|Institutional Source||Beutler Lab|
|Gene Name||cyclin B2|
|Is this an essential gene?||Possibly essential (E-score: 0.725)|
|Stock #||R0042 (G1)|
|Chromosomal Location||70407692-70421547 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 70419053 bp|
|Amino Acid Change||Valine to Alanine at position 34 (V34A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000034742 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000034742]|
|Predicted Effect||probably benign
AA Change: V34A
PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
AA Change: V34A
|Meta Mutation Damage Score||0.068|
|Coding Region Coverage||
|Validation Efficiency||100% (71/71)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in reduced body weight and reduced litter size. Homozygous pups are underrepresented in litters from a heterozygous intercross. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ccnb2||
(F):5'- CTCCATCTGCACTGGTTTCACAGAG -3'
(R):5'- CAGCATATTCACCTTACCAGGGTAGC -3'
(F):5'- CACTTTGGTGGGCAGAGC -3'
(R):5'- ACCTTACCAGGGTAGCTCTGAC -3'