Incidental Mutation 'IGL00401:Gm10220'
ID6468
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10220
Ensembl Gene ENSMUSG00000067698
Gene Namepredicted gene 10220
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.437) question?
Stock #IGL00401
Quality Score
Status
Chromosome5
Chromosomal Location26114764-26121421 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 26118611 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 146 (F146Y)
Ref Sequence ENSEMBL: ENSMUSP00000085569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088236]
Predicted Effect possibly damaging
Transcript: ENSMUST00000088236
AA Change: F146Y

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000085569
Gene: ENSMUSG00000067698
AA Change: F146Y

DomainStartEndE-ValueType
Pfam:Takusan 50 134 1.6e-25 PFAM
low complexity region 235 259 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alk T A 17: 71,895,748 D1164V probably damaging Het
Baiap3 T G 17: 25,244,328 L964F probably damaging Het
Cacna2d2 T A 9: 107,514,873 V471E probably damaging Het
Carmil3 C T 14: 55,498,298 T569M probably damaging Het
Dapk2 G T 9: 66,268,778 probably benign Het
Eps15l1 A T 8: 72,384,838 Y291* probably null Het
Fancd2 T C 6: 113,564,396 probably null Het
Fmnl2 T G 2: 53,114,917 D674E probably damaging Het
Foxq1 A T 13: 31,559,277 I121F probably damaging Het
Galnt13 C T 2: 54,516,535 probably benign Het
Git1 T C 11: 77,498,956 probably benign Het
Gm7353 A G 7: 3,110,630 noncoding transcript Het
Hspa9 G A 18: 34,938,580 probably benign Het
Kptn A G 7: 16,120,125 D56G possibly damaging Het
Krtap4-13 A T 11: 99,809,717 C39S unknown Het
Lgsn A G 1: 31,203,566 K243R possibly damaging Het
Lyz2 C T 10: 117,282,185 V20I probably benign Het
Mettl3 T A 14: 52,296,967 probably benign Het
Myh6 T A 14: 54,953,417 M934L probably benign Het
Nmnat2 A G 1: 153,094,117 probably null Het
Pias2 T A 18: 77,133,211 C381S probably damaging Het
Psme4 T C 11: 30,821,079 probably benign Het
Smc4 T A 3: 69,030,379 D887E probably damaging Het
Sorcs2 C A 5: 36,037,401 probably null Het
Tet2 T C 3: 133,466,882 E1873G possibly damaging Het
Txlng T A X: 162,782,309 K341* probably null Het
Ugt2b37 T A 5: 87,242,481 T369S possibly damaging Het
Usp46 C A 5: 74,003,171 V302F probably damaging Het
Zfp292 A G 4: 34,808,683 C1454R probably benign Het
Other mutations in Gm10220
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01782:Gm10220 APN 5 26117023 missense probably damaging 1.00
IGL03194:Gm10220 APN 5 26121233 missense probably damaging 1.00
IGL03218:Gm10220 APN 5 26118698 missense probably damaging 0.99
IGL03255:Gm10220 APN 5 26116901 missense possibly damaging 0.93
R3014:Gm10220 UTSW 5 26117828 missense probably damaging 0.99
R3883:Gm10220 UTSW 5 26116910 missense possibly damaging 0.70
R4577:Gm10220 UTSW 5 26117871 missense probably benign
R5484:Gm10220 UTSW 5 26117932 missense possibly damaging 0.59
R6358:Gm10220 UTSW 5 26120305 intron probably null
Posted On2012-04-20