Mutagenetix > Incidental Mutation

Incidental Mutation 'R0211:Zfp872'

66410

Institutional Source

Beutler Lab

Gene Symbol

Zfp872

Ensembl Gene

ENSMUSG00000074472

Gene Name

zinc finger protein 872

Synonyms

9530015I07Rik

MMRRC Submission

038462-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

R0211 (G1)

Quality Score

113

Status

Not validated

Chromosome

Chromosomal Location

22099462-22113419 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 22111469 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 316 (I316N)

Ref Sequence

ENSEMBL: ENSMUSP00000136074 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091508] [ENSMUST00000178901] [ENSMUST00000217301]

AlphaFold

Q3UVL3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000091508
AA Change: I315N

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000089089
Gene: ENSMUSG00000074472
AA Change: I315N

Domain	Start	End	E-Value	Type
KRAB	3	74	6.16e-15	SMART
ZnF_C2H2	99	121	1.64e-1	SMART
ZnF_C2H2	137	159	3.63e-3	SMART
ZnF_C2H2	165	187	5.14e-3	SMART
ZnF_C2H2	193	215	1.58e-3	SMART
ZnF_C2H2	221	243	2.75e-3	SMART
ZnF_C2H2	249	271	4.47e-3	SMART
ZnF_C2H2	277	299	2.57e-3	SMART
ZnF_C2H2	305	327	2.75e-3	SMART
ZnF_C2H2	333	355	3.58e-2	SMART
ZnF_C2H2	361	383	4.05e-1	SMART
ZnF_C2H2	389	411	2.43e-4	SMART
ZnF_C2H2	417	439	1.26e-2	SMART
ZnF_C2H2	445	463	1.27e2	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000178901
AA Change: I316N

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000136074
Gene: ENSMUSG00000074472
AA Change: I316N

Domain	Start	End	E-Value	Type
KRAB	4	75	6.16e-15	SMART
ZnF_C2H2	100	122	1.64e-1	SMART
ZnF_C2H2	138	160	3.63e-3	SMART
ZnF_C2H2	166	188	5.14e-3	SMART
ZnF_C2H2	194	216	1.58e-3	SMART
ZnF_C2H2	222	244	2.75e-3	SMART
ZnF_C2H2	250	272	4.47e-3	SMART
ZnF_C2H2	278	300	2.57e-3	SMART
ZnF_C2H2	306	328	2.75e-3	SMART
ZnF_C2H2	334	356	3.58e-2	SMART
ZnF_C2H2	362	384	4.05e-1	SMART
ZnF_C2H2	390	412	2.43e-4	SMART
ZnF_C2H2	418	440	1.26e-2	SMART
ZnF_C2H2	446	464	1.27e2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000187399

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217297

Predicted Effect

probably benign
Transcript: ENSMUST00000217301

Coding Region Coverage

1x: 96.9%
3x: 92.1%
10x: 58.4%
20x: 15.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	T	C	12: 71,262,870 (GRCm39)	L1401P	possibly damaging	Het
Adgrf1	T	C	17: 43,607,581 (GRCm39)	L100P	probably damaging	Het
Akt1	T	C	12: 112,621,576 (GRCm39)	T407A	probably damaging	Het
Arnt	T	A	3: 95,383,460 (GRCm39)	M242K	probably damaging	Het
Atad5	T	G	11: 79,986,473 (GRCm39)	V520G	probably benign	Het
Cbr2	T	A	11: 120,621,614 (GRCm39)	I88L	probably benign	Het
Ccdc51	T	C	9: 108,918,441 (GRCm39)	M10T	probably benign	Het
Cryba1	T	A	11: 77,609,693 (GRCm39)	Y179F	probably damaging	Het
Dcaf4	T	A	12: 83,582,735 (GRCm39)	F277I	probably damaging	Het
Ddost	G	A	4: 138,036,913 (GRCm39)	V159M	probably damaging	Het
Dnase2a	A	G	8: 85,635,417 (GRCm39)		probably benign	Het
Efcc1	A	T	6: 87,726,136 (GRCm39)	T312S	probably benign	Het
Ermard	A	T	17: 15,242,205 (GRCm39)	Q127L	probably damaging	Het
Ggnbp2	G	A	11: 84,731,139 (GRCm39)	T325M	probably damaging	Het
H2-T5	T	C	17: 36,478,899 (GRCm39)	T117A	probably damaging	Het
Ift74	C	T	4: 94,567,492 (GRCm39)	T395I	probably benign	Het
Irf8	A	T	8: 121,466,714 (GRCm39)	D53V	probably damaging	Het
Itgad	A	G	7: 127,803,813 (GRCm39)	Y69C	probably damaging	Het
Lpin3	A	T	2: 160,740,601 (GRCm39)	D382V	probably damaging	Het
Map4k3	C	T	17: 80,952,270 (GRCm39)	A179T	probably damaging	Het
Nck1	A	T	9: 100,379,820 (GRCm39)	W144R	probably damaging	Het
Nin	T	G	12: 70,061,649 (GRCm39)	T2072P	probably damaging	Het
Nop2	T	G	6: 125,118,307 (GRCm39)	L529R	probably damaging	Het
Nynrin	T	C	14: 56,109,255 (GRCm39)	F1454S	probably benign	Het
Or10ak7	T	A	4: 118,791,467 (GRCm39)	M191L	probably benign	Het
Or5b101	T	C	19: 13,005,646 (GRCm39)	T16A	possibly damaging	Het
Or8j3c	A	C	2: 86,253,451 (GRCm39)	S190A	probably damaging	Het
Pcdhb10	A	T	18: 37,547,059 (GRCm39)	M712L	probably benign	Het
Pcx	C	T	19: 4,670,227 (GRCm39)	A935V	probably damaging	Het
Pdzd7	A	G	19: 45,022,106 (GRCm39)	V514A	possibly damaging	Het
Plxnb1	T	A	9: 108,932,731 (GRCm39)	Y568*	probably null	Het
Rgr	T	G	14: 36,768,925 (GRCm39)	T37P	probably damaging	Het
Rpusd2	A	G	2: 118,868,893 (GRCm39)	S439G	probably benign	Het
Slc6a21	A	C	7: 44,937,667 (GRCm39)	T653P	possibly damaging	Het
Spdef	C	T	17: 27,933,894 (GRCm39)	R309H	probably damaging	Het
Srp68	A	T	11: 116,156,377 (GRCm39)	Y84N	probably damaging	Het
Tmem63b	T	A	17: 45,972,839 (GRCm39)	M652L	probably benign	Het
Tnk1	A	G	11: 69,746,007 (GRCm39)	V306A	probably damaging	Het
Tnnc2	T	A	2: 164,619,404 (GRCm39)	I147F	probably damaging	Het
Tyw3	T	C	3: 154,293,132 (GRCm39)	N181S	probably damaging	Het
Unc79	T	A	12: 103,039,051 (GRCm39)	S682T	probably benign	Het
Wasl	G	T	6: 24,633,892 (GRCm39)	A124E	probably damaging	Het
Zfp287	T	C	11: 62,605,743 (GRCm39)	H388R	probably damaging	Het
Zfp335	T	C	2: 164,749,612 (GRCm39)	T262A	probably damaging	Het
Zfp457	C	G	13: 67,441,211 (GRCm39)	G359R	probably benign	Het

Other mutations in Zfp872

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0211:Zfp872	UTSW	9	22,111,469 (GRCm39)	missense	probably damaging	0.98
R1162:Zfp872	UTSW	9	22,110,910 (GRCm39)	missense	possibly damaging	0.84
R1793:Zfp872	UTSW	9	22,111,349 (GRCm39)	missense	probably damaging	1.00
R3432:Zfp872	UTSW	9	22,111,750 (GRCm39)	nonsense	probably null
R4633:Zfp872	UTSW	9	22,108,490 (GRCm39)	critical splice donor site	probably null
R4647:Zfp872	UTSW	9	22,111,057 (GRCm39)	missense	possibly damaging	0.80
R4675:Zfp872	UTSW	9	22,108,701 (GRCm39)	missense	probably damaging	0.99
R6189:Zfp872	UTSW	9	22,108,427 (GRCm39)	missense	probably benign	0.01
R6240:Zfp872	UTSW	9	22,111,180 (GRCm39)	missense	probably damaging	1.00
R6852:Zfp872	UTSW	9	22,111,355 (GRCm39)	missense	probably damaging	1.00
R7001:Zfp872	UTSW	9	22,111,912 (GRCm39)	missense	probably damaging	1.00
R7036:Zfp872	UTSW	9	22,111,856 (GRCm39)	missense	probably benign	0.08
R7834:Zfp872	UTSW	9	22,111,406 (GRCm39)	missense	probably damaging	0.97
R8364:Zfp872	UTSW	9	22,111,540 (GRCm39)	missense	probably damaging	1.00
R8385:Zfp872	UTSW	9	22,111,407 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

Posted On

2013-08-19