Incidental Mutation 'R0056:Stk10'
ID 64360
Institutional Source Beutler Lab
Gene Symbol Stk10
Ensembl Gene ENSMUSG00000020272
Gene Name serine/threonine kinase 10
Synonyms Lok, Gek1
MMRRC Submission 038350-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R0056 (G1)
Quality Score 105
Status Not validated
Chromosome 11
Chromosomal Location 32483305-32574587 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 32567851 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 884 (N884K)
Ref Sequence ENSEMBL: ENSMUSP00000099885 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102821]
AlphaFold O55098
Predicted Effect possibly damaging
Transcript: ENSMUST00000102821
AA Change: N884K

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000099885
Gene: ENSMUSG00000020272
AA Change: N884K

DomainStartEndE-ValueType
S_TKc 36 294 8.66e-92 SMART
low complexity region 316 334 N/A INTRINSIC
low complexity region 544 577 N/A INTRINSIC
Pfam:PKK 586 724 1.9e-41 PFAM
Pfam:PKK 754 894 2.2e-37 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted disruption of this gene results in enhanced cell adhesion in mitogen-stimulated T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 12 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bms1 A T 6: 118,382,190 (GRCm39) D449E probably benign Het
Etv3 T C 3: 87,443,135 (GRCm39) Y240H possibly damaging Het
Fscb T G 12: 64,521,021 (GRCm39) R148S possibly damaging Het
Mapk6 A G 9: 75,296,098 (GRCm39) Y467H possibly damaging Het
Marf1 C T 16: 13,960,398 (GRCm39) A549T probably damaging Het
Mogat1 T G 1: 78,500,407 (GRCm39) M157R probably damaging Het
Pold2 T A 11: 5,822,338 (GRCm39) S444C possibly damaging Het
Robo4 G A 9: 37,315,773 (GRCm39) R342Q probably benign Het
Satb1 T A 17: 52,047,231 (GRCm39) I695F probably damaging Het
Snapc1 C T 12: 74,021,806 (GRCm39) R81C probably damaging Het
Tex15 A G 8: 34,072,055 (GRCm39) H2534R probably benign Het
Ticam2 G T 18: 46,693,401 (GRCm39) Q229K possibly damaging Het
Other mutations in Stk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01105:Stk10 APN 11 32,527,740 (GRCm39) missense probably benign 0.33
IGL01285:Stk10 APN 11 32,560,653 (GRCm39) missense possibly damaging 0.91
IGL01983:Stk10 APN 11 32,539,460 (GRCm39) missense probably benign 0.05
IGL03177:Stk10 APN 11 32,564,592 (GRCm39) missense probably damaging 1.00
IGL03183:Stk10 APN 11 32,554,143 (GRCm39) missense possibly damaging 0.50
coquet UTSW 11 32,527,764 (GRCm39) missense
legacy UTSW 11 32,554,166 (GRCm39) nonsense probably null
mignon UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R0481_stk10_383 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
FR4976:Stk10 UTSW 11 32,564,520 (GRCm39) critical splice acceptor site probably benign
R0003:Stk10 UTSW 11 32,539,460 (GRCm39) missense probably benign 0.05
R0008:Stk10 UTSW 11 32,537,305 (GRCm39) splice site probably benign
R0076:Stk10 UTSW 11 32,553,722 (GRCm39) missense probably benign
R0227:Stk10 UTSW 11 32,567,859 (GRCm39) missense probably damaging 1.00
R0440:Stk10 UTSW 11 32,554,190 (GRCm39) missense probably damaging 1.00
R0454:Stk10 UTSW 11 32,546,724 (GRCm39) missense probably damaging 0.99
R0481:Stk10 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
R0504:Stk10 UTSW 11 32,567,882 (GRCm39) missense probably benign 0.04
R0790:Stk10 UTSW 11 32,548,653 (GRCm39) missense probably benign 0.00
R1439:Stk10 UTSW 11 32,567,919 (GRCm39) missense probably damaging 0.98
R1539:Stk10 UTSW 11 32,483,440 (GRCm39) missense possibly damaging 0.85
R1770:Stk10 UTSW 11 32,572,464 (GRCm39) missense possibly damaging 0.94
R4304:Stk10 UTSW 11 32,560,634 (GRCm39) missense probably damaging 0.97
R4430:Stk10 UTSW 11 32,483,552 (GRCm39) missense possibly damaging 0.81
R4702:Stk10 UTSW 11 32,505,172 (GRCm39) missense probably benign 0.28
R4797:Stk10 UTSW 11 32,548,471 (GRCm39) missense probably benign 0.01
R5447:Stk10 UTSW 11 32,554,166 (GRCm39) nonsense probably null
R5801:Stk10 UTSW 11 32,546,748 (GRCm39) missense probably benign 0.01
R5802:Stk10 UTSW 11 32,546,748 (GRCm39) missense probably benign 0.01
R6129:Stk10 UTSW 11 32,565,871 (GRCm39) missense probably damaging 1.00
R6154:Stk10 UTSW 11 32,553,654 (GRCm39) splice site probably null
R6175:Stk10 UTSW 11 32,553,761 (GRCm39) missense possibly damaging 0.46
R6185:Stk10 UTSW 11 32,527,749 (GRCm39) missense probably benign 0.13
R6520:Stk10 UTSW 11 32,538,839 (GRCm39) missense probably damaging 1.00
R6824:Stk10 UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R7259:Stk10 UTSW 11 32,548,497 (GRCm39) missense probably benign 0.00
R7649:Stk10 UTSW 11 32,527,764 (GRCm39) missense
R8331:Stk10 UTSW 11 32,538,928 (GRCm39) missense
R8847:Stk10 UTSW 11 32,539,427 (GRCm39) missense
R9252:Stk10 UTSW 11 32,538,915 (GRCm39) missense
R9367:Stk10 UTSW 11 32,538,878 (GRCm39) missense
X0027:Stk10 UTSW 11 32,537,361 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACATGCAGAGTTGTGGATAGTGGC -3'
(R):5'- GGAGGATTCAGATGTTCCAGGCAG -3'

Sequencing Primer
(F):5'- cacccgactgctcttcc -3'
(R):5'- TTCCTTCAGGCTCTGGTTGT -3'
Posted On 2013-08-06