Incidental Mutation 'R0697:Vmn1r84'
| ID |
63891 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r84
|
| Ensembl Gene |
ENSMUSG00000066803 |
| Gene Name |
vomeronasal 1 receptor 84 |
| Synonyms |
V1rg11 |
| MMRRC Submission |
038881-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.049)
|
| Stock # |
R0697 (G1)
|
| Quality Score |
100 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
12095735-12096691 bp(-) (GRCm39) |
| Type of Mutation |
start codon destroyed |
| DNA Base Change (assembly) |
A to T
at 12096690 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 1
(M1K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083405
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086228]
[ENSMUST00000226408]
[ENSMUST00000227427]
[ENSMUST00000228653]
|
| AlphaFold |
Q8R284 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000086228
AA Change: M1K
PolyPhen 2
Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000083405
Gene: ENSMUSG00000066803
AA Change: M1K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
16 |
312 |
3.7e-11 |
PFAM |
|
Pfam:V1R
|
45 |
308 |
1.9e-22 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177845
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226408
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226811
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227427
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228653
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228741
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.5%
- 20x: 95.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1cf |
C |
A |
19: 31,888,567 (GRCm39) |
A99E |
probably damaging |
Het |
| Aig1 |
T |
C |
10: 13,705,069 (GRCm39) |
N72S |
probably benign |
Het |
| Atad2 |
T |
C |
15: 57,968,939 (GRCm39) |
I857M |
possibly damaging |
Het |
| Ceacam15 |
A |
C |
7: 16,407,445 (GRCm39) |
L24* |
probably null |
Het |
| Cpsf2 |
A |
G |
12: 101,949,443 (GRCm39) |
H53R |
probably benign |
Het |
| Crh |
C |
A |
3: 19,748,241 (GRCm39) |
G134C |
probably damaging |
Het |
| Cyp2g1 |
A |
T |
7: 26,514,152 (GRCm39) |
K253* |
probably null |
Het |
| Dna2 |
T |
C |
10: 62,785,120 (GRCm39) |
V79A |
probably benign |
Het |
| Dsc2 |
A |
G |
18: 20,174,509 (GRCm39) |
V549A |
probably damaging |
Het |
| Etl4 |
G |
T |
2: 20,748,672 (GRCm39) |
V135F |
probably damaging |
Het |
| Frk |
A |
G |
10: 34,483,833 (GRCm39) |
H398R |
probably benign |
Het |
| Gfra1 |
A |
C |
19: 58,258,555 (GRCm39) |
S271A |
probably benign |
Het |
| Htr1b |
T |
C |
9: 81,513,516 (GRCm39) |
I364V |
possibly damaging |
Het |
| Kcnh5 |
A |
T |
12: 75,023,305 (GRCm39) |
C588S |
possibly damaging |
Het |
| Kif13a |
G |
A |
13: 47,001,813 (GRCm39) |
T70I |
probably benign |
Het |
| Klra6 |
T |
C |
6: 129,993,687 (GRCm39) |
I195V |
probably benign |
Het |
| Nras |
T |
C |
3: 102,967,616 (GRCm39) |
Y71H |
possibly damaging |
Het |
| Sirt5 |
T |
C |
13: 43,539,052 (GRCm39) |
F274L |
probably damaging |
Het |
| Synj1 |
T |
C |
16: 90,757,503 (GRCm39) |
T882A |
probably benign |
Het |
| Zfhx4 |
A |
T |
3: 5,466,793 (GRCm39) |
E2317V |
probably damaging |
Het |
| Zfp345 |
A |
T |
2: 150,314,829 (GRCm39) |
I236K |
probably benign |
Het |
|
| Other mutations in Vmn1r84 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02505:Vmn1r84
|
APN |
7 |
12,096,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
K3955:Vmn1r84
|
UTSW |
7 |
12,095,884 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0360:Vmn1r84
|
UTSW |
7 |
12,095,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0399:Vmn1r84
|
UTSW |
7 |
12,095,794 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1613:Vmn1r84
|
UTSW |
7 |
12,096,460 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1636:Vmn1r84
|
UTSW |
7 |
12,096,522 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1872:Vmn1r84
|
UTSW |
7 |
12,096,555 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4022:Vmn1r84
|
UTSW |
7 |
12,095,857 (GRCm39) |
missense |
probably benign |
|
|
R4923:Vmn1r84
|
UTSW |
7 |
12,095,743 (GRCm39) |
missense |
probably benign |
|
|
R5189:Vmn1r84
|
UTSW |
7 |
12,096,385 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5275:Vmn1r84
|
UTSW |
7 |
12,095,741 (GRCm39) |
missense |
probably benign |
|
|
R5721:Vmn1r84
|
UTSW |
7 |
12,096,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn1r84
|
UTSW |
7 |
12,095,841 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7261:Vmn1r84
|
UTSW |
7 |
12,096,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7513:Vmn1r84
|
UTSW |
7 |
12,095,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7573:Vmn1r84
|
UTSW |
7 |
12,095,787 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8039:Vmn1r84
|
UTSW |
7 |
12,095,935 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8814:Vmn1r84
|
UTSW |
7 |
12,096,385 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn1r84
|
UTSW |
7 |
12,096,586 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Z1177:Vmn1r84
|
UTSW |
7 |
12,096,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAACCCCAGTTGTACCATTATGTGAG -3'
(R):5'- GCTGGATTACAGGAGTGAATCAGGTC -3'
Sequencing Primer
(F):5'- CTTGAGATAATAACCAAGGAATTGGC -3'
(R):5'- TTACAGGAGTGAATCAGGTCTACTG -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation