Incidental Mutation 'R0095:Or5p81'
ID 64033
Institutional Source Beutler Lab
Gene Symbol Or5p81
Ensembl Gene ENSMUSG00000096209
Gene Name olfactory receptor family 5 subfamily P member 81
Synonyms MOR204-34, GA_x6K02T2PBJ9-10997715-10998659, Olfr510
MMRRC Submission 038381-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R0095 (G1)
Quality Score 115
Status Not validated
Chromosome 7
Chromosomal Location 108265625-108267569 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 108267252 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 210 (I210L)
Ref Sequence ENSEMBL: ENSMUSP00000149693 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076289] [ENSMUST00000213979] [ENSMUST00000216331] [ENSMUST00000217170]
AlphaFold Q8VEW6
Predicted Effect probably benign
Transcript: ENSMUST00000076289
AA Change: I210L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000075637
Gene: ENSMUSG00000096209
AA Change: I210L

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 3e-50 PFAM
Pfam:7tm_1 44 293 4e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210621
AA Change: I210L
Predicted Effect probably benign
Transcript: ENSMUST00000213979
AA Change: I210L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000216331
AA Change: I210L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000217170
AA Change: I210L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Meta Mutation Damage Score 0.1337 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anxa8 G A 14: 33,808,028 (GRCm39) A6T probably benign Het
Bicc1 T A 10: 70,796,988 (GRCm39) I42F probably damaging Het
Cutc T C 19: 43,741,638 (GRCm39) W13R probably benign Het
F5 A T 1: 164,019,537 (GRCm39) R671* probably null Het
Fer A T 17: 64,248,321 (GRCm39) E361V possibly damaging Het
Hnrnpa3 G T 2: 75,492,040 (GRCm39) R52L probably damaging Het
Igsf10 A T 3: 59,238,617 (GRCm39) Y521* probably null Het
Lratd2 T C 15: 60,695,425 (GRCm39) Y107C probably damaging Het
Mmp1a G A 9: 7,465,621 (GRCm39) G186D possibly damaging Het
Naip1 T C 13: 100,559,591 (GRCm39) T1138A probably benign Het
Necab1 T A 4: 14,960,027 (GRCm39) N307Y possibly damaging Het
Plekha5 T C 6: 140,474,323 (GRCm39) F84L probably damaging Het
Rpl6 T G 5: 121,343,902 (GRCm39) V115G possibly damaging Het
Sec16a A T 2: 26,315,772 (GRCm39) probably null Het
Tpsg1 T C 17: 25,591,528 (GRCm39) W43R probably damaging Het
Unc45a T C 7: 79,979,291 (GRCm39) D567G probably damaging Het
Usp30 T A 5: 114,243,901 (GRCm39) F157I probably damaging Het
Zfp345 T A 2: 150,314,220 (GRCm39) H439L probably damaging Het
Other mutations in Or5p81
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00909:Or5p81 APN 7 108,266,907 (GRCm39) missense possibly damaging 0.61
IGL00952:Or5p81 APN 7 108,267,445 (GRCm39) missense possibly damaging 0.89
IGL01358:Or5p81 APN 7 108,266,869 (GRCm39) missense possibly damaging 0.90
IGL01663:Or5p81 APN 7 108,267,098 (GRCm39) missense probably benign 0.01
IGL02686:Or5p81 APN 7 108,267,093 (GRCm39) missense probably benign 0.00
PIT4466001:Or5p81 UTSW 7 108,266,743 (GRCm39) missense possibly damaging 0.52
R0095:Or5p81 UTSW 7 108,267,252 (GRCm39) missense probably benign 0.00
R0792:Or5p81 UTSW 7 108,267,364 (GRCm39) missense probably damaging 1.00
R0925:Or5p81 UTSW 7 108,267,400 (GRCm39) missense probably benign 0.00
R1829:Or5p81 UTSW 7 108,266,851 (GRCm39) missense probably benign 0.24
R2092:Or5p81 UTSW 7 108,266,869 (GRCm39) frame shift probably null
R2483:Or5p81 UTSW 7 108,266,869 (GRCm39) frame shift probably null
R3619:Or5p81 UTSW 7 108,267,057 (GRCm39) missense probably benign 0.00
R4386:Or5p81 UTSW 7 108,267,460 (GRCm39) missense probably damaging 0.99
R5298:Or5p81 UTSW 7 108,267,279 (GRCm39) missense probably benign 0.00
R5622:Or5p81 UTSW 7 108,267,289 (GRCm39) missense probably benign
R6079:Or5p81 UTSW 7 108,267,412 (GRCm39) missense probably damaging 0.97
R6138:Or5p81 UTSW 7 108,267,412 (GRCm39) missense probably damaging 0.97
R8359:Or5p81 UTSW 7 108,267,518 (GRCm39) missense probably benign 0.00
R8848:Or5p81 UTSW 7 108,266,929 (GRCm39) missense probably benign 0.03
R8994:Or5p81 UTSW 7 108,267,169 (GRCm39) missense probably damaging 0.96
R9360:Or5p81 UTSW 7 108,266,977 (GRCm39) missense probably damaging 1.00
R9439:Or5p81 UTSW 7 108,266,626 (GRCm39) start codon destroyed probably null 0.97
R9641:Or5p81 UTSW 7 108,267,516 (GRCm39) missense probably damaging 0.98
U15987:Or5p81 UTSW 7 108,267,412 (GRCm39) missense probably damaging 0.97
Z1177:Or5p81 UTSW 7 108,267,043 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTTGTGGCAATCTGCAATCCACTG -3'
(R):5'- CCAAGCTGTTTCTTCAGAGCACCC -3'

Sequencing Primer
(F):5'- CCAAACAAGTGTGTATCCAATTGC -3'
(R):5'- TGGGAATCACCACCATGTAG -3'
Posted On 2013-08-06