Incidental Mutation 'R0720:Adgrf2'
ID 63532
Institutional Source Beutler Lab
Gene Symbol Adgrf2
Ensembl Gene ENSMUSG00000057899
Gene Name adhesion G protein-coupled receptor F2
Synonyms PGR20, Gpr111
MMRRC Submission 038902-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0720 (G1)
Quality Score 208
Status Validated
Chromosome 17
Chromosomal Location 43007021-43053070 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43024063 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 136 (I136T)
Ref Sequence ENSEMBL: ENSMUSP00000109244 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113614]
AlphaFold E9Q4J9
Predicted Effect probably damaging
Transcript: ENSMUST00000113614
AA Change: I136T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000109244
Gene: ENSMUSG00000057899
AA Change: I136T

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
GPS 325 376 2.05e-4 SMART
Pfam:7tm_2 378 625 4.1e-29 PFAM
Meta Mutation Damage Score 0.2078 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.7%
  • 20x: 95.9%
Validation Efficiency 98% (44/45)
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter allele exhibit normal viability and fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bbs7 T C 3: 36,646,572 (GRCm39) D416G probably damaging Het
Commd4 G T 9: 57,062,718 (GRCm39) D179E probably benign Het
Cyp3a57 T C 5: 145,327,213 (GRCm39) probably benign Het
Dnah5 A G 15: 28,314,007 (GRCm39) N1941S probably null Het
Dynap T C 18: 70,374,055 (GRCm39) D157G unknown Het
Entrep2 A G 7: 64,469,658 (GRCm39) probably benign Het
Eri3 T C 4: 117,410,242 (GRCm39) probably null Het
Fbxo25 A G 8: 13,985,222 (GRCm39) Y305C probably damaging Het
Flt4 C T 11: 49,527,166 (GRCm39) probably benign Het
Fxr2 A G 11: 69,530,241 (GRCm39) D36G probably benign Het
Gas2l3 T C 10: 89,249,805 (GRCm39) T438A probably benign Het
Gcm1 A T 9: 77,971,923 (GRCm39) Y288F possibly damaging Het
Gm3164 C A 14: 4,442,719 (GRCm38) S218R probably benign Het
Hipk2 C T 6: 38,675,491 (GRCm39) R1029H probably damaging Het
Htra3 T C 5: 35,811,453 (GRCm39) I392M probably damaging Het
Kansl1l T C 1: 66,840,515 (GRCm39) M262V possibly damaging Het
Lrrc47 T C 4: 154,104,344 (GRCm39) probably null Het
Macf1 A T 4: 123,326,718 (GRCm39) N4926K probably damaging Het
Mllt10 T C 2: 18,201,406 (GRCm39) S631P probably benign Het
Nlrp14 A G 7: 106,781,220 (GRCm39) H139R probably benign Het
Or1e34 T A 11: 73,778,688 (GRCm39) N170I probably benign Het
Or5w20 A T 2: 87,727,013 (GRCm39) T157S probably benign Het
Ptger2 T C 14: 45,226,590 (GRCm39) C57R probably benign Het
Rhot1 T C 11: 80,114,769 (GRCm39) V59A probably damaging Het
Rmdn2 G A 17: 79,975,458 (GRCm39) probably null Het
Rxfp2 G T 5: 149,967,584 (GRCm39) K148N probably benign Het
Sec23a G A 12: 59,018,057 (GRCm39) T623M probably damaging Het
Smcr8 T C 11: 60,669,269 (GRCm39) L139P probably damaging Het
Spag6l A T 16: 16,584,960 (GRCm39) probably benign Het
Taar1 T C 10: 23,796,971 (GRCm39) I223T probably damaging Het
Tdo2 G T 3: 81,870,065 (GRCm39) A269E probably damaging Het
Tnfsf18 A G 1: 161,331,156 (GRCm39) Y102C possibly damaging Het
Tns1 A G 1: 73,964,740 (GRCm39) L1297P probably benign Het
Txndc8 C T 4: 57,984,245 (GRCm39) probably benign Het
Ubr5 T C 15: 37,973,235 (GRCm39) N2622S probably damaging Het
Vmn2r99 T A 17: 19,599,305 (GRCm39) F330I probably benign Het
Zdhhc2 T A 8: 40,925,948 (GRCm39) probably null Het
Other mutations in Adgrf2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Adgrf2 APN 17 43,025,206 (GRCm39) splice site probably benign
IGL01089:Adgrf2 APN 17 43,021,049 (GRCm39) missense probably damaging 1.00
IGL01601:Adgrf2 APN 17 43,020,940 (GRCm39) missense probably benign
IGL01765:Adgrf2 APN 17 43,030,426 (GRCm39) missense probably benign 0.06
IGL02946:Adgrf2 APN 17 43,021,384 (GRCm39) missense probably damaging 1.00
R0498:Adgrf2 UTSW 17 43,025,206 (GRCm39) splice site probably benign
R0831:Adgrf2 UTSW 17 43,021,334 (GRCm39) missense probably damaging 0.96
R1664:Adgrf2 UTSW 17 43,025,305 (GRCm39) missense possibly damaging 0.92
R2008:Adgrf2 UTSW 17 43,021,013 (GRCm39) missense probably damaging 0.96
R2306:Adgrf2 UTSW 17 43,024,010 (GRCm39) missense possibly damaging 0.92
R2519:Adgrf2 UTSW 17 43,021,298 (GRCm39) missense probably damaging 1.00
R3713:Adgrf2 UTSW 17 43,023,979 (GRCm39) missense probably damaging 1.00
R3736:Adgrf2 UTSW 17 43,021,903 (GRCm39) missense probably benign 0.32
R4272:Adgrf2 UTSW 17 43,021,013 (GRCm39) missense probably damaging 0.99
R4273:Adgrf2 UTSW 17 43,021,013 (GRCm39) missense probably damaging 0.99
R4422:Adgrf2 UTSW 17 43,024,046 (GRCm39) missense probably benign
R4732:Adgrf2 UTSW 17 43,021,645 (GRCm39) missense probably damaging 1.00
R4733:Adgrf2 UTSW 17 43,021,645 (GRCm39) missense probably damaging 1.00
R4906:Adgrf2 UTSW 17 43,022,084 (GRCm39) missense probably benign
R5053:Adgrf2 UTSW 17 43,021,334 (GRCm39) missense probably damaging 0.96
R5078:Adgrf2 UTSW 17 43,021,877 (GRCm39) missense probably damaging 1.00
R5089:Adgrf2 UTSW 17 43,020,988 (GRCm39) missense probably benign 0.00
R5147:Adgrf2 UTSW 17 43,021,574 (GRCm39) missense probably damaging 0.99
R5953:Adgrf2 UTSW 17 43,021,229 (GRCm39) missense probably damaging 1.00
R5968:Adgrf2 UTSW 17 43,026,063 (GRCm39) critical splice donor site probably null
R6791:Adgrf2 UTSW 17 43,021,774 (GRCm39) missense probably benign 0.02
R7138:Adgrf2 UTSW 17 43,021,874 (GRCm39) missense probably damaging 1.00
R7612:Adgrf2 UTSW 17 43,025,271 (GRCm39) missense possibly damaging 0.68
R7670:Adgrf2 UTSW 17 43,022,263 (GRCm39) missense probably damaging 1.00
R8291:Adgrf2 UTSW 17 43,021,451 (GRCm39) missense probably damaging 1.00
R8418:Adgrf2 UTSW 17 43,021,477 (GRCm39) missense probably benign 0.01
R8510:Adgrf2 UTSW 17 43,030,431 (GRCm39) nonsense probably null
R9736:Adgrf2 UTSW 17 43,022,212 (GRCm39) missense probably benign 0.42
X0061:Adgrf2 UTSW 17 43,023,965 (GRCm39) missense probably benign 0.37
X0067:Adgrf2 UTSW 17 43,021,559 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCCCCAATGAGATAACCTACTGTCCG -3'
(R):5'- GGCTGTCCTTTCAGAAGACCAGATTAG -3'

Sequencing Primer
(F):5'- GAGATAACCTACTGTCCGGTCTG -3'
(R):5'- GGTCAAGATATTCTACCCTAGATGC -3'
Posted On 2013-07-30