Incidental Mutation 'IGL00576:Zfp933'
| ID |
6527 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp933
|
| Ensembl Gene |
ENSMUSG00000059423 |
| Gene Name |
zinc finger protein 933 |
| Synonyms |
2810408P10Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
IGL00576
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
147907443-147932823 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 147910778 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 273
(C273S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101343
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105718]
[ENSMUST00000135798]
|
| AlphaFold |
Q6PEE4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105718
AA Change: C273S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101343
Gene: ENSMUSG00000059423
AA Change: C273S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
9.49e-16 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
4.79e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000116174
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135798
|
| SMART Domains |
Protein: ENSMUSP00000118300
Gene: ENSMUSG00000059423
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
34 |
8e-18 |
BLAST |
|
PDB:2I13|B
|
32 |
98 |
1e-12 |
PDB |
|
SCOP:d1fgja_
|
33 |
98 |
5e-13 |
SMART |
|
Blast:PHD
|
44 |
98 |
6e-11 |
BLAST |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ak8 |
T |
C |
2: 28,632,729 (GRCm39) |
L316P |
probably damaging |
Het |
| Ampd3 |
C |
T |
7: 110,388,028 (GRCm39) |
|
probably benign |
Het |
| Arhgap42 |
C |
A |
9: 8,997,621 (GRCm39) |
E835* |
probably null |
Het |
| Arid2 |
G |
A |
15: 96,254,639 (GRCm39) |
V162M |
probably damaging |
Het |
| Atp2a2 |
C |
T |
5: 122,596,146 (GRCm39) |
|
probably null |
Het |
| Bmper |
A |
G |
9: 23,317,899 (GRCm39) |
D506G |
probably damaging |
Het |
| Clca4b |
A |
G |
3: 144,631,108 (GRCm39) |
F251L |
probably damaging |
Het |
| Col12a1 |
T |
C |
9: 79,554,934 (GRCm39) |
D2048G |
probably damaging |
Het |
| Dnhd1 |
G |
A |
7: 105,341,882 (GRCm39) |
S1227N |
probably damaging |
Het |
| Dpp8 |
T |
A |
9: 64,951,111 (GRCm39) |
H182Q |
probably benign |
Het |
| Drosha |
A |
G |
15: 12,883,280 (GRCm39) |
K798E |
probably damaging |
Het |
| Gbp8 |
A |
G |
5: 105,165,754 (GRCm39) |
|
probably benign |
Het |
| Hectd1 |
A |
G |
12: 51,806,092 (GRCm39) |
I1843T |
probably damaging |
Het |
| Kansl1l |
T |
C |
1: 66,763,733 (GRCm39) |
N772S |
possibly damaging |
Het |
| Lrrc37 |
A |
G |
11: 103,508,212 (GRCm39) |
|
probably benign |
Het |
| Ndst2 |
T |
C |
14: 20,774,552 (GRCm39) |
R835G |
probably benign |
Het |
| Psme4 |
T |
C |
11: 30,773,145 (GRCm39) |
V836A |
possibly damaging |
Het |
| Ptpn21 |
G |
A |
12: 98,699,860 (GRCm39) |
S18F |
probably damaging |
Het |
| Reln |
T |
C |
5: 22,359,948 (GRCm39) |
H192R |
probably benign |
Het |
| Tcf20 |
A |
G |
15: 82,740,276 (GRCm39) |
F392L |
probably damaging |
Het |
| Ttc21a |
T |
C |
9: 119,794,885 (GRCm39) |
F1024L |
probably damaging |
Het |
| Vezf1 |
T |
A |
11: 87,964,470 (GRCm39) |
C19* |
probably null |
Het |
| Wdr47 |
A |
G |
3: 108,526,050 (GRCm39) |
N191S |
probably benign |
Het |
| Zfp7 |
T |
G |
15: 76,775,101 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Zfp933 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03377:Zfp933
|
APN |
4 |
147,913,168 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
F5770:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
FR4340:Zfp933
|
UTSW |
4 |
147,910,186 (GRCm39) |
frame shift |
probably null |
|
|
FR4548:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
frame shift |
probably null |
|
|
R0388:Zfp933
|
UTSW |
4 |
147,910,899 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0523:Zfp933
|
UTSW |
4 |
147,910,919 (GRCm39) |
nonsense |
probably null |
|
|
R0539:Zfp933
|
UTSW |
4 |
147,911,005 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1672:Zfp933
|
UTSW |
4 |
147,910,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4049:Zfp933
|
UTSW |
4 |
147,910,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4895:Zfp933
|
UTSW |
4 |
147,910,892 (GRCm39) |
nonsense |
probably null |
|
|
R5133:Zfp933
|
UTSW |
4 |
147,911,321 (GRCm39) |
missense |
probably benign |
|
|
R5786:Zfp933
|
UTSW |
4 |
147,912,864 (GRCm39) |
splice site |
probably null |
|
|
R5891:Zfp933
|
UTSW |
4 |
147,911,231 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6111:Zfp933
|
UTSW |
4 |
147,913,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6382:Zfp933
|
UTSW |
4 |
147,910,325 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6968:Zfp933
|
UTSW |
4 |
147,910,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Zfp933
|
UTSW |
4 |
147,910,636 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7555:Zfp933
|
UTSW |
4 |
147,910,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7902:Zfp933
|
UTSW |
4 |
147,911,058 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8319:Zfp933
|
UTSW |
4 |
147,912,910 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8688:Zfp933
|
UTSW |
4 |
147,911,249 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9019:Zfp933
|
UTSW |
4 |
147,911,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF024:Zfp933
|
UTSW |
4 |
147,910,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF028:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
frame shift |
probably null |
|
|
RF035:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
makesense |
probably null |
|
|
RF043:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
frame shift |
probably null |
|
|
V7581:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V7582:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V7583:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Posted On |
2012-04-20 |
Incidental Mutation