Incidental Mutation 'R0692:Sema4f'
ID 63375
Institutional Source Beutler Lab
Gene Symbol Sema4f
Ensembl Gene ENSMUSG00000000627
Gene Name sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
Synonyms Sema W
MMRRC Submission 038877-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0692 (G1)
Quality Score 114
Status Not validated
Chromosome 6
Chromosomal Location 82888865-82916724 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) CCAGCAGCAGCAGCAGCAGC to CCAGCAGCAGCAGCAGC at 82916511 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144745 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000641] [ENSMUST00000203271]
AlphaFold Q9Z123
Predicted Effect probably benign
Transcript: ENSMUST00000000641
SMART Domains Protein: ENSMUSP00000000641
Gene: ENSMUSG00000000627

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Sema 71 502 2.23e-170 SMART
PSI 518 569 2.64e-12 SMART
Blast:Sema 607 656 5e-20 BLAST
transmembrane domain 665 687 N/A INTRINSIC
low complexity region 722 735 N/A INTRINSIC
low complexity region 743 751 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000203271
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203911
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of semaphorin family of membrane-bound and secreted proteins that are involved in guiding axonal growth. The encoded protein is a transmembrane protein localized to the glutamatergic synapses via its association with a synapse-associated scaffolding protein. In oligodendrocyte precursor cells, the encoded protein contributes to the outward migration and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add3 T A 19: 53,205,383 (GRCm39) D44E probably damaging Het
Bpifb5 T C 2: 154,076,616 (GRCm39) V421A probably benign Het
Clk4 C T 11: 51,172,155 (GRCm39) R273* probably null Het
Cmya5 A T 13: 93,230,357 (GRCm39) L1577* probably null Het
Col14a1 G C 15: 55,205,134 (GRCm39) G88A unknown Het
Helz2 A G 2: 180,882,674 (GRCm39) C40R probably benign Het
Kcng1 T A 2: 168,104,683 (GRCm39) I388F probably damaging Het
Krt35 T C 11: 99,983,896 (GRCm39) E368G possibly damaging Het
Krt81 T C 15: 101,358,053 (GRCm39) D400G possibly damaging Het
Mcm3ap T C 10: 76,319,003 (GRCm39) C744R probably damaging Het
Or5m3b A G 2: 85,872,516 (GRCm39) M286V probably benign Het
Pde6c A T 19: 38,168,698 (GRCm39) Y788F probably damaging Het
Plxnc1 A G 10: 94,673,362 (GRCm39) probably null Het
Rflnb T C 11: 75,918,279 (GRCm39) D62G probably benign Het
Slc12a1 T A 2: 125,036,082 (GRCm39) Y651* probably null Het
Srbd1 T C 17: 86,443,888 (GRCm39) T113A probably benign Het
Svopl A T 6: 37,994,131 (GRCm39) L300Q probably damaging Het
Trim41 C T 11: 48,699,077 (GRCm39) probably null Het
Vmn1r23 C A 6: 57,903,110 (GRCm39) E223* probably null Het
Other mutations in Sema4f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00339:Sema4f APN 6 82,914,155 (GRCm39) missense probably benign 0.00
IGL01661:Sema4f APN 6 82,895,036 (GRCm39) unclassified probably benign
docking UTSW 6 82,890,626 (GRCm39) nonsense probably null
flagman UTSW 6 82,895,540 (GRCm39) missense probably benign 0.02
R0054:Sema4f UTSW 6 82,896,674 (GRCm39) splice site probably benign
R0054:Sema4f UTSW 6 82,896,674 (GRCm39) splice site probably benign
R0243:Sema4f UTSW 6 82,916,447 (GRCm39) missense possibly damaging 0.87
R0893:Sema4f UTSW 6 82,912,948 (GRCm39) splice site probably benign
R1708:Sema4f UTSW 6 82,894,975 (GRCm39) missense probably damaging 1.00
R1833:Sema4f UTSW 6 82,895,540 (GRCm39) missense probably benign 0.02
R1867:Sema4f UTSW 6 82,894,824 (GRCm39) missense possibly damaging 0.84
R1899:Sema4f UTSW 6 82,895,010 (GRCm39) missense probably benign 0.00
R1933:Sema4f UTSW 6 82,907,908 (GRCm39) missense probably damaging 1.00
R1934:Sema4f UTSW 6 82,907,908 (GRCm39) missense probably damaging 1.00
R2433:Sema4f UTSW 6 82,916,490 (GRCm39) missense possibly damaging 0.66
R3801:Sema4f UTSW 6 82,895,608 (GRCm39) missense possibly damaging 0.88
R4116:Sema4f UTSW 6 82,894,887 (GRCm39) missense probably benign 0.25
R4745:Sema4f UTSW 6 82,895,265 (GRCm39) missense probably damaging 1.00
R5187:Sema4f UTSW 6 82,894,631 (GRCm39) missense probably benign 0.45
R6015:Sema4f UTSW 6 82,916,553 (GRCm39) unclassified probably benign
R6043:Sema4f UTSW 6 82,896,634 (GRCm39) missense probably damaging 0.99
R6110:Sema4f UTSW 6 82,914,085 (GRCm39) missense probably damaging 0.97
R6378:Sema4f UTSW 6 82,894,613 (GRCm39) nonsense probably null
R6449:Sema4f UTSW 6 82,894,851 (GRCm39) missense probably benign 0.09
R6452:Sema4f UTSW 6 82,894,643 (GRCm39) missense probably benign 0.36
R6854:Sema4f UTSW 6 82,894,983 (GRCm39) missense probably damaging 1.00
R7159:Sema4f UTSW 6 82,894,864 (GRCm39) missense possibly damaging 0.63
R7475:Sema4f UTSW 6 82,891,355 (GRCm39) missense possibly damaging 0.94
R7555:Sema4f UTSW 6 82,891,037 (GRCm39) missense probably benign 0.01
R7780:Sema4f UTSW 6 82,890,941 (GRCm39) missense possibly damaging 0.95
R8254:Sema4f UTSW 6 82,894,382 (GRCm39) missense probably damaging 1.00
R8828:Sema4f UTSW 6 82,894,874 (GRCm39) nonsense probably null
R8828:Sema4f UTSW 6 82,894,873 (GRCm39) missense probably benign 0.02
R8862:Sema4f UTSW 6 82,891,081 (GRCm39) missense probably benign 0.02
R9166:Sema4f UTSW 6 82,890,626 (GRCm39) nonsense probably null
R9218:Sema4f UTSW 6 82,890,480 (GRCm39) missense probably benign 0.08
R9340:Sema4f UTSW 6 82,890,890 (GRCm39) missense probably damaging 1.00
R9690:Sema4f UTSW 6 82,912,652 (GRCm39) missense probably damaging 1.00
X0026:Sema4f UTSW 6 82,912,661 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- ATGGCTGTCACTGGAGTTAGCAGG -3'
(R):5'- AGTCGGGTTGTGTTTCATCTCACC -3'

Sequencing Primer
(F):5'- CTGGAGTTAGCAGGGCAGG -3'
(R):5'- GTGTTTCATCTCACCGCTGC -3'
Posted On 2013-07-30