Incidental Mutation 'R0023:Dhrs11'
ID 64832
Institutional Source Beutler Lab
Gene Symbol Dhrs11
Ensembl Gene ENSMUSG00000034449
Gene Name dehydrogenase/reductase 11
Synonyms dehydrogenase/reductase (SDR family) member 11
MMRRC Submission 038318-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0023 (G1)
Quality Score 150
Status Not validated
Chromosome 11
Chromosomal Location 84711682-84719820 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 84713976 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Histidine at position 125 (L125H)
Ref Sequence ENSEMBL: ENSMUSP00000043467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018549] [ENSMUST00000047560] [ENSMUST00000151496]
AlphaFold Q3U0B3
Predicted Effect probably benign
Transcript: ENSMUST00000018549
SMART Domains Protein: ENSMUSP00000018549
Gene: ENSMUSG00000018405

DomainStartEndE-ValueType
SpoU_sub_bind 49 127 3.31e-11 SMART
Pfam:SpoU_methylase 143 299 3.2e-31 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000047560
AA Change: L125H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000043467
Gene: ENSMUSG00000034449
AA Change: L125H

DomainStartEndE-ValueType
Pfam:adh_short 12 214 1.4e-46 PFAM
Pfam:KR 13 154 1.7e-11 PFAM
Pfam:Epimerase 14 251 4.8e-7 PFAM
Pfam:adh_short_C2 18 245 1.8e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139076
Predicted Effect probably benign
Transcript: ENSMUST00000151496
SMART Domains Protein: ENSMUSP00000122267
Gene: ENSMUSG00000034449

DomainStartEndE-ValueType
Pfam:adh_short 12 49 6.3e-8 PFAM
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.8%
  • 20x: 96.2%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm1 A C 4: 144,255,567 (GRCm39) D329A probably damaging Het
Abcc12 T A 8: 87,264,962 (GRCm39) H661L probably damaging Het
Abcg4 A G 9: 44,186,672 (GRCm39) Y491H probably damaging Het
Acsbg2 C G 17: 57,154,710 (GRCm39) A481P probably damaging Het
Aknad1 T A 3: 108,688,501 (GRCm39) C610S probably benign Het
Ang4 G T 14: 52,001,860 (GRCm39) Y29* probably null Het
Aqp11 A T 7: 97,375,896 (GRCm39) I251N possibly damaging Het
Arid1a G T 4: 133,418,487 (GRCm39) T1032K unknown Het
Atg16l1 T C 1: 87,717,187 (GRCm39) V538A probably benign Het
Bbs1 C T 19: 4,956,042 (GRCm39) A44T probably damaging Het
Bpifa3 A C 2: 153,980,070 (GRCm39) H234P probably damaging Het
Btbd9 A T 17: 30,749,188 (GRCm39) V42E probably damaging Het
Carmil3 C G 14: 55,730,333 (GRCm39) S15R probably damaging Het
Casp8ap2 A G 4: 32,640,185 (GRCm39) D413G probably damaging Het
Cfap44 T A 16: 44,241,583 (GRCm39) F651L probably benign Het
Clcn3 A T 8: 61,386,104 (GRCm39) probably benign Het
Crip3 A G 17: 46,741,920 (GRCm39) K136E probably damaging Het
Ctr9 G A 7: 110,643,154 (GRCm39) A509T possibly damaging Het
D930020B18Rik T C 10: 121,525,726 (GRCm39) S367P probably damaging Het
Dst C T 1: 34,228,200 (GRCm39) P1606L probably damaging Het
Efcab7 A T 4: 99,758,834 (GRCm39) probably benign Het
Eif2ak4 A C 2: 118,293,202 (GRCm39) S1253R probably damaging Het
Emc1 A G 4: 139,098,320 (GRCm39) D767G probably damaging Het
Fads1 G A 19: 10,164,261 (GRCm39) probably benign Het
Fbxw26 T C 9: 109,547,079 (GRCm39) T449A probably benign Het
Frrs1 T C 3: 116,690,437 (GRCm39) F27L probably damaging Het
Fry T C 5: 150,374,563 (GRCm39) S2358P possibly damaging Het
Gas6 A C 8: 13,520,344 (GRCm39) L448R probably damaging Het
Hikeshi T C 7: 89,569,412 (GRCm39) probably benign Het
Ifngr1 C T 10: 19,485,197 (GRCm39) R399* probably null Het
Itga2 G A 13: 115,007,032 (GRCm39) S432L possibly damaging Het
Knl1 C T 2: 118,933,030 (GRCm39) T2063I possibly damaging Het
Lyzl6 A G 11: 103,527,697 (GRCm39) V9A probably benign Het
Macf1 A T 4: 123,382,107 (GRCm39) probably benign Het
Myo6 T C 9: 80,190,816 (GRCm39) V789A possibly damaging Het
Myo9b A T 8: 71,786,412 (GRCm39) R693W probably damaging Het
Nasp A G 4: 116,462,968 (GRCm39) probably benign Het
Nr1i3 T C 1: 171,044,900 (GRCm39) F247L probably damaging Het
Plekhs1 T G 19: 56,466,948 (GRCm39) S260A probably damaging Het
Rpl21-ps6 T C 17: 56,222,536 (GRCm39) noncoding transcript Het
Rtcb A T 10: 85,785,315 (GRCm39) probably benign Het
Sppl2a T A 2: 126,755,213 (GRCm39) probably null Het
Suco A T 1: 161,673,154 (GRCm39) probably null Het
Tnn T A 1: 159,932,498 (GRCm39) T1075S probably benign Het
Traf3 T A 12: 111,209,912 (GRCm39) C169* probably null Het
Ucp3 G T 7: 100,134,250 (GRCm39) V288L probably benign Het
Ulk3 C A 9: 57,497,639 (GRCm39) C4* probably null Het
Vmn1r73 A T 7: 11,490,997 (GRCm39) T272S probably benign Het
Vmn2r115 G A 17: 23,565,252 (GRCm39) E380K probably benign Het
Vmn2r3 T A 3: 64,182,787 (GRCm39) N304I probably damaging Het
Xylt1 G T 7: 117,233,928 (GRCm39) G485V probably damaging Het
Yars1 A G 4: 129,090,981 (GRCm39) T130A probably benign Het
Zfp652 A T 11: 95,644,295 (GRCm39) R205* probably null Het
Other mutations in Dhrs11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02217:Dhrs11 APN 11 84,713,221 (GRCm39) nonsense probably null
R1583:Dhrs11 UTSW 11 84,713,943 (GRCm39) missense probably damaging 1.00
R1985:Dhrs11 UTSW 11 84,719,633 (GRCm39) missense probably damaging 1.00
R2433:Dhrs11 UTSW 11 84,719,745 (GRCm39) unclassified probably benign
R3911:Dhrs11 UTSW 11 84,712,579 (GRCm39) missense probably damaging 1.00
R4510:Dhrs11 UTSW 11 84,716,342 (GRCm39) makesense probably null
R4511:Dhrs11 UTSW 11 84,716,342 (GRCm39) makesense probably null
R4798:Dhrs11 UTSW 11 84,719,626 (GRCm39) missense probably benign 0.03
R5936:Dhrs11 UTSW 11 84,716,350 (GRCm39) nonsense probably null
R6162:Dhrs11 UTSW 11 84,719,605 (GRCm39) missense probably damaging 1.00
R9591:Dhrs11 UTSW 11 84,719,584 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GAATGAGCTTCAGCAGAGAGATCCC -3'
(R):5'- CTGAGCAGAGTGACTGGTTTCCTG -3'

Sequencing Primer
(F):5'- TTCAGCAGAGAGATCCCTATCG -3'
(R):5'- GGAGGCTCATTCCTCATGC -3'
Posted On 2013-08-06