably damaging 1.00
R3176:Fcgbp UTSW 7 27,791,086 (GRCm39) missense probably damaging 0.99
R3177:Fcgbp UTSW 7 27,791,086 (GRCm39) missense probably damaging 0.99
R3276:Fcgbp UTSW 7 27,791,086 (GRCm39) missense probably damaging 0.99
R3277:Fcgbp UTSW 7 27,791,086 (GRCm39) missense probably damaging 0.99
R3623:Fcgbp UTSW 7 27,800,701 (GRCm39) missense probably damaging 1.00
R3730:Fcgbp UTSW 7 27,784,882 (GRCm39) missense possibly damaging 0.82
R3935:Fcgbp UTSW 7 27,774,824 (GRCm39) missense probably benign 0.00
R3936:Fcgbp UTSW 7 27,774,824 (GRCm39) missense probably benign 0.00
R4041:Fcgbp UTSW 7 27,813,404 (GRCm39) missense probably benign 0.01
R4056:Fcgbp UTSW 7 27,803,541 (GRCm39) missense probably benign 0.09
R4057:Fcgbp UTSW 7 27,803,541 (GRCm39) missense probably benign 0.09
R4705:Fcgbp UTSW 7 27,806,721 (GRCm39) missense probably benign 0.44
R4708:Fcgbp UTSW 7 27,794,386 (GRCm39) missense probably benign 0.00
R4710:Fcgbp UTSW 7 27,794,386 (GRCm39) missense probably benign 0.00
R4779:Fcgbp UTSW 7 27,794,362 (GRCm39) missense probably damaging 1.00
R4820:Fcgbp UTSW 7 27,813,383 (GRCm39) missense probably damaging 1.00
R4863:Fcgbp UTSW 7 27,785,769 (GRCm39) missense probably benign 0.33
R4926:Fcgbp UTSW 7 27,785,660 (GRCm39) missense probably damaging 0.99
R4947:Fcgbp UTSW 7 27,789,237 (GRCm39) missense probably benign 0.00
R4979:Fcgbp UTSW 7 27,816,995 (GRCm39) missense probably benign 0.06
R5002:Fcgbp UTSW 7 27,785,528 (GRCm39) splice site probably null
R5219:Fcgbp UTSW 7 27,803,510 (GRCm39) missense probably damaging 1.00
R5241:Fcgbp UTSW 7 27,784,624 (GRCm39) missense probably damaging 1.00
R5301:Fcgbp UTSW 7 27,793,099 (GRCm39) missense possibly damaging 0.93
R5306:Fcgbp UTSW 7 27,791,243 (GRCm39) missense probably damaging 1.00
R5335:Fcgbp UTSW 7 27,789,159 (GRCm39) missense probably damaging 1.00
R5399:Fcgbp UTSW 7 27,804,480 (GRCm39) missense probably benign 0.05
R5418:Fcgbp UTSW 7 27,784,738 (GRCm39) missense probably damaging 1.00
R5527:Fcgbp UTSW 7 27,793,060 (GRCm39) missense probably benign
R5583:Fcgbp UTSW 7 27,791,004 (GRCm39) missense probably damaging 1.00
R5698:Fcgbp UTSW 7 27,791,447 (GRCm39) missense possibly damaging 0.95
R5780:Fcgbp UTSW 7 27,784,643 (GRCm39) missense probably benign 0.02
R5813:Fcgbp UTSW 7 27,800,919 (GRCm39) missense possibly damaging 0.64
R5910:Fcgbp UTSW 7 27,784,928 (GRCm39) splice site probably benign
R5936:Fcgbp UTSW 7 27,786,117 (GRCm39) missense probably damaging 0.98
R5992:Fcgbp UTSW 7 27,819,959 (GRCm39) missense probably benign 0.05
R6091:Fcgbp UTSW 7 27,804,390 (GRCm39) missense possibly damaging 0.90
R6372:Fcgbp UTSW 7 27,806,433 (GRCm39) missense probably damaging 1.00
R6488:Fcgbp UTSW 7 27,792,963 (GRCm39) missense probably damaging 0.96
R6548:Fcgbp UTSW 7 27,791,343 (GRCm39) missense probably benign 0.00
R6553:Fcgbp UTSW 7 27,813,404 (GRCm39) missense possibly damaging 0.79
R6585:Fcgbp UTSW 7 27,813,404 (GRCm39) missense possibly damaging 0.79
R6695:Fcgbp UTSW 7 27,785,695 (GRCm39) nonsense probably null
R6711:Fcgbp UTSW 7 27,789,098 (GRCm39) missense probably damaging 0.99
R6803:Fcgbp UTSW 7 27,802,637 (GRCm39) missense probably benign 0.00
R6822:Fcgbp UTSW 7 27,806,781 (GRCm39) missense probably damaging 1.00
R6907:Fcgbp UTSW 7 27,784,443 (GRCm39) missense probably damaging 1.00
R6912:Fcgbp UTSW 7 27,789,129 (GRCm39) missense probably benign 0.15
R6924:Fcgbp UTSW 7 27,793,248 (GRCm39) missense probably benign
R6943:Fcgbp UTSW 7 27,791,477 (GRCm39) missense probably benign 0.22
R7060:Fcgbp UTSW 7 27,791,358 (GRCm39) missense probably benign 0.20
R7103:Fcgbp UTSW 7 27,784,387 (GRCm39) missense probably benign 0.00
R7208:Fcgbp UTSW 7 27,803,446 (GRCm39) missense probably benign 0.01
R7291:Fcgbp UTSW 7 27,800,817 (GRCm39) missense probably benign 0.00
R7301:Fcgbp UTSW 7 27,792,861 (GRCm39) missense possibly damaging 0.65
R7404:Fcgbp UTSW 7 27,800,932 (GRCm39) missense probably damaging 1.00
R7426:Fcgbp UTSW 7 27,785,949 (GRCm39) missense probably benign 0.00
R7459:Fcgbp UTSW 7 27,806,710 (GRCm39) missense possibly damaging 0.65
R7475:Fcgbp UTSW 7 27,802,401 (GRCm39) missense probably damaging 0.99
R7505:Fcgbp UTSW 7 27,789,099 (GRCm39) missense probably damaging 0.97
R7517:Fcgbp UTSW 7 27,784,794 (GRCm39) missense probably damaging 1.00
R7519:Fcgbp UTSW 7 27,785,724 (GRCm39) missense probably damaging 1.00
R7524:Fcgbp UTSW 7 27,802,391 (GRCm39) missense probably damaging 1.00
R7649:Fcgbp UTSW 7 27,790,928 (GRCm39) missense possibly damaging 0.88
R7782:Fcgbp UTSW 7 27,784,460 (GRCm39) nonsense probably null
R7820:Fcgbp UTSW 7 27,819,784 (GRCm39) missense probably benign 0.01
R7831:Fcgbp UTSW 7 27,806,404 (GRCm39) missense probably damaging 0.98
R7835:Fcgbp UTSW 7 27,816,632 (GRCm39) missense possibly damaging 0.64
R7947:Fcgbp UTSW 7 27,803,595 (GRCm39) critical splice donor site probably null
R8086:Fcgbp UTSW 7 27,813,389 (GRCm39) missense probably damaging 1.00
R8137:Fcgbp UTSW 7 27,804,496 (GRCm39) missense probably damaging 1.00
R8154:Fcgbp UTSW 7 27,784,507 (GRCm39) missense probably benign 0.00
R8169:Fcgbp UTSW 7 27,784,919 (GRCm39) critical splice donor site probably null
R8176:Fcgbp UTSW 7 27,791,174 (GRCm39) missense possibly damaging 0.88
R8193:Fcgbp UTSW 7 27,804,276 (GRCm39) missense probably damaging 1.00
R8313:Fcgbp UTSW 7 27,785,769 (GRCm39) missense probably benign 0.00
R8350:Fcgbp UTSW 7 27,793,614 (GRCm39) missense probably benign 0.02
R8382:Fcgbp UTSW 7 27,816,762 (GRCm39) missense probably benign 0.00
R8393:Fcgbp UTSW 7 27,806,815 (GRCm39) missense probably benign 0.18
R8438:Fcgbp UTSW 7 27,789,231 (GRCm39) missense probably benign 0.25
R8489:Fcgbp UTSW 7 27,804,435 (GRCm39) missense possibly damaging 0.94
R8495:Fcgbp UTSW 7 27,785,978 (GRCm39) missense probably damaging 1.00
R8707:Fcgbp UTSW 7 27,819,920 (GRCm39) missense probably benign 0.01
R8736:Fcgbp UTSW 7 27,805,621 (GRCm39) missense probably benign 0.05
R8816:Fcgbp UTSW 7 27,784,412 (GRCm39) missense probably benign 0.09
R8905:Fcgbp UTSW 7 27,785,934 (GRCm39) missense probably damaging 1.00
R9031:Fcgbp UTSW 7 27,790,908 (GRCm39) missense possibly damaging 0.89
R9063:Fcgbp UTSW 7 27,791,277 (GRCm39) missense probably damaging 1.00
R9180:Fcgbp UTSW 7 27,803,198 (GRCm39) nonsense probably null
R9262:Fcgbp UTSW 7 27,819,952 (GRCm39) missense probably damaging 1.00
R9439:Fcgbp UTSW 7 27,803,436 (GRCm39) missense possibly damaging 0.60
R9526:Fcgbp UTSW 7 27,790,937 (GRCm39) missense probably damaging 1.00
R9603:Fcgbp UTSW 7 27,802,563 (GRCm39) missense probably damaging 1.00
R9635:Fcgbp UTSW 7 27,800,832 (GRCm39) missense probably benign 0.40
R9703:Fcgbp UTSW 7 27,806,400 (GRCm39) missense probably damaging 0.98
R9711:Fcgbp UTSW 7 27,793,000 (GRCm39) missense probably benign 0.00
R9733:Fcgbp UTSW 7 27,803,012 (GRCm39) missense probably damaging 1.00
RF002:Fcgbp UTSW 7 27,789,180 (GRCm39) missense probably benign
X0028:Fcgbp UTSW 7 27,803,445 (GRCm39) missense possibly damaging 0.48
Z1186:Fcgbp UTSW 7 27,791,072 (GRCm39) missense probably benign
Z1186:Fcgbp UTSW 7 27,789,180 (GRCm39) missense probably benign
Z1186:Fcgbp UTSW 7 27,785,616 (GRCm39) missense probably benign
Z1186:Fcgbp UTSW 7 27,803,309 (GRCm39) missense probably benign 0.09
Z1186:Fcgbp UTSW 7 27,792,770 (GRCm39) missense probably benign
Posted On 2012-04-20