Incidental Mutation 'R0241:Or4p21'
ID 66168
Institutional Source Beutler Lab
Gene Symbol Or4p21
Ensembl Gene ENSMUSG00000075124
Gene Name olfactory receptor family 4 subfamily P member 21
Synonyms Gm13757, MOR225-16_p, MOR225-7P, GA_x6K02T2Q125-49934557-49933640, Olfr1182, MOR225-8P, MOR225-8P, Olfr1536-ps1
MMRRC Submission 038479-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R0241 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 88276363-88279465 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88276889 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 131 (M131K)
Ref Sequence ENSEMBL: ENSMUSP00000136580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102619] [ENSMUST00000126038] [ENSMUST00000179450]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000102619
AA Change: M131K

PolyPhen 2 Score 0.476 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000099679
Gene: ENSMUSG00000075125
AA Change: M131K

DomainStartEndE-ValueType
low complexity region 24 34 N/A INTRINSIC
Pfam:7tm_1 39 285 7.2e-26 PFAM
Pfam:7tm_4 137 278 3.5e-39 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000126038
AA Change: M131K

PolyPhen 2 Score 0.476 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000179450
AA Change: M131K

PolyPhen 2 Score 0.476 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000136580
Gene: ENSMUSG00000090097
AA Change: M131K

DomainStartEndE-ValueType
Pfam:7tm_4 26 303 1.4e-49 PFAM
Pfam:7tm_1 39 285 1.5e-13 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.6%
  • 3x: 97.1%
  • 10x: 89.8%
  • 20x: 65.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck2 T A 6: 39,560,752 (GRCm39) V380E probably benign Het
Anapc1 A T 2: 128,470,549 (GRCm39) M1527K possibly damaging Het
Bicra A T 7: 15,709,070 (GRCm39) M1188K probably damaging Het
Brd7 G A 8: 89,072,478 (GRCm39) R331W probably benign Het
Cactin A G 10: 81,158,486 (GRCm39) T151A probably benign Het
Cadps G A 14: 12,376,675 (GRCm38) T1274M probably damaging Het
Catsper3 T C 13: 55,952,667 (GRCm39) M175T probably damaging Het
Chd5 A G 4: 152,450,589 (GRCm39) D605G probably damaging Het
Chst12 G A 5: 140,510,054 (GRCm39) R227H possibly damaging Het
Cobl A T 11: 12,204,524 (GRCm39) V644E probably benign Het
Ddx31 A G 2: 28,738,303 (GRCm39) T155A probably damaging Het
Dnah3 T C 7: 119,521,953 (GRCm39) Q4069R probably damaging Het
Dnah8 T C 17: 30,984,653 (GRCm39) I3117T probably damaging Het
Doc2b A G 11: 75,663,387 (GRCm39) V355A probably damaging Het
Dock10 A T 1: 80,556,340 (GRCm39) S578T probably benign Het
Fcer2a A G 8: 3,738,796 (GRCm39) probably null Het
Fmnl1 G A 11: 103,072,996 (GRCm39) probably null Het
Git2 T C 5: 114,871,290 (GRCm39) E208G probably damaging Het
Hs6st3 T C 14: 119,376,232 (GRCm39) F136L probably benign Het
Hydin G A 8: 111,124,655 (GRCm39) V555I probably benign Het
Kmt2b A G 7: 30,276,494 (GRCm39) L1726S probably damaging Het
Loxl3 A G 6: 83,027,114 (GRCm39) D615G probably damaging Het
Nfasc C A 1: 132,564,731 (GRCm39) A70S probably benign Het
Or4d1 T A 11: 87,804,860 (GRCm39) N291Y probably damaging Het
Or52n4 A G 7: 104,294,450 (GRCm39) M41T probably benign Het
Or5g29 A G 2: 85,421,154 (GRCm39) K90R probably benign Het
Pde7b A G 10: 20,311,962 (GRCm39) C239R probably damaging Het
Pdzd2 A T 15: 12,368,027 (GRCm39) L2654Q probably damaging Het
Pgap1 T C 1: 54,575,110 (GRCm39) probably null Het
Proz T A 8: 13,115,356 (GRCm39) M124K probably benign Het
Raet1d A G 10: 22,247,328 (GRCm39) T135A probably benign Het
Rapgef1 A G 2: 29,592,682 (GRCm39) N558S possibly damaging Het
Sfi1 CCTCTC CCTCTCTC 11: 3,127,419 (GRCm39) probably benign Het
Simc1 G T 13: 54,698,338 (GRCm39) L1319F probably damaging Het
Sspo A G 6: 48,438,429 (GRCm39) E1499G possibly damaging Het
Tas2r118 T C 6: 23,969,338 (GRCm39) Y241C probably damaging Het
Tbck A G 3: 132,430,636 (GRCm39) E344G probably benign Het
Tcam1 G A 11: 106,174,904 (GRCm39) E120K probably benign Het
Tmbim7 A T 5: 3,716,866 (GRCm39) Y66F probably benign Het
Vil1 T C 1: 74,465,853 (GRCm39) L548P probably damaging Het
Wdr3 A G 3: 100,052,973 (GRCm39) V593A probably damaging Het
Zan T C 5: 137,420,084 (GRCm39) T2858A unknown Het
Zbtb37 A T 1: 160,847,939 (GRCm39) V356E probably benign Het
Zfp36 C T 7: 28,077,759 (GRCm39) V50I probably damaging Het
Zfp563 A T 17: 33,323,659 (GRCm39) S85C possibly damaging Het
Other mutations in Or4p21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00984:Or4p21 APN 2 88,276,539 (GRCm39) missense probably damaging 1.00
IGL01986:Or4p21 APN 2 88,276,839 (GRCm39) missense probably benign 0.00
IGL02416:Or4p21 APN 2 88,277,174 (GRCm39) missense probably benign 0.38
IGL03018:Or4p21 APN 2 88,277,163 (GRCm39) missense probably damaging 1.00
R0241:Or4p21 UTSW 2 88,276,889 (GRCm39) missense possibly damaging 0.48
R0627:Or4p21 UTSW 2 88,276,563 (GRCm39) missense probably damaging 1.00
R0634:Or4p21 UTSW 2 88,276,961 (GRCm39) missense probably benign 0.10
R1305:Or4p21 UTSW 2 88,276,646 (GRCm39) nonsense probably null
R1353:Or4p21 UTSW 2 88,276,895 (GRCm39) missense probably benign 0.42
R1765:Or4p21 UTSW 2 88,276,367 (GRCm39) missense probably damaging 1.00
R1974:Or4p21 UTSW 2 88,276,853 (GRCm39) missense probably damaging 0.97
R1990:Or4p21 UTSW 2 88,277,033 (GRCm39) missense probably damaging 1.00
R2196:Or4p21 UTSW 2 88,277,054 (GRCm39) missense probably benign 0.10
R2974:Or4p21 UTSW 2 88,276,918 (GRCm39) nonsense probably null
R4794:Or4p21 UTSW 2 88,276,691 (GRCm39) missense probably benign 0.12
R5495:Or4p21 UTSW 2 88,276,401 (GRCm39) missense probably benign 0.03
R5771:Or4p21 UTSW 2 88,276,652 (GRCm39) missense possibly damaging 0.94
R6654:Or4p21 UTSW 2 88,277,016 (GRCm39) missense possibly damaging 0.80
R6756:Or4p21 UTSW 2 88,277,078 (GRCm39) missense possibly damaging 0.78
R8070:Or4p21 UTSW 2 88,277,003 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2013-08-19