Mutagenetix > Incidental Mutation

Incidental Mutation 'R0240:Dpy19l2'

65855

Institutional Source

Beutler Lab

Gene Symbol

Dpy19l2

Ensembl Gene

ENSMUSG00000085576

Gene Name

dpy-19 like 2

Synonyms

4932443J21Rik

MMRRC Submission

038478-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R0240 (G1)

Quality Score

186

Status

Not validated

Chromosome

Chromosomal Location

24468343-24607589 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 24569876 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Aspartic acid at position 359 (A359D)

Ref Sequence

ENSEMBL: ENSMUSP00000132092 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000133010]

AlphaFold

P0CW70

Predicted Effect

probably damaging
Transcript: ENSMUST00000133010
AA Change: A359D

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000132092
Gene: ENSMUSG00000085576
AA Change: A359D

Domain	Start	End	E-Value	Type
Pfam:Dpy19	129	772	3.1e-233	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 98.7%
3x: 97.3%
10x: 91.2%
20x: 69.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male sterility associated with globozoospermia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 83 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsf3	T	C	8: 123,506,920 (GRCm39)	L71P	probably damaging	Het
Adamts2	A	T	11: 50,666,201 (GRCm39)	D399V	probably damaging	Het
Adck2	T	A	6: 39,560,752 (GRCm39)	V380E	probably benign	Het
Ankrd27	T	A	7: 35,318,864 (GRCm39)	L585Q	probably damaging	Het
Atp7a	T	A	X: 105,153,447 (GRCm39)	N1117K	probably damaging	Het
Cacna1d	T	A	14: 29,818,926 (GRCm39)	M1210L	probably benign	Het
Cotl1	C	T	8: 120,567,063 (GRCm39)	W26*	probably null	Het
Csmd3	T	C	15: 47,492,635 (GRCm39)	T3000A	probably benign	Het
Ddhd2	A	T	8: 26,229,617 (GRCm39)		probably null	Het
Dnah8	T	C	17: 30,984,653 (GRCm39)	I3117T	probably damaging	Het
Dnm3	G	T	1: 162,181,194 (GRCm39)	Q162K	probably benign	Het
Eif4g3	A	G	4: 137,897,873 (GRCm39)	K1025R	probably damaging	Het
Eml2	C	A	7: 18,918,797 (GRCm39)	Y82*	probably null	Het
Eml6	A	G	11: 29,742,367 (GRCm39)	V1057A	possibly damaging	Het
Espl1	T	C	15: 102,220,976 (GRCm39)	S911P	probably benign	Het
Flrt1	A	T	19: 7,074,475 (GRCm39)		probably benign	Het
G3bp1	G	A	11: 55,382,854 (GRCm39)	G139D	probably damaging	Het
Galc	A	T	12: 98,218,293 (GRCm39)	H186Q	probably damaging	Het
Ganab	A	G	19: 8,890,177 (GRCm39)	D702G	possibly damaging	Het
Hdac10	T	C	15: 89,010,085 (GRCm39)	E291G	possibly damaging	Het
Hectd3	T	G	4: 116,859,810 (GRCm39)	V749G	probably damaging	Het
Kcnh1	T	A	1: 192,187,648 (GRCm39)	I703N	probably benign	Het
Kcnma1	G	A	14: 23,544,647 (GRCm39)	T505I	probably damaging	Het
Kctd11	A	G	11: 69,770,640 (GRCm39)	C133R	probably damaging	Het
Lama3	A	T	18: 12,672,880 (GRCm39)		probably null	Het
Lamb3	T	C	1: 193,017,335 (GRCm39)	L842P	probably damaging	Het
Lipk	G	A	19: 34,024,210 (GRCm39)	R336H	probably benign	Het
Lrrc24	T	A	15: 76,607,409 (GRCm39)	D58V	probably damaging	Het
Milr1	G	A	11: 106,645,722 (GRCm39)	W88*	probably null	Het
Mmp10	A	G	9: 7,506,544 (GRCm39)	D340G	probably damaging	Het
Mybpc1	T	A	10: 88,391,600 (GRCm39)	Y285F	possibly damaging	Het
Ncoa3	A	G	2: 165,896,320 (GRCm39)	T408A	probably benign	Het
Nefm	T	A	14: 68,358,583 (GRCm39)	K484*	probably null	Het
Nfasc	A	G	1: 132,529,721 (GRCm39)	S814P	probably damaging	Het
Nlrp4a	T	C	7: 26,161,941 (GRCm39)	V863A	probably benign	Het
Nos1	C	T	5: 118,005,948 (GRCm39)	P223S	probably benign	Het
Or13c7	T	A	4: 43,854,512 (GRCm39)	S68T	probably damaging	Het
Or4c108	A	T	2: 88,803,740 (GRCm39)	L165Q	probably damaging	Het
Or5an6	A	T	19: 12,372,327 (GRCm39)	E233D	probably benign	Het
Or8k41	A	G	2: 86,313,730 (GRCm39)	S119P	possibly damaging	Het
Otog	C	A	7: 45,913,456 (GRCm39)		probably null	Het
Pacs1	A	T	19: 5,206,402 (GRCm39)	I261N	possibly damaging	Het
Pbx1	G	A	1: 168,031,051 (GRCm39)	T189I	possibly damaging	Het
Pcnx1	T	C	12: 81,993,792 (GRCm39)	I908T	possibly damaging	Het
Pdxdc1	A	T	16: 13,697,309 (GRCm39)	W124R	probably damaging	Het
Phex	C	A	X: 155,969,214 (GRCm39)	D587Y	probably damaging	Het
Plcb3	A	T	19: 6,940,363 (GRCm39)	D435E	probably benign	Het
Plce1	A	C	19: 38,717,330 (GRCm39)	K1373T	probably damaging	Het
Prkcd	G	A	14: 30,324,045 (GRCm39)	A311V	probably damaging	Het
Ptpn3	A	T	4: 57,232,374 (GRCm39)	S421T	probably benign	Het
Ptprs	T	C	17: 56,743,087 (GRCm39)		probably null	Het
Qrich1	A	G	9: 108,411,333 (GRCm39)	D286G	probably damaging	Het
Rcc1	C	A	4: 132,060,226 (GRCm39)	G393V	probably damaging	Het
Reln	T	C	5: 22,311,043 (GRCm39)	N290S	probably benign	Het
Rhpn1	C	T	15: 75,585,971 (GRCm39)	T628I	probably benign	Het
Rnf224	T	C	2: 25,126,219 (GRCm39)	T45A	probably damaging	Het
Rpa1	A	G	11: 75,219,513 (GRCm39)	V137A	probably benign	Het
Rps6ka1	C	A	4: 133,575,842 (GRCm39)	Q693H	probably benign	Het
Scn2a	G	T	2: 65,566,118 (GRCm39)	V1381F	probably benign	Het
Scp2	T	A	4: 107,955,275 (GRCm39)	H112L	probably benign	Het
Sdk1	T	C	5: 141,984,502 (GRCm39)	W696R	probably damaging	Het
Slc26a7	C	A	4: 14,532,651 (GRCm39)	V408F	probably damaging	Het
Slc28a2	T	A	2: 122,285,008 (GRCm39)	I332N	probably benign	Het
Slc45a4	T	A	15: 73,453,755 (GRCm39)	E674D	probably benign	Het
Smpd3	T	C	8: 106,991,788 (GRCm39)	E255G	probably damaging	Het
Snx29	C	T	16: 11,478,417 (GRCm39)	R658W	probably damaging	Het
Sppl2a	A	T	2: 126,762,256 (GRCm39)	M275K	probably benign	Het
Stac	T	C	9: 111,464,089 (GRCm39)	N59S	probably damaging	Het
Stk25	A	T	1: 93,554,782 (GRCm39)	L131Q	probably damaging	Het
Thbs1	C	A	2: 117,944,874 (GRCm39)	N229K	probably damaging	Het
Tmx2	A	T	2: 84,506,186 (GRCm39)	H89Q	probably damaging	Het
Trappc3l	A	T	10: 33,974,928 (GRCm39)	R119*	probably null	Het
Ublcp1	G	T	11: 44,349,104 (GRCm39)	Y243*	probably null	Het
Usp24	C	A	4: 106,271,601 (GRCm39)	C2158*	probably null	Het
Usp34	A	T	11: 23,383,206 (GRCm39)	K2088N	probably damaging	Het
Vmn1r53	G	C	6: 90,200,925 (GRCm39)	S133C	probably damaging	Het
Vmn2r52	A	G	7: 9,893,327 (GRCm39)	V604A	probably damaging	Het
Vmn2r93	A	G	17: 18,525,061 (GRCm39)	K240E	probably benign	Het
Wdr13	T	G	X: 7,994,284 (GRCm39)	D242A	probably damaging	Het
Wwp1	C	T	4: 19,641,734 (GRCm39)		probably null	Het
Zan	G	A	5: 137,396,624 (GRCm39)	H4311Y	unknown	Het
Zc3h12c	C	A	9: 52,055,383 (GRCm39)	R123L	possibly damaging	Het
Zfp318	C	T	17: 46,707,739 (GRCm39)	P266S	probably benign	Het

Other mutations in Dpy19l2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00954:Dpy19l2	APN	9	24,494,114 (GRCm39)	missense	probably damaging	1.00
IGL01137:Dpy19l2	APN	9	24,569,858 (GRCm39)	missense	possibly damaging	0.78
IGL01586:Dpy19l2	APN	9	24,578,271 (GRCm39)	missense	probably benign	0.16
IGL02245:Dpy19l2	APN	9	24,607,321 (GRCm39)	missense	probably benign
IGL02507:Dpy19l2	APN	9	24,542,563 (GRCm39)	missense	probably benign	0.01
IGL02541:Dpy19l2	APN	9	24,569,943 (GRCm39)	missense	probably benign	0.00
IGL02644:Dpy19l2	APN	9	24,569,888 (GRCm39)	missense	probably damaging	1.00
IGL03144:Dpy19l2	APN	9	24,557,603 (GRCm39)	missense	possibly damaging	0.92
Deferential	UTSW	9	24,607,110 (GRCm39)	missense	probably benign	0.41
polite	UTSW	9	24,572,039 (GRCm39)	missense	possibly damaging	0.91
BB004:Dpy19l2	UTSW	9	24,607,197 (GRCm39)	missense	probably benign	0.00
BB014:Dpy19l2	UTSW	9	24,607,197 (GRCm39)	missense	probably benign	0.00
R0022:Dpy19l2	UTSW	9	24,607,420 (GRCm39)	missense	probably benign
R0029:Dpy19l2	UTSW	9	24,469,397 (GRCm39)	missense	probably damaging	0.97
R0066:Dpy19l2	UTSW	9	24,557,679 (GRCm39)	splice site	probably benign
R0066:Dpy19l2	UTSW	9	24,557,679 (GRCm39)	splice site	probably benign
R0089:Dpy19l2	UTSW	9	24,607,089 (GRCm39)	missense	probably benign	0.01
R0240:Dpy19l2	UTSW	9	24,569,876 (GRCm39)	missense	probably damaging	1.00
R0349:Dpy19l2	UTSW	9	24,607,218 (GRCm39)	missense	possibly damaging	0.89
R0491:Dpy19l2	UTSW	9	24,607,324 (GRCm39)	missense	probably benign	0.09
R0519:Dpy19l2	UTSW	9	24,469,391 (GRCm39)	missense	probably benign	0.30
R1398:Dpy19l2	UTSW	9	24,492,559 (GRCm39)	splice site	probably benign
R1465:Dpy19l2	UTSW	9	24,580,618 (GRCm39)	missense	probably benign	0.04
R1465:Dpy19l2	UTSW	9	24,580,618 (GRCm39)	missense	probably benign	0.04
R1576:Dpy19l2	UTSW	9	24,495,798 (GRCm39)	missense	probably benign
R1606:Dpy19l2	UTSW	9	24,492,511 (GRCm39)	missense	probably benign
R2157:Dpy19l2	UTSW	9	24,592,076 (GRCm39)	missense	probably benign	0.02
R2157:Dpy19l2	UTSW	9	24,495,928 (GRCm39)	missense	probably benign	0.00
R2402:Dpy19l2	UTSW	9	24,492,544 (GRCm39)	missense	probably damaging	1.00
R2409:Dpy19l2	UTSW	9	24,569,924 (GRCm39)	missense	probably benign	0.00
R3196:Dpy19l2	UTSW	9	24,607,285 (GRCm39)	missense	probably damaging	1.00
R3419:Dpy19l2	UTSW	9	24,492,501 (GRCm39)	missense	probably damaging	1.00
R4884:Dpy19l2	UTSW	9	24,539,476 (GRCm39)	nonsense	probably null
R5289:Dpy19l2	UTSW	9	24,607,293 (GRCm39)	missense	probably benign
R5950:Dpy19l2	UTSW	9	24,492,430 (GRCm39)	missense	probably benign	0.10
R6470:Dpy19l2	UTSW	9	24,572,039 (GRCm39)	missense	possibly damaging	0.91
R7028:Dpy19l2	UTSW	9	24,539,547 (GRCm39)	missense	probably benign	0.15
R7051:Dpy19l2	UTSW	9	24,495,789 (GRCm39)	missense	probably benign	0.00
R7095:Dpy19l2	UTSW	9	24,607,110 (GRCm39)	missense	probably benign	0.41
R7649:Dpy19l2	UTSW	9	24,607,459 (GRCm39)	start codon destroyed	probably null	0.53
R7927:Dpy19l2	UTSW	9	24,607,197 (GRCm39)	missense	probably benign	0.00
R7936:Dpy19l2	UTSW	9	24,469,454 (GRCm39)	missense	probably damaging	1.00
R8076:Dpy19l2	UTSW	9	24,591,988 (GRCm39)	missense	probably damaging	1.00
R8259:Dpy19l2	UTSW	9	24,580,702 (GRCm39)	missense	probably benign	0.08
R8473:Dpy19l2	UTSW	9	24,492,526 (GRCm39)	missense	probably benign
R9493:Dpy19l2	UTSW	9	24,530,459 (GRCm39)	missense	probably damaging	1.00
X0067:Dpy19l2	UTSW	9	24,496,833 (GRCm39)	missense	probably benign	0.00
Z1088:Dpy19l2	UTSW	9	24,572,120 (GRCm39)	splice site	probably null
Z1177:Dpy19l2	UTSW	9	24,557,655 (GRCm39)	missense	probably benign	0.13

Predicted Primers

Posted On

2013-08-19