Incidental Mutation 'R0708:Or8d2b'
ID 63858
Institutional Source Beutler Lab
Gene Symbol Or8d2b
Ensembl Gene ENSMUSG00000064333
Gene Name olfactory receptor family 8 subfamily D member 2D
Synonyms MOR171-8, Olfr926, GA_x6K02T2PVTD-32573036-32573962
MMRRC Submission 038891-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R0708 (G1)
Quality Score 89
Status Not validated
Chromosome 9
Chromosomal Location 38788474-38789400 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38788571 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 33 (V33E)
Ref Sequence ENSEMBL: ENSMUSP00000077405 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078289]
AlphaFold Q9EQ98
Predicted Effect probably damaging
Transcript: ENSMUST00000078289
AA Change: V33E

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000077405
Gene: ENSMUSG00000064333
AA Change: V33E

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 2.9e-53 PFAM
Pfam:7TM_GPCR_Srsx 32 282 8.6e-7 PFAM
Pfam:7tm_1 38 287 1.6e-20 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Brdt A T 5: 107,506,766 (GRCm39) K450* probably null Het
Cand2 G A 6: 115,780,766 (GRCm39) E1217K probably damaging Het
Col9a1 A T 1: 24,276,342 (GRCm39) Q750L possibly damaging Het
Dnah6 A T 6: 73,189,605 (GRCm39) S14R probably benign Het
Enox1 A G 14: 77,830,352 (GRCm39) N319S probably benign Het
Frs2 G A 10: 116,909,997 (GRCm39) T455M probably damaging Het
Glra3 C T 8: 56,578,399 (GRCm39) probably benign Het
Gmppa T C 1: 75,419,218 (GRCm39) F375S probably damaging Het
Hectd4 G A 5: 121,424,526 (GRCm39) probably null Het
Hgf C A 5: 16,771,761 (GRCm39) C129* probably null Het
Insc T A 7: 114,444,381 (GRCm39) V456E probably damaging Het
Ints14 G A 9: 64,891,266 (GRCm39) V416I probably benign Het
Klk1b11 T C 7: 43,647,152 (GRCm39) F29L possibly damaging Het
Ogfod1 C T 8: 94,765,673 (GRCm39) L79F possibly damaging Het
Orc3 A T 4: 34,597,368 (GRCm39) I224N probably damaging Het
Papss2 T C 19: 32,614,616 (GRCm39) F111L probably damaging Het
Poc1b A G 10: 98,990,992 (GRCm39) D291G probably null Het
Prl8a8 A T 13: 27,695,528 (GRCm39) M72K possibly damaging Het
Ptpn7 C A 1: 135,062,285 (GRCm39) T77K probably damaging Het
Ptpro T C 6: 137,363,251 (GRCm39) S462P probably benign Het
Rab3gap2 T A 1: 184,982,123 (GRCm39) S392T probably damaging Het
Sema4d A G 13: 51,866,755 (GRCm39) V245A probably benign Het
Sgcb A T 5: 73,798,225 (GRCm39) probably null Het
Slc24a1 T A 9: 64,855,172 (GRCm39) K578N unknown Het
Sptbn1 A T 11: 30,064,739 (GRCm39) V1920E probably damaging Het
Tecr A T 8: 84,299,738 (GRCm39) I101N probably damaging Het
Tectb T C 19: 55,179,984 (GRCm39) F277L probably benign Het
Tgs1 T A 4: 3,586,152 (GRCm39) L343H probably benign Het
Thbs4 C A 13: 92,909,694 (GRCm39) G368W probably damaging Het
Zfp558 T C 9: 18,368,123 (GRCm39) S222G possibly damaging Het
Other mutations in Or8d2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01886:Or8d2b APN 9 38,788,844 (GRCm39) missense probably damaging 0.97
IGL02315:Or8d2b APN 9 38,789,353 (GRCm39) missense probably damaging 1.00
IGL02626:Or8d2b APN 9 38,788,784 (GRCm39) missense probably benign 0.05
IGL03001:Or8d2b APN 9 38,789,374 (GRCm39) missense probably benign
IGL03085:Or8d2b APN 9 38,788,959 (GRCm39) missense probably benign
R0365:Or8d2b UTSW 9 38,788,481 (GRCm39) missense probably benign 0.00
R0600:Or8d2b UTSW 9 38,789,111 (GRCm39) missense probably damaging 0.99
R1178:Or8d2b UTSW 9 38,789,051 (GRCm39) missense probably damaging 1.00
R1762:Or8d2b UTSW 9 38,789,081 (GRCm39) missense probably damaging 0.98
R1856:Or8d2b UTSW 9 38,788,892 (GRCm39) missense possibly damaging 0.58
R1924:Or8d2b UTSW 9 38,789,147 (GRCm39) missense probably damaging 1.00
R2267:Or8d2b UTSW 9 38,789,359 (GRCm39) missense probably benign 0.00
R3729:Or8d2b UTSW 9 38,788,547 (GRCm39) missense probably damaging 1.00
R4290:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4292:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4293:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4295:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4973:Or8d2b UTSW 9 38,789,400 (GRCm39) makesense probably null
R5026:Or8d2b UTSW 9 38,789,195 (GRCm39) missense possibly damaging 0.95
R5086:Or8d2b UTSW 9 38,789,087 (GRCm39) missense probably damaging 1.00
R5103:Or8d2b UTSW 9 38,788,872 (GRCm39) missense probably damaging 1.00
R5817:Or8d2b UTSW 9 38,788,673 (GRCm39) missense probably damaging 1.00
R5998:Or8d2b UTSW 9 38,789,165 (GRCm39) missense probably damaging 0.99
R6101:Or8d2b UTSW 9 38,788,604 (GRCm39) missense possibly damaging 0.95
R6105:Or8d2b UTSW 9 38,788,604 (GRCm39) missense possibly damaging 0.95
R6176:Or8d2b UTSW 9 38,788,673 (GRCm39) missense probably damaging 1.00
R6403:Or8d2b UTSW 9 38,788,538 (GRCm39) missense probably damaging 0.97
R8116:Or8d2b UTSW 9 38,789,026 (GRCm39) missense probably damaging 0.98
R8144:Or8d2b UTSW 9 38,788,662 (GRCm39) missense probably damaging 1.00
R8972:Or8d2b UTSW 9 38,789,150 (GRCm39) missense probably benign 0.00
R9520:Or8d2b UTSW 9 38,789,039 (GRCm39) missense probably benign 0.22
R9550:Or8d2b UTSW 9 38,788,937 (GRCm39) missense probably benign 0.00
R9614:Or8d2b UTSW 9 38,789,281 (GRCm39) missense probably damaging 0.98
RF014:Or8d2b UTSW 9 38,789,196 (GRCm39) missense probably benign 0.14
X0022:Or8d2b UTSW 9 38,788,952 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- GACGTGGCTTAAAGAGAGGTAGTCAGTA -3'
(R):5'- CAGCAGGTAGCCTTCTGAAATAGCTAAA -3'

Sequencing Primer
(F):5'- gaggtagaaagaggagaagtatatgg -3'
(R):5'- GCTGAGTCATGCACTCCTTAAAG -3'
Posted On 2013-07-30