Incidental Mutation 'R0053:Zfp13'
ID 64346
Institutional Source Beutler Lab
Gene Symbol Zfp13
Ensembl Gene ENSMUSG00000062012
Gene Name zinc finger protein 13
Synonyms Krox-8, Zfp-13
MMRRC Submission 038347-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R0053 (G1)
Quality Score 147
Status Validated
Chromosome 17
Chromosomal Location 23794818-23818461 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23795122 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 483 (I483N)
Ref Sequence ENSEMBL: ENSMUSP00000111178 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057029] [ENSMUST00000115516] [ENSMUST00000227952]
AlphaFold P10754
Predicted Effect probably damaging
Transcript: ENSMUST00000057029
AA Change: I476N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000054595
Gene: ENSMUSG00000062012
AA Change: I476N

DomainStartEndE-ValueType
KRAB 117 179 7.54e-10 SMART
ZnF_C2H2 259 281 7.37e-4 SMART
ZnF_C2H2 287 309 1.2e-3 SMART
ZnF_C2H2 315 337 5.9e-3 SMART
ZnF_C2H2 343 365 1.26e-2 SMART
ZnF_C2H2 371 393 9.73e-4 SMART
ZnF_C2H2 399 421 2.12e-4 SMART
ZnF_C2H2 427 449 1.18e-2 SMART
ZnF_C2H2 455 477 6.52e-5 SMART
low complexity region 480 503 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000115516
AA Change: I483N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000111178
Gene: ENSMUSG00000062012
AA Change: I483N

DomainStartEndE-ValueType
KRAB 124 186 7.54e-10 SMART
ZnF_C2H2 266 288 7.37e-4 SMART
ZnF_C2H2 294 316 1.2e-3 SMART
ZnF_C2H2 322 344 5.9e-3 SMART
ZnF_C2H2 350 372 1.26e-2 SMART
ZnF_C2H2 378 400 9.73e-4 SMART
ZnF_C2H2 406 428 2.12e-4 SMART
ZnF_C2H2 434 456 1.18e-2 SMART
ZnF_C2H2 462 484 6.52e-5 SMART
low complexity region 487 510 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226550
Predicted Effect probably benign
Transcript: ENSMUST00000227952
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228942
Meta Mutation Damage Score 0.1124 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.9%
  • 20x: 96.5%
Validation Efficiency 100% (67/67)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ada A T 2: 163,574,212 (GRCm39) V148D probably damaging Het
Alpi T C 1: 87,026,512 (GRCm39) D493G probably benign Het
Atp10b A G 11: 43,107,391 (GRCm39) probably benign Het
AY761185 A T 8: 21,434,546 (GRCm39) probably benign Het
Cadm1 C T 9: 47,710,712 (GRCm39) T205I probably damaging Het
Capn3 A G 2: 120,322,318 (GRCm39) I413V possibly damaging Het
Cblb C T 16: 51,963,164 (GRCm39) T369I probably damaging Het
Ccdc54 T A 16: 50,410,597 (GRCm39) N223I probably benign Het
Cdc25c A G 18: 34,868,488 (GRCm39) V294A probably benign Het
Cep170 A T 1: 176,609,946 (GRCm39) S122T possibly damaging Het
Chd1 A G 17: 15,967,451 (GRCm39) N849D probably damaging Het
Cspg4b T C 13: 113,505,023 (GRCm39) W2051R probably benign Het
Dpp3 A G 19: 4,973,154 (GRCm39) C147R probably damaging Het
Dst A G 1: 34,333,631 (GRCm39) probably null Het
Fbxw9 T A 8: 85,791,083 (GRCm39) L250Q probably damaging Het
Gpr75 A T 11: 30,842,571 (GRCm39) Q492L possibly damaging Het
Gramd4 T A 15: 86,014,339 (GRCm39) probably benign Het
Hivep2 T C 10: 14,007,865 (GRCm39) C1488R probably damaging Het
Hjurp G C 1: 88,204,937 (GRCm39) probably benign Het
Inava C T 1: 136,155,288 (GRCm39) V106I probably benign Het
Insr A G 8: 3,205,683 (GRCm39) S1369P probably damaging Het
Insrr A C 3: 87,707,759 (GRCm39) D67A probably damaging Het
Irf2 T A 8: 47,271,886 (GRCm39) Y158N probably benign Het
Katnbl1 A G 2: 112,234,586 (GRCm39) R23G probably benign Het
Lamb2 T A 9: 108,363,936 (GRCm39) C987* probably null Het
Lzts2 T C 19: 45,014,746 (GRCm39) probably benign Het
Mmp14 T A 14: 54,676,109 (GRCm39) probably benign Het
Mycbpap A G 11: 94,402,562 (GRCm39) Y258H probably damaging Het
Nav3 A G 10: 109,602,778 (GRCm39) probably benign Het
Or10j7 T C 1: 173,011,845 (GRCm39) D52G probably benign Het
Or4c100 T A 2: 88,356,507 (GRCm39) N193K probably damaging Het
Parp10 T A 15: 76,126,446 (GRCm39) L247F probably damaging Het
Pcsk6 C T 7: 65,633,451 (GRCm39) probably benign Het
Pgap3 A T 11: 98,281,924 (GRCm39) V129D probably benign Het
Pibf1 A G 14: 99,377,993 (GRCm39) Y373C probably damaging Het
Plcb1 A G 2: 135,136,835 (GRCm39) E310G probably benign Het
Plin3 T C 17: 56,586,892 (GRCm39) D385G probably damaging Het
Pole A T 5: 110,441,206 (GRCm39) D220V probably damaging Het
Ptprk T A 10: 28,351,105 (GRCm39) F533I probably damaging Het
Resf1 T A 6: 149,229,088 (GRCm39) D711E probably benign Het
Rufy1 A T 11: 50,292,292 (GRCm39) M499K probably benign Het
Scn1a T G 2: 66,130,119 (GRCm39) D1232A probably benign Het
Sec23ip T C 7: 128,346,891 (GRCm39) L49P probably damaging Het
Sf3b1 G A 1: 55,039,532 (GRCm39) Q698* probably null Het
Shprh A T 10: 11,070,116 (GRCm39) probably null Het
Snd1 C A 6: 28,745,334 (GRCm39) probably benign Het
Stab1 C T 14: 30,862,644 (GRCm39) A2260T possibly damaging Het
Stpg2 A G 3: 138,918,082 (GRCm39) Q60R probably benign Het
Strn T C 17: 78,964,363 (GRCm39) H687R possibly damaging Het
Tgfb3 A T 12: 86,124,603 (GRCm39) I35N probably damaging Het
Tnks2 T C 19: 36,852,765 (GRCm39) S166P probably damaging Het
Tyw5 G A 1: 57,440,597 (GRCm39) T55M probably damaging Het
Usp19 A G 9: 108,374,369 (GRCm39) probably null Het
Other mutations in Zfp13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02236:Zfp13 APN 17 23,799,739 (GRCm39) splice site probably benign
IGL02447:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02449:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02450:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02466:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02468:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02471:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02473:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02474:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02475:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02491:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02511:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL02558:Zfp13 APN 17 23,795,072 (GRCm39) missense probably benign 0.05
IGL03030:Zfp13 APN 17 23,799,819 (GRCm39) missense probably benign 0.01
IGL03388:Zfp13 APN 17 23,795,888 (GRCm39) missense probably benign 0.00
R0053:Zfp13 UTSW 17 23,795,122 (GRCm39) missense probably damaging 1.00
R1514:Zfp13 UTSW 17 23,795,386 (GRCm39) missense probably damaging 1.00
R2420:Zfp13 UTSW 17 23,795,186 (GRCm39) missense probably damaging 1.00
R3433:Zfp13 UTSW 17 23,795,602 (GRCm39) missense probably damaging 0.99
R4458:Zfp13 UTSW 17 23,800,150 (GRCm39) missense probably benign 0.01
R4650:Zfp13 UTSW 17 23,799,112 (GRCm39) missense probably damaging 1.00
R4824:Zfp13 UTSW 17 23,795,797 (GRCm39) missense possibly damaging 0.95
R5088:Zfp13 UTSW 17 23,796,035 (GRCm39) nonsense probably null
R5110:Zfp13 UTSW 17 23,799,834 (GRCm39) missense probably benign 0.02
R5384:Zfp13 UTSW 17 23,800,156 (GRCm39) missense probably damaging 1.00
R7302:Zfp13 UTSW 17 23,800,036 (GRCm39) missense probably damaging 1.00
R8443:Zfp13 UTSW 17 23,795,866 (GRCm39) missense probably benign
R9728:Zfp13 UTSW 17 23,799,788 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GCCAAGGGCACAGCTTGAAATC -3'
(R):5'- TTGGAAGAGCTTCAGCCACCAC -3'

Sequencing Primer
(F):5'- ACTGGCTAAGACCCAGCG -3'
(R):5'- ACTGGTGAGAAGCCCTACG -3'
Posted On 2013-08-06