Mutagenetix > Incidental Mutation

Incidental Mutation 'R0414:Myadm'

66507

Institutional Source

Beutler Lab

Gene Symbol

Myadm

Ensembl Gene

ENSMUSG00000068566

Gene Name

myeloid-associated differentiation marker

Synonyms

D7Wsu62e

MMRRC Submission

038616-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

R0414 (G1)

Quality Score

217

Status

Validated

Chromosome

Chromosomal Location

3337563-3347871 bp(+) (GRCm39)

Type of Mutation

frame shift

DNA Base Change (assembly)

AC to ACC at 3345276 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145426 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000096744] [ENSMUST00000164553] [ENSMUST00000203328] [ENSMUST00000203566] [ENSMUST00000204541]

AlphaFold

O35682

Predicted Effect

probably null
Transcript: ENSMUST00000096744

SMART Domains

Protein: ENSMUSP00000094505
Gene: ENSMUSG00000068566

Domain	Start	End	E-Value	Type
low complexity region	3	20	N/A	INTRINSIC
Pfam:MARVEL	25	151	7.2e-16	PFAM
Pfam:MARVEL	162	311	1.6e-19	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000164553

SMART Domains

Protein: ENSMUSP00000131318
Gene: ENSMUSG00000068566

Domain	Start	End	E-Value	Type
low complexity region	3	20	N/A	INTRINSIC
Pfam:MARVEL	25	151	5.6e-16	PFAM
Pfam:MARVEL	162	311	1.3e-19	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000203328

SMART Domains

Protein: ENSMUSP00000144984
Gene: ENSMUSG00000068566

Domain	Start	End	E-Value	Type
low complexity region	3	20	N/A	INTRINSIC
Pfam:MARVEL	25	151	5.6e-16	PFAM
Pfam:MARVEL	162	311	1.3e-19	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000203566

SMART Domains

Protein: ENSMUSP00000145120
Gene: ENSMUSG00000068566

Domain	Start	End	E-Value	Type
low complexity region	3	20	N/A	INTRINSIC
Pfam:MARVEL	25	151	5.6e-16	PFAM
Pfam:MARVEL	162	311	1.3e-19	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203600

Predicted Effect

probably null
Transcript: ENSMUST00000204541

SMART Domains

Protein: ENSMUSP00000145426
Gene: ENSMUSG00000068566

Domain	Start	End	E-Value	Type
low complexity region	3	20	N/A	INTRINSIC
Pfam:MARVEL	25	81	4.3e-9	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.6%
20x: 93.6%

Validation Efficiency

96% (64/67)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700016H13Rik	A	T	5: 103,797,356 (GRCm39)	V51E	probably benign	Het
Abo	T	C	2: 26,733,428 (GRCm39)	Y259C	probably damaging	Het
Adamts5	A	G	16: 85,674,794 (GRCm39)	S457P	probably damaging	Het
Alk	G	T	17: 72,206,281 (GRCm39)		probably benign	Het
Alpk2	A	G	18: 65,439,230 (GRCm39)	I1188T	probably benign	Het
Ambra1	T	C	2: 91,706,084 (GRCm39)	S730P	possibly damaging	Het
Arhgef2	T	C	3: 88,539,575 (GRCm39)		probably benign	Het
Atpsckmt	T	A	15: 31,617,148 (GRCm39)	Y126*	probably null	Het
B3gnt7	T	C	1: 86,233,351 (GRCm39)	I82T	probably damaging	Het
B4galnt3	T	C	6: 120,193,526 (GRCm39)	D400G	probably benign	Het
Bag4	A	G	8: 26,258,025 (GRCm39)	V434A	possibly damaging	Het
Cfap251	A	G	5: 123,425,476 (GRCm39)		probably null	Het
Cfc1	A	G	1: 34,576,409 (GRCm39)	D130G	probably damaging	Het
Chd4	T	C	6: 125,084,443 (GRCm39)	Y692H	probably damaging	Het
Cilp2	A	G	8: 70,335,643 (GRCm39)	S452P	probably benign	Het
Clec2m	T	C	6: 129,303,813 (GRCm39)		probably benign	Het
Crybg2	GAGAAGAAG	GAGAAG	4: 133,799,947 (GRCm39)		probably benign	Het
Dnah2	T	C	11: 69,390,064 (GRCm39)	D727G	probably benign	Het
Dock10	C	A	1: 80,513,650 (GRCm39)	V1129F	possibly damaging	Het
Dsc1	A	T	18: 20,221,411 (GRCm39)	I688N	possibly damaging	Het
Dyrk1a	C	G	16: 94,464,701 (GRCm39)	T103R	probably damaging	Het
Ebf1	C	T	11: 44,815,297 (GRCm39)	R304*	probably null	Het
Eif2s2	A	G	2: 154,726,381 (GRCm39)		probably benign	Het
Endov	T	G	11: 119,390,397 (GRCm39)	Y8*	probably null	Het
Eps15	T	A	4: 109,223,677 (GRCm39)	D485E	probably damaging	Het
Fam118a	C	A	15: 84,929,890 (GRCm39)	S39R	probably damaging	Het
Fbxo22	T	A	9: 55,130,910 (GRCm39)	M393K	possibly damaging	Het
Firrm	T	C	1: 163,795,890 (GRCm39)	I434V	probably benign	Het
Gab1	A	G	8: 81,526,918 (GRCm39)	I60T	probably damaging	Het
Gapvd1	A	G	2: 34,583,439 (GRCm39)	L1059P	probably benign	Het
Gbp5	A	G	3: 142,213,674 (GRCm39)		probably null	Het
Glb1l2	T	A	9: 26,676,400 (GRCm39)	K487*	probably null	Het
H1f1	A	G	13: 23,948,141 (GRCm39)		probably benign	Het
Hmcn1	T	C	1: 150,591,573 (GRCm39)	I1875M	possibly damaging	Het
Jkamp	T	C	12: 72,140,919 (GRCm39)		probably null	Het
Kprp	C	T	3: 92,733,020 (GRCm39)	C10Y	probably damaging	Het
Lrig2	A	G	3: 104,401,372 (GRCm39)		probably null	Het
Lrrn3	T	A	12: 41,503,939 (GRCm39)	N126I	probably damaging	Het
Mug1	T	C	6: 121,833,513 (GRCm39)	F325L	probably benign	Het
Nagk	C	T	6: 83,774,249 (GRCm39)	R87*	probably null	Het
Nipal4	T	A	11: 46,052,735 (GRCm39)	I77F	probably damaging	Het
Or4c112	A	G	2: 88,853,490 (GRCm39)	Y286H	probably damaging	Het
Osbp2	T	C	11: 3,769,932 (GRCm39)	H250R	probably damaging	Het
Pcx	T	C	19: 4,657,670 (GRCm39)	V378A	possibly damaging	Het
Pfkp	T	A	13: 6,643,246 (GRCm39)	H524L	probably benign	Het
Picalm	A	T	7: 89,838,406 (GRCm39)	N370I	possibly damaging	Het
Plcl2	A	C	17: 50,914,983 (GRCm39)	D664A	possibly damaging	Het
Ptpn5	G	A	7: 46,732,884 (GRCm39)	P320S	probably benign	Het
Scn3a	T	A	2: 65,356,326 (GRCm39)		probably benign	Het
Sfswap	A	G	5: 129,581,115 (GRCm39)	D96G	possibly damaging	Het
Slfn1	A	G	11: 83,012,096 (GRCm39)	I71V	probably benign	Het
Spata1	A	G	3: 146,181,943 (GRCm39)		probably null	Het
Stx18	T	C	5: 38,262,349 (GRCm39)		probably benign	Het
Suox	T	A	10: 128,507,326 (GRCm39)	H234L	probably benign	Het
Tbc1d17	T	C	7: 44,495,483 (GRCm39)	S114G	probably benign	Het
Tfeb	T	A	17: 48,099,224 (GRCm39)		probably null	Het
Tnks	A	C	8: 35,320,463 (GRCm39)	V736G	probably damaging	Het
Wdhd1	T	C	14: 47,514,045 (GRCm39)	T4A	probably benign	Het

Other mutations in Myadm

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00321:Myadm	APN	7	3,345,739 (GRCm39)	missense	possibly damaging	0.79
IGL01075:Myadm	APN	7	3,345,762 (GRCm39)	missense	probably damaging	1.00
IGL03342:Myadm	APN	7	3,345,403 (GRCm39)	missense	possibly damaging	0.93
R0005:Myadm	UTSW	7	3,346,080 (GRCm39)	nonsense	probably null
R0269:Myadm	UTSW	7	3,345,273 (GRCm39)	missense	unknown
R0413:Myadm	UTSW	7	3,345,276 (GRCm39)	frame shift	probably null
R0666:Myadm	UTSW	7	3,345,865 (GRCm39)	missense	probably damaging	0.98
R3036:Myadm	UTSW	7	3,346,059 (GRCm39)	missense	probably benign
R4275:Myadm	UTSW	7	3,345,618 (GRCm39)	missense	probably benign	0.01
R4606:Myadm	UTSW	7	3,345,916 (GRCm39)	nonsense	probably null
R5764:Myadm	UTSW	7	3,345,768 (GRCm39)	missense	possibly damaging	0.93
R6558:Myadm	UTSW	7	3,345,577 (GRCm39)	missense	probably damaging	1.00
R6835:Myadm	UTSW	7	3,346,192 (GRCm39)	missense	possibly damaging	0.69
R8933:Myadm	UTSW	7	3,345,433 (GRCm39)	missense	probably benign	0.00

Predicted Primers

Posted On

2013-08-19