Incidental Mutation 'R0697:Ceacam15'
| ID |
63892 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ceacam15
|
| Ensembl Gene |
ENSMUSG00000078795 |
| Gene Name |
CEA cell adhesion molecule 15 |
| Synonyms |
C430002N04Rik |
| MMRRC Submission |
038881-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R0697 (G1)
|
| Quality Score |
128 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
16405256-16409630 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to C
at 16407445 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 24
(L24*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104138
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000108498]
|
| AlphaFold |
A0A0B4J1L0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000108498
AA Change: L24*
|
| SMART Domains |
Protein: ENSMUSP00000104138
Gene: ENSMUSG00000078795
AA Change: L24*
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
39 |
140 |
1.28e-1 |
SMART |
|
IGc2
|
156 |
220 |
2.68e-4 |
SMART |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.5%
- 20x: 95.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1cf |
C |
A |
19: 31,888,567 (GRCm39) |
A99E |
probably damaging |
Het |
| Aig1 |
T |
C |
10: 13,705,069 (GRCm39) |
N72S |
probably benign |
Het |
| Atad2 |
T |
C |
15: 57,968,939 (GRCm39) |
I857M |
possibly damaging |
Het |
| Cpsf2 |
A |
G |
12: 101,949,443 (GRCm39) |
H53R |
probably benign |
Het |
| Crh |
C |
A |
3: 19,748,241 (GRCm39) |
G134C |
probably damaging |
Het |
| Cyp2g1 |
A |
T |
7: 26,514,152 (GRCm39) |
K253* |
probably null |
Het |
| Dna2 |
T |
C |
10: 62,785,120 (GRCm39) |
V79A |
probably benign |
Het |
| Dsc2 |
A |
G |
18: 20,174,509 (GRCm39) |
V549A |
probably damaging |
Het |
| Etl4 |
G |
T |
2: 20,748,672 (GRCm39) |
V135F |
probably damaging |
Het |
| Frk |
A |
G |
10: 34,483,833 (GRCm39) |
H398R |
probably benign |
Het |
| Gfra1 |
A |
C |
19: 58,258,555 (GRCm39) |
S271A |
probably benign |
Het |
| Htr1b |
T |
C |
9: 81,513,516 (GRCm39) |
I364V |
possibly damaging |
Het |
| Kcnh5 |
A |
T |
12: 75,023,305 (GRCm39) |
C588S |
possibly damaging |
Het |
| Kif13a |
G |
A |
13: 47,001,813 (GRCm39) |
T70I |
probably benign |
Het |
| Klra6 |
T |
C |
6: 129,993,687 (GRCm39) |
I195V |
probably benign |
Het |
| Nras |
T |
C |
3: 102,967,616 (GRCm39) |
Y71H |
possibly damaging |
Het |
| Sirt5 |
T |
C |
13: 43,539,052 (GRCm39) |
F274L |
probably damaging |
Het |
| Synj1 |
T |
C |
16: 90,757,503 (GRCm39) |
T882A |
probably benign |
Het |
| Vmn1r84 |
A |
T |
7: 12,096,690 (GRCm39) |
M1K |
probably null |
Het |
| Zfhx4 |
A |
T |
3: 5,466,793 (GRCm39) |
E2317V |
probably damaging |
Het |
| Zfp345 |
A |
T |
2: 150,314,829 (GRCm39) |
I236K |
probably benign |
Het |
|
| Other mutations in Ceacam15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03367:Ceacam15
|
APN |
7 |
16,409,512 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R0144:Ceacam15
|
UTSW |
7 |
16,407,116 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0517:Ceacam15
|
UTSW |
7 |
16,407,445 (GRCm39) |
nonsense |
probably null |
|
|
R0612:Ceacam15
|
UTSW |
7 |
16,407,445 (GRCm39) |
nonsense |
probably null |
|
|
R1077:Ceacam15
|
UTSW |
7 |
16,406,000 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1257:Ceacam15
|
UTSW |
7 |
16,405,949 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1389:Ceacam15
|
UTSW |
7 |
16,405,988 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4602:Ceacam15
|
UTSW |
7 |
16,405,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Ceacam15
|
UTSW |
7 |
16,407,391 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4674:Ceacam15
|
UTSW |
7 |
16,407,410 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4675:Ceacam15
|
UTSW |
7 |
16,407,410 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4745:Ceacam15
|
UTSW |
7 |
16,407,259 (GRCm39) |
missense |
probably benign |
|
|
R5296:Ceacam15
|
UTSW |
7 |
16,407,121 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5510:Ceacam15
|
UTSW |
7 |
16,406,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6210:Ceacam15
|
UTSW |
7 |
16,407,214 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7414:Ceacam15
|
UTSW |
7 |
16,407,235 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8110:Ceacam15
|
UTSW |
7 |
16,407,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8341:Ceacam15
|
UTSW |
7 |
16,405,928 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9553:Ceacam15
|
UTSW |
7 |
16,407,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Ceacam15
|
UTSW |
7 |
16,409,531 (GRCm39) |
start codon destroyed |
probably null |
0.00 |
|
Z1176:Ceacam15
|
UTSW |
7 |
16,409,508 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAGTTGAAGCGAATCGCTGGAC -3'
(R):5'- AGCCAGGGGTTGACTGCAAATAC -3'
Sequencing Primer
(F):5'- GCGAATCGCTGGACTTTTTATAATG -3'
(R):5'- gccagggaaagcatcactaac -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation