Incidental Mutation 'IGL00471:Morn1'
| ID |
6514 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Morn1
|
| Ensembl Gene |
ENSMUSG00000029049 |
| Gene Name |
MORN repeat containing 1 |
| Synonyms |
4930417P05Rik, 2900057D20Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00471
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
155171034-155229962 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 155176785 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamine
at position 140
(K140Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116690
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030915]
[ENSMUST00000127457]
[ENSMUST00000132367]
[ENSMUST00000155775]
|
| AlphaFold |
A2RTS7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000030915
AA Change: K140Q
PolyPhen 2
Score 0.779 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000030915
Gene: ENSMUSG00000029049
AA Change: K140Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MORN
|
23 |
35 |
1.4e-3 |
PFAM |
|
MORN
|
37 |
58 |
4.11e-6 |
SMART |
|
MORN
|
60 |
81 |
2.41e-1 |
SMART |
|
MORN
|
84 |
105 |
1.43e-1 |
SMART |
|
MORN
|
107 |
128 |
8.05e0 |
SMART |
|
MORN
|
130 |
151 |
2.06e-6 |
SMART |
|
MORN
|
153 |
174 |
7.56e-5 |
SMART |
|
MORN
|
176 |
197 |
1.2e0 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000127457
AA Change: K140Q
PolyPhen 2
Score 0.811 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000116690
Gene: ENSMUSG00000029049
AA Change: K140Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MORN
|
23 |
35 |
5.5e-4 |
PFAM |
|
MORN
|
37 |
58 |
4.11e-6 |
SMART |
|
MORN
|
60 |
81 |
2.41e-1 |
SMART |
|
MORN
|
84 |
105 |
1.43e-1 |
SMART |
|
MORN
|
107 |
128 |
8.05e0 |
SMART |
|
MORN
|
130 |
151 |
2.06e-6 |
SMART |
|
MORN
|
153 |
174 |
7.56e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129180
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000132367
AA Change: K140Q
PolyPhen 2
Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000116794
Gene: ENSMUSG00000029049
AA Change: K140Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MORN
|
23 |
35 |
6.8e-4 |
PFAM |
|
MORN
|
37 |
58 |
4.11e-6 |
SMART |
|
MORN
|
60 |
81 |
2.41e-1 |
SMART |
|
MORN
|
84 |
105 |
1.43e-1 |
SMART |
|
MORN
|
107 |
128 |
8.05e0 |
SMART |
|
MORN
|
130 |
151 |
2.06e-6 |
SMART |
|
MORN
|
153 |
174 |
7.56e-5 |
SMART |
|
MORN
|
176 |
197 |
1.2e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155375
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000155775
AA Change: K103Q
PolyPhen 2
Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000123207
Gene: ENSMUSG00000029049
AA Change: K103Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MORN
|
23 |
35 |
2.7e-4 |
PFAM |
|
MORN
|
37 |
58 |
4.11e-6 |
SMART |
|
MORN
|
60 |
81 |
2.41e-1 |
SMART |
|
MORN
|
93 |
114 |
2.06e-6 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrv1 |
A |
G |
13: 81,657,661 (GRCm39) |
V2793A |
probably damaging |
Het |
| Agbl2 |
A |
G |
2: 90,631,389 (GRCm39) |
Y249C |
probably damaging |
Het |
| Anks1 |
T |
C |
17: 28,277,390 (GRCm39) |
S1082P |
possibly damaging |
Het |
| Barhl2 |
C |
T |
5: 106,603,365 (GRCm39) |
A265T |
possibly damaging |
Het |
| C4b |
T |
G |
17: 34,953,403 (GRCm39) |
T1027P |
probably damaging |
Het |
| Clec4d |
A |
T |
6: 123,251,732 (GRCm39) |
I205F |
probably damaging |
Het |
| Cpeb2 |
A |
T |
5: 43,443,174 (GRCm39) |
Y955F |
probably damaging |
Het |
| Cst13 |
T |
A |
2: 148,672,224 (GRCm39) |
M133K |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,871,405 (GRCm39) |
L2418P |
probably damaging |
Het |
| Gli3 |
T |
C |
13: 15,898,354 (GRCm39) |
|
probably null |
Het |
| Hgfac |
C |
A |
5: 35,203,870 (GRCm39) |
H463N |
probably damaging |
Het |
| Hlx |
A |
T |
1: 184,463,792 (GRCm39) |
F183I |
probably damaging |
Het |
| Ighv1-5 |
T |
G |
12: 114,477,093 (GRCm39) |
I70L |
probably benign |
Het |
| Ltbp2 |
T |
C |
12: 84,837,838 (GRCm39) |
T1181A |
probably damaging |
Het |
| Nek1 |
A |
T |
8: 61,496,318 (GRCm39) |
M358L |
probably benign |
Het |
| Pcbd2 |
C |
T |
13: 55,924,413 (GRCm39) |
|
probably benign |
Het |
| Pramel7 |
A |
T |
2: 87,321,429 (GRCm39) |
L202Q |
probably damaging |
Het |
| Shq1 |
A |
G |
6: 100,641,444 (GRCm39) |
S146P |
probably benign |
Het |
| Slc25a21 |
T |
C |
12: 56,764,922 (GRCm39) |
|
probably null |
Het |
| Slc26a7 |
A |
T |
4: 14,548,403 (GRCm39) |
|
probably benign |
Het |
| Sspo |
G |
A |
6: 48,475,147 (GRCm39) |
|
probably benign |
Het |
| Stam2 |
T |
C |
2: 52,610,947 (GRCm39) |
D25G |
probably damaging |
Het |
| Tbx18 |
A |
T |
9: 87,587,676 (GRCm39) |
D480E |
possibly damaging |
Het |
| Tmem26 |
A |
T |
10: 68,614,511 (GRCm39) |
I309F |
possibly damaging |
Het |
| Ube2c |
A |
G |
2: 164,613,213 (GRCm39) |
T44A |
probably benign |
Het |
|
| Other mutations in Morn1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01143:Morn1
|
APN |
4 |
155,176,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02214:Morn1
|
APN |
4 |
155,176,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03112:Morn1
|
APN |
4 |
155,177,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0091:Morn1
|
UTSW |
4 |
155,229,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0573:Morn1
|
UTSW |
4 |
155,195,473 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0639:Morn1
|
UTSW |
4 |
155,173,960 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0918:Morn1
|
UTSW |
4 |
155,171,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2041:Morn1
|
UTSW |
4 |
155,175,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Morn1
|
UTSW |
4 |
155,176,770 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5831:Morn1
|
UTSW |
4 |
155,185,733 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6897:Morn1
|
UTSW |
4 |
155,171,112 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8178:Morn1
|
UTSW |
4 |
155,213,160 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8505:Morn1
|
UTSW |
4 |
155,177,792 (GRCm39) |
missense |
unknown |
|
|
| Posted On |
2012-04-20 |
Incidental Mutation