Incidental Mutation 'R0057:Zfp770'
ID 64369
Institutional Source Beutler Lab
Gene Symbol Zfp770
Ensembl Gene ENSMUSG00000040321
Gene Name zinc finger protein 770
Synonyms 6430601A21Rik
MMRRC Submission 038351-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.233) question?
Stock # R0057 (G1)
Quality Score 86
Status Validated
Chromosome 2
Chromosomal Location 114023937-114031945 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 114027713 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 119 (R119*)
Ref Sequence ENSEMBL: ENSMUSP00000052194 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050668]
AlphaFold Q8BIQ8
Predicted Effect probably null
Transcript: ENSMUST00000050668
AA Change: R119*
SMART Domains Protein: ENSMUSP00000052194
Gene: ENSMUSG00000040321
AA Change: R119*

DomainStartEndE-ValueType
ZnF_C2H2 31 53 1.18e-2 SMART
ZnF_C2H2 59 81 4.11e-2 SMART
ZnF_C2H2 85 107 3.58e-2 SMART
ZnF_C2H2 164 186 2.09e-3 SMART
ZnF_C2H2 192 214 3.58e-2 SMART
ZnF_C2H2 220 242 3.29e-1 SMART
ZnF_C2H2 298 318 1.93e2 SMART
low complexity region 341 354 N/A INTRINSIC
ZnF_C2H2 485 507 5.9e-3 SMART
ZnF_C2H2 513 535 1.82e-3 SMART
low complexity region 576 595 N/A INTRINSIC
ZnF_C2H2 640 662 9.58e-3 SMART
ZnF_C2H2 668 690 7.37e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123562
Meta Mutation Damage Score 0.9712 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 95.9%
Validation Efficiency 100% (50/50)
Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam23 T A 1: 63,610,078 (GRCm39) H693Q probably damaging Het
Ap5z1 T C 5: 142,456,144 (GRCm39) probably benign Het
Bloc1s6 T A 2: 122,586,141 (GRCm39) probably benign Het
Caskin1 A G 17: 24,723,870 (GRCm39) N886S probably damaging Het
Ctse G T 1: 131,591,109 (GRCm39) D97Y probably damaging Het
Dcaf11 T C 14: 55,806,767 (GRCm39) V490A probably benign Het
Dctn1 A G 6: 83,156,874 (GRCm39) H7R probably benign Het
Dscam A C 16: 96,474,936 (GRCm39) W1209G probably damaging Het
Fcsk C T 8: 111,620,400 (GRCm39) probably benign Het
Gna11 A G 10: 81,366,774 (GRCm39) M312T probably benign Het
Hacd2 T A 16: 34,895,997 (GRCm39) V105D probably damaging Het
Htra4 C A 8: 25,528,824 (GRCm39) V23L probably benign Het
Marf1 C T 16: 13,960,398 (GRCm39) A549T probably damaging Het
Msh4 C T 3: 153,575,318 (GRCm39) A686T probably benign Het
Nbas T A 12: 13,440,958 (GRCm39) M1096K probably benign Het
Or5m10b C A 2: 85,699,597 (GRCm39) Y220* probably null Het
Ppp1r16a C T 15: 76,574,999 (GRCm39) probably benign Het
Prlr A G 15: 10,328,509 (GRCm39) Y328C probably damaging Het
Ros1 C T 10: 52,056,287 (GRCm39) V68I probably benign Het
Shmt2 G A 10: 127,356,917 (GRCm39) T31M possibly damaging Het
Snapc1 C T 12: 74,021,806 (GRCm39) R81C probably damaging Het
Tas2r135 A G 6: 42,383,354 (GRCm39) T298A probably benign Het
Tmem175 C T 5: 108,787,428 (GRCm39) H92Y probably damaging Het
Top3a C T 11: 60,631,510 (GRCm39) A951T probably benign Het
Trpc4ap T C 2: 155,482,406 (GRCm39) E528G possibly damaging Het
Trpm6 T C 19: 18,764,119 (GRCm39) C242R probably benign Het
Vwa7 G A 17: 35,243,523 (GRCm39) S710N possibly damaging Het
Zfa-ps A T 10: 52,421,202 (GRCm39) noncoding transcript Het
Other mutations in Zfp770
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Zfp770 APN 2 114,026,413 (GRCm39) missense probably benign 0.20
IGL00478:Zfp770 APN 2 114,027,946 (GRCm39) missense probably damaging 1.00
IGL01539:Zfp770 APN 2 114,027,574 (GRCm39) missense probably damaging 0.99
IGL01778:Zfp770 APN 2 114,026,719 (GRCm39) missense probably damaging 0.96
IGL02596:Zfp770 APN 2 114,026,308 (GRCm39) missense probably benign 0.11
IGL03227:Zfp770 APN 2 114,027,570 (GRCm39) nonsense probably null
R0057:Zfp770 UTSW 2 114,027,713 (GRCm39) nonsense probably null
R1081:Zfp770 UTSW 2 114,027,608 (GRCm39) missense probably damaging 1.00
R1446:Zfp770 UTSW 2 114,027,514 (GRCm39) missense probably damaging 0.99
R4477:Zfp770 UTSW 2 114,027,365 (GRCm39) missense probably damaging 1.00
R4597:Zfp770 UTSW 2 114,027,251 (GRCm39) missense possibly damaging 0.46
R4964:Zfp770 UTSW 2 114,027,868 (GRCm39) missense probably benign 0.24
R4966:Zfp770 UTSW 2 114,027,868 (GRCm39) missense probably benign 0.24
R5259:Zfp770 UTSW 2 114,027,674 (GRCm39) missense probably benign 0.00
R5440:Zfp770 UTSW 2 114,026,596 (GRCm39) missense probably benign 0.42
R5910:Zfp770 UTSW 2 114,026,713 (GRCm39) nonsense probably null
R5941:Zfp770 UTSW 2 114,028,027 (GRCm39) missense possibly damaging 0.83
R6074:Zfp770 UTSW 2 114,026,870 (GRCm39) missense possibly damaging 0.68
R6341:Zfp770 UTSW 2 114,027,240 (GRCm39) missense probably benign 0.14
R7181:Zfp770 UTSW 2 114,027,872 (GRCm39) missense probably damaging 1.00
R7288:Zfp770 UTSW 2 114,026,142 (GRCm39) nonsense probably null
R7935:Zfp770 UTSW 2 114,027,305 (GRCm39) missense probably benign 0.00
R8119:Zfp770 UTSW 2 114,027,508 (GRCm39) missense probably damaging 1.00
R8304:Zfp770 UTSW 2 114,027,891 (GRCm39) missense probably damaging 1.00
R9356:Zfp770 UTSW 2 114,026,917 (GRCm39) missense possibly damaging 0.83
R9657:Zfp770 UTSW 2 114,027,766 (GRCm39) missense probably damaging 0.97
R9663:Zfp770 UTSW 2 114,026,949 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGCAGGAAGACACTTGTGTCCATTG -3'
(R):5'- CAACTCGTTCATCTGGAGAGGCATC -3'

Sequencing Primer
(F):5'- AAAAGCATCCTGCTTTGCG -3'
(R):5'- GTGAAGCATCAACAGCTTCAC -3'
Posted On 2013-08-06