Incidental Mutation 'R0335:Cad'
| ID |
65209 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cad
|
| Ensembl Gene |
ENSMUSG00000013629 |
| Gene Name |
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| Synonyms |
2410008J01Rik |
| MMRRC Submission |
038544-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.968)
|
| Stock # |
R0335 (G1)
|
| Quality Score |
137 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
31212124-31235823 bp(+) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
G to A
at 31231329 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144679
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000013773]
[ENSMUST00000200953]
[ENSMUST00000201182]
[ENSMUST00000202795]
[ENSMUST00000202973]
|
| AlphaFold |
B2RQC6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000013773
|
| SMART Domains |
Protein: ENSMUSP00000013773
Gene: ENSMUSG00000013629
| Domain | Start | End | E-Value | Type |
|---|
|
CPSase_sm_chain
|
1 |
139 |
8.81e-80 |
SMART |
|
Pfam:GATase
|
179 |
356 |
4.7e-47 |
PFAM |
|
low complexity region
|
397 |
407 |
N/A |
INTRINSIC |
|
Pfam:ATP-grasp_4
|
511 |
692 |
1.2e-15 |
PFAM |
|
Pfam:CPSase_L_D2
|
514 |
718 |
1.8e-85 |
PFAM |
|
Pfam:ATP-grasp
|
522 |
690 |
1.5e-9 |
PFAM |
|
Pfam:Dala_Dala_lig_C
|
527 |
687 |
2.2e-10 |
PFAM |
|
CPSase_L_D3
|
798 |
921 |
9.7e-59 |
SMART |
|
Pfam:ATP-grasp_4
|
1044 |
1223 |
1.8e-23 |
PFAM |
|
Pfam:CPSase_L_D2
|
1047 |
1250 |
3.1e-28 |
PFAM |
|
Pfam:Dala_Dala_lig_C
|
1054 |
1242 |
2.3e-7 |
PFAM |
|
Pfam:ATP-grasp
|
1055 |
1222 |
2.1e-12 |
PFAM |
|
MGS
|
1327 |
1428 |
1.35e-7 |
SMART |
|
Pfam:Amidohydro_1
|
1462 |
1730 |
7.4e-12 |
PFAM |
|
low complexity region
|
1820 |
1839 |
N/A |
INTRINSIC |
|
low complexity region
|
1864 |
1880 |
N/A |
INTRINSIC |
|
Pfam:OTCace_N
|
1924 |
2065 |
1.9e-44 |
PFAM |
|
Pfam:OTCace
|
2071 |
2221 |
7.6e-37 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200917
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200953
|
| SMART Domains |
Protein: ENSMUSP00000144307
Gene: ENSMUSG00000013629
| Domain | Start | End | E-Value | Type |
|---|
|
CPSase_sm_chain
|
1 |
139 |
8.81e-80 |
SMART |
|
Pfam:GATase
|
179 |
356 |
4.5e-47 |
PFAM |
|
low complexity region
|
397 |
407 |
N/A |
INTRINSIC |
|
Pfam:CPSase_L_D2
|
514 |
616 |
1.5e-34 |
PFAM |
|
Pfam:Dala_Dala_lig_C
|
527 |
625 |
2.4e-7 |
PFAM |
|
Pfam:CPSase_L_D2
|
614 |
655 |
4.9e-15 |
PFAM |
|
CPSase_L_D3
|
735 |
858 |
9.7e-59 |
SMART |
|
Pfam:ATP-grasp_4
|
981 |
1160 |
1.7e-23 |
PFAM |
|
Pfam:CPSase_L_D2
|
984 |
1187 |
3e-28 |
PFAM |
|
Pfam:Dala_Dala_lig_C
|
991 |
1179 |
2.3e-7 |
PFAM |
|
Pfam:ATP-grasp
|
992 |
1159 |
2.1e-12 |
PFAM |
|
MGS
|
1264 |
1365 |
1.35e-7 |
SMART |
|
Pfam:Amidohydro_1
|
1399 |
1667 |
7.1e-12 |
PFAM |
|
low complexity region
|
1757 |
1776 |
N/A |
INTRINSIC |
|
low complexity region
|
1801 |
1817 |
N/A |
INTRINSIC |
|
Pfam:OTCace_N
|
1861 |
2002 |
1.8e-44 |
PFAM |
|
Pfam:OTCace
|
2008 |
2158 |
7.3e-37 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000201182
|
| SMART Domains |
Protein: ENSMUSP00000144684
Gene: ENSMUSG00000013629
| Domain | Start | End | E-Value | Type |
|---|
|
CPSase_sm_chain
|
1 |
139 |
8.81e-80 |
SMART |
|
Pfam:GATase
|
179 |
356 |
4.5e-47 |
PFAM |
|
low complexity region
|
397 |
407 |
N/A |
INTRINSIC |
|
Pfam:ATP-grasp_4
|
511 |
692 |
1.1e-15 |
PFAM |
|
Pfam:CPSase_L_D2
|
514 |
718 |
1.7e-85 |
PFAM |
|
Pfam:ATP-grasp
|
522 |
690 |
1.4e-9 |
PFAM |
|
Pfam:Dala_Dala_lig_C
|
527 |
687 |
2.1e-10 |
PFAM |
|
CPSase_L_D3
|
798 |
921 |
9.7e-59 |
SMART |
|
Pfam:ATP-grasp_4
|
1044 |
1223 |
1.7e-23 |
PFAM |
|
Pfam:CPSase_L_D2
|
1047 |
1250 |
3e-28 |
PFAM |
|
Pfam:Dala_Dala_lig_C
|
1054 |
1242 |
2.3e-7 |
PFAM |
|
Pfam:ATP-grasp
|
1055 |
1222 |
2.1e-12 |
PFAM |
|
MGS
|
1327 |
1428 |
1.35e-7 |
SMART |
|
Pfam:Amidohydro_1
|
1462 |
1730 |
7.1e-12 |
PFAM |
|
low complexity region
|
1820 |
1839 |
N/A |
INTRINSIC |
|
low complexity region
|
1864 |
1880 |
N/A |
INTRINSIC |
|
Pfam:OTCace_N
|
1949 |
1994 |
1.4e-11 |
PFAM |
|
Pfam:OTCace
|
2000 |
2150 |
7.3e-37 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201256
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201870
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202391
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000202795
|
| SMART Domains |
Protein: ENSMUSP00000144009
Gene: ENSMUSG00000013629
| Domain | Start | End | E-Value | Type |
|---|
|
CPSase_sm_chain
|
1 |
139 |
8.81e-80 |
SMART |
|
Pfam:GATase
|
179 |
356 |
1.9e-47 |
PFAM |
|
low complexity region
|
397 |
407 |
N/A |
INTRINSIC |
|
Pfam:ATP-grasp_4
|
511 |
692 |
5.9e-16 |
PFAM |
|
Pfam:CPSase_L_D2
|
514 |
718 |
1.2e-85 |
PFAM |
|
Pfam:ATP-grasp
|
522 |
690 |
7.3e-10 |
PFAM |
|
Pfam:Dala_Dala_lig_C
|
527 |
687 |
1.3e-10 |
PFAM |
|
CPSase_L_D3
|
798 |
921 |
9.7e-59 |
SMART |
|
Pfam:ATP-grasp_4
|
1044 |
1223 |
8.9e-24 |
PFAM |
|
Pfam:CPSase_L_D2
|
1047 |
1250 |
2.1e-28 |
PFAM |
|
Pfam:Dala_Dala_lig_C
|
1054 |
1242 |
1.3e-7 |
PFAM |
|
Pfam:ATP-grasp
|
1055 |
1222 |
1.1e-12 |
PFAM |
|
MGS
|
1327 |
1428 |
1.35e-7 |
SMART |
|
Pfam:Amidohydro_1
|
1462 |
1730 |
2.5e-11 |
PFAM |
|
low complexity region
|
1820 |
1839 |
N/A |
INTRINSIC |
|
low complexity region
|
1864 |
1880 |
N/A |
INTRINSIC |
|
Pfam:OTCace_N
|
1970 |
2004 |
4.6e-11 |
PFAM |
|
Pfam:OTCace
|
2010 |
2160 |
9.9e-37 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202827
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000202973
|
| SMART Domains |
Protein: ENSMUSP00000144679
Gene: ENSMUSG00000013629
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1gkra1
|
1 |
84 |
4e-28 |
SMART |
|
PDB:4C6N|A
|
1 |
119 |
4e-58 |
PDB |
|
low complexity region
|
156 |
170 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.6%
- 10x: 94.6%
- 20x: 87.5%
|
| Validation Efficiency |
100% (89/89) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts12 |
G |
T |
15: 11,311,144 (GRCm39) |
D1134Y |
possibly damaging |
Het |
| Add3 |
A |
G |
19: 53,225,259 (GRCm39) |
T460A |
probably benign |
Het |
| Amer3 |
A |
C |
1: 34,618,381 (GRCm39) |
|
probably benign |
Het |
| Arhgap22 |
C |
T |
14: 33,081,065 (GRCm39) |
|
probably benign |
Het |
| Arhgap32 |
T |
G |
9: 32,171,056 (GRCm39) |
S1279A |
probably benign |
Het |
| Bcas1 |
G |
A |
2: 170,260,601 (GRCm39) |
T26M |
probably damaging |
Het |
| Begain |
A |
T |
12: 109,004,860 (GRCm39) |
F256I |
probably damaging |
Het |
| Bltp1 |
T |
C |
3: 37,023,301 (GRCm39) |
V2210A |
probably damaging |
Het |
| Cabin1 |
A |
T |
10: 75,492,883 (GRCm39) |
I1804N |
probably damaging |
Het |
| Carmil1 |
G |
A |
13: 24,257,966 (GRCm39) |
S762L |
probably damaging |
Het |
| Ccdc93 |
T |
A |
1: 121,420,706 (GRCm39) |
L529Q |
probably damaging |
Het |
| Cdh12 |
T |
A |
15: 21,578,635 (GRCm39) |
|
probably null |
Het |
| Cep15 |
A |
G |
14: 12,301,266 (GRCm38) |
E124G |
possibly damaging |
Het |
| Clip2 |
T |
A |
5: 134,564,069 (GRCm39) |
|
probably benign |
Het |
| Cmip |
T |
C |
8: 118,172,105 (GRCm39) |
I480T |
probably damaging |
Het |
| Cnot1 |
A |
T |
8: 96,498,628 (GRCm39) |
I203K |
probably benign |
Het |
| Col18a1 |
G |
A |
10: 76,895,197 (GRCm39) |
P1155S |
probably damaging |
Het |
| Col1a2 |
T |
A |
6: 4,531,956 (GRCm39) |
|
probably benign |
Het |
| Crybg3 |
A |
T |
16: 59,364,503 (GRCm39) |
L2373Q |
probably damaging |
Het |
| D130043K22Rik |
A |
T |
13: 25,071,860 (GRCm39) |
I935F |
probably damaging |
Het |
| Dapl1 |
T |
A |
2: 59,326,938 (GRCm39) |
D61E |
possibly damaging |
Het |
| Def6 |
A |
G |
17: 28,447,043 (GRCm39) |
D558G |
possibly damaging |
Het |
| Dnah6 |
T |
C |
6: 73,046,382 (GRCm39) |
|
probably benign |
Het |
| Dvl2 |
G |
A |
11: 69,891,861 (GRCm39) |
|
probably benign |
Het |
| Ecd |
A |
C |
14: 20,370,802 (GRCm39) |
V639G |
probably benign |
Het |
| Epg5 |
C |
T |
18: 78,029,687 (GRCm39) |
T1350M |
probably benign |
Het |
| Erbb4 |
C |
A |
1: 68,298,418 (GRCm39) |
M657I |
probably benign |
Het |
| Evi5 |
T |
C |
5: 107,960,277 (GRCm39) |
R431G |
probably benign |
Het |
| Fbxo11 |
G |
A |
17: 88,323,041 (GRCm39) |
A115V |
possibly damaging |
Het |
| Fgfr2 |
T |
C |
7: 129,797,979 (GRCm39) |
T192A |
probably benign |
Het |
| Gas7 |
C |
T |
11: 67,552,878 (GRCm39) |
A146V |
possibly damaging |
Het |
| Gatad2b |
T |
A |
3: 90,263,489 (GRCm39) |
S529T |
probably benign |
Het |
| Gm10722 |
G |
T |
9: 3,001,048 (GRCm39) |
Q41H |
probably null |
Het |
| Gm10801 |
G |
C |
2: 98,494,352 (GRCm39) |
R143T |
possibly damaging |
Het |
| Gm7535 |
A |
G |
17: 18,131,374 (GRCm39) |
|
probably benign |
Het |
| Gstm1 |
T |
A |
3: 107,920,012 (GRCm39) |
N193I |
possibly damaging |
Het |
| Heatr5b |
G |
A |
17: 79,135,375 (GRCm39) |
P252L |
probably benign |
Het |
| Hmgb1 |
A |
G |
5: 148,987,441 (GRCm39) |
V36A |
probably benign |
Het |
| Hrh1 |
G |
T |
6: 114,457,193 (GRCm39) |
W158L |
probably damaging |
Het |
| Ighv6-4 |
T |
C |
12: 114,370,294 (GRCm39) |
M53V |
probably benign |
Het |
| Iqgap2 |
T |
A |
13: 95,772,141 (GRCm39) |
D1346V |
probably damaging |
Het |
| Kcng3 |
A |
T |
17: 83,895,166 (GRCm39) |
N433K |
possibly damaging |
Het |
| Kif1a |
T |
A |
1: 92,980,288 (GRCm39) |
|
probably benign |
Het |
| Lctl |
C |
A |
9: 64,026,169 (GRCm39) |
Q75K |
probably benign |
Het |
| Ldb3 |
T |
A |
14: 34,300,608 (GRCm39) |
I89F |
possibly damaging |
Het |
| Lrrc49 |
A |
T |
9: 60,584,378 (GRCm39) |
L156Q |
probably damaging |
Het |
| Mark2 |
G |
T |
19: 7,259,193 (GRCm39) |
T83K |
probably benign |
Het |
| Ms4a15 |
A |
T |
19: 10,957,574 (GRCm39) |
D170E |
probably damaging |
Het |
| Msantd2 |
A |
G |
9: 37,434,056 (GRCm39) |
S99G |
possibly damaging |
Het |
| Nemf |
G |
T |
12: 69,400,577 (GRCm39) |
T124N |
probably benign |
Het |
| Nlrp9c |
A |
T |
7: 26,093,561 (GRCm39) |
F35I |
possibly damaging |
Het |
| Nwd2 |
A |
G |
5: 63,962,116 (GRCm39) |
I567V |
probably benign |
Het |
| Optn |
C |
T |
2: 5,028,926 (GRCm39) |
G526R |
probably damaging |
Het |
| Or11l3 |
T |
C |
11: 58,516,566 (GRCm39) |
Y102C |
probably damaging |
Het |
| Or13p8 |
A |
G |
4: 118,584,367 (GRCm39) |
I308V |
probably null |
Het |
| Or5v1b |
A |
C |
17: 37,841,533 (GRCm39) |
I222L |
probably benign |
Het |
| Or7g16 |
T |
A |
9: 18,727,290 (GRCm39) |
Q100L |
probably damaging |
Het |
| Pdk4 |
T |
C |
6: 5,491,138 (GRCm39) |
E209G |
probably benign |
Het |
| Plch1 |
T |
C |
3: 63,618,399 (GRCm39) |
Q712R |
probably damaging |
Het |
| Pnpla1 |
T |
A |
17: 29,105,852 (GRCm39) |
V569E |
possibly damaging |
Het |
| Prkar2a |
A |
T |
9: 108,596,457 (GRCm39) |
D134V |
probably damaging |
Het |
| Ptov1 |
T |
A |
7: 44,514,046 (GRCm39) |
Q40L |
possibly damaging |
Het |
| Ptprq |
T |
C |
10: 107,544,589 (GRCm39) |
I314V |
probably benign |
Het |
| Rabl2 |
T |
C |
15: 89,468,169 (GRCm39) |
K66E |
probably damaging |
Het |
| Rnf38 |
A |
G |
4: 44,152,507 (GRCm39) |
V19A |
possibly damaging |
Het |
| Scn2a |
T |
A |
2: 65,512,435 (GRCm39) |
W191R |
probably damaging |
Het |
| Sec22b |
T |
A |
3: 97,828,572 (GRCm39) |
F212I |
possibly damaging |
Het |
| Sec24c |
T |
A |
14: 20,738,783 (GRCm39) |
|
probably null |
Het |
| Septin2 |
T |
C |
1: 93,423,321 (GRCm39) |
S51P |
probably damaging |
Het |
| Serpinb1a |
T |
C |
13: 33,032,639 (GRCm39) |
N90S |
probably damaging |
Het |
| Slc1a2 |
C |
T |
2: 102,574,208 (GRCm39) |
T206I |
probably benign |
Het |
| Slc25a19 |
C |
A |
11: 115,515,032 (GRCm39) |
R42L |
probably damaging |
Het |
| St14 |
G |
A |
9: 31,002,620 (GRCm39) |
|
probably benign |
Het |
| Stxbp1 |
C |
T |
2: 32,692,917 (GRCm39) |
|
probably benign |
Het |
| Tas2r131 |
C |
T |
6: 132,934,792 (GRCm39) |
V6I |
probably benign |
Het |
| Tdo2 |
T |
A |
3: 81,871,307 (GRCm39) |
M235L |
probably benign |
Het |
| Tenm3 |
T |
G |
8: 48,685,140 (GRCm39) |
H2432P |
probably damaging |
Het |
| Tmprss15 |
C |
T |
16: 78,821,630 (GRCm39) |
|
probably benign |
Het |
| Tmx1 |
A |
G |
12: 70,500,030 (GRCm39) |
N30D |
probably benign |
Het |
| Tom1 |
A |
G |
8: 75,791,020 (GRCm39) |
|
probably null |
Het |
| Top2a |
T |
C |
11: 98,913,781 (GRCm39) |
N20S |
probably benign |
Het |
| Ttc23l |
T |
A |
15: 10,540,049 (GRCm39) |
T145S |
probably benign |
Het |
| Unc13b |
T |
A |
4: 43,236,983 (GRCm39) |
M3351K |
possibly damaging |
Het |
| Vmn1r47 |
T |
C |
6: 89,999,641 (GRCm39) |
S258P |
probably damaging |
Het |
| Vmn2r8 |
T |
G |
5: 108,945,317 (GRCm39) |
|
probably null |
Het |
| Vps11 |
T |
C |
9: 44,265,135 (GRCm39) |
Q641R |
probably null |
Het |
| Wapl |
T |
A |
14: 34,414,281 (GRCm39) |
I381N |
probably damaging |
Het |
| Zmym6 |
G |
A |
4: 127,016,601 (GRCm39) |
G794E |
probably damaging |
Het |
|
| Other mutations in Cad |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00821:Cad
|
APN |
5 |
31,218,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00908:Cad
|
APN |
5 |
31,216,398 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01068:Cad
|
APN |
5 |
31,219,114 (GRCm39) |
splice site |
probably benign |
|
|
IGL01638:Cad
|
APN |
5 |
31,224,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02483:Cad
|
APN |
5 |
31,218,170 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02499:Cad
|
APN |
5 |
31,226,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02691:Cad
|
APN |
5 |
31,212,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03002:Cad
|
APN |
5 |
31,212,330 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4696001:Cad
|
UTSW |
5 |
31,229,438 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0212:Cad
|
UTSW |
5 |
31,235,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0317:Cad
|
UTSW |
5 |
31,229,665 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0401:Cad
|
UTSW |
5 |
31,231,330 (GRCm39) |
unclassified |
probably benign |
|
|
R0445:Cad
|
UTSW |
5 |
31,230,053 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0494:Cad
|
UTSW |
5 |
31,234,856 (GRCm39) |
unclassified |
probably benign |
|
|
R0532:Cad
|
UTSW |
5 |
31,219,531 (GRCm39) |
splice site |
probably benign |
|
|
R0539:Cad
|
UTSW |
5 |
31,232,801 (GRCm39) |
splice site |
probably benign |
|
|
R0578:Cad
|
UTSW |
5 |
31,216,120 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0590:Cad
|
UTSW |
5 |
31,219,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0638:Cad
|
UTSW |
5 |
31,235,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0831:Cad
|
UTSW |
5 |
31,224,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1329:Cad
|
UTSW |
5 |
31,216,926 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1513:Cad
|
UTSW |
5 |
31,226,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1531:Cad
|
UTSW |
5 |
31,233,563 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1763:Cad
|
UTSW |
5 |
31,218,295 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1785:Cad
|
UTSW |
5 |
31,215,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1786:Cad
|
UTSW |
5 |
31,215,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Cad
|
UTSW |
5 |
31,215,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2165:Cad
|
UTSW |
5 |
31,219,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3103:Cad
|
UTSW |
5 |
31,219,018 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3113:Cad
|
UTSW |
5 |
31,231,481 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R3762:Cad
|
UTSW |
5 |
31,232,890 (GRCm39) |
splice site |
probably null |
|
|
R3847:Cad
|
UTSW |
5 |
31,218,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Cad
|
UTSW |
5 |
31,231,366 (GRCm39) |
missense |
probably benign |
0.06 |
|
R3943:Cad
|
UTSW |
5 |
31,229,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4213:Cad
|
UTSW |
5 |
31,229,688 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4458:Cad
|
UTSW |
5 |
31,218,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4562:Cad
|
UTSW |
5 |
31,215,477 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4629:Cad
|
UTSW |
5 |
31,227,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4717:Cad
|
UTSW |
5 |
31,224,030 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4811:Cad
|
UTSW |
5 |
31,232,034 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5044:Cad
|
UTSW |
5 |
31,212,365 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5630:Cad
|
UTSW |
5 |
31,217,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5660:Cad
|
UTSW |
5 |
31,234,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6008:Cad
|
UTSW |
5 |
31,226,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6029:Cad
|
UTSW |
5 |
31,212,327 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6073:Cad
|
UTSW |
5 |
31,219,906 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6240:Cad
|
UTSW |
5 |
31,230,322 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6260:Cad
|
UTSW |
5 |
31,224,144 (GRCm39) |
missense |
probably null |
|
|
R7145:Cad
|
UTSW |
5 |
31,224,956 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7303:Cad
|
UTSW |
5 |
31,217,557 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7352:Cad
|
UTSW |
5 |
31,215,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7382:Cad
|
UTSW |
5 |
31,233,173 (GRCm39) |
missense |
probably benign |
|
|
R7387:Cad
|
UTSW |
5 |
31,219,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7455:Cad
|
UTSW |
5 |
31,231,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7596:Cad
|
UTSW |
5 |
31,226,392 (GRCm39) |
missense |
probably benign |
|
|
R7627:Cad
|
UTSW |
5 |
31,217,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7898:Cad
|
UTSW |
5 |
31,218,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8022:Cad
|
UTSW |
5 |
31,226,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8115:Cad
|
UTSW |
5 |
31,218,271 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8511:Cad
|
UTSW |
5 |
31,233,165 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8523:Cad
|
UTSW |
5 |
31,215,450 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8690:Cad
|
UTSW |
5 |
31,232,500 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8697:Cad
|
UTSW |
5 |
31,231,945 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8698:Cad
|
UTSW |
5 |
31,234,819 (GRCm39) |
missense |
probably benign |
|
|
R8699:Cad
|
UTSW |
5 |
31,233,605 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8803:Cad
|
UTSW |
5 |
31,226,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9262:Cad
|
UTSW |
5 |
31,225,009 (GRCm39) |
missense |
probably null |
|
|
R9272:Cad
|
UTSW |
5 |
31,218,576 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9287:Cad
|
UTSW |
5 |
31,230,000 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9314:Cad
|
UTSW |
5 |
31,234,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9609:Cad
|
UTSW |
5 |
31,228,018 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9665:Cad
|
UTSW |
5 |
31,229,703 (GRCm39) |
missense |
probably benign |
0.28 |
|
RF001:Cad
|
UTSW |
5 |
31,217,556 (GRCm39) |
critical splice donor site |
probably benign |
|
|
RF012:Cad
|
UTSW |
5 |
31,217,556 (GRCm39) |
critical splice donor site |
probably benign |
|
|
X0021:Cad
|
UTSW |
5 |
31,225,475 (GRCm39) |
missense |
probably null |
1.00 |
|
X0022:Cad
|
UTSW |
5 |
31,229,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Cad
|
UTSW |
5 |
31,232,472 (GRCm39) |
missense |
probably benign |
0.25 |
|
Z1177:Cad
|
UTSW |
5 |
31,225,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGTGCCCCAACTCAAGCTGTAGG -3'
(R):5'- CTGTCAAGGGTCAAGGGTCAAGTC -3'
Sequencing Primer
(F):5'- TCCTTAAGCACAGGGATTGAC -3'
(R):5'- CTACATAGGTGTCCTCCTGGAGAG -3'
|
| Posted On |
2013-08-08 |
Incidental Mutation