Incidental Mutation 'R0057:Zfp770'
ID |
64369 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp770
|
Ensembl Gene |
ENSMUSG00000040321 |
Gene Name |
zinc finger protein 770 |
Synonyms |
6430601A21Rik |
MMRRC Submission |
038351-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.233)
|
Stock # |
R0057 (G1)
|
Quality Score |
86 |
Status
|
Validated
|
Chromosome |
2 |
Chromosomal Location |
114023937-114031945 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
T to A
at 114027713 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Stop codon
at position 119
(R119*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000052194
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000050668]
|
AlphaFold |
Q8BIQ8 |
Predicted Effect |
probably null
Transcript: ENSMUST00000050668
AA Change: R119*
|
SMART Domains |
Protein: ENSMUSP00000052194 Gene: ENSMUSG00000040321 AA Change: R119*
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
31 |
53 |
1.18e-2 |
SMART |
ZnF_C2H2
|
59 |
81 |
4.11e-2 |
SMART |
ZnF_C2H2
|
85 |
107 |
3.58e-2 |
SMART |
ZnF_C2H2
|
164 |
186 |
2.09e-3 |
SMART |
ZnF_C2H2
|
192 |
214 |
3.58e-2 |
SMART |
ZnF_C2H2
|
220 |
242 |
3.29e-1 |
SMART |
ZnF_C2H2
|
298 |
318 |
1.93e2 |
SMART |
low complexity region
|
341 |
354 |
N/A |
INTRINSIC |
ZnF_C2H2
|
485 |
507 |
5.9e-3 |
SMART |
ZnF_C2H2
|
513 |
535 |
1.82e-3 |
SMART |
low complexity region
|
576 |
595 |
N/A |
INTRINSIC |
ZnF_C2H2
|
640 |
662 |
9.58e-3 |
SMART |
ZnF_C2H2
|
668 |
690 |
7.37e-4 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123562
|
Meta Mutation Damage Score |
0.9712 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.9%
- 10x: 97.7%
- 20x: 95.9%
|
Validation Efficiency |
100% (50/50) |
Allele List at MGI |
All alleles(4) : Targeted(3) Gene trapped(1)
|
Other mutations in this stock |
Total: 28 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam23 |
T |
A |
1: 63,610,078 (GRCm39) |
H693Q |
probably damaging |
Het |
Ap5z1 |
T |
C |
5: 142,456,144 (GRCm39) |
|
probably benign |
Het |
Bloc1s6 |
T |
A |
2: 122,586,141 (GRCm39) |
|
probably benign |
Het |
Caskin1 |
A |
G |
17: 24,723,870 (GRCm39) |
N886S |
probably damaging |
Het |
Ctse |
G |
T |
1: 131,591,109 (GRCm39) |
D97Y |
probably damaging |
Het |
Dcaf11 |
T |
C |
14: 55,806,767 (GRCm39) |
V490A |
probably benign |
Het |
Dctn1 |
A |
G |
6: 83,156,874 (GRCm39) |
H7R |
probably benign |
Het |
Dscam |
A |
C |
16: 96,474,936 (GRCm39) |
W1209G |
probably damaging |
Het |
Fcsk |
C |
T |
8: 111,620,400 (GRCm39) |
|
probably benign |
Het |
Gna11 |
A |
G |
10: 81,366,774 (GRCm39) |
M312T |
probably benign |
Het |
Hacd2 |
T |
A |
16: 34,895,997 (GRCm39) |
V105D |
probably damaging |
Het |
Htra4 |
C |
A |
8: 25,528,824 (GRCm39) |
V23L |
probably benign |
Het |
Marf1 |
C |
T |
16: 13,960,398 (GRCm39) |
A549T |
probably damaging |
Het |
Msh4 |
C |
T |
3: 153,575,318 (GRCm39) |
A686T |
probably benign |
Het |
Nbas |
T |
A |
12: 13,440,958 (GRCm39) |
M1096K |
probably benign |
Het |
Or5m10b |
C |
A |
2: 85,699,597 (GRCm39) |
Y220* |
probably null |
Het |
Ppp1r16a |
C |
T |
15: 76,574,999 (GRCm39) |
|
probably benign |
Het |
Prlr |
A |
G |
15: 10,328,509 (GRCm39) |
Y328C |
probably damaging |
Het |
Ros1 |
C |
T |
10: 52,056,287 (GRCm39) |
V68I |
probably benign |
Het |
Shmt2 |
G |
A |
10: 127,356,917 (GRCm39) |
T31M |
possibly damaging |
Het |
Snapc1 |
C |
T |
12: 74,021,806 (GRCm39) |
R81C |
probably damaging |
Het |
Tas2r135 |
A |
G |
6: 42,383,354 (GRCm39) |
T298A |
probably benign |
Het |
Tmem175 |
C |
T |
5: 108,787,428 (GRCm39) |
H92Y |
probably damaging |
Het |
Top3a |
C |
T |
11: 60,631,510 (GRCm39) |
A951T |
probably benign |
Het |
Trpc4ap |
T |
C |
2: 155,482,406 (GRCm39) |
E528G |
possibly damaging |
Het |
Trpm6 |
T |
C |
19: 18,764,119 (GRCm39) |
C242R |
probably benign |
Het |
Vwa7 |
G |
A |
17: 35,243,523 (GRCm39) |
S710N |
possibly damaging |
Het |
Zfa-ps |
A |
T |
10: 52,421,202 (GRCm39) |
|
noncoding transcript |
Het |
|
Other mutations in Zfp770 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00090:Zfp770
|
APN |
2 |
114,026,413 (GRCm39) |
missense |
probably benign |
0.20 |
IGL00478:Zfp770
|
APN |
2 |
114,027,946 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01539:Zfp770
|
APN |
2 |
114,027,574 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01778:Zfp770
|
APN |
2 |
114,026,719 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02596:Zfp770
|
APN |
2 |
114,026,308 (GRCm39) |
missense |
probably benign |
0.11 |
IGL03227:Zfp770
|
APN |
2 |
114,027,570 (GRCm39) |
nonsense |
probably null |
|
R0057:Zfp770
|
UTSW |
2 |
114,027,713 (GRCm39) |
nonsense |
probably null |
|
R1081:Zfp770
|
UTSW |
2 |
114,027,608 (GRCm39) |
missense |
probably damaging |
1.00 |
R1446:Zfp770
|
UTSW |
2 |
114,027,514 (GRCm39) |
missense |
probably damaging |
0.99 |
R4477:Zfp770
|
UTSW |
2 |
114,027,365 (GRCm39) |
missense |
probably damaging |
1.00 |
R4597:Zfp770
|
UTSW |
2 |
114,027,251 (GRCm39) |
missense |
possibly damaging |
0.46 |
R4964:Zfp770
|
UTSW |
2 |
114,027,868 (GRCm39) |
missense |
probably benign |
0.24 |
R4966:Zfp770
|
UTSW |
2 |
114,027,868 (GRCm39) |
missense |
probably benign |
0.24 |
R5259:Zfp770
|
UTSW |
2 |
114,027,674 (GRCm39) |
missense |
probably benign |
0.00 |
R5440:Zfp770
|
UTSW |
2 |
114,026,596 (GRCm39) |
missense |
probably benign |
0.42 |
R5910:Zfp770
|
UTSW |
2 |
114,026,713 (GRCm39) |
nonsense |
probably null |
|
R5941:Zfp770
|
UTSW |
2 |
114,028,027 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6074:Zfp770
|
UTSW |
2 |
114,026,870 (GRCm39) |
missense |
possibly damaging |
0.68 |
R6341:Zfp770
|
UTSW |
2 |
114,027,240 (GRCm39) |
missense |
probably benign |
0.14 |
R7181:Zfp770
|
UTSW |
2 |
114,027,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R7288:Zfp770
|
UTSW |
2 |
114,026,142 (GRCm39) |
nonsense |
probably null |
|
R7935:Zfp770
|
UTSW |
2 |
114,027,305 (GRCm39) |
missense |
probably benign |
0.00 |
R8119:Zfp770
|
UTSW |
2 |
114,027,508 (GRCm39) |
missense |
probably damaging |
1.00 |
R8304:Zfp770
|
UTSW |
2 |
114,027,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R9356:Zfp770
|
UTSW |
2 |
114,026,917 (GRCm39) |
missense |
possibly damaging |
0.83 |
R9657:Zfp770
|
UTSW |
2 |
114,027,766 (GRCm39) |
missense |
probably damaging |
0.97 |
R9663:Zfp770
|
UTSW |
2 |
114,026,949 (GRCm39) |
missense |
probably benign |
0.01 |
|
Predicted Primers |
PCR Primer
(F):5'- GGCAGGAAGACACTTGTGTCCATTG -3'
(R):5'- CAACTCGTTCATCTGGAGAGGCATC -3'
Sequencing Primer
(F):5'- AAAAGCATCCTGCTTTGCG -3'
(R):5'- GTGAAGCATCAACAGCTTCAC -3'
|
Posted On |
2013-08-06 |