Incidental Mutation 'R0037:Dusp26'
ID 64628
Institutional Source Beutler Lab
Gene Symbol Dusp26
Ensembl Gene ENSMUSG00000039661
Gene Name dual specificity phosphatase 26
Synonyms 2310043K02Rik
MMRRC Submission 038331-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0037 (G1)
Quality Score 81
Status Not validated
Chromosome 8
Chromosomal Location 31579555-31587074 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 31586388 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 203 (R203H)
Ref Sequence ENSEMBL: ENSMUSP00000126397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036631] [ENSMUST00000161713] [ENSMUST00000170204]
AlphaFold Q9D700
Predicted Effect unknown
Transcript: ENSMUST00000036631
AA Change: R203H
SMART Domains Protein: ENSMUSP00000046794
Gene: ENSMUSG00000039661
AA Change: R203H

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160700
Predicted Effect unknown
Transcript: ENSMUST00000161713
AA Change: R203H
SMART Domains Protein: ENSMUSP00000124949
Gene: ENSMUSG00000039661
AA Change: R203H

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162551
Predicted Effect unknown
Transcript: ENSMUST00000170204
AA Change: R203H
SMART Domains Protein: ENSMUSP00000126397
Gene: ENSMUSG00000039661
AA Change: R203H

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.8%
  • 20x: 96.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Allele List at MGI
Other mutations in this stock
Total: 10 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ect2l A G 10: 18,018,845 (GRCm39) L517P probably damaging Het
Il5ra T A 6: 106,719,647 (GRCm39) Y62F probably damaging Het
Lrp4 A G 2: 91,301,548 (GRCm39) T43A probably benign Het
Pfas A G 11: 68,890,862 (GRCm39) Y350H probably damaging Het
Ppp1r16b T A 2: 158,599,129 (GRCm39) I367N probably damaging Het
Ralgapb T C 2: 158,279,331 (GRCm39) L139S probably damaging Het
Swap70 T A 7: 109,863,287 (GRCm39) N205K possibly damaging Het
Trim24 A T 6: 37,934,484 (GRCm39) N733I probably damaging Het
Ttn A G 2: 76,693,616 (GRCm39) probably null Het
Uggt1 A T 1: 36,225,013 (GRCm39) D540E probably benign Het
Other mutations in Dusp26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00964:Dusp26 APN 8 31,584,136 (GRCm39) missense probably benign 0.01
R0394:Dusp26 UTSW 8 31,581,987 (GRCm39) missense probably benign 0.16
R1792:Dusp26 UTSW 8 31,581,963 (GRCm39) missense probably benign 0.01
R4454:Dusp26 UTSW 8 31,584,172 (GRCm39) missense probably damaging 0.99
R4854:Dusp26 UTSW 8 31,584,165 (GRCm39) missense probably damaging 1.00
R5638:Dusp26 UTSW 8 31,584,169 (GRCm39) missense probably damaging 1.00
R6212:Dusp26 UTSW 8 31,584,252 (GRCm39) missense probably damaging 1.00
R6337:Dusp26 UTSW 8 31,586,325 (GRCm39) missense probably damaging 1.00
R7083:Dusp26 UTSW 8 31,581,747 (GRCm39) intron probably benign
R8754:Dusp26 UTSW 8 31,581,805 (GRCm39) intron probably benign
R8945:Dusp26 UTSW 8 31,586,367 (GRCm39) missense unknown
R8970:Dusp26 UTSW 8 31,584,232 (GRCm39) missense probably damaging 1.00
R9742:Dusp26 UTSW 8 31,584,198 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAGCAGTCTCTCAGATGTTTCTGCC -3'
(R):5'- ATGTGTCTGCAACCCTGACATCC -3'

Sequencing Primer
(F):5'- TCAGATGTTTCTGCCTTCCTC -3'
(R):5'- TGAGTCATTTGGGCACACC -3'
Posted On 2013-08-06