Incidental Mutation 'R0051:Dcp2'
ID 64313
Institutional Source Beutler Lab
Gene Symbol Dcp2
Ensembl Gene ENSMUSG00000024472
Gene Name decapping mRNA 2
Synonyms 2410015D23Rik, 5730537H01Rik
MMRRC Submission 038345-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.957) question?
Stock # R0051 (G1)
Quality Score 189
Status Validated
Chromosome 18
Chromosomal Location 44513569-44558036 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 44538441 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000025350 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025350]
AlphaFold Q9CYC6
Predicted Effect probably benign
Transcript: ENSMUST00000025350
SMART Domains Protein: ENSMUSP00000025350
Gene: ENSMUSG00000024472

DomainStartEndE-ValueType
DCP2 10 94 4.23e-50 SMART
Pfam:NUDIX 97 219 6.5e-17 PFAM
low complexity region 240 258 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 93.8%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik A G 7: 29,278,526 (GRCm39) noncoding transcript Het
Abr T A 11: 76,363,328 (GRCm39) Q163L probably benign Het
Ankrd11 C A 8: 123,616,481 (GRCm39) C2457F probably damaging Het
Anks3 G C 16: 4,765,613 (GRCm39) T163S probably benign Het
Cacna1d G A 14: 29,833,052 (GRCm39) P908S probably damaging Het
Ccdc146 C A 5: 21,521,902 (GRCm39) R374L possibly damaging Het
Cdc45 G T 16: 18,613,524 (GRCm39) A348E probably damaging Het
Cfap46 A G 7: 139,255,951 (GRCm39) C300R probably damaging Het
Cimap1a C A 7: 140,430,134 (GRCm39) probably benign Het
Coq2 T C 5: 100,811,551 (GRCm39) N146S probably benign Het
Dalrd3 T C 9: 108,449,414 (GRCm39) V120A possibly damaging Het
Ddx39a A G 8: 84,447,251 (GRCm39) K137R possibly damaging Het
Diaph3 A G 14: 87,274,890 (GRCm39) probably null Het
Dmbt1 G T 7: 130,721,225 (GRCm39) R1668L possibly damaging Het
Dnah7a T G 1: 53,560,245 (GRCm39) probably benign Het
Dpp7 A G 2: 25,246,107 (GRCm39) Y49H possibly damaging Het
Drd5 A G 5: 38,477,957 (GRCm39) S317G probably benign Het
Ecpas A G 4: 58,832,729 (GRCm39) L877S probably damaging Het
Ecsit C T 9: 21,987,584 (GRCm39) V152I probably benign Het
Eeig1 G A 2: 32,448,065 (GRCm39) R58Q possibly damaging Het
Emc1 T A 4: 139,102,474 (GRCm39) M923K possibly damaging Het
Fcrl6 A T 1: 172,426,320 (GRCm39) L159Q probably benign Het
Frrs1 T C 3: 116,678,946 (GRCm39) probably benign Het
Hspd1 A G 1: 55,121,205 (GRCm39) probably benign Het
Impg2 T A 16: 56,078,411 (GRCm39) S458T probably damaging Het
Klf17 T C 4: 117,617,589 (GRCm39) Y256C probably damaging Het
Lnx2 A G 5: 146,966,163 (GRCm39) F319L probably damaging Het
Mafg G T 11: 120,520,430 (GRCm39) R57S probably damaging Het
Med13l T A 5: 118,880,720 (GRCm39) W1271R probably damaging Het
Mrgprb1 A G 7: 48,096,962 (GRCm39) S24P probably benign Het
Mtrf1l T C 10: 5,763,384 (GRCm39) E315G probably damaging Het
Naip1 T C 13: 100,547,509 (GRCm39) E1239G probably damaging Het
Ncaph2 T C 15: 89,253,867 (GRCm39) S320P probably damaging Het
Nek11 A G 9: 105,095,738 (GRCm39) probably benign Het
Nlrp2 A T 7: 5,325,333 (GRCm39) probably benign Het
Rbm26 A C 14: 105,389,976 (GRCm39) V216G possibly damaging Het
Rnf115 A G 3: 96,692,338 (GRCm39) D178G probably damaging Het
Rtel1 C T 2: 180,992,449 (GRCm39) Q424* probably null Het
Rwdd4a A G 8: 47,990,400 (GRCm39) probably benign Het
Ryr3 T C 2: 112,699,420 (GRCm39) D890G probably damaging Het
Scarb1 C A 5: 125,358,164 (GRCm39) probably null Het
Serpina10 A G 12: 103,593,156 (GRCm39) probably benign Het
Slc12a5 T A 2: 164,828,583 (GRCm39) W508R probably damaging Het
Slc43a2 T C 11: 75,453,676 (GRCm39) C225R probably damaging Het
Slc6a9 T C 4: 117,722,056 (GRCm39) F440L probably damaging Het
Stac3 G A 10: 127,344,017 (GRCm39) R305H probably damaging Het
Stk32b A G 5: 37,616,940 (GRCm39) probably benign Het
Syna A T 5: 134,588,397 (GRCm39) L184H probably damaging Het
Tmprss7 T C 16: 45,494,302 (GRCm39) N401S probably damaging Het
Tut4 T G 4: 108,384,201 (GRCm39) S1089R probably damaging Het
Yeats2 T A 16: 20,012,474 (GRCm39) Y557* probably null Het
Zfp352 T C 4: 90,112,522 (GRCm39) S221P probably damaging Het
Zfp575 A G 7: 24,285,512 (GRCm39) V43A probably benign Het
Zfp775 A G 6: 48,597,706 (GRCm39) T527A probably benign Het
Other mutations in Dcp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02801:Dcp2 APN 18 44,550,778 (GRCm39) missense probably damaging 1.00
belay UTSW 18 44,529,019 (GRCm39) missense probably damaging 0.99
PIT4431001:Dcp2 UTSW 18 44,545,638 (GRCm39) missense probably benign 0.15
R0515:Dcp2 UTSW 18 44,532,798 (GRCm39) missense probably benign 0.41
R0761:Dcp2 UTSW 18 44,543,300 (GRCm39) missense probably benign 0.01
R1696:Dcp2 UTSW 18 44,533,391 (GRCm39) missense probably damaging 1.00
R1803:Dcp2 UTSW 18 44,528,984 (GRCm39) missense probably damaging 1.00
R1928:Dcp2 UTSW 18 44,538,638 (GRCm39) critical splice donor site probably null
R1964:Dcp2 UTSW 18 44,529,038 (GRCm39) missense possibly damaging 0.50
R2014:Dcp2 UTSW 18 44,543,363 (GRCm39) missense probably benign 0.00
R2209:Dcp2 UTSW 18 44,538,581 (GRCm39) nonsense probably null
R4167:Dcp2 UTSW 18 44,529,034 (GRCm39) missense probably damaging 1.00
R4668:Dcp2 UTSW 18 44,548,429 (GRCm39) splice site probably null
R4877:Dcp2 UTSW 18 44,550,659 (GRCm39) missense probably benign 0.11
R5147:Dcp2 UTSW 18 44,550,662 (GRCm39) nonsense probably null
R5559:Dcp2 UTSW 18 44,538,554 (GRCm39) missense probably damaging 1.00
R6533:Dcp2 UTSW 18 44,532,731 (GRCm39) missense probably benign 0.25
R7406:Dcp2 UTSW 18 44,543,254 (GRCm39) missense probably benign 0.00
R7469:Dcp2 UTSW 18 44,529,019 (GRCm39) missense probably damaging 0.99
R7850:Dcp2 UTSW 18 44,533,415 (GRCm39) nonsense probably null
R8054:Dcp2 UTSW 18 44,538,774 (GRCm39) missense probably benign 0.02
R8315:Dcp2 UTSW 18 44,529,071 (GRCm39) missense probably benign 0.01
R9422:Dcp2 UTSW 18 44,538,361 (GRCm39) missense probably damaging 1.00
R9423:Dcp2 UTSW 18 44,538,361 (GRCm39) missense probably damaging 1.00
R9424:Dcp2 UTSW 18 44,538,361 (GRCm39) missense probably damaging 1.00
R9425:Dcp2 UTSW 18 44,538,361 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCATAAGAAGGGGCTTGGTCCTA -3'
(R):5'- GCAGCAGTGAGGCCAGTTTTACAG -3'

Sequencing Primer
(F):5'- AAGAAGGGGCTTGGTCCTAATTATC -3'
(R):5'- GGCCATAAAAAACTTATTAGGTGC -3'
Posted On 2013-08-06